Oncology Commons^™

Calibration Of A Novel Microdosimetry System For In Vitro Applications Of Actinide Radiopharmaceuticals, Lydia J. Wilson, Brian Miller, George Tabatadze, Firas Mourtada

Department of Radiation Oncology Posters

Background

• Alpha-emitting radionuclides show promise for targeted radiopharmaceutical therapy (TRT).
• High linear energy transfer and short range cause highly localized DNA damage for effective cancer cell eradication.
• However, distributions of radioactivity and absorbed dose on the cellular scale remain elusive.
• Progress toward understanding α-TRT radiobiologic response, evaluating novel α-TRT drug efficacy, and optimizing administration for personalized treatments will require knowledge of radioactivity and absorbed dose distributions.
• A novel real-time α camera, the ionizing radiation quantum imaging detector (iQID), has successfully mapped the microdistribution of α-emitting radionuclides in mouse and human tissues [1].

Organ-Specific Dosimetry Following Radiopharmaceutical Therapy For Metastatic Prostate Cancer, Frank J. Arturi, Nilanjan Haldar, Shray Jain, Gia Nguyen, Jessie Dinome, Firas Mourtada, Lydia J. Wilson, Phd

Department of Radiation Oncology Posters

Introduction

• Radiopharmaceutical Therapy (RPT) uses radioactive agents to target cancer at the cellular level
• Lu-177 targeting prostate-specific membrane antigen (PSMA), known as 177Lu- PSMA-617, can be used to treat metastatic, castration-resistant prostate cancer (mCRPC)
• 177Lu-PSMA-617 treatments use a standard dose and treatment regimen for all patients
• Patients exhibit different side effects and tumor response during treatment

Results Of A Prospective Trial To Evaluate Novel Lung Function Imaging For Lung Cancer Surgery, Lydia J. Wilson, Phd, Richard Castillo, Phd, Edward Castillo, Phd, Bernard Jones, Phd, Moyed Miften, Phd, Lindsey Olsen, Phd, Vikas Aragam, Phd, Robert A. Meguid, Md, Mph, Crystal J. Erickson, Md, Amanda Young, Msn, Matthew Blum, Md, Tyler Grenda, Md, Julie Barta, Md, Benjamin Leiby, Phd, Timothy Waxweiler, Md, Brian Kavanagh, Md, Mph, John D. Mitchell, Md, Yevgeniy Vinogradskiy, Phd

Department of Radiation Oncology Posters

Background

• Surgery is the primary form of definitive treatment for early-stage lung cancer.
• Poor lung function before surgery places patients at high risk of pulmonary complications after resection.
• Surgeons evaluate patient fitness for surgery using pulmonary function tests (PFTs) to calculate the predicted postoperative PFT (ppoPFT).
• Conventional ppoPFT calculations assume homogeneous lung function, which can be inaccurate.
• 4DCT-ventilation is a novel lung function imaging modality developed in radiation oncology that uses 4DCT data to calculate high-resolution ventilation maps.

3d Bioprinting The Tumor Microenvironment For Immunotherapy Development, Molly Leyda, Tykeem Manor, John Szarejko, Douglas Myers, John M. Perry

Posters

The tumor microenvironment (TME) is a complex system that plays a crucial role in tumor progression, immune evasion, and therapy resistance. The TME is composed of various cell types, including tumor cells, stromal cells, and immune cells such as macrophages. Macrophages are versatile myeloid cells which can exhibit both pro-tumoral and anti-tumoral functions, depending on their phenotype and the TME context. M1 macrophages have demonstrated promising pro-inflammatory and anti-tumor effects, while tumor associated M2 macrophages (TAMs) play an anti-inflammatory role and promote tumor immune escape. Understanding the complex interactions between TAMs and the TME is, therefore, essential for developing effective …

Ehealth Cancer-Related Fatigue Intervention Single Arm Study, Anne Fleischer, Samantha Gelhaus, Emily Flohre, Caroline Frazee, Mary I. Fisher, Carrie Pickering

University of Dayton Doctor of Physical Therapy Annual Research Symposium

Purpose/Hypothesis: Cancer related fatigue (CRF), a sense of physical, emotional and cognitive tiredness not relieved by rest, negatively affects function. Prevalence is reported to be 59-100% throughout the care continuum. Exercise and psychosocial interventions are supported as effective treatment options, yet barriers to personalized care include time and distance to travel for care. The purpose of this pilot study was to evaluate the effectiveness of personalized exercise prescribed by physical therapy (PT), and occupational goal setting and tasks prescribed by occupational therapy (OT) on physical function.

Number of Subjects: 16 adults with cancer and fatigue ≥4/10.

Materials and Methods: Over …

Sdrnas Participate In The Maintenance And Onset Of Prostate Cancer, Neil Chaudhary

Poster Presentations

What is an sdRNA? Noncoding RNA (ncRNA) is a class of RNA that includes microRNA (miRNA) and small nucleolar RNA (snoRNA). Fragments excised from ncRNAs are known as noncodingderived RNA (ndRNA). A certain class of ndRNAs that are derived from snoRNAs have been denoted as Small Nucleolar Derived RNAs (sdRNAs). Our lab has previously hypothesized and demonstrated that sdRNAs display regulatory functions on target genes, similar to the functions of miRNAs. sdRNAs are almost identical to microRNAs and differ mainly in their source of origin.

Our lab has shown that sdRNA-93 is frequently misexpressed in breast cancer cell lines and …

Diagnosis Of Mosaic Rasopathy In A Child With Rhabdomyosarcoma, Meagan Vacek, Paige Johnson, Midhat S. Farooqi, Kristi M. Canty, Dihong Zhou, Brendan Lanpher, Wendy Allen-Rhoades, Erin M. Guest

Posters

Background: Phacomatosis pigmentokeratotica (PPK) is a subtype of epidermal nevus syndrome characterized by the co-existence of a sebaceous nevus and a speckled lentiginous nevus and described in approximately 30 cases in literature. PPK is now recognized as a mosaic RASopathy due a postzygotic mutation in the Ras-Raf-MEK-ERK pathway. RAS variants are also known to contribute to tumorigenesis, in some pediatric cancers, including rhabdomyosarcoma. Objective: Describe the presentation and evaluation of a child with pelvic rhabdomyosarcoma and evolving skin lesions found to have a rare mosaic-RASopathy. Design/Method: Case Report Results: The patient is a former 32-week premature female who presented to …

Increasing Palliative Care Team Involvement In Pediatric Hematopoietic Stem Cell Transplant Patients, Meagan Vacek, Lisa Tarbell, Melissa List, Erin Hall, Jennifer Linebarger, Kelstan Ellis, Gina Jones, Joel Thompson

Posters

Background: Palliative care facilitates communication, helps with physical and psychological symptom management, and assists in goals of care and advance care planning discussions.1 Multiple organizations, including the American Academy of Pediatrics and American Society of Clinical Oncology encourage palliative care engagement and their involvement with hematopoietic stem cell transplant (HSCT) patients has been shown to be beneficial as HSCT is associated with a high degree of morbidity and possible mortality.2-3 Objective: To increase the number of PaCT consults for patients receiving HSCT for our targeted diagnoses from 48% to 75% by December 2023. Methods: Chart review was conducted for patients …

A Guidebook For Latina Breast Cancer Survivors & Occupational Therapy Practitioners, Abigail Hernandez, Leslie Khan-Farooqi, Mary Ann Smith

Spring 2024 Virtual OTD Capstone Symposium

Many Latina women diagnosed with breast cancer face psychosocial challenges and do not have access or the necessary resources to assist them with these challenges which may lead to decreased quality of life. This study is designed to address the most common psychosocial issues associated with breast cancer to assist Latina women as well as occupational therapy practitioners.

Prevención Del Cáncer De Cuello Uterino, Mary Luz Monroy Rubiano, Claudia Viviana Jiménez Ángel, Sandra Patricia Urueña Carmona

Ciencias de la Salud

Este libro es una estrategia de promoción de la salud y prevención del cáncer de cuello uterino, desarrollada por los grupos de investigación SATTWA y TATAMASALUD. Basado en un proyecto realizado en Girardot, ofrece a las mujeres herramientas para identificar los aspectos clave del cáncer de cuello uterino, subraya la importancia del autocuidado y proporciona información básica para su prevención. Con estadísticas alarmantes sobre su prevalencia y mortalidad en Colombia, esta guía presenta información científica de manera accesible e ilustrada, permitiendo a las lectores compartir y difundir este conocimiento en sus comunidades. Unidas en una meta común, es posible reducir …

Social Needs Risk And Patient Outcomes With Supportive Oncology Care, Rebecca Cammy, Lcsw, Joshua Banks, Ma

Department of Medical Oncology Posters

Objective

This study utilized social risk data in the electronic heath record collected in routine clinical practice and examined relationships with supportive oncology care contacts and patient outcomes.

Prognostic Properties Of Kras Gene Mutation Subtypes In Resected Pancreatic Cancer, Faria Nusrat, Eliyahu Gorgov, Md, Wilbur Bowne, Md, Obehioye Isesele, Akshay Khanna, Harish Lavu, Md, Aditi Jain, Phd, Charles J. Yeo, Md, Avinoam Nevler, Md

Alpha Omega Alpha Research Symposium Posters

Introduction

• Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and therapy-resistant cancer with an overall 5-year survival rate of almost 12%, making it among the most lethal of all major cancers.¹
• PDAC has a distinct genomic profile, with somatic KRAS protooncogene mutations in ~90% of cases.^2,3
• Current literature has not reached a consensus on disease prognosis based on KRAS mutation subtype.^2-5

Unleashing Wellness: Exploring The Impact Of Pet Therapy On Anxiety Reduction, Quality Of Life, And Treatment Adherence In Pediatric Oncology Patients, Karina Brouwer

Nursing | Student Research Posters

Pet therapy is a complementary type of therapeutics in which a person and animal have a guided interaction with the purpose of helping someone cope with physical and/or mental illness. Animal-assisted therapy is used in numerous settings and has been shown to reduce stress, lower blood pressure and heart rate, and decrease anxiety and depression (Husson University, 2022). In particular, pediatric oncology patients have enormous amounts of stress in their lives, which leads to increased anxiety and decreased quality of life (Children's Cancer Cause, 2023). While evidence shows that integrating pet therapy in pediatric oncology patients produces significant benefits on …

Addressing Burden In Caregivers Of Older Adults With Cancer, Lora Rhodes, Lcsw, Kristine Swartz, Md, Caroline Glavin, Lsw, Charlotte Zuber, Kuang-Yi Wen, Phd

Department of Medical Oncology Posters

Background

Forty-two million adults in the United States are providing unpaid care for a family member or friend over the age of 50. For approximately 2.5 million of these caregivers, cancer is the primary illness or disability of their care recipient (National Alliance for Caregiving and AARP, 2020). As baby boomers continue to age, and the number of cancer survivors continues to increase, the need for informal caregivers will expand exponentially.

While Comprehensive Geriatric Assessment (CGA) is recommended for older patients with cancer and distress screening is recommended for all cancer patients, there are currently no recommendations regarding screening for …

Nutritional Support For Oncology Patients: Role For The Pcp, Annabelle S. Feist

Family Medicine Clerkship Student Projects

Adequate nutrition is a key prognostic factor in the treatment outcomes of patients with cancer diagnoses. Despite the increased morbidity and mortality of malnutrition, the importance of nutrition for oncology patients is often not well communicated and not well understood by patients. Part of this issue stems from the limited information most patient can absorb at any given doctors appointment, especially regarding their cancer. Primary care providers hold a unique position to fill this gap and have the information be heard and retained given their usual role in addressing overall health. This project compiles resources in an easily accessible and …