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Articles 2611 - 2640 of 14465

Full-Text Articles in Mental and Social Health

Using A Transitional Care Program To Prepare Patients To Take Care Of Themselves After Leaving The Hospital, Reach Dissemination Committee, Maine, Usa Apr 2024

Using A Transitional Care Program To Prepare Patients To Take Care Of Themselves After Leaving The Hospital, Reach Dissemination Committee, Maine, Usa

REACH: Research Evidence-to-Action for Community Health

Some patients have difficulty caring for themselves after they return home from a hospital stay.


Peer-Navigator Support For Latinx Patients With Serious Mental Illness, Reach Dissemination Committee, Maine, Usa Apr 2024

Peer-Navigator Support For Latinx Patients With Serious Mental Illness, Reach Dissemination Committee, Maine, Usa

REACH: Research Evidence-to-Action for Community Health

People who have a serious mental illness (SMI), are at higher risk for other health problems.


Does A Peer-Led Program With Wellness Coaching Improve Wellness Among People With Serious Mental Illness?, Reach Dissemination Committee Apr 2024

Does A Peer-Led Program With Wellness Coaching Improve Wellness Among People With Serious Mental Illness?, Reach Dissemination Committee

REACH: Research Evidence-to-Action for Community Health

People with serious mental illness, or SMI, such as bipolar disorder or schizophrenia often also have long-term physical health problems.


Hubungan Presepsi Dukungan Sosial Teman Sebaya Dan Supervisor Dengan Tingkat Burnout Mahasiswa Saat Melaksanakan Praktikum : Studi Pada Mahasiswa Ilmu, Zatadini K. Paradasa, Getar Hati Apr 2024

Hubungan Presepsi Dukungan Sosial Teman Sebaya Dan Supervisor Dengan Tingkat Burnout Mahasiswa Saat Melaksanakan Praktikum : Studi Pada Mahasiswa Ilmu, Zatadini K. Paradasa, Getar Hati

Jurnal Ilmu Kesejahteraan Sosial

Students assigned with field practice (practicum) are prone to experiencing burnout. This study focuses on Social Welfare students who are currently undertaking practicum assignments. Burnout conditions can disrupt their social functioning and impacting target groups, institutions, and universities. One factor related to burnout is social support perceived by students. However, there is still minimal research related to burnout and social support among practicum students from social departments in Indonesia. Therefore, this study aims to describe the relationship between social support and burnout. This study uses a quantitative approach with descriptive objectives. The sample in this study was …


Examining Effects Of State Policies To Monitor Mental Health Medicines For Children In Foster Care, Reach Dissemination Committee, Maine, Usa Apr 2024

Examining Effects Of State Policies To Monitor Mental Health Medicines For Children In Foster Care, Reach Dissemination Committee, Maine, Usa

REACH: Research Evidence-to-Action for Community Health

Antipsychotics can have long-term risks but help treat conditions like schizophrenia.


Evaluating A Training Program For Rural Doctors And Nursing Home Staff On Safe Medicine Use For Patients With Dementia And Nursing Home Residents, Reach Dissemination Committee, Maine, Usa Apr 2024

Evaluating A Training Program For Rural Doctors And Nursing Home Staff On Safe Medicine Use For Patients With Dementia And Nursing Home Residents, Reach Dissemination Committee, Maine, Usa

REACH: Research Evidence-to-Action for Community Health

Program goal: Reduce unnecessary use of certain medications without worsening symptoms


Behavioral Health Integration And Outcomes That Matter To Patients: A Longitudinal Mixed-Methods Observational Study, Reach Dissemination Committee, Maine, Usa Apr 2024

Behavioral Health Integration And Outcomes That Matter To Patients: A Longitudinal Mixed-Methods Observational Study, Reach Dissemination Committee, Maine, Usa

REACH: Research Evidence-to-Action for Community Health

The study team hypothesized that patients would have a better experience over time in clinics that had greater degrees of behavioral health integration.


Understanding University Support For Suicide Bereavement And Bereaved Experiences: A Phenomenological Study, Kristin May Anderson, Neishamia B. Kayizzi, Brittany M. Lee, Addalee K. Lyon Apr 2024

Understanding University Support For Suicide Bereavement And Bereaved Experiences: A Phenomenological Study, Kristin May Anderson, Neishamia B. Kayizzi, Brittany M. Lee, Addalee K. Lyon

LMU Theses and Dissertations

In recent years, a multitude of literature have discussed the turbulent nature for young adults to navigate the difficulties of suicide bereavement with lack of support. This experience can be further cumbersome when the bereavement is co-occurring within an academic profession, such as attending university. This study explored three participants experience of suicide bereavement support at a university level, utilizing a phenomenological arts-based approach for inquiry. Data analysis revealed eight common themes that reflect the university students' lived experiences of the phenomenon discussed: Acknowledgment of the communicated loss by faculty, provision of academic support, lack/absence of practice, reluctance, emotional response, …


Willingness To Utilize A Mobile Treatment Unit In Five Counties At The Epicenter Of The Us Rural Opioid Epidemic., Snigdha R. Peddireddy, Melvin D. Livingston Iii, April M. Young, Patricia R. Freeman, Umedjon Ibragimov, Kelli A. Komro, Michelle R. Lofwall, Carrie B. Oser, Michele Staton, Hannah L. F. Cooper Apr 2024

Willingness To Utilize A Mobile Treatment Unit In Five Counties At The Epicenter Of The Us Rural Opioid Epidemic., Snigdha R. Peddireddy, Melvin D. Livingston Iii, April M. Young, Patricia R. Freeman, Umedjon Ibragimov, Kelli A. Komro, Michelle R. Lofwall, Carrie B. Oser, Michele Staton, Hannah L. F. Cooper

Epidemiology and Environmental Health Faculty Publications

INTRODUCTION: US federal policies are evolving to expand the provision of mobile treatment units (MTUs) offering medications for opioid use disorder (MOUD). Mobile MOUD services are critical for rural areas with poor geographic access to fixed-site treatment providers. This study explored willingness to utilize an MTU among a sample of people who use opioids in rural Eastern Kentucky counties at the epicenter of the US opioid epidemic.

METHODS: The study analyzed Cross-sectional survey data from the Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE) study covering five rural counties in the state. Logistic regression models investigated the …


Acceso A La Salud De Mujeres Migrantes Venezolanas En La Ciudad Autónoma De Buenos Aires (2024) / Female Venezuelan Migrants’ Access To Healthcare In Autonomous City Of Buenos Aires (2024), Karen Gonzalez Apr 2024

Acceso A La Salud De Mujeres Migrantes Venezolanas En La Ciudad Autónoma De Buenos Aires (2024) / Female Venezuelan Migrants’ Access To Healthcare In Autonomous City Of Buenos Aires (2024), Karen Gonzalez

Independent Study Project (ISP) Collection

Esta investigación se enfoca en indagar y describir el acceso al sector de salud en la población de mujeres migrantes venezolanas con trabajos como monotributistas que residen en la Ciudad Autónoma de Buenos Aires (CABA). En la última década, Venezuela se ha enfrentado a una crisis económica y humanitaria. Esta crisis ha provocado una ola de migración sin precedentes por todo el mundo. Dentro del Cono Sur, Argentina se cataloga como el sexto país receptor de migrantes venezolanos. Considerando las leyes de migración y el sistema de salud universal en Argentina, me propuse describir las barreras de acceso a la …


A Manualized Occupational Therapy Communication Skills Module For Clients With Ptsd, Lacey Kinard, Steven M. Gerardi Apr 2024

A Manualized Occupational Therapy Communication Skills Module For Clients With Ptsd, Lacey Kinard, Steven M. Gerardi

Spring 2024 Virtual OTD Capstone Symposium

Individuals with post-traumatic stress disorder (PTSD) experience a variety of barriers and challenges that impact their daily occupational performance, engagement, well-being, and quality of life. There is a lack of research in the area of manualized occupational therapy (OT) treatment options for people with PTSD. Literature has expressed a need for the development of a manual-based OT treatment program for people with PTSD with communication skills training as an intervention component. The purpose of this project is to create a manualized OT communication skills intervention module for occupational therapists to implement with clients with PTSD for improved occupational performance and …


Occupational Therapy For People With Dementia Who Have Occupational Performance Challenges Due To Depression, Ally Frazier, Steven M. Gerardi Apr 2024

Occupational Therapy For People With Dementia Who Have Occupational Performance Challenges Due To Depression, Ally Frazier, Steven M. Gerardi

Spring 2024 Virtual OTD Capstone Symposium

Individuals with dementia experience a multitude of barriers and challenges that impact their daily engagement throughout the environment. In addition, although the pandemic has concluded, noxious effects are still influencing people's lives. Residential care facilities have noticed continual acts of isolation that are presenting as barriers in mental health. Depression has known to be a common comorbidity in the ailment of dementia. Occupational therapy (OT) practitioners have the unique and valuable role in working with this population to target beyond the biomechanical aspects of a resident. Identifying barriers for mastery in leisure pursuits throughout someone’s day is crucial. When residents …


Reciprocal Relationships Between Stress And Depressive Symptoms: The Essential Role Of The Nucleus Accumbens, Yizhou Ma, Peter Kochunov, Mark D Kvarta, Tara Legates, Bhim M Adhikari, Joshua Chiappelli, Andrew Van Der Vaart, Eric L Goldwaser, Heather Bruce, Kathryn S Hatch, Si Gao, Shuo Chen, Ann Summerfelt, Thomas E Nichols, L Elliot Hong Apr 2024

Reciprocal Relationships Between Stress And Depressive Symptoms: The Essential Role Of The Nucleus Accumbens, Yizhou Ma, Peter Kochunov, Mark D Kvarta, Tara Legates, Bhim M Adhikari, Joshua Chiappelli, Andrew Van Der Vaart, Eric L Goldwaser, Heather Bruce, Kathryn S Hatch, Si Gao, Shuo Chen, Ann Summerfelt, Thomas E Nichols, L Elliot Hong

Faculty, Staff and Student Publications

BACKGROUND: Stress and depression have a reciprocal relationship, but the neural underpinnings of this reciprocity are unclear. We investigated neuroimaging phenotypes that facilitate the reciprocity between stress and depressive symptoms.

METHODS: In total, 22 195 participants (52.0% females) from the population-based UK Biobank study completed two visits (initial visit: 2006-2010, age = 55.0 ± 7.5 [40-70] years; second visit: 2014-2019; age = 62.7 ± 7.5 [44-80] years). Structural equation modeling was used to examine the longitudinal relationship between self-report stressful life events (SLEs) and depressive symptoms. Cross-sectional data were used to examine the overlap between neuroimaging correlates of SLEs and …


A Scoping Review Of The Literature On The Application And Usefulness Of The Problem Management Plus (Pm+) Intervention Around The World, Patrick Nzivo Mwangala, Anita Kerubo, Moses Nyongesa, Amina Abubakar Apr 2024

A Scoping Review Of The Literature On The Application And Usefulness Of The Problem Management Plus (Pm+) Intervention Around The World, Patrick Nzivo Mwangala, Anita Kerubo, Moses Nyongesa, Amina Abubakar

Institute for Human Development, East Africa

Background: Given the high rates of common mental disorders and limited resources, task-shifting psychosocial interventions are needed to provide adequate care. One such intervention developed by the World Health Organization is Problem Management Plus (PM+).

Aims: This review maps the evidence regarding the extent of application and usefulness of the PM+ intervention, i.e. adaptability, feasibility, effectiveness and scalability, since it was introduced in 2016.

Method: We conducted a scoping review of seven literature databases and grey literature from January 2015 to February 2024, to identify peer-reviewed and grey literature on PM+ around the world.

Results: Out of 6739 potential records, …


Tavr In Older Adults, Abdulla A Damluji, Gwen Bernacki, Jonathan Afilalo, Radmila Lyubarova, Ariela R Orkaby, Min Ji Kwak, Scott Hummel, James N Kirkpatrick, Mathew S Maurer, Nanette Wenger, Michael W Rich, Dae Hyun Kim, Roberta Y Wang, Daniel E Forman, Ashok Krishnaswami Apr 2024

Tavr In Older Adults, Abdulla A Damluji, Gwen Bernacki, Jonathan Afilalo, Radmila Lyubarova, Ariela R Orkaby, Min Ji Kwak, Scott Hummel, James N Kirkpatrick, Mathew S Maurer, Nanette Wenger, Michael W Rich, Dae Hyun Kim, Roberta Y Wang, Daniel E Forman, Ashok Krishnaswami

Faculty, Staff and Student Publications

Calcific aortic stenosis can be considered a model for geriatric cardiovascular conditions due to a confluence of factors. The remarkable technological development of transcatheter aortic valve replacement was studied initially on older adult populations with prohibitive or high-risk for surgical valve replacement. Through these trials, the cardiovascular community has recognized that stratification of these chronologically older adults can be improved incrementally by invoking the concept of frailty and other geriatric risks. Given the complexity of the aging process, stratification by chronological age should only be the initial step but is no longer sufficient to optimally quantify cardiovascular and noncardiovascular risk. …


Comparison Of Perceived Stress In First-Year Pre-Med Students And First-Year Medical Students At Usd, Maggie Derner Apr 2024

Comparison Of Perceived Stress In First-Year Pre-Med Students And First-Year Medical Students At Usd, Maggie Derner

Honors Thesis

Stress can be caused by many factors, including money, relationships, promotions, grades, and responsibilities. In college, these stressors can be exacerbated. This research dives into stress in both undergraduate students as well as medical students. Previous literature has indicated that high levels of stress are present in students, and it is likely to have negative effects on the students, whether that is their mental or physical well-being. Schools have put interventions in place to help combat the stress levels present in their students. At the University of South Dakota (USD) and USD Sanford School of Medicine (USD SSOM), perceived stress …


Evaluation Of Dietary Probiotic Supplements On Methamphetamine-Induced Impulsive Action In Rats Maintained On A Differential Reinforcement Of Low Rate Schedule, Kaitlyn Steck Apr 2024

Evaluation Of Dietary Probiotic Supplements On Methamphetamine-Induced Impulsive Action In Rats Maintained On A Differential Reinforcement Of Low Rate Schedule, Kaitlyn Steck

Masters Theses

Substance Use Disorder (SUD) is a chronic, debilitating condition often comorbid with anxiety and depression. Both SUD and affective disorders are characterized by cognitive dysfunction, including impaired decision-making and impulsivity. A mounting body of research implicates gut microbiome alterations as a contributing factor to the pathophysiology of affective disorders. No published studies have assessed behavioral effects of dietary interventions targeting psychostimulant-induced gut microbiome changes. The present study utilized a differential reinforcement of low rate responding schedule (DRL 18 s) as a behavioral index of drug-induced impulsive action to determine if a dietary probiotic supplement alters the behavioral effects of (+)-methamphetamine …


The New Professional: Prioritize Self-Care To Avoid Burnout, Amrita Patel Dds Apr 2024

The New Professional: Prioritize Self-Care To Avoid Burnout, Amrita Patel Dds

The Journal of the Michigan Dental Association

In this inaugural column, “The New Dentist”, Dr. Amrita Patel shares her journey of recognizing and combating burnout in dentistry. She emphasizes the importance of self-care, boundary-setting, delegation, and seeking support. By prioritizing these strategies, professionals can safeguard their well-being, enhance job satisfaction, and deliver quality patient care without falling victim to burnout's detrimental effects.


Imaging In The Fitness Industry: A Connection To Body Dysmorphic Disorder In Women, Joseliz Andujar Pimentel Apr 2024

Imaging In The Fitness Industry: A Connection To Body Dysmorphic Disorder In Women, Joseliz Andujar Pimentel

Posters - 2024

Body Dysmorphic Disorder (BDD) is a psychiatric illness characterized by distress and excessive preoccupation with perceived defects in physical appearance that are not at all, or only slightly, observable to others (American Psychiatric Association, 2013). BDD can be found in many individuals; among these individuals are women in the fitness industry. This is due to the idea that there is an “ideal” body image portrayed by fitness industries that provoke women to compare themselves. This study examined a variety of fitness websites consisting of fitness apparel websites and fitness websites, where the models used in each website were examined for …


Use Of Mobile Technology To Identify Behavioral Mechanisms Linked To Mental Health Outcomes In Kenya: Protocol For Development And Validation Of A Predictive Model, Willie Njoroge, Rachel Maina, Frank Elena, Lukoye Atwoli, Anthony Ngugi, Srijan Sen, Stephen Wong, Linda Khakali, Andrew Aballa, James Orwa, Moses Nyongesa, Jasmit Shah, Amina Abubakar, Zul Merali Apr 2024

Use Of Mobile Technology To Identify Behavioral Mechanisms Linked To Mental Health Outcomes In Kenya: Protocol For Development And Validation Of A Predictive Model, Willie Njoroge, Rachel Maina, Frank Elena, Lukoye Atwoli, Anthony Ngugi, Srijan Sen, Stephen Wong, Linda Khakali, Andrew Aballa, James Orwa, Moses Nyongesa, Jasmit Shah, Amina Abubakar, Zul Merali

Brain and Mind Institute

Objective:This study proposes to identify and validate weighted sensor stream signatures that predict near-term risk of a major depressive episode and future mood among healthcare workers in Kenya.

Approach: The study will deploy a mobile application (app) platform and use novel data science analytic approaches (Artificial Intelligence and Machine Learning) to identifying predictors of mental health disorders among 500 randomly sampled healthcare workers from five healthcare facilities in Nairobi, Kenya.

Expectation: This study will lay the basis for creating agile and scalable systems for rapid diagnostics that could inform precise interventions for mitigating depression and ensure a healthy, resilient …


Kajian Literatur Distribusi Kompensasi Dampak Tempat Pengelolahan Sampah Terpadu (Tpst) Bantargebang: Analisis Keadilan Distributif Dan Keadilan Sosial, Wahyu Pratama Tamba Apr 2024

Kajian Literatur Distribusi Kompensasi Dampak Tempat Pengelolahan Sampah Terpadu (Tpst) Bantargebang: Analisis Keadilan Distributif Dan Keadilan Sosial, Wahyu Pratama Tamba

Jurnal Ilmu Kesejahteraan Sosial

The waste problem in Jakarta is a complex issue related to the large volume of waste, dependence on Bantargebang TPST, and the various environmental impacts caused. Waste from Jakarta brought to Bantargebang TPST reaches 6,500-7,000 tons daily. This TPST hurts the environment and the health of the surrounding community, as well as the risk of ARI, air pollution, groundwater pollution, and environmental aesthetics. As compensation for these negative impacts, the DKI Jakarta Provincial Government allocates compensation funds for affected communities. This is regulated in Article 10 letter (e) of DKI Jakarta Regional Regulation number 4 of 2019 which states that …


Telaah Konsep Asset Bassed Comunity Development Bagi Pembangunan Pariwisata Berbasis Masyarakat, Silva Amanda, Rudi Saprudin Darwis Apr 2024

Telaah Konsep Asset Bassed Comunity Development Bagi Pembangunan Pariwisata Berbasis Masyarakat, Silva Amanda, Rudi Saprudin Darwis

Jurnal Ilmu Kesejahteraan Sosial

The tourism sector is one of the sectors that contributes the largest foreign exchange in Indonesia. To develop this, the Ministry of Tourism and Creative Economy continues to encourage the community-based tourism industry, with one of them developing a tourist village program. One way to realize the tourist village program in Indonesia is to use the Asset Based Community Development approach by emphasizing the use of potential assets owned by an area. The purpose of this research is to identify the potential or assets that exist in a village/region that can be developed into a tourist village by emphasizing community …


Effects Of The Communities That Heal (Cth) Intervention On Perceived Opioid-Related Community Stigma In The Healing Communities Study: Results Of A Multi-Site, Community-Level, Cluster-Randomized Trial, Alissa Davis, Hannah K. Knudsen, Daniel M. Walker, Deborah Chassler, Karsten Lunze, Philip M. Westgate, Emmanuel Oga, Sandra Rodriguez, Sylvia Tan, Janae Holloway, Sharon L. Walsh, Carrie B. Oser, R. Craig Lefebvre, Laura C. Fanucchi, Lashawn Glasgow, Ann Scheck Mcalearney, Hilary L. Surratt, Michael W. Konstan, Terry T-K Huang, Patricia Lebaron, Julie Nakayima, Michael D. Stein, Maria Rudorf, Monica Nouvong, Elizabeth N. Kinnard, Nabila El-Bassel, Jess Tilley, Aaron Macoubray, Caroline Savitzky, Amy Farmer, Donna Beers, Pamela Salsberry, Timothy R. Huerta Apr 2024

Effects Of The Communities That Heal (Cth) Intervention On Perceived Opioid-Related Community Stigma In The Healing Communities Study: Results Of A Multi-Site, Community-Level, Cluster-Randomized Trial, Alissa Davis, Hannah K. Knudsen, Daniel M. Walker, Deborah Chassler, Karsten Lunze, Philip M. Westgate, Emmanuel Oga, Sandra Rodriguez, Sylvia Tan, Janae Holloway, Sharon L. Walsh, Carrie B. Oser, R. Craig Lefebvre, Laura C. Fanucchi, Lashawn Glasgow, Ann Scheck Mcalearney, Hilary L. Surratt, Michael W. Konstan, Terry T-K Huang, Patricia Lebaron, Julie Nakayima, Michael D. Stein, Maria Rudorf, Monica Nouvong, Elizabeth N. Kinnard, Nabila El-Bassel, Jess Tilley, Aaron Macoubray, Caroline Savitzky, Amy Farmer, Donna Beers, Pamela Salsberry, Timothy R. Huerta

Behavioral Science Faculty Publications

BACKGROUND: Community stigma against people with opioid use disorder (OUD) and intervention stigma (e.g., toward naloxone) exacerbate the opioid overdose crisis. We examined the effects of the Communities that HEAL (CTH) intervention on perceived opioid-related community stigma by stakeholders in the HEALing Communities Study (HCS).

METHODS: We collected three surveys from community coalition members in 66 communities across four states participating in HCS. Communities were randomized into Intervention (Wave 1) or Wait-list Control (Wave 2) arms. We conducted multilevel linear mixed models to compare changes in primary outcomes of community stigma toward people treated for OUD, naloxone, and medication for …


Balancing Wellness And Leadership: Exploring Black Women Administrators’ Subjective Well-Being, Resilience, And Radical Self-Care In Higher Education, Lashae Grottis Apr 2024

Balancing Wellness And Leadership: Exploring Black Women Administrators’ Subjective Well-Being, Resilience, And Radical Self-Care In Higher Education, Lashae Grottis

Electronic Theses and Dissertations

Leaders in higher education experience high and unrealistic demands for their skills, time, and energy, causing stress, competing priorities, burnout, compromised health, and attrition. However, unlike other racial and gender groups, Black women higher education administrators experienced these challenges more intensely. As a result of chronic stress associated with being undervalued and overworked, discriminatory and unwelcoming workplaces, and intersectional biases, Black women leaders are leaving higher education workplaces. Despite the link between gendered racism and unwellness, little is known about the problem from a positive leadership perspective. This study addressed the lack of knowledge of the wellness strategies Black women …


The Moderating Effects Of Hiv Relevant Factors On The Relationship Between Intimate Partner Violence And Intention To Start Hiv Pre-Exposure Prophylaxis (Prep) Among Cisgender Women, Shimrit Keddem, Victoria Frye, Annet Davis, Beryl A Koblin, Hong-Van Tieu, Rachele K Lipsky, Vijay Nandi, Anne M Teitelman Apr 2024

The Moderating Effects Of Hiv Relevant Factors On The Relationship Between Intimate Partner Violence And Intention To Start Hiv Pre-Exposure Prophylaxis (Prep) Among Cisgender Women, Shimrit Keddem, Victoria Frye, Annet Davis, Beryl A Koblin, Hong-Van Tieu, Rachele K Lipsky, Vijay Nandi, Anne M Teitelman

Faculty, Staff and Students Publications

Background:

Intimate partner violence (IPV) and HIV are serious and related public health problems that detrimentally impact women’s health. Because women who experience IPV are more likely to acquire HIV, it is critical to promote HIV prevention strategies, such as HIV pre-exposure prophylaxis (PrEP), that increase autonomy.

Setting:

This study of cis-gender women eligible for HIV PrEP took place between 2017 and 2019 in Philadelphia and New York City.

Methods:

This study aimed to examine the relationship between four types of IPV (control, psychological, psychological, physical, sexual) and intention to start PrEP among PrEP-eligible cisgender women; and assess the extent …


Virtual Multi-Institutional Tumor Board: A Strategy For Personalized Diagnoses And Management Of Rare Cns Tumors, James L Rogers, Thomas Wall, Alvina A Acquaye-Mallory, Lisa Boris, Yeonju Kim, Kenneth Aldape, Martha M Quezado, John A Butman, James G Smirniotopoulos, Huma Chaudhry, Christina I Tsien, Prashant Chittiboina, Kareem Zaghloul, Orwa Aboud, Nicholas G Avgeropoulos, Eric C Burton, David M Cachia, Karan S Dixit, Jan Drappatz, Erin M Dunbar, Peter Forsyth, Edina Komlodi-Pasztor, Jacob Mandel, Byram H Ozer, Eudocia Q Lee, Surabhi Ranjan, Rimas V Lukas, Margarita Raygada, Michael E Salacz, Matthew A Smith-Cohn, James Snyder, Ariane Soldatos, Brett J Theeler, Brigitte C Widemann, Kevin A Camphausen, John D Heiss, Terri S Armstrong, Mark R Gilbert, Marta Penas-Prado Apr 2024

Virtual Multi-Institutional Tumor Board: A Strategy For Personalized Diagnoses And Management Of Rare Cns Tumors, James L Rogers, Thomas Wall, Alvina A Acquaye-Mallory, Lisa Boris, Yeonju Kim, Kenneth Aldape, Martha M Quezado, John A Butman, James G Smirniotopoulos, Huma Chaudhry, Christina I Tsien, Prashant Chittiboina, Kareem Zaghloul, Orwa Aboud, Nicholas G Avgeropoulos, Eric C Burton, David M Cachia, Karan S Dixit, Jan Drappatz, Erin M Dunbar, Peter Forsyth, Edina Komlodi-Pasztor, Jacob Mandel, Byram H Ozer, Eudocia Q Lee, Surabhi Ranjan, Rimas V Lukas, Margarita Raygada, Michael E Salacz, Matthew A Smith-Cohn, James Snyder, Ariane Soldatos, Brett J Theeler, Brigitte C Widemann, Kevin A Camphausen, John D Heiss, Terri S Armstrong, Mark R Gilbert, Marta Penas-Prado

Faculty, Staff and Students Publications

PURPOSE: Multidisciplinary tumor boards (MTBs) integrate clinical, molecular, and radiological information and facilitate coordination of neuro-oncology care. During the COVID-19 pandemic, our MTB transitioned to a virtual and multi-institutional format. We hypothesized that this expansion would allow expert review of challenging neuro-oncology cases and contribute to the care of patients with limited access to specialized centers.

METHODS: We retrospectively reviewed records from virtual MTBs held between 04/2020-03/2021. Data collected included measures of potential clinical impact, including referrals to observational or therapeutic studies, referrals for specialized neuropathology analysis, and whether molecular findings led to a change in diagnosis and/or guided management …


Neural And Behavioural State Switching During Hippocampal Dentate Spikes, Jordan S Farrell, Ernie Hwaun, Barna Dudok, Ivan Soltesz Apr 2024

Neural And Behavioural State Switching During Hippocampal Dentate Spikes, Jordan S Farrell, Ernie Hwaun, Barna Dudok, Ivan Soltesz

Faculty, Staff and Students Publications

Distinct brain and behavioural states are associated with organized neural population dynamics that are thought to serve specific cognitive functions13. Memory replay events, for example, occur during synchronous population events called sharp-wave ripples in the hippocampus while mice are in an ‘offline’ behavioural state, enabling cognitive mechanisms such as memory consolidation and planning411. But how does the brain re-engage with the external world during this behavioural state and permit access to current sensory information or promote new memory formation? Here we found that the hippocampal dentate spike, an understudied population event that …


Novel Approach To Difficult Spinal Reconstruction: Bilateral Simultaneous Rib And Iliac Crest Vascularized Bone Graft Spinoplastic Surgery, Maria Shvedova, Isra Abdulwadood, Daniel M Vernik, Max A Shrout, Jonathan L Jeger, Dylon C Buchanan, Alexander Ropper, Sebastian Winocour, Michael Bohl, Maziyar A Kalani, Edward M Reece Apr 2024

Novel Approach To Difficult Spinal Reconstruction: Bilateral Simultaneous Rib And Iliac Crest Vascularized Bone Graft Spinoplastic Surgery, Maria Shvedova, Isra Abdulwadood, Daniel M Vernik, Max A Shrout, Jonathan L Jeger, Dylon C Buchanan, Alexander Ropper, Sebastian Winocour, Michael Bohl, Maziyar A Kalani, Edward M Reece

Faculty, Staff and Students Publications

Pseudoarthrosis is a severe complication of spinal fusion surgery with occurrence rates as high as 35%-40%. Current options of revision surgery to correct pseudoarthrosis frequently carry high failure rates and risk of developing junctional kyphosis. Pedicled vascularized bone grafts (VBGs) are an innovative approach to boost spinal fusion rates via improving structural integrity and increasing the delivery of blood to the donor site. This versatile technique can be performed at different spinal levels without additional skin incisions and with minimal added operative time. Here we present the first bilateral rib and iliac crest VBG spinoplastic surgery performed to augment spinal …


Sphingosine-1-Phosphate Inhibition Increases Endoplasmic Reticulum Stress To Enhance Oxaliplatin Sensitivity In Pancreatic Cancer, Zachary Gao, Harinarayanan Janakiraman, Yang Xiao, Sung Wook Kang, Jiangling Dong, Jasmine Choi, Besim Ogretmen, Hyun-Sung Lee, Ernest Ramsay Camp Apr 2024

Sphingosine-1-Phosphate Inhibition Increases Endoplasmic Reticulum Stress To Enhance Oxaliplatin Sensitivity In Pancreatic Cancer, Zachary Gao, Harinarayanan Janakiraman, Yang Xiao, Sung Wook Kang, Jiangling Dong, Jasmine Choi, Besim Ogretmen, Hyun-Sung Lee, Ernest Ramsay Camp

Faculty, Staff and Students Publications

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer resistant to current therapies, including oxaliplatin (Oxa). Growing evidence supports the ability of cancers to harness sphingolipid metabolism for survival. Sphingosine-1-phosphate (S1P) is an anti-apoptotic, pro-survival mediator that can influence cellular functions such as endoplasmic reticulum (ER) stress. We hypothesize that PDAC drives dysregulated sphingolipid metabolism and that S1P inhibition can enhance ER stress to improve therapeutic response to Oxa in PDAC.

METHODS: RNA sequencing data of sphingolipid mediators from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression Project (GTEx) datasets were analyzed. Murine and human PDAC cell lines were treated …


The Role Of Between-Session Homework In Cognitive-Behavioral Therapy For Comorbid Obsessive-Compulsive Disorder And Autism: A Case Vignette, Molly J Church, Katie H Mangen, Jordan T Stiede, Samuel D Spencer, Eric A Storch Apr 2024

The Role Of Between-Session Homework In Cognitive-Behavioral Therapy For Comorbid Obsessive-Compulsive Disorder And Autism: A Case Vignette, Molly J Church, Katie H Mangen, Jordan T Stiede, Samuel D Spencer, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

Objective: Cognitive-behavioral therapy (CBT), which includes a decided emphasis on exposure and response/ritual prevention (ERP) and between-session practice of treatment principles, has consistently demonstrated efficacy for the treatment of obsessive-compulsive disorder (OCD) and is a gold standard, recommended first-line treatment. CBT with ERP has been successfully adapted to fit the needs of autistic individuals with OCD. The present article provides a brief overview of CBT for OCD and outlines special considerations and adaptations needed when working with patients with OCD and comorbid autism, with an emphasis on the importance of between-session homework.

Method: A case vignette is presented.

Results: This …