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Articles 1 - 4 of 4
Full-Text Articles in Nanotechnology
Nanomaterials And Nanotechnologies: Approaching The Crest Of This Big Wave, Vuk Uskoković
Nanomaterials And Nanotechnologies: Approaching The Crest Of This Big Wave, Vuk Uskoković
Pharmacy Faculty Articles and Research
Nanomaterials are typically considered as solid physical structures that comprise grain boundaries at the resolution of less than 100 nanometers, whereby nanotechnologies are depicted as dealing with the design of various applications based on employing the former. Some of the essential features of nanomaterials and the scientific approaches to their investigation are discussed in the course of this work. The real reason for the current scientific and technological interest in the physical effects at nanoscale is linked with the historic trend of refinement of human knowledge and of the corresponding ability to manipulate with the structural patterns of the Universe. …
Three Models Of Anthrax Toxin Effects On The Map-Kinase Pathway And Macrophage Survival, Daniel J. Schneider
Three Models Of Anthrax Toxin Effects On The Map-Kinase Pathway And Macrophage Survival, Daniel J. Schneider
Theses and Dissertations
Lethal factor (LF), a component of anthrax toxin, is the primary virulence factor that allows Bacillus anthracis to evade the immune response by blocking the activation of mitogen-activated protein kinase (MAPK) enzymes. This research modifies three published MAPK models to reflect this signal inhibition and to estimate a first-order reaction rate by fitting the models to published viability data for two macrophage cell lines cultured with the LF-producing Bacillus anthracis-Vollum1B strain. One model appears to be ill-suited for this purpose because not all relevant MAPK components could be integrated into the inhibition equations. Despite different underlying parameters and values, the …
Synthesis Of Multifunctional Nanogels Using A Protected Macromonomer Approach, Neetu Singh, L. Andrew Lyon
Synthesis Of Multifunctional Nanogels Using A Protected Macromonomer Approach, Neetu Singh, L. Andrew Lyon
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Nanoparticles possessing multiple functionalities provide synthetic handles for varied surface chemistries, making them useful for a range of applications such as biotargeting and drug delivery. However, the combination of interfering functionalities on the same particle is often challenging. We have employed a synthetic scheme involving chemical protection/deprotection to combine interfering functional groups on the same hydrogel nanoparticle. The synthesis of amine-containing poly(N-isopropylacrylamide) nanogels was carried out via free radical precipitation polymerization by incorporating a Fmoc-protected amine poly(ethylene glycol) (PEG) macromonomer. The Fmoc group was then removed to obtain free amines, which were shown to be available for conjugation. We further …
Size-Controlled Synthesis Of Monodisperse Core/Shell Nanogels, William H. Blackburn, L. Andrew Lyon
Size-Controlled Synthesis Of Monodisperse Core/Shell Nanogels, William H. Blackburn, L. Andrew Lyon
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Small, monodisperse nanogels (similar to 50-nm radius) were synthesized by free-radical precipitation polymerization and were characterized using a suite of light scattering and chromatography methods. Nanogels were synthesized with either N-isopropylacrylamide or N-isopropylmethacrylamide as the main monomer, with acrylic acid or 4-acrylamidofluorescein as a comonomer and N,N'-methylenebis(acrylamide) as a cross-linker. By varying the surfactant and initiator concentrations, particle size was controlled while maintaining excellent monodispersity. An amine-containing shell was added to these core particles to facilitate subsequent bioconjugation. Successful conjugation of folic acid to the particles was demonstrated as an example of how such materials might be employed in a …