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Full-Text Articles in Oncology
Photodynamic Therapy, Ashley Thomas
Photodynamic Therapy, Ashley Thomas
McCabe Thesis Collection
Photodynamic therapy is a new treatment that is being introduced into the veterinary community. Photodynamic therapy is the use of light activated chemotherapy to kill cancer cells (Dougherty, 1998). It has already been approved by the US Food and Drug Administration to be used as a form of cancer treatment in humans, but has not been carried over to the veterinary community. That is until now. Photodynamic therapy is now being tested in the veterinary community in hopes to find the same results that the human medical community has when dealing with certain types of cancer. They also hope to …
Characterization Of Mouse Prostate Tumor-Infiltrating Leukocytes, Daniel Alan Holterman
Characterization Of Mouse Prostate Tumor-Infiltrating Leukocytes, Daniel Alan Holterman
Theses and Dissertations in Biomedical Sciences
Prostate cancer is the most common form of non-cutaneous cancer among men in the United States and the second most common cause of cancer-related death among men with approximately 189,000 new cases diagnosed and 30,200 deaths of the disease in 2002. Prostate cancer can be a treatable disease but once it becomes metastatic there are no acceptable therapies. For this reason, immunotherapy has been attempted but the results have been disappointing. The TRAMP model was used to evaluate specific interactions between an intact murine immune system and a prostate tumor that expressed a naturally processed weak tumor antigen. Vaccination trials …
Synergistic Interactions Of Chlorambucil, Dha, And Trail In Jurkat And H460 Human Cancer Cells, Jennifer Ellen Bush-O'Donnell
Synergistic Interactions Of Chlorambucil, Dha, And Trail In Jurkat And H460 Human Cancer Cells, Jennifer Ellen Bush-O'Donnell
Theses, Dissertations and Capstones
Traditional chemotherapeutic drugs are prone to toxicity and may result in secondary cancers. In recent years much attention has been garnered by alternate methods of cancer treatment with fewer side effects, including immunotherapy and administration of ω-3 fatty acids, both of which have been shown to cause apoptosis in cancer cells. Docosahexaenoic acid (DHA), a fatty acid, is a normal component of cell membranes and is safe for systemic administration. The cytokine TRAIL (tumor necrosis factorrelated apoptosis-inducing ligand) is able to induce apoptosis in cancer cells while sparing normal tissue. In this study, the alkylating agent chlorambucil (CLB) was combined …
The Role Of Ap-1 Transcription Complex In Retinoic Acid-Dependent B16 Melanoma Cell Growth Arrest And Differentiation, Ying Huang
Theses, Dissertations and Capstones
Our laboratory has been studying the effects of all-trans retinoic acid (atRA) on the growth and differentiation of the B16 mouse melanoma cells. RA inhibits both anchorage-dependent and –independent growth and stimulates melanin production in B16 cells, which are accompanied by an increase in AP-1 activity. To further investigate the RA-induced AP-1 activity, I established clones of B16 stably expressing an AP-1-luciferase reporter gene. Treatment of these clones with phorbol dibutyrate (PDB), a known activator of AP-1, rapidly increased AP-1 activity which reached its maximum level at 2-4 h and returned to baseline level by 24 h. In contrast, RA …
Storying The Body : Women's Narratives Through The Lens Of Breast Cancer, Janet A. Griffin
Storying The Body : Women's Narratives Through The Lens Of Breast Cancer, Janet A. Griffin
Theses : Honours
What can women's narratives contribute to our understanding of breast cancer and to feminist theories of the body? This thesis explores the meanings women construct to make sense of embodied experiences of breast cancer, and the profound experience of breast loss. Rich contextual data was elicited from in depth, guided conversations with five premenopausal women who have undergone mastectomy. Adopting feminist methodology, biographic-narrative was used to place the body at the heart of inquiry. This thesis explores the personal and theoretical meanings of mastectomy, embedded in the larger story of how these five women experience their breasts, throughout their lives. …