Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 3 of 3
Full-Text Articles in Pathology
Gene Expression Profiles In Primary Pancreatic Tumors And Metastatic Lesions Of Ela-C-Myc Transgenic Mice, Archana Thakur, Aliccia Bollig, Jiusheng Wu, Dezhong J. Liao
Gene Expression Profiles In Primary Pancreatic Tumors And Metastatic Lesions Of Ela-C-Myc Transgenic Mice, Archana Thakur, Aliccia Bollig, Jiusheng Wu, Dezhong J. Liao
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
Pancreatic carcinoma usually is a fatal disease with no cure, mainly due to its invasion and metastasis prior to diagnosis. We analyzed the gene expression profiles of paired primary pancreatic tumors and metastatic lesions from Ela-c-myc transgenic mice in order to identify genes that may be involved in the pancreatic cancer progression. Differentially expressed selected genes were verified by semi-quantitative and quantitative RT-PCR. To further evaluate the relevance of some of the selected differentially expressed genes, we investigated their expression pattern in human pancreatic cancer cell lines with high and low metastatic potentials.
Results
Data indicate that genes …
Comparison Of Thin-Prep And Cell Block Preparation For The Evaluation Of Thyroid Epithelial Lesions On Fine Needle Aspiration Biopsy, Husain A. Saleh, Jamal Hammoud, Richard Zakaria, Aurang Khan
Comparison Of Thin-Prep And Cell Block Preparation For The Evaluation Of Thyroid Epithelial Lesions On Fine Needle Aspiration Biopsy, Husain A. Saleh, Jamal Hammoud, Richard Zakaria, Aurang Khan
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
The objective of this study was to compare the utility of Thin-Prep (TP) cytologic preparation with that of Cell Block (CB) preparation in the diagnosis of thyroid lesions, mainly follicular epithelial lesions, by fine needle aspiration biopsy (FNAB). Feasibility of using the TP slides for immunocytochemical stains is also discussed.
Methods
A total of 126 consecutive cases of thyroid FNAB with TP slides and 128 consecutive cases of thyroid FNAB with CB slides were reviewed blindly by two cytopathologists. The presence of colloid, follicular cells, macrophages and lymphocytes/plasma cells were recorded and scored 0–4 on each case based …
Fine Needle Aspiration Biopsy Of Intraoral And Oropharyngeal Mass Lesions, Husain A. Saleh, Lewis Clayman, Haitham Masri
Fine Needle Aspiration Biopsy Of Intraoral And Oropharyngeal Mass Lesions, Husain A. Saleh, Lewis Clayman, Haitham Masri
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
Fine needle aspiration (FNA) biopsy has been rarely used in oral and oropharyngeal lesions. The goal of this study was to assess the value and accuracy of FNA biopsy in the diagnosis of oral and oropharyngeal lesions particularly in regards to discriminating benign from malignant tumors.
Methods
Sixteen cases of FNA biopsies obtained of various intraoral and oropharyngeal masses or lesions performed at our institution during the eight-year period from 1998 to 2006 were retrospectively reviewed. The aspiration cytologic diagnoses were correlated with the histologic examination of the corresponding resected lesions.
Results
Sixteen cases of intraoral lesions evaluated …