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Full-Text Articles in Oncology
Photodynamic Therapy As An Effective Therapeutic Approach In Mame Models Of Triple Negative And Inflammatory Breast Cancers, Neha Aggarwal
Photodynamic Therapy As An Effective Therapeutic Approach In Mame Models Of Triple Negative And Inflammatory Breast Cancers, Neha Aggarwal
Wayne State University Dissertations
Introduction: Photodynamic therapy (PDT) is a minimally invasive, FDA approved therapy for
treatment of several indications including endobronchial and esophageal cancers that are
accessible to light. Triple negative breast cancer (TNBC) and inflammatory breast cancer (IBC)
are aggressive and lethal subtypes of breast cancer that spread to chest wall and dermal
lymphatics, respectively, sites that would be accessible to light. Both TNBC and IBC patients
have a relatively poor survival rate due to lack of targeted therapies. Use of PDT is
underexplored for breast cancers but has been proposed for treatment of subtypes for which a
targeted therapy is unavailable. …
A Role For Reactive Oxygen Species In Photodynamic Therapy, Michael Price
A Role For Reactive Oxygen Species In Photodynamic Therapy, Michael Price
Wayne State University Dissertations
Photodynamic therapy (PDT) is based on the ability of certain photosensitizing agents to selectively localize in neoplastic cells and their vasculature. Subsequent irradiation at a wavelength corresponding to a photosensitizer absorbance band excites the photosensitizer molecules, leading to energy transfer reactions and fluorescence. It was initially concluded that the phototoxic effect occurred when energy from the excited state of the photosensitizer was transferred to dissolved oxygen to form singlet oxygen. This product has a very brief half-life and will cause cellular damage only in the immediate vicinity of its formation. But an excited-state photosensitizer can also interact with oxygen to …