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Full-Text Articles in Pathology
P90/Cip2a Regulates Lung Cancer Cell Proliferation And Cell Apoptosis Via The Akt Signaling Pathway, Ningjing Lei
P90/Cip2a Regulates Lung Cancer Cell Proliferation And Cell Apoptosis Via The Akt Signaling Pathway, Ningjing Lei
Open Access Theses & Dissertations
Cancerous inhibitor of PP2A (CIP2A) is an intracellular endogenous protein phosphatase 2A (PP2A) inhibitor with oncogenic activities. Initially identified as a tumor-associated antigen (TAA) in gastric and liver cancer patients, CIP2A was overexpressed in a variety of cancer types. And the overexpression of CIP2A in cancer cell is associated with increased cell proliferation and decreased cell apoptosis. However, the mechanism of CIP2A in cancer progression is still poorly understood. Here, we reported the evidence that CIP2A can regulate AKT phosphorylation at S473 under growth factor stimulation and our results also showed that CIP2A might regulate cell proliferation and cell apoptosis …