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Tensional Forces Influence Gene Expression And Sutural State Of Rat Calvariae In Vitro, S. Tholpady, T. Freyman, Debbie Chachra, R. Ogle
Tensional Forces Influence Gene Expression And Sutural State Of Rat Calvariae In Vitro, S. Tholpady, T. Freyman, Debbie Chachra, R. Ogle
Debbie Chachra
BACKGROUND:
Theories regarding the cause of craniosynostosis that are more than 15 years old cite the role that tensional forces play in the normal and abnormal development of the cranial suture. These theories highlight the effect of stress bands originating from the skull base to the vertex, guiding sutural development.
METHODS:
In this study, the normally fusing posterior intrafrontal suture of the rat was subjected to 3 mN of tensional force for 30 minutes per day. The suture was then assessed for patency, proliferation, apoptosis, and transforming growth factor (TGF)-beta signaling components.
RESULTS:
Sutures that were subjected to tensional force …