Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Institution
- Keyword
-
- Alu RNA (1)
- Ambystoma (1)
- Animals (1)
- Chloride Channels (1)
- Chlorides (1)
-
- Electric Conductivity (1)
- Inhibit (1)
- Membrane Potentials (1)
- Method (1)
- Monell Chemical Senses Center (1)
- Patch-Clamp Techniques (1)
- Pennsylvania (1)
- Philadelphia (1)
- Poster (1)
- Retinal Cone Photoreceptor Cells (1)
- Therapeutic (1)
- Thereof (1)
- Thomas Jefferson University (1)
- Unilateral olfactory thresholds in a chemosensory clinic population (1)
- United States (1)
- Publication
- File Type
Articles 1 - 3 of 3
Full-Text Articles in Ophthalmology
Chloride Equilibrium Potential In Salamander Cones., Wallace B. Thoreson, Eric J. Bryson
Chloride Equilibrium Potential In Salamander Cones., Wallace B. Thoreson, Eric J. Bryson
Journal Articles: Ophthalmology
BACKGROUND: GABAergic inhibition and effects of intracellular chloride ions on calcium channel activity have been proposed to regulate neurotransmission from photoreceptors. To assess the impact of these and other chloride-dependent mechanisms on release from cones, the chloride equilibrium potential (ECl) was determined in red-sensitive, large single cones from the tiger salamander retinal slice.
RESULTS: Whole cell recordings were done using gramicidin perforated patch techniques to maintain endogenous Cl- levels. Membrane potentials were corrected for liquid junction potentials. Cone resting potentials were found to average -46 mV. To measure ECl, we applied long depolarizing steps to activate the calcium-activated chloride current …
Method Of Inhibiting Alu Rna And Therapeutic Uses Thereof, Jayakrishna Ambati
Method Of Inhibiting Alu Rna And Therapeutic Uses Thereof, Jayakrishna Ambati
Ophthalmology and Visual Science Faculty Patents
The presently-disclosed subject matter includes methods of identifying an Alu RNA inhibitor, and methods and compo sitions for inhibiting Alu RNA. Methods and compositions can be used for the treatment of geographic atrophy and other conditions of interest.
Unilateral Olfactory Thresholds In A Chemosensory Clinic Population, Beverly Cowart, Edmund Pribitkin, David Rosen, Christopher Klock, Timothy Laflam
Unilateral Olfactory Thresholds In A Chemosensory Clinic Population, Beverly Cowart, Edmund Pribitkin, David Rosen, Christopher Klock, Timothy Laflam
Department of Otolaryngology - Head and Neck Surgery Faculty Papers
Poster presentation at 26th Annual Meeting of the Association of Chemoreception Sciences in Sarasota Florida, April 21-25, 2004.
INTRODUCTION
Because there is the possibility of unilateral loss of olfactory function or differential degrees of olfactory dysfunction in the two nostrils, unilateral tests of olfactory threshold sensitivity are routinely included in many chemosensory clinical test batteries to supplement bilateral tests (e.g., Cain et al., 1988; Hummel et al., 1997). Surprisingly, however, the results of unilateral testing in patients with chemosensory complaints have not been extensively reported. Thus, it is unclear how useful these additional measures are in characterizing individual patients.
A …