Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Diseases (19)
- Otorhinolaryngologic Diseases (14)
- Oncology (11)
- Pediatrics (7)
- Surgery (6)
-
- Medical Sciences (5)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (3)
- Neoplasms (3)
- Plastic Surgery (3)
- Public Health (3)
- Diagnosis (2)
- Life Sciences (2)
- Medical Genetics (2)
- Pathological Conditions, Signs and Symptoms (2)
- Physical Sciences and Mathematics (2)
- Radiology (2)
- Anatomy (1)
- Artificial Intelligence and Robotics (1)
- Biomedical Informatics (1)
- Biostatistics (1)
- Clinical Epidemiology (1)
- Computer Sciences (1)
- Dentistry (1)
- Emergency Medicine (1)
- Health Services Research (1)
- Immunology and Infectious Disease (1)
- Immunotherapy (1)
- Keyword
-
- Social determinants of health (4)
- Head and neck cancer (3)
- Squamous cell carcinoma (3)
- Antisense oligonucleotides (2)
- Deafness (2)
-
- Digital divide (2)
- Digital inequity (2)
- Free flap (2)
- Head and neck reconstruction (2)
- Hearing (2)
- Hearing loss (2)
- Immunotherapy (2)
- Oropharyngeal cancer (2)
- Outcomes (2)
- Salivary gland cancer (2)
- ADGRV1 (1)
- Adenocarcinoma (1)
- Adenoid cystic carcinoma (1)
- Adjuvant therapy (1)
- Anatomic subsites (1)
- Angiofibroma (1)
- Artificial intelligence (1)
- Artificial neural network (1)
- Balance (1)
- Bioinformatics (1)
- Biopsy (1)
- Chemotherapy (1)
- Chronic sialadenitis (1)
- Cochlear implantation (1)
- Color doppler (1)
- Publication
- Publication Type
Articles 31 - 31 of 31
Full-Text Articles in Otolaryngology
Direct Delivery Of Antisense Oligonucleotides To The Middle And Inner Ear Improves Hearing And Balance In Usher Mice, Jennifer J. Lentz, Bifeng Pan, Abhilash Ponnath, Christopher M. Tran, Carl Nist-Lund, Alice Galvin, Hannah Goldberg, Katelyn N. Robillard, Francine M. Jodelka, Hamilton E. Farris, Jun Huang, Tianwen Chen, Hong Zhu, Wu Zhou, Frank Rigo, Michelle L. Hastings, Gwenaëlle S.G. Géléoc
Direct Delivery Of Antisense Oligonucleotides To The Middle And Inner Ear Improves Hearing And Balance In Usher Mice, Jennifer J. Lentz, Bifeng Pan, Abhilash Ponnath, Christopher M. Tran, Carl Nist-Lund, Alice Galvin, Hannah Goldberg, Katelyn N. Robillard, Francine M. Jodelka, Hamilton E. Farris, Jun Huang, Tianwen Chen, Hong Zhu, Wu Zhou, Frank Rigo, Michelle L. Hastings, Gwenaëlle S.G. Géléoc
School of Medicine Faculty Publications
Usher syndrome is a syndromic form of hereditary hearing impairment that includes sensorineural hearing loss and delayed-onset retinitis pigmentosa (RP). Type 1 Usher syndrome (USH1) is characterized by congenital profound sensorineural hearing impairment and vestibular areflexia, with adolescent-onset RP. Systemic treatment with antisense oligonucleotides (ASOs) targeting the human USH1C c.216G>A splicing mutation in a knockin mouse model of USH1 restores hearing and balance. Herein, we explore the effect of delivering ASOs locally to the ear to treat hearing and vestibular dysfunction associated with Usher syndrome. Three localized delivery strategies were investigated in USH1C mice: inner ear injection, trans-tympanic membrane …