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Articles 211 - 240 of 506
Full-Text Articles in Pediatrics
Characterization Of Low Resource Utilization Observation Status Hospitalizations Within Children's Hospitals, David C. Synhorst
Characterization Of Low Resource Utilization Observation Status Hospitalizations Within Children's Hospitals, David C. Synhorst
Research Days
No abstract provided.
Impact Of A Mobile Device-Based Clinical Decision Support Tool On Guideline Adherence And Mental Workload Among Trainee And Attending Physicians, Katherine M. Richardson
Impact Of A Mobile Device-Based Clinical Decision Support Tool On Guideline Adherence And Mental Workload Among Trainee And Attending Physicians, Katherine M. Richardson
Presentations
This study evaluated PedsGuide, an app used to evaluate serious bacterial infections in febrile infants.
A High-Throughput Screen Indicates Gemcitabine And Jak Inhibitors May Be Useful For Treating Pediatric Aml, Christina D. Drenberg, Anang Shelat, Jinjun Dang, Anitria Cotton, Shelley J. Orwick, Mengyu Li, Jae Yoon Jeon, Qiang Fu, Daelynn R. Buelow, Marissa Pioso, Shuiying Hu, Hiroto Inaba, Raul C. Ribeiro, Jeffrey E. Rubnitz, Tanja A. Gruber, R. Kiplin Guy, Sharyn D. Baker
A High-Throughput Screen Indicates Gemcitabine And Jak Inhibitors May Be Useful For Treating Pediatric Aml, Christina D. Drenberg, Anang Shelat, Jinjun Dang, Anitria Cotton, Shelley J. Orwick, Mengyu Li, Jae Yoon Jeon, Qiang Fu, Daelynn R. Buelow, Marissa Pioso, Shuiying Hu, Hiroto Inaba, Raul C. Ribeiro, Jeffrey E. Rubnitz, Tanja A. Gruber, R. Kiplin Guy, Sharyn D. Baker
Pharmaceutical Sciences Faculty Publications
Improvement in survival has been achieved for children and adolescents with AML but is largely attributed to enhanced supportive care as opposed to the development of better treatment regimens. High risk subtypes continue to have poor outcomes with event free survival rates < 40% despite the use of high intensity chemotherapy in combination with hematopoietic stem cell transplant. Here we combine high-throughput screening, intracellular accumulation assays, and in vivo efficacy studies to identify therapeutic strategies for pediatric AML. We report therapeutics not currently used to treat AML, gemcitabine and cabazitaxel, have broad anti-leukemic activity across subtypes and are more effective relative to the AML standard of care, cytarabine, both in vitro and in vivo. JAK inhibitors are selective for acute megakaryoblastic leukemia and significantly prolong survival in multiple preclinical models. Our approach provides advances in the development of treatment strategies for pediatric AML.
Challenges Of Training And Delivery Of Pediatric Surgical Services In Developing Economies: A Perspective From Pakistan, Amir Humza Sohail, Muhammad Hassaan Arif Maan, Mohammed Sachal, Muhammad Soban
Challenges Of Training And Delivery Of Pediatric Surgical Services In Developing Economies: A Perspective From Pakistan, Amir Humza Sohail, Muhammad Hassaan Arif Maan, Mohammed Sachal, Muhammad Soban
Medical College Documents
Background: As the pediatric population requiring health services rises globally, developing countries are struggling to cater to the growing burden of non-communicable diseases - particularly those requiring specialized surgical care.
Main body: Despite the literature supporting specialized pediatric surgical care, the developing world is far from meeting the American Pediatric Surgical Association (APSA) Manpower taskforce recommendation of at least 1 qualified pediatric surgeon per 100,000 patients (0-15 years-old). In Pakistan, there is an unmet surgical need in the pediatric population due to a multitude of short shortcomings, notably in quality and quantity of the training programs on offer, and urgent …
The Effect Of Antihypertensive Medications Dosing On Blood Pressure Control And Left Ventricular Hypertrophy In Children With Chronic Kidney Disease, Benjamin A. Matta
The Effect Of Antihypertensive Medications Dosing On Blood Pressure Control And Left Ventricular Hypertrophy In Children With Chronic Kidney Disease, Benjamin A. Matta
Research Days
No abstract provided.
Relationship Between Hemolytic Index Early In Life And Development Of Abnormal Transcranial Doppler Velocities In Pediatric Patients With Sickle Cell Anemia, Derrick L. Goubeaux
Relationship Between Hemolytic Index Early In Life And Development Of Abnormal Transcranial Doppler Velocities In Pediatric Patients With Sickle Cell Anemia, Derrick L. Goubeaux
Research Days
No abstract provided.
Methotrexate Polyglutamates And The Potential Role In Pediatric Inflammatory Bowel Disease, Ryan Morrow
Methotrexate Polyglutamates And The Potential Role In Pediatric Inflammatory Bowel Disease, Ryan Morrow
Research Days
No abstract provided.
Maximal Oxygen Consumption Recovery Delay In A Fontan Population, Karoline Krzywda
Maximal Oxygen Consumption Recovery Delay In A Fontan Population, Karoline Krzywda
Research Days
No abstract provided.
Effect Of Crohn’S Disease On Villous Length And Cyp3a4 Expression In The Pediatric Small Intestine, Brian D. Chapron
Effect Of Crohn’S Disease On Villous Length And Cyp3a4 Expression In The Pediatric Small Intestine, Brian D. Chapron
Research Days
No abstract provided.
Does Palliative Care Involvement Influence Location Of Death?, Joy L. Solano
Does Palliative Care Involvement Influence Location Of Death?, Joy L. Solano
Research Days
No abstract provided.
Predictive Performance Of Existing Population Pharmacokinetic Models Of Tacrolimus In Pediatric Kidney Transplant Recipients, Alenka Chapron
Predictive Performance Of Existing Population Pharmacokinetic Models Of Tacrolimus In Pediatric Kidney Transplant Recipients, Alenka Chapron
Research Days
No abstract provided.
Thyrotoxicosis Presenting With Nondiabetic Ketoacidosis In A 4 Year Old Female, Henry S. Jeng Dr
Thyrotoxicosis Presenting With Nondiabetic Ketoacidosis In A 4 Year Old Female, Henry S. Jeng Dr
Research Days
No abstract provided.
Lymphocytic Lobulitis Presenting In An Adolescent Female: A Case Report, Kevin Meilak Md
Lymphocytic Lobulitis Presenting In An Adolescent Female: A Case Report, Kevin Meilak Md
Research Days
No abstract provided.
Characterization Of The Relative Contribution Of Cyp2d6 And Cyp3a4 To The Metabolism Of Pimozide, Brian D. Chapron
Characterization Of The Relative Contribution Of Cyp2d6 And Cyp3a4 To The Metabolism Of Pimozide, Brian D. Chapron
Research Days
No abstract provided.
Cd30-Positive, Ebv-Positive T-Cell Lymphoma Associated With Chronic Active Ebv Infection: Successful Treatment With Brentuximab Vedotin, Sarah E. Mc Dermott
Cd30-Positive, Ebv-Positive T-Cell Lymphoma Associated With Chronic Active Ebv Infection: Successful Treatment With Brentuximab Vedotin, Sarah E. Mc Dermott
Research Days
No abstract provided.
A Unique Model For Perinatal Palliative Care In A Level Iv Neonatal Intensive Care Unit, Kelstan L. Ellis Do, Megan Tucker Md
A Unique Model For Perinatal Palliative Care In A Level Iv Neonatal Intensive Care Unit, Kelstan L. Ellis Do, Megan Tucker Md
Research Days
No abstract provided.
Preventing Osteosarcoma Progression With Small Molecular Inhibitors Targeting Macrophage Migration Inhibitory Factor : Cd74 Interaction, Sana Farooki
Research Days
No abstract provided.
Can Point-Of-Care Betahydroxybutyrate Testing Be Used To Predict Diabetic Ketoacidosis In The Pediatric Emergency Department?, Michelle Knoll
Can Point-Of-Care Betahydroxybutyrate Testing Be Used To Predict Diabetic Ketoacidosis In The Pediatric Emergency Department?, Michelle Knoll
Research Days
No abstract provided.
Failure Of Methotrexate Monotherapy And Subsequent Response To Tumor Necrosis Factor Inhibitors In Pediatric Non-Infectious Uveitis, Basak Can Ermerak Md
Failure Of Methotrexate Monotherapy And Subsequent Response To Tumor Necrosis Factor Inhibitors In Pediatric Non-Infectious Uveitis, Basak Can Ermerak Md
Research Days
No abstract provided.
Thyrotoxicosis Presenting With Nondiabetic Ketoacidosis In A 4 Year Old Female: A Case Report, Henry S. Jeng, Michelle Knoll, Figen Ugrasbul
Thyrotoxicosis Presenting With Nondiabetic Ketoacidosis In A 4 Year Old Female: A Case Report, Henry S. Jeng, Michelle Knoll, Figen Ugrasbul
Posters
Objective: To raise awareness that thyrotoxicosis should be on the differential diagnosis for ketoacidosis in the pediatric population
Permanent Junctional Reciprocating Tachycardia In Infants And Children, Ranjit I. Kylat Md, Ricardo A. Samson
Permanent Junctional Reciprocating Tachycardia In Infants And Children, Ranjit I. Kylat Md, Ricardo A. Samson
School of Medicine Faculty Research
Permanent junctional reciprocating tachycardia (PJRT) is a rare form of supraventricular tachycardia (SVT). It generally presents in infants but can be difficult to diagnose. The characteristic EKG findings, response to Adenosine and persistence or frequent recurrences are helpful in making the diagnosis. It is usually difficult to manage with the initial and single medications used in SVT. Many patients are misdiagnosed and not treated effectively and end up having end stage cardiomyopathy and are diagnosed in patients referred for transplant. Hence all patients referred for a cardiac transplant with dilated cardiomyopathy need to be evaluated for this arrhythmia. If appropriate …
Effect Of Intravenous Phenobarbital On Left Ventricular Myocardial Contractility Determined By Echocardiography In Children., Arpan R. Doshi, Monesha Gupta Malhotra, Duraisamy Balaguru, Devendra Amre, Christian Erikson
Effect Of Intravenous Phenobarbital On Left Ventricular Myocardial Contractility Determined By Echocardiography In Children., Arpan R. Doshi, Monesha Gupta Malhotra, Duraisamy Balaguru, Devendra Amre, Christian Erikson
Manuscripts, Articles, Book Chapters and Other Papers
Introduction: Animal studies and rare human studies have suggested a negative effect of barbiturates on cardiac function. Although intravenous (IV) phenobarbital is used routinely in children in the clinical setting, studies in children are lacking. We performed a study to evaluate effect of IV phenobarbital loading on myocardial systolic function of children.
Methods: In a prospective pilot study in children without congenital heart defects, the effect of IV phenobarbital was evaluated on the left ventricular systolic function measured by ejection fraction (EF) by Simpson's method via an echocardiogram. Any child less than 18 years of age who received IV loading …
The Disproportionate Impact Of Obesity Among Hospitalized Children, Kathyrn Kyler
The Disproportionate Impact Of Obesity Among Hospitalized Children, Kathyrn Kyler
Research Days
No abstract provided.
Operative Times In Adolescent Idiopathic Scoliosis Surgery. What Do They Mean?, Joanne Abby Marasigan
Operative Times In Adolescent Idiopathic Scoliosis Surgery. What Do They Mean?, Joanne Abby Marasigan
Research Days
No abstract provided.
Comparison Of Post-Operative Pain Control Modalities For Pectus Excavatum Repair, Charlene Dekonenko
Comparison Of Post-Operative Pain Control Modalities For Pectus Excavatum Repair, Charlene Dekonenko
Research Days
No abstract provided.
Is It Possible To Predict The Need Of Gastrostomy Tube In Nicu Patients With Short Bowel Syndrome?, Katherine Black
Is It Possible To Predict The Need Of Gastrostomy Tube In Nicu Patients With Short Bowel Syndrome?, Katherine Black
Research Days
No abstract provided.
Retrospective Chart Review: Pediatric Demographics In Children Presenting With Acute Neurological Deficit Concerning For Acute Ischemic Stroke: An Evaluation Of The Stroke Alert Process, Tiffany Barkley Do
Research Days
No abstract provided.
Developmental Intervention Patterns In A Level Iv Neonatal Intensive Care Unit (Nicu), Grace Winningham
Developmental Intervention Patterns In A Level Iv Neonatal Intensive Care Unit (Nicu), Grace Winningham
Research Days
No abstract provided.
Herpes Simplex Virus Whole Genome Sequencing For Antiviral Resistance In A Child With Dock8 Deficiency And Chronic Infection, Sean Stout
Research Days
No abstract provided.
Chronic Cavitary Pulmonary Aspergillosis With Aspergilloma In A Previously Healthy Teenager, Michael D. Mcdowell Jr
Chronic Cavitary Pulmonary Aspergillosis With Aspergilloma In A Previously Healthy Teenager, Michael D. Mcdowell Jr
Research Days
No abstract provided.