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Full-Text Articles in Pathology
Gene Expression Profiles Among Murine Strains Segregate With Distinct Differences In The Progression Of Radiation-Induced Lung Disease., Isabel L. Jackson, Fitsum Baye, Chirayu Pankaj Goswami, Barry P. Katz, Andrew Zodda, Radmila Pavlovic, Ganga Gurung, Don Winans, Zeljko Vujaskovic
Gene Expression Profiles Among Murine Strains Segregate With Distinct Differences In The Progression Of Radiation-Induced Lung Disease., Isabel L. Jackson, Fitsum Baye, Chirayu Pankaj Goswami, Barry P. Katz, Andrew Zodda, Radmila Pavlovic, Ganga Gurung, Don Winans, Zeljko Vujaskovic
Jefferson Hospital Staff Papers and Presentations
Molecular mechanisms underlying development of acute pneumonitis and/or late fibrosis following thoracic irradiation remain poorly understood. Here, we hypothesize that heterogeneity in disease progression and phenotypic expression of radiation-induced lung disease (RILD) across murine strains presents an opportunity to better elucidate mechanisms driving tissue response toward pneumonitis and/or fibrosis. Distinct differences in disease progression were observed in age- and sex-matched CBA/J, C57L/J and C57BL/6J mice over 1 year after graded doses of whole-thorax lung irradiation (WTLI). Separately, comparison of gene expression profiles in lung tissue 24 h post-exposure demonstrated >5000 genes to be differentially expressed (P<0.01; >twofold change) between strains …