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Is Combination Nivolumab And Ipilimumab Safe And Effective In Patients With Melanoma?, Jacob L. Toscano
Is Combination Nivolumab And Ipilimumab Safe And Effective In Patients With Melanoma?, Jacob L. Toscano
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this selective EBM review is to determine whether or not combination nivolumab and ipilimumab is safe and effective in patients with melanoma.
Study design: Review of two randomized controlled trials (RCTs) published in 2015, and one cohort study published in 2013.
Data Sources: All of the articles were published in English language, peer reviewed journals and were found using PubMed and Cochrane databases.
Outcomes Measured: The safety of combination nivolumab and ipilimumab was measured by treatment-related grade 3 or 4 adverse effects. The effectiveness was measured by progression-free survival, which is based …