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Effects Of Asenapine On Agitation And Hostility In Adults With Acute Manic Or Mixed Episodes Associated With Bipolar I Disorder, Leslie L. Citrome, R Landbloom, C Chang, W Earley
Effects Of Asenapine On Agitation And Hostility In Adults With Acute Manic Or Mixed Episodes Associated With Bipolar I Disorder, Leslie L. Citrome, R Landbloom, C Chang, W Earley
NYMC Faculty Publications
BACKGROUND:
Bipolar disorder is associated with an increased risk of aggression. However, effective management of hostility and/or agitation symptoms may prevent patients from becoming violent. This analysis investigated the efficacy of the antipsychotic asenapine on hostility and agitation in patients with bipolar I disorder.
METHODS:
Data were pooled from three randomized, double-blind, placebo-controlled, Phase III trials of asenapine in adults with manic or mixed episodes of bipolar I disorder (NCT00159744, NCT00159796, and NCT00764478). Post hoc analyses assessed the changes from baseline to day 21 on the Young Mania Rating Scale (YMRS) and the Positive and Negative …