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Radiation fibrosis

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Full-Text Articles in Plastic Surgery

The Use Of Np-110, A Rhamm Peptide Mimetic, Reduces Capsule Fibrosis In A Novel Rodent Model Of Radiation-Induced Capsular Contracture, Kathryn Minkhorst Jul 2024

The Use Of Np-110, A Rhamm Peptide Mimetic, Reduces Capsule Fibrosis In A Novel Rodent Model Of Radiation-Induced Capsular Contracture, Kathryn Minkhorst

Electronic Thesis and Dissertation Repository

Capsular contracture is a common complication of breast implant reconstructive surgery, which can be particularly devastating in the setting of post-mastectomy radiation. The objective of this thesis was to evaluate the effect of RHAMM function-blocking peptide mimetic NP-110 on a novel rodent model for radiation-induced capsular contracture. The model consisted of female rats who underwent surgery to place a 2cc silicone implant under the right fourth mammary fat pad. Animals received local injection of 100ug of NP-110 or scrambled control peptide followed by 26Gy of targeted ionizing radiation. Clinically, NP-110 treated animals showed decreased post-radiation fibrotic change. Masson’s trichrome and …


Development Of A Novel Rodent Model Of Radiation-Induced Implant Capsular Contracture, Tanya Delyzer Jun 2022

Development Of A Novel Rodent Model Of Radiation-Induced Implant Capsular Contracture, Tanya Delyzer

Electronic Thesis and Dissertation Repository

Radiation-induced implant capsular contracture is a challenging complication of post-mastectomy breast reconstruction. The objective of this thesis was to establish a novel rodent model that replicates the critical properties of this complication. Retired breeder female Sprague-Dawley rats underwent surgery with custom smooth silicone implants placed under the right 4th mammary fat pad. Half these rats received 26Gy of ionizing radiation to the implant and fat pad. Radiated implants had both higher Baker grades of capsular contracture and Kumar scores denoting radiation-induced fibrosis. Irradiated capsules showed increased Masson’s trichrome staining and significantly higher hydroxyproline to total protein ratio compared to …


The Promotion Of Adipogenesis In A Rat Model Of Radiation-Induced Mammary Fat Pad Fibrosis, Jessica Truong Sep 2017

The Promotion Of Adipogenesis In A Rat Model Of Radiation-Induced Mammary Fat Pad Fibrosis, Jessica Truong

Electronic Thesis and Dissertation Repository

Radiofibrosis of the breast makes satisfactory breast tissue reconstruction challenging and is associated with complications. Autologous fat grafting can improve surgical outcomes but fat retention is variable. We developed RHAMM peptide mimetics (NPI-110) that decrease tissue fibrosis and increase mammary fat pad adipogenesis by promoting the differentiation of mesenchymal progenitor cells into adipocytes. We tested the efficacy of NPI-110 in a rat model of radiation-induced mammary fat pad fibrosis. Effects of radiation and NPI-110 were quantified by visible skin changes, fat pad volume estimates using high frequency ultrasound, mRNA expression of genes involved in fibrosis (Collagen-1:Collagen-1, TGFß1) and adipogenesis (PPARγ, …