Oncology Commons^™

The Impact Of Post-Mastectomy Radiation Therapy On Male Breast Cancer Patients--A Case Series, Edward Yu, Hiromichi Suzuki, Jawaid Younus, Tarek Elfiki, Larry Stitt, Gary Yau, Olga Vujovic, Francisco Perera, Michael Lock, Patricia Tai

Michael Lock

OBJECTIVE: To assess the impact of radiation management on male breast cancer (MBC) at London Regional Cancer Program (LRCP).

METHODS AND MATERIALS: Men with a diagnosis of breast cancer referred to LRCP were reviewed. The seventh American Joint Committee on Cancer staging system was used. Patients treated with and without post-mastectomy radiation therapy (PMRT) were analyzed. Disease-free survival (DFS) was defined as time duration from diagnosis to first recurrence. Overall survival (OS) was defined as time duration from pathologic diagnosis to death or last follow-up with any death defined as an event. Survival estimates were obtained using Kaplan-Meier methodology.

RESULTS: …

Prediction Of Radiation Pneumonitis By Dose-Volume Histogram Parameters In Lung Cancer--A Systematic Review, George Rodrigues, Michael Lock, David D'Souza, Edward Yu, Jake Van Dyk

Michael Lock

BACKGROUND AND PURPOSE: To perform a systematic review of the predictive ability of various dose-volume histogram (DVH) parameters (V(dose), mean lung dose (MLD), and normal tissue complication probability (NTCP)) in the incidence of radiation pneumonitis (RP) caused by external-beam radiation therapy.

METHODS AND MATERIALS: Studies assessing the relationship between CT-based DVH reduction parameters and RP rate in radically treated lung cancer were eligible for the review. Synonyms for RP, lung cancer, DVH and its associated parameters (NTCP, V(20), V(30), MLD) were combined in a search strategy involving electronic databases, secondary reference searching, and consultation with experts. Individual or group data …

Oncolog, Volume 57, Number 10, October 2012, Jill Delsigne, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

• Treatments May Alleviate and Reverse Central Nervous System Radiation Necrosis: Although radiation therapy is effective against many tumors of the brain and spine, it also damages normal tissue
• INBRIEF: Bevacizumab With High-Dose Chemotherapy Shows Promise for Cisplatin-Refractory Germ Cell Tumors
• Compass: Early-Stage Testicular Cancer-Postsurgical treatment varies according to tumor stage and histology
• HOUSE CALL: Online Cancer Support Networks-Patients and caregivers find support online

Oncolog, Volume 57, Number 04, April 2012, Joe Munch, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

• Biology, More Than Chemotherapy Timing, Drives Locoregional Recurrence in Patients Who Undergo Breast-Conserving Therapy: The management of breast cancer, like that of many cancers, often requires a little bit of everything: surgery, radiation therapy, and systemic therapy with chemotherapeutic drugs or other agents
• New Treatments for Acute Myelogenous Leukemia May Improve Patient Outcomes: Acute myelogenous leukemia (AML) is an aggressive and deadly malignancy, nut new treatments are being developed that may prolong remissions
• HOUSE CALL: Controlling Nausea and Vomiting from Chemotherapy: Several techniques can be used to prevent or reduce this side effect

Latest Update On The Clinical Features And Management Of Merkel Cell Carcinoma, Ahmed Nadeem Abbasi, Sumaiya Zahid

Department of Radiation Oncology

Merkel cell carcinoma (MCC), is a rare, highly malignant skin tumour, with a poor prognosis. Though the aetiology of MCC is not known, but there are several features that it shares with melanoma. These include the natural history, clinical features and behaviour, e.g. an early spread to nodal sites, high local recurrence rate and early metastasis. Incidence of MCC is seen to be increased in immunosuppressed transplant patients, in patients with rheumatoid arthritis and in B cell malignancies, with a strong male predominance. Despite the ongoing research and advancement, MCC yet poses a challenge to the clinicians because of its …

Oncolog, Volume 57, Number 02, February 2012, Don Norwood, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

• Pediatric and Adult Cancer Patients Face Different Issues in Care, Survivorship: The challenges faced by children and adults with cancer can differ markedly, even when they have the same type of cancer
• Palliative Care May Offer Survival Benefits: Recent studies indicate that palliative care, which has been shown to improve quality of life in patients with advanced cancer, may also help patients live longer
• INBRIEF: Targeted Therapy Causes Chronic Lymphocytic Leukemia Remission/Study Finds Acupuncture Can Prevent Radiation-Induced Chronic Dry Mouth
• HOUSE CALL: Understanding the risks, benefits, and purpose of a trial can help cancer patients decide whether to participate

Acr Appropriateness Criteria®  Resectable Rectal Cancer, William E. Jones Iii, Charles R. Thomas Jr, Joseph M. Herman, May Abdel-Wahab, Nilofer Azad, William Blackstock, Prajnan Das, Karyn A. Goodman, Theodore S. Hong, Salma K. Jabbour, Andre A. Konski, Albert C. Koong, Miguel Rodriguez-Bigas, William Small Jr, Jennifer Zook, W Suh

Wayne State University Associated BioMed Central Scholarship

Abstract

The management of resectable rectal cancer continues to be guided by clinical trials and advances in technique. Although surgical advances including total mesorectal excision continue to decrease rates of local recurrence, the management of locally advanced disease (T3-T4 or N+) benefits from a multimodality approach including neoadjuvant concomitant chemotherapy and radiation. Circumferential resection margin, which can be determined preoperatively via MRI, is prognostic. Toxicity associated with radiation therapy is decreased by placing the patient in the prone position on a belly board, however for patients who cannot tolerate prone positioning, IMRT decreases the volume of normal tissue irradiated. The …