Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Pathology
A New Pipeline For Clinico-Pathological And Molecular Placental Research Utilizing Ffpe Tissues., Jiaqi J O'Reilly, Stephanie Barak, Anna A Penn
A New Pipeline For Clinico-Pathological And Molecular Placental Research Utilizing Ffpe Tissues., Jiaqi J O'Reilly, Stephanie Barak, Anna A Penn
Pathology Faculty Publications
The placenta is at the core of many pregnancy pathologies, but we have limited knowledge about placental function because of two key research barriers: 1) lack of guidelines for sample collection and pathologic diagnosis; and 2) limited tools are available for molecular analysis of stored placental samples. We aimed to create a searchable, population-based placental database of pathologic diagnoses, and to validate molecular methods for gene expression studies of matching formalin fixed paraffin embedded (FFPE) placental blocks. Our database has over 1000 pregnancies coded for clinical diagnosis with corresponding FFPE blocks that are available for gene expression studies. RNA harvested …