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Articles 1 - 5 of 5
Full-Text Articles in Ophthalmology
Consanguineous Marriage Resulting In Homozygous Occurrence Of X-Linked Retinoschisis In Girls, Azam Ali, Agha Hassan Feroze, Zulfiqar H. Rizvi, Tausif- Ur -Rehman
Consanguineous Marriage Resulting In Homozygous Occurrence Of X-Linked Retinoschisis In Girls, Azam Ali, Agha Hassan Feroze, Zulfiqar H. Rizvi, Tausif- Ur -Rehman
Section of Ophthalmology
Purpose: To investigate a family afflicted with X-linked retinoschisis and to determine the pedigree leading to such an occurrence.Design: Observational case series.
Methods: Visual acuities were measured at The Aga Khan University Hospital Ophthalmology clinic. Slit-lamp examination, direct and indirect ophthalmoscopies were performed on each of the seven members of this family. The pedigree was established by appropriate questioning about the rest of their family.
Results: The pedigree revealed the homozygosity of the four daughters for the XLRS mutations borne out of the consanguineous marriage between an affected father and a carrier mother.
Conclusions: This is the first report showing …
Vegf164-Mediated Inflammation Is Required For Pathological, But Not Physiological, Ischemia-Induced Retinal Neovascularization, Susumu Ishida, Tomohiko Usui, Kenji Yamashiro, Yuichi Kaji, Shiro Amano, Yuichiro Ogura, Tetsuo Hida, Yoshihisa Oguchi, Jayakrishna Ambati, Joan W. Miller, Evangelos S. Gragoudas, Yin-Shan Ng, Patricia A. D'Amore, David T. Shima, Anthony P. Adamis
Vegf164-Mediated Inflammation Is Required For Pathological, But Not Physiological, Ischemia-Induced Retinal Neovascularization, Susumu Ishida, Tomohiko Usui, Kenji Yamashiro, Yuichi Kaji, Shiro Amano, Yuichiro Ogura, Tetsuo Hida, Yoshihisa Oguchi, Jayakrishna Ambati, Joan W. Miller, Evangelos S. Gragoudas, Yin-Shan Ng, Patricia A. D'Amore, David T. Shima, Anthony P. Adamis
Ophthalmology and Visual Science Faculty Publications
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted. During pathological neovascularization, both the absolute and relative expression levels for VEGF164 increased to a greater degree than during physiological neovascularization. Furthermore, extensive leukocyte adhesion was observed at the leading edge of pathological, but not physiological, neovascularization. When a VEGF164-specific neutralizing aptamer was administered, it potently suppressed the leukocyte adhesion and pathological neovascularization, whereas it had little or no effect on physiological neovascularization. In parallel experiments, genetically altered VEGF164 …
Age, Gender, Biometry, Refractive Error, And The Anterior Chamber Angle Among Alaskan Eskimos, Robert Wojciechowski, Nathan Congdon, William Anninger, Aimee Teo Broman
Age, Gender, Biometry, Refractive Error, And The Anterior Chamber Angle Among Alaskan Eskimos, Robert Wojciechowski, Nathan Congdon, William Anninger, Aimee Teo Broman
Dartmouth Scholarship
The prevalence of angle-closure glaucoma (ACG) is greater for Eskimos/Inuit than it is for any other ethnic group in the world. Although it has been suggested that this prevalence may be due to a population tendency toward shallower anterior chamber angles, available evidence for other populations such as Chinese with high rates of ACG has not consistently demonstrated such a tendency.
The Role And Regulation Of Heat Shock Protein 27 In Retinal Ischemic Preconditioning, Norris Andrew Whitlock
The Role And Regulation Of Heat Shock Protein 27 In Retinal Ischemic Preconditioning, Norris Andrew Whitlock
MUSC Theses and Dissertations
Introduction: Vision loss resulting from retinal ischemia is associated with several systemic and ocular diseases. In the retina, ischemia is thought to lead to neuronal cell death by initiating a series of events that include oxidative stress, glutamate excitotoxicity, and intracellular Ca2+ overload. Attempts to prevent ischemic retinal degeneration have included the use of NMDA receptor antagonists, Ca2+ channel blockers, and antioxidants. These treatments have had limited success due to incomplete retinal protection and development of adverse side-effects. This has caused researchers to look toward endogenous protective mechanisms, such as ischemic preconditioning (IPC) in order to identify new strategies to …
Structure And Functional Effects Of Age-Related Posttranslational Modifications Of Aquaporin 0 In The Normal Human Lens, Lauren Elizabeth Smith-Ball
Structure And Functional Effects Of Age-Related Posttranslational Modifications Of Aquaporin 0 In The Normal Human Lens, Lauren Elizabeth Smith-Ball
MUSC Theses and Dissertations
Aquaporin 0 (AQP0, MIP), a water channel protein found in the ocular lens fiber cells, has been proposed to maintain osmotic homeostasis by contributing to an internal circulatory system within the avascular lens. The formation of cataracts in patients with mutations in the AQP0 gene and in heterozygous AQP0 deficient mice suggests that AQP0 is necessary for establishing and preserving lens transparency. Previous structural characterization of AQP0 revealed that the C-terminus, a putative regulatory domain, is subject to many age-related posttranslational modifications. The goal of the present study was to map the spatial distribution of posttranslationally modified forms of AQP0 …