Mental and Social Health Commons^™

Therapeutic Decisions And Implications In Patients With Attention Deficit Hyperactivity Disorder Versus Bipolar Disorder: Key Insights For Clinicians, Ngozi Adaralegbe, Ayotomide Oyelakin, Omobusayo Omotayo

Faculty, Staff and Student Publications

Attention deficit hyperactivity disorder (ADHD) and pediatric bipolar disorder (BD) are conditions that often manifest in childhood and can persist into adulthood. Due to the similarities in their clinical presentations, it is crucial for clinicians to have a thorough understanding of these disorders. Accurate differentiation of symptoms is essential for making precise diagnoses, as this directly influences treatment decisions and affects the overall functioning and quality of life of those impacted. Considered here is the case of a teenage male who initially presented with impulsivity and was diagnosed with ADHD. However, upon further evaluation, his diagnosis was revised to BD. …

A Culturally Responsive Approach To Mindfulness And Mental Health Informal Education, Anastasia Jerbic-Gonzalez

UNLV Theses, Dissertations, Professional Papers, and Capstones

The qualitative study examined the mental health aspects of marginalized elementary school students in addition to constructing and implementing a culturally responsive and sustaining mindfulness program to observe if there were improvements regarding emotional regulation and awareness. To achieve this, I constructed a culturally responsive and sustaining mindfulness program, implemented this program, and studied the responses from students. The research questions that fueled this study include: (1) What types of negative emotions do marginalized elementary students experience? What is the root cause for marginalized students experiencing negative emotions during their elementary school years? (2) How can incorporating mindfulness techniques embedded …

Engagement And Retention Of College Students With Anxiety And Depressive Symptoms In A Digital Mental Health Intervention Using A Brief Peer Support Model, Emily A. Kline

Theses, Dissertations and Culminating Projects

Digital mental health interventions (DMHIs) show promise in improving access to mental health care for college students suffering from depression and anxiety symptoms. Nonetheless, the usefulness of DMHIs is limited by high user attrition. Leveraging peer support among college populations may be a feasible and cost-effective option to improve DMHI engagement and improve mental health outcomes. This open pilot study evaluated the feasibility, acceptability, and initial efficacy of a skill-based peer support group in enhancing user engagement in a DMHI for depression and anxiety symptoms. Participants were 20 undergraduate students at a university in New Jersey with elevated depression and …

Poly (Adp-Ribose) Polymerase-1 (Parp1) Expression In The Frontal Cortex And Hippocampus In Major Depressive Disorder (Mdd) And Suicide, Ramona Faith Fulkerson

Electronic Theses and Dissertations

Major Depressive Disorder (MDD) is a prevalent psychiatric disorder that has a complex pathophysiology. In this study we evaluate the expression of PARP1 and the downstream alarmin protein high mobility group box 1 (HMGB1) in two brain areas that have demonstrated pathology in MDD. MDD donors were compared to controls. MDD subgroups that died by suicide were also compared to those that did not die by suicide. Immunoblotting to determine PARP1 and HMGB1 protein expression was performed in white and grey matter from the frontal cortex and the hippocampus. In BA10 white and grey matter, PARP1 protein expression was significantly …

Comparative Effectiveness Research Trial For Antidepressant Incomplete And Non-Responders With Treatment Resistant Depression (Ascertain-Trd) A Randomized Clinical Trial, George I Papakostas, Madhukar H Trivedi, Richard C Shelton, Dan V Iosifescu, Michael E Thase, Manish K Jha, Sanjay J Mathew, Charles Debattista, Mehmet E Dokucu, Olga Brawman-Mintzer, Glenn W Currier, William Vaughn Mccall, Mandana Modirrousta, Matthew Macaluso, Alexander Bystritsky, Fidel Vila Rodriguez, Erik B Nelson, Albert S Yeung, Anna Feeney, Leslie C Macgregor, Thomas Carmody, Maurizio Fava

Staff and Researcher Publications

Further research is needed to help improve both the standard of care and the outcome for patients with treatment-resistant depression. A particularly critical evidence gap exists with respect to whether pharmacological or non-pharmacological augmentation is superior to antidepressant switch, or vice-versa. The objective of this study was to compare the effectiveness of augmentation with aripiprazole or repetitive transcranial magnetic stimulation versus switching to the antidepressant venlafaxine XR (or duloxetine for those not eligible to receive venlafaxine) for treatment-resistant depression. In this multi-site, 8-week, randomized, open-label study, 278 subjects (196 females and 82 males, mean age 45.6 years (SD 15.3)) with …

Stricken By The Worst Type Of Sickness: The Communal Reaction And Response To Impaired Individuals In The Middle Ages, Alice Holland

Dissertations and Theses

Medieval communities often approached trouble within the fold collectively. This includes concerns over the health and safety of their individual members. This thesis examines the communal perception and treatment of disabled individuals in the Middle Ages. Using four twelfth-century miracle collections, The Miracles of Saint Gibrian (1145), The Life and Miracles of William of Norwich (1150-1172), The Miracles of Our Lady of Rocamadour (1172-1173), and The Miracles of Thomas Becket (1173-1179), I examine how communities created systems of care for their impaired members. In using these sources, which tell the stories of common individuals traveling to shrines for a saint's …

Safer: Sub-Hypergraph Attention-Based Neural Network For Predicting Effective Responses To Dose Combinations, Yi-Ching Tang, Rongbin Li, Jing Tang, W Jim Zheng, Xiaoqian Jiang

Faculty, Staff and Student Publications

BACKGROUND: The potential benefits of drug combination synergy in cancer medicine are significant, yet the risks must be carefully managed due to the possibility of increased toxicity. Although artificial intelligence applications have demonstrated notable success in predicting drug combination synergy, several key challenges persist: (1) Existing models often predict average synergy values across a restricted range of testing dosages, neglecting crucial dose amounts and the mechanisms of action of the drugs involved. (2) Many graph-based models rely on static protein-protein interactions, failing to adapt to dynamic and higher-order relationships. These limitations constrain the applicability of current methods.

RESULTS: We introduce …

Application Of An Opioid Risk Assessment Tool For Patients With Pain Presenting To The Emergency Department With Drug-Seeking Behaviors, Darian L. Stephens

Doctor of Nursing Practice Final Project Abstract

PURPOSE The purpose of this quality improvement project was to introduce the Screener and Opioid Assessment for Patients with Pain- Revised (SOAPP-R) tool to identify patients in the emergency department (ED) at risk for opioid abuse.

BACKGROUND The project was implemented in a 13-bed freestanding ED that can treat medical emergencies as well as provide substance abuse detoxification services.

METHODOLOGY A systematic approach that combined quantitative and qualitative data was used during the pre-implementation and implementation periods. The clinical staff was educated on the process of implementing the SOAPP-R tool. Those who were identified as at risk for opioid abuse …

The College Campus, A Place Of Learning, And A Place Of Healing, Huma Bashir, Joshua Francis

Human Services Faculty Publications

The COVID-19 pandemic and its aftermath have precipitated a marked increase in mental health needs among college students. Lockdowns, the sudden shift to remote learning, and social distancing mandates have compounded existing challenges, highlighting a trend that has evolved over the past two decades. Despite heightened demand for mental health support, colleges struggle to meet these needs amid the emotional aftermath of COVID-19 effectively. Recognizing the pivotal role of higher education institutions in shaping future leaders and addressing and enhancing the mental well-being of the college community is imperative to foster an environment conducive to learning and healing. This paper …

Graduate Healthcare Students' Mental Health: A Pilot Study, Soriya S. Ung-Koy, Lindsay Gietzen

Pacific Journal of Health

This pilot study investigates the mental health of healthcare professional doctoral students, focusing on stress, anxiety, and depression, which can lead to burnout. These students are responsible for intense academic demands, personal lives, and professional careers.

This study explored student mental health in the Doctor of Medical Science (DMSc)/ Doctor of Health Science (DHSc) programs at the University of the Pacific's School of Health Sciences. The study contributes to existing literature, exploring how educational experiences impact healthcare students' mental health, behaviors, and symptoms.

The DASS-21 survey tool was utilized to assess anxiety, depression, and stress symptoms during their graduate studies. …

Self-Harm In Female Youth With Undiagnosed Adhd: Implementing American Academy Of Pediatrics Screening Guidelines, Roselie M. Woodard

Dissertations

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. If undiagnosed or untreated, ADHD can lead to severe psychosocial issues such as academic failure, substance abuse, unplanned pregnancy, and incarceration. The financial burden in the U.S. from diagnostic errors creates an immense, rising fiscal impact. Early diagnosis and management are crucial to prevent these complications.

Females with ADHD, particularly those with the inattentive subtype, often face diagnostic challenges due to symptom masking and over-compensation. This results in poorer cognitive functioning and self-esteem compared to males with ADHD. ADHD is linked to autonomic nervous …

Prediction Of Mild Cognitive Impairment Status: Pilot Study Of Machine Learning Models Based On Longitudinal Data From Fitness Trackers, Qidi Xu, Yejin Kim, Karen Chung, Paul Schulz, Assaf Gottlieb

Faculty, Staff and Student Publications

BACKGROUND: Early signs of Alzheimer disease (AD) are difficult to detect, causing diagnoses to be significantly delayed to time points when brain damage has already occurred and current experimental treatments have little effect on slowing disease progression. Tracking cognitive decline at early stages is critical for patients to make lifestyle changes and consider new and experimental therapies. Frequently studied biomarkers are invasive and costly and are limited for predicting conversion from normal to mild cognitive impairment (MCI).

OBJECTIVE: This study aimed to use data collected from fitness trackers to predict MCI status.

METHODS: In this pilot study, fitness trackers were …

A Confirmatory Factor Analysis Of The Psi-4-Sf In Parents Of Children With Autism Spectrum Disorder, Paige Weir

LSU Doctoral Dissertations

The factor structure of the Parenting Stress Index - Short Form (PSI-4-SF) was evaluated among parents of children with autism spectrum disorder (ASD). Two hypotheses were tested: (1) the original PSI-4-SF model would yield an unsatisfactory fit, and (2) a three-factor alternative model would improve fit compared to the original and other models. A sample of 205 parent-child dyads was analyzed using confirmatory factor analysis (CFA) with the lavaan package in R Studio. Preliminary analyses included descriptive statistics, normality checks, and assessments of skewness and kurtosis. Results supported the first hypothesis, showing poor fit indices for the original PSI-4-SF model. …

Formative Research About Shared Decision Making In The Treatment Of Opioid Use Disorder In Pregnant Women, Ruth Jeminiwa, Phd, Fadel Dadabaev, Pharmd, Heeyoung Kim, Pharmd, Caroline Popielaski, Pharmd, Sohyeon Park, Pharmd, Meghan Gannon, Phd Msph, Diane Abatemarco, Phd, Msw, Ronald Myers, Phd, Dsw

College of Pharmacy Posters

Background

• Shared Decision Making (SDM) is an evidence-based practice that involves a discussion between a health care professional and patient to reach a mutual agreed upon treatment plan.(1)
• A recent nationally-representative study indicates that only 39% of physicians use SDM for 50% or fewer Pregnant Women with Opioid Use Disorders (PWOUD).(2)
• Little is known about factors that affect SDM among PWOUD. This research project aimed to address this knowledge gap.

Brain-Age Prediction: Systematic Evaluation Of Site Effects, And Sample Age Range And Size, Yuetong Yu, Hao-Qi Cui, Shalaila S Haas, Faye New, Nicole Sanford, Kevin Yu, Denghuang Zhan, Guoyuan Yang, Jia-Hong Gao, Dongtao Wei, Jiang Qiu, Nerisa Banaj, Dorret I Boomsma, Alan Breier, Henry Brodaty, Randy L Buckner, Jan K Buitelaar, Dara M Cannon, Xavier Caseras, Vincent P Clark, Patricia J Conrod, Fabrice Crivello, Eveline A Crone, Udo Dannlowski, Christopher G Davey, Lieuwe De Haan, Greig I De Zubicaray, Annabella Di Giorgio, Lukas Fisch, Simon E Fisher, Barbara Franke, David C Glahn, Dominik Grotegerd, Oliver Gruber, Raquel E Gur, Ruben C Gur, Tim Hahn, Ben J Harrison, Sean Hatton, Ian B Hickie, Hilleke E Hulshoff Pol, Alec J Jamieson, Terry L Jernigan, Jiyang Jiang, Andrew J Kalnin, Sim Kang, Nicole A Kochan, Anna Kraus, Jim Lagopoulos, Luisa Lazaro, Brenna C Mcdonald, Colm Mcdonald, Katie L Mcmahon, Benson Mwangi, Fabrizio Piras, Raul Rodriguez-Cruces, Jessica Royer, Perminder S Sachdev, Theodore D Satterthwaite, Andrew J Saykin, Gunter Schumann, Pierluigi Sevaggi, Jordan W Smoller, Jair C Soares, Gianfranco Spalletta, Christian K Tamnes, Julian N Trollor, Dennis Van't Ent, Daniela Vecchio, Henrik Walter, Yang Wang, Bernd Weber, Wei Wen, Lara M Wierenga, Steven C R Williams, Mon-Ju Wu, Giovana B Zunta-Soares, Boris Bernhardt, Paul Thompson, Sophia Frangou, Ruiyang Ge, Enigma‐Lifespan Working Group

Faculty, Staff and Student Publications

Structural neuroimaging data have been used to compute an estimate of the biological age of the brain (brain‐age) which has been associated with other biologically and behaviorally meaningful measures of brain development and aging. The ongoing research interest in brain‐age has highlighted the need for robust and publicly available brain‐age models pre‐trained on data from large samples of healthy individuals. To address this need we have previously released a developmental brain‐age model. Here we expand this work to develop, empirically validate, and disseminate a pre‐trained brain‐age model to cover most of the human lifespan. To achieve this, we selected the …

Bayesian Varying-Effects Vector Autoregressive Models For Inference Of Brain Connectivity Networks And Covariate Effects In Pediatric Traumatic Brain Injury, Yangfan Ren, Nathan Osborne, Christine B Peterson, Dana M Demaster, Linda Ewing-Cobbs, Marina Vannucci

Faculty, Staff and Student Publications

In this article, we develop an analytical approach for estimating brain connectivity networks that accounts for subject heterogeneity. More specifically, we consider a novel extension of a multi-subject Bayesian vector autoregressive model that estimates group-specific directed brain connectivity networks and accounts for the effects of covariates on the network edges. We adopt a flexible approach, allowing for (possibly) nonlinear effects of the covariates on edge strength via a novel Bayesian nonparametric prior that employs a weighted mixture of Gaussian processes. For posterior inference, we achieve computational scalability by implementing a variational Bayes scheme. Our approach enables simultaneous estimation of group-specific …

Case Report Of A Brief Modular Anxiety Intervention For Integrated Primary Care: Addressing Clinician Feasibility Concerns And Barriers To Using Manualized Treatments, Katherine Buckheit, Robyn L. Shepardson, Luke Mitzel, Risa B. Weisberg, Stephen A. Maisto, Jennifer Funderburk

The Journal of Integrated Primary Care

Individuals with anxiety symptoms commonly present in primary care settings and prefer behavioral health (versus pharmacotherapy) treatment, but behavioral health interventions are underutilized. Primary care behavioral health (PCBH) models, in which embedded behavioral health providers deliver behavioral treatment in primary care, may help address the gap in provision of anxiety treatment. However, evidence-based anxiety treatment options feasible for delivery in primary care are limited, and clinicians often report concerns about using manualized interventions. Recent recommendations by the U.S. Preventative Services Task Force to increase anxiety screening among adults in primary care may result in increased identification of individuals with anxiety …

Towards Addressing Mental Health In Rural Louisiana: Blueberry Supplementation As A Natural Intervention, Katy E. Venable

LSU Doctoral Dissertations

Depression and anxiety are major public health issues; however, there is an unmet need for novel effective and accessible treatments, particularly in rural communities. Blueberries are an unexplored nutraceutical for these conditions due to their excellent nutritional profile, with particularly high levels of polyphenols and anthocyanins and benefits on mood, cognition, and health. Therefore, we conducted a double-blind, randomized pilot study in a rural population. We employed a cross-over design to test the effects of 12 weeks daily ingestion of 24 g of whole freeze-dried blueberry powder versus placebo on symptoms of depression and anxiety in those diagnosed with depression …

Framing The Path To Fitness: Age Differences In Response To Framed Exercise Messages, Iliya Sherif, David B. Taullahu, Alyssa R. Minton, Joseph A. Mikels

DePaul Discoveries

Physical activity is one of the most protective health behaviors one can engage in, yet 75% of active adults in the US, meaning those who exercise regularly, fall short of the recommended levels of physical activity, with an even greater percentage of older adults living inactive lives, meaning they exercise minimally and engage in prolonged sedentary behavior (CDC, 2019). The goal of the current study was to explore different types of message framing targeted at encouraging older and younger adults to exercise. We recruited older adults (n = 184; Mage = 69.45 years, age range: 65- 80 years) and younger …

Improving Identification Of Complicated Alcohol Withdrawal Syndrome Using The Prediction Of Alcohol Withdrawal Severity Scale, Kristin Hagopian

Dissertations

Problem: Individuals who drink alcohol excessively are at great risk for alcohol withdrawal syndrome (AWS) when hospitalized. Symptoms and their severity differ for everyone, and research shows that the identification and treatment of AWS is challenging and often inadequate. Mild AWS is often overtreated, while moderate to severe AWS is often underdiagnosed and undertreated, placing individuals at risk for longer hospital stays, more time needed in critical care units, and a variety of unintended consequences.

Methods: This evidence-based practice project had a pre-post intervention design in which the Prediction of Alcohol Withdrawal Severity Scale (PAWSS) was implemented to promptly identify …

Bridging The Gap: Psychopharmacologic Education And Side Effect Screening For Non-Prescribing Mental Health Professionals, Elaine Fitzgerald

Dissertations

Abstract

Problem: The United States is experiencing a growing demand for pediatric mental health support. Surges in mental health diagnoses and psychotropic medication prescriptions have occurred, compounded by a shortage of psychiatric providers. Non-prescribing mental health professionals are well-positioned to recognize psychotropic medication side effects. However, psychologists and counselors lack formal pharmacology education.

Methods: The quality improvement (QI) initiative was guided by the Plan-Do-Study-Act (PDSA) model. The evidence-based psychopharmacologic education for non-prescribers utilized a quasi-experimental pre- and post- test design. Data collected from clinicians included knowledge, confidence, and skill concerning psychotropic medications. The Psychotropic Medication Monitoring Checklist (PMMC) screen clients …

Depression Screening And Education For Immigrants To Increase Access To Care, Viktoriya Ivantsova

Dissertations

Abstract

Problem: Immigrants are at risk for developing mental health disorders due to multiple factors including social, cultural, or economic factors. This can result in a lower quality of life and an increased chance of further disabilities. Although immigrants are at increased risk for the development of mental health disorders, studies show that utilization of available services and resources are low. Additionally, organizations that provide services to immigrants may not be implementing screening and psychoeducation.

Methods: This quality improvement (QI) project followed a descriptive, observational design along with an educational intervention. Using convenience sampling for recruitment, Russian and/or Ukrainian adults …

Implementing A Brief Intervention For Smoking Cessation In An Inpatient Psychiatric Facility, Erika Gotway

Dissertations

Abstract

Problem: Smoking is a leading cause of various preventable diseases, and those who experience mental illness smoke cigarettes at a higher rate than the general population. Brief intervention is a type counseling that has proven successful in encouraging smokers to quit. The “5 A’s” is a type of brief intervention which stands for: Ask, Advise, Assess, Assist, Arrange. Addressing the smoking epidemic among individuals with mental illness is not only essential for improving their overall well-being, but also for reducing health disparities and enhancing the effectiveness of existing mental health interventions.

Methods: The approach to this project was a …

Nourish: Promoting Body Acceptance Through Christ-Centered Identity In Female Collegiate Cross Country Runners, Kirsten E. Howland, Melinda B. Smith

Movement and Being: The Journal of the Christian Society for Kinesiology, Leisure and Sports Studies

Competitive runners are at increased risk for developing eating disorders (EDs), which can have serious effects on both sport and life. Clinical and psychological treatments for EDs are largely ineffective; therefore, to reduce the incidence of disordered eating in young runners, there is a need for preventative programs focused on shifting cultural attitudes and mindset. The purpose of this study was to implement and evaluate Nourish, a Biblically-based pilot program designed to promote body appreciation and a holistic view of the self through rooting identity in Christ. Seven members of the women’s cross country team at a private Division …

Thai Americans: A Poem Collection Featuring "Bilingual หมา Standard Poodle" And "Last Name กู Too Long", Simon Boonsripaisal, Ravadee Boonsripaisal

Journal of Southeast Asian American Education and Advancement

This is a co-authored poem collection focusing on Thai American life. In Bilingual หมา Standard Poodle, interactions and observations are made between a Thai American family and their supportive standard poodle named Pumpkin. This poem interjects on the disaggregated Southeast Asian American experience with inclusion of a pet companion. In Last Name กู Too Long, a Thai American graduate student discusses with their mother the challenges of gaining employment. This poem brings attention to hiring bias in the screening and interview process.

Mhealth Intervention For Elevated Blood Pressure Among College Students: Single-Arm Intervention Study, Dieu-My T. Tran, Catherine E. Dingley, Roger Bonilla

Nursing Faculty Research

Background: Current evidence reveals a growing pattern of hypertension among young adults, significantly increasing their risk for cardiovascular disease later in life. Young adults, particularly those of college age, often develop risk factors related to lifestyle choices in diet, exercise, and alcohol consumption. Developing useful interventions that can assist with screening and possible behavioral modifications that are suitable and appealing to college-aged young adults could help with early identification and intervention for hypertension. Recent studies indicate mobile health (mHealth) apps are acceptable and effective for communication and message delivery among this population.

Objective: The purpose of this study was to …

Hampton's Hump- A Rare Radiographic Finding In Pulmonary Embolism, Tanshi Anand

Digital Journal of Clinical Medicine

Background- Pulmonary embolism is a condition that is characterized by occlusion of the pulmonary circulation, usually originating from deep vein thrombosis in the lower extremities. This condition is difficult to diagnose as it can present with a wide spectrum of nonspecific symptoms, making it a life-threatening illness.

Case Description- A 50-year-old man with a medical history of deep vein thrombosis, ischemic heart disease, dilated cardiomyopathy with left ventricular dysfunction, diabetes, hypertension, and COPD presented with fever, cough with expectoration, orthopnea, and exertional dyspnea. A routine X-ray was done and revealed Hampton’s hump, a rare radiographic finding persistent with possible …

Buprenorphine Vs. Morphine: Impact On Neonatal Opioid Withdrawal Syndrome (Nows) Outcomes In A Single Center Retrospective Study, Saminathan Anbalagan, V. Anderson, Michael Favara, D. Stark, David Carola, Kolawole Solarin, Susan Adeniyi-Jones, Walter K. Kraft, Zubair H. Aghai

Jefferson Hospital Staff Papers and Presentations

Objectives: To compare clinical outcomes for infants with neonatal opioid withdrawal syndrome (NOWS) treated with buprenorphine or morphine.

Study design: Retrospective study of infants born ≥35 weeks’ gestation and admitted to the NICU for NOWS treatment between 2011 and 2022. Length of treatment, length of stay in the hospital, and the need for secondary medications were compared between buprenorphine and morphine treated neonates. Multiple regression analysis was performed, adjusting for baseline differences and confounders.

Results: 417 neonates were treated with morphine and 232 with buprenorphine. The buprenorphine group had shorter treatment days [-10.8 days; 95% CI: -8.08 to …

Development Of A Student-Run, Faculty-Directed Pbc, Olivia Holloway, Angela Blackwell, Julie Seidle

Summer 2024 OTD Capstone Symposium

Benefits of creating a student-run, faculty-directed, community-based Pro Bono Clinic for community members to engage in the occupation of gardening.

York County Rural Communties Opioid Response Implementation Iv Grant: Interim Evaluation Report, Katie Rosingana Ba, Evelyn Ali Bs, Gordon Mcintire Ba, Sarah Mclaughlin Mph, Mary Lindsey Smith Phd

Substance Use Research & Evaluation

This interim evaluation report has been developed for the York County Rural Communities Opioid Response Program, an RCORP-Implementation IV grant awarded to MaineHealth and funded by the Health Resources & Services Administration (HRSA). A main goal of this grant project is to understand the needs of individuals impacted by substance use disorders who have faced structural inequalities to access, in both correctional and heath care settings. The project utilizes a collaborative coalition that is community based, the Rural York Community Coalition (RYCC). For more information, please contact Lindsey Smith at [email protected]