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Full-Text Articles in Ophthalmology

Exploring A Short-Wavelength Sensitive Cone Mechanism To Brightness And Discomfort Glare, David Glabe Apr 2012

Exploring A Short-Wavelength Sensitive Cone Mechanism To Brightness And Discomfort Glare, David Glabe

David K Glabe

Yellow lenses have long been reported to alter visual perception, including subjective impressions of brightness and discomfort glare. To date, no consensus has been reached regarding the physiological mechanism behind this altered perception, although recent research suggests a possible short-wavelength sensitive cone (S-cone) mechanism. An experiment was conducted to test the hypothesis that S-cones are responsible for the perceived increase in brightness and decrease in discomfort glare perception when viewing through yellow lenses. Thirty participants were asked to use neutral density filters to match perception of brightness and discomfort glare through colored filters and with no filters in low and …

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An Improved Diagnostic Test For Rod Cone Dysplasia 1 (Rcdl) Using Allele-Specific Polymerase Chain Reaction, Kunal Ray, Maria Lara Tejero, Victoria Baldwin, Gustavo Aguirre Dec 1995

An Improved Diagnostic Test For Rod Cone Dysplasia 1 (Rcdl) Using Allele-Specific Polymerase Chain Reaction, Kunal Ray, Maria Lara Tejero, Victoria Baldwin, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

Purpose. To develop an improved diagnostic test for rod-cone dysplasia type 1 (rcdl). The rcdl phenotype is an early onset, autosomal recessive disease caused by a mutation in the canine rod cyclic GMP phosphodiesterase (β-subunit (PDE6B) gene. A G to A transition in codon 807 at nucleotide position 2420 results in a stop codon. This is the only disease causing mutation detected so far in the canine PDE6B gene.
Methods. Allele specific primers were designed in which the 3' end had the nucleotide corresponding to either the wild type or the mutant rcdl allele. PCR was …

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