Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Animals (1)
- Antibodies (1)
- Antibodies, Neutralizing (1)
- Antibodies, Viral (1)
- COVID-19 (1)
-
- COVID-19 Vaccines (1)
- COVID-19 vaccines (1)
- Colonic Neoplasms (1)
- Colorectal Neoplasms/pathology (1)
- Colorectal Neoplasms/physiopathology (1)
- Colorectal cancer (1)
- Coronavirus (1)
- DNA Primers (1)
- Department of Microbiology and Immunology (1)
- Gene Expression (1)
- Homeodomain Proteins/biosynthesis (1)
- Homeodomain Proteins/chemistry (1)
- Homeodomain Proteins/genetics (1)
- Neoplastic (1)
- Neutralizing (1)
- Rabies (1)
- Rabies Vaccines (1)
- Rabies vaccines (1)
- Rabies virus (1)
- Regulation (1)
- SARS-COV-2 (1)
- SARS-CoV-2 (1)
- Spike Glycoprotein, Coronavirus (1)
Articles 1 - 2 of 2
Full-Text Articles in Pathology
A Single Dose Of The Deactivated Rabies-Virus Vectored Covid-19 Vaccine, Coravax, Is Highly Efficacious And Alleviates Lung Inflammation In The Hamster Model, Drishya Kurup, Christoph Wirblich, Leila Zabihi Diba, Rachael Lambert, Megan Watson, Noor Shaikh, Holly Ramage, Charalambos Solomides, Matthias J Schnell
A Single Dose Of The Deactivated Rabies-Virus Vectored Covid-19 Vaccine, Coravax, Is Highly Efficacious And Alleviates Lung Inflammation In The Hamster Model, Drishya Kurup, Christoph Wirblich, Leila Zabihi Diba, Rachael Lambert, Megan Watson, Noor Shaikh, Holly Ramage, Charalambos Solomides, Matthias J Schnell
Department of Microbiology and Immunology Faculty Papers
Without sufficient herd immunity through either vaccination or natural infection, the coronavirus disease 2019 pandemic is unlikely to be controlled. Waning immunity with the currently approved vaccines suggests the need to evaluate vaccines causing the induction of long-term responses. Here, we report the immunogenicity and efficacy of our adjuvanted single-dose Rabies-vectored SARS-CoV-2 S1 vaccine, CORAVAX, in hamsters. CORAVAX induces high SARS-CoV-2 S1-specific and virus-neutralizing antibodies (VNAs) that prevent weight loss, viral loads, disease, lung inflammation, and the cytokine storm in hamsters. We also observed high Rabies VNA titers. In summary, CORAVAX is a promising dual-antigen vaccine candidate for clinical evaluation …
A Conserved Tissue-Specific Homeodomain-Less Isoform Of Meis1 Is Downregulated In Colorectal Cancer., Richard C Crist, Jacquelyn J Roth, Scott A Waldman, Arthur M Buchberg
A Conserved Tissue-Specific Homeodomain-Less Isoform Of Meis1 Is Downregulated In Colorectal Cancer., Richard C Crist, Jacquelyn J Roth, Scott A Waldman, Arthur M Buchberg
Department of Microbiology and Immunology Faculty Papers
Colorectal cancer is one of the most common cancers in developed nations and is the result of both environmental and genetic factors. Many of the genetic lesions observed in colorectal cancer alter expression of homeobox genes, which encode homeodomain transcription factors. The MEIS1 homeobox gene is known to be involved in several hematological malignancies and solid tumors and recent evidence suggests that expression of the MEIS1 transcript is altered in colorectal cancer. Despite this potential connection, little is known about the role of the gene in the intestines. We probed murine gastrointestinal tissue samples with an N-terminal Meis1 antibody, revealing …