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Oncology Commons

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University of Texas MD Anderson Cancer Center

Molecular Targeted Therapy

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Full-Text Articles in Oncology

Oncolog, Volume 63, Number 07, July 2018, Sarah Bronson, Bryan Tutt Jul 2018

Oncolog, Volume 63, Number 07, July 2018, Sarah Bronson, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

  • FGFR Inhibition for Bladder Cancer: Erdafitinib has favorable response rate in advanced bladder cancers, including those that do not respond to immunotherapy
  • INBRIEF: Targeted Therapies Matched to Tumor-Specific Mutations Prolong Survival
  • Managing High-Risk Breast Lesions: Strong provider recommendation for preventive therapy increases its use in women with lobular carcinoma in situ, atypical hyperplasia
  • Aerosolized Gemcitabine for Pulmonary Metastases: Clinical trials tests novel chemotherapy delivery system for patients with lung metastases from osteosarcoma or other solid tumors
  • HOUSE CALL: What the national Cancer Institute Does- Resources for cancer patients, caregivers, physicians, researchers


Oncolog, Volume 63, Number 02, February 2018, Sarah Bronson, Bryan Tutt Feb 2018

Oncolog, Volume 63, Number 02, February 2018, Sarah Bronson, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

  • Radiation Therapy for Liver Cancer: Clinical trials expand treatment options for patients with primary liver cancer
  • Proton Therapy for Breast Cancer May Avoid Heart Damage: Trial compares cardiotoxicity of proton-and photon-based radiation therapy to the breast/chest wall and lymph nodes
  • New targeted Therapies for Leukemia: New treatments target CD123, BCL2 proteins in acute myelogenous leukemia, blastic plasmacytoid dendritic cell neoplasm
  • HOUSE CALL: Supportive Care for Cancer Patients- Supportive care treats the whole patient, not just the cancer


Oncolog, Volume 61, Number 11-12, November - December 2016, Brandon C. Strubberg, Sarah Bronson, Stephanie Deming, E Nielsen Nov 2016

Oncolog, Volume 61, Number 11-12, November - December 2016, Brandon C. Strubberg, Sarah Bronson, Stephanie Deming, E Nielsen

OncoLog MD Anderson's Report to Physicians (All issues)

  • Innovative Trial Investigates Molecular Drivers of Triple-Negative Breast Cancer: A new clinical trial focusing on molecular biomarkers of triple-negative breast cancer (TNBC) is attempting to advance targeted therapy against the deadly disease.
  • Smac Mimetics Show Activity against Myelofibrosis: Not all cases of myelofibrosis respond well to ruxolitinib, the only drug approved for this disease. However, early studies indicate that a new class of drugs, Smac mimetics, can achieve a response in some patients with myelofibrosis.
  • Urothelial Cancer Subtypes Predict Treatment Response: Subtypes of urothelial cancer identified through gene expression profiling predict which patients are most likely to respond to neoadjuvant …


Oncolog, Volume 60, Number 09, September 2015, Sarah Bronson, Bryan Tutt, K. Nair Sep 2015

Oncolog, Volume 60, Number 09, September 2015, Sarah Bronson, Bryan Tutt, K. Nair

OncoLog MD Anderson's Report to Physicians (All issues)

  • Enhanced Surgical Recovery Programs Improve Perioperative Outcomes for Cancer Patients: For patients undergoing cancer surgery, potential complications and long recovery times can delay the delivery of additional life-saving therapy. To improve patients' perioperative outcomes and clear the way for timely administration of additional therapies, several surgical teams at The University of Texas MD Anderson Cancer Center gave begun using enhanced surgical recovery programs (ESRPs).
  • New Treatments for Respiratory Viruses in Immunocompromised Patients: Viral respiratory infections are a major concern for immunocompromised patients, in whom such infections are difficult to treat and can lead to pneumonia and even death. Although few …


Oncolog, Volume 60, Number 04, April 2015, Jill Deisigne, Joe Munch, Bryan Tutt, Sarah Bronson Apr 2015

Oncolog, Volume 60, Number 04, April 2015, Jill Deisigne, Joe Munch, Bryan Tutt, Sarah Bronson

OncoLog MD Anderson's Report to Physicians (All issues)

  • Multidisciplinary Globe-Sparing Treatment for Lacrimal Gland Carcinoma Preserves Vision and Minimizes Morbidity: Until recently, the treatment of lacrimal gland carcinoma almost always required removal of the eye. But for some patients with these tumors, globe-sparing surgery followed by radiation therapy can preserve vision and decrease ocular morbidity and facial disfigurement.
  • Novel Trial Design Streamlines Development of Breast Cancer Therapies: Developing a cancer-fighting drug can take around a billion dollars and a dozen or more years. Even then, fail in clinical trials. To identify effective cancer therapies more quickly and efficiently, researchers have tuned to an innovative clinical model in which …


Oncolog, Volume 59, Number 10, October 2014, Sarah Bronson, Kathryn L. Hale, Roberto Molar-Candanosa, K. Stuyck Oct 2014

Oncolog, Volume 59, Number 10, October 2014, Sarah Bronson, Kathryn L. Hale, Roberto Molar-Candanosa, K. Stuyck

OncoLog MD Anderson's Report to Physicians (All issues)

  • New Drugs for Myeloproliferative Neoplasms Ease Suffering and Extend Life: A new class of drugs has redefined treatment for patients with myeloproliferative neoplasms by easing their symptom burden while extending their lives
  • Neoadjuvant Targeted Therapy May Offer Multiple Benefits for Patients with Locally Advanced Renal Cancer: Despite definitive treatment with nephrectomy, locally advanced renal cancer recurs in 20%-30% of patients, substantially reducing their chance for long-term survival. To prevent such recurrences and prolong survival, urologic oncologists are studying the integration of targeted molecular therapies with surgical treatments
  • New Combination Therapy Offers Potential to Cure FLT3-ITD Acute Myelogenous Leukemia: A new …


Oncolog, Volume 59, Number 07, July 2014, Sarah Bronson, Joe Munch, Bryan Tutt, K. Stuyck Jul 2014

Oncolog, Volume 59, Number 07, July 2014, Sarah Bronson, Joe Munch, Bryan Tutt, K. Stuyck

OncoLog MD Anderson's Report to Physicians (All issues)

  • Side Effects of Targeted Molecular Agents Vary According to Mechanism of Action: The main side effects of cytotoxic chemotherapy are notorious. But the side effects of newer, targeted molecular agents are less well known, so patients receiving such drugs may not know what to expect and may require additional guidance from physicians
  • INBRIEF: Study Finds Less Frequent Bisphosphonate Treatment Equivalent to Standard Regimen
  • RAS Mutation Status May predict Outcomes After Surgery for Colorectal Cancer Liver Metastases
  • HPV Test Does Not Replace Pap Test for Cervical cancer Screening: The recent approval of a human papillomavirus (HPV) test for cervical cancer screening …


Oncolog, Volume 59, Number 04, April 2014, Zach Bohannan, Joe Munch, J. Delsigne Apr 2014

Oncolog, Volume 59, Number 04, April 2014, Zach Bohannan, Joe Munch, J. Delsigne

OncoLog MD Anderson's Report to Physicians (All issues)

  • New fat Grafting Technique Improves Aesthetic Outcomes Following Head and Neck Reconstructive Surgery: A new gat grafting technique is enabling reconstructive surgeons to maximize aesthetic outcomes following major reconstruction for head and neck cancer treatment-related defects
  • INBRIEF: Invasive Bladder Cancer Subtypes Resemble Breast Cancer Subtypes
  • New Kinase Inhibitors Hold Promise for Chronic Lymphocytic Leukemia, Other B-Cell Malignancies: New targeted therapies against chronic lymphocytic leukemia (CLL) are eliciting overall response rates similar to those achieved using standard chemoimmunotherapy but with fewer toxic effects
  • HOUSE CALL: Animal-Assisted Therapy- Interacting with pets helps recovery


Oncolog, Volume 59, Number 02, February 2014, Sarah Bronson, Kathryn L. Hale, Bryan Tutt, M. Yeoman Feb 2014

Oncolog, Volume 59, Number 02, February 2014, Sarah Bronson, Kathryn L. Hale, Bryan Tutt, M. Yeoman

OncoLog MD Anderson's Report to Physicians (All issues)

  • New Approaches Revolutionize the Treatment of Advanced Melanoma: Recent breakthroughs in immunotherapy and targeted therapy have improved outcomes for patients with advanced melanoma
  • Comprehensive Tobacco Treatment Approach Helps Patients Quit on Their Terms: Kicking a tobacco habit is a formidable task. Quitting tobacco after a diagnosis of cancer, can be even more difficult
  • Targeted Drug Shows Promise Against Advanced Breast Cancer: Adding the experimental kinase inhibitor palbociclib to standard hormonal therapy may delay disease progression in patients with advanced breast cancer that is estrogen receptor (ER) positive and human epidermal growth factor receptor 2 (HER@) negative
  • HOUSE CALL: Avoiding Food-Drug …


Oncolog, Volume 59, Number 01, January 2014, Joe Munch, Jill Delsigne, M. Yeoman Jan 2014

Oncolog, Volume 59, Number 01, January 2014, Joe Munch, Jill Delsigne, M. Yeoman

OncoLog MD Anderson's Report to Physicians (All issues)

  • Addressing Fertility Issues in Cancer Patients: For some newly diagnosed cancer patients, whether they will be able to have children after treatment is the furthest question from their minds-until the risks of therapy bring it front-and-center
  • INBRIEF: Intensity-Modulated Proton Therapy May Reduce Side Effects of Oropharyngeal Carcinoma Treatment
  • Medical Advances Improve Bile Duct Cancer Treatment: Cholangiocarcinoma, the most common bile duct cancer, is a clinically silent disease in its early stages; patients usually present with advanced disease, which carries a poor prognosis
  • HOUSE CALL: Weight Loss Tips for Breast Cancer Survivors-Losing excess weight has multiple benefits


Oncolog, Volume 58, Number 08, August 2013, Bryan Tutt, Sarah Bronson Aug 2013

Oncolog, Volume 58, Number 08, August 2013, Bryan Tutt, Sarah Bronson

OncoLog MD Anderson's Report to Physicians (All issues)

  • Specialized Care Improves Lives of patients With Head and Neck Lymphedema: A unique program is producing dramatic results for patients with head and neck lymphedema, a side effect of cancer treatment that can interfere with patient's ability to speak, swallow, or breath
  • Targeted Cancer Therapies May Help Overcome Resistance to Radiation Therapy: Some cancer cells are resilient enough to withstand and recover from the damage to their DNA caused by radiation therapy. But recent studies have shown that adding molecularly targeted agents to radiation therapy can prevent the repair of this radiation-induced damage and therapy improve the treatment response of …


Oncolog, Volume 58, Number 03, March 2013, Sarah Bronson, Zach Bohannan, Bryan Tutt Mar 2013

Oncolog, Volume 58, Number 03, March 2013, Sarah Bronson, Zach Bohannan, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

  • Advances in Pulmonary Medicine Facilitate Cancer Diagnosis, Treatment: The lungs present unique challenges in cancer diagnosis and treatment-navigating a maze of bronchi to find and sample tissue that will lead to an accurate diagnosis of lung cancer, for example, or deciding whether to proceed with treatment for cancer in the presence of concomitant lung disease
  • New Drugs Increase Treatment Options for Patients with Imatinib-Resistant Chronic Myeloid Leukemia: In the past year, several new targeted drugs have been approved as second-line treatments for imatinib-resistant chronic myeloid leukemia (CML). These drugs include the second-generation tyrosine kinase inhibitor bosutinib and the third-generation tyrosine …


Oncolog Volume 55, Number 09, September 2010, Sunita Patterson, John Lebas Sep 2010

Oncolog Volume 55, Number 09, September 2010, Sunita Patterson, John Lebas

OncoLog MD Anderson's Report to Physicians (All issues)

  • Tiny Particales, vast Potential-Coming soon to the clinic: nanoparticles that deliver therapy straight to tumor cells, bypassing normal cells and many toxic effects
  • Non-Hodgkin Lymphomas: Targeted Therapies Leading Treatment Advances
  • HOUSE CALL: Writing for Wellness: Keeping a Journal
  • INBRIEF: Study Shows Abnormal Cells in Blood Increase with Lung Cancer Stage


Oncolog Volume 55, Number 06, June 2010, John Lebas Jun 2010

Oncolog Volume 55, Number 06, June 2010, John Lebas

OncoLog MD Anderson's Report to Physicians (All issues)

  • The BATTLE Results Are IN: Phase II trial reveals molecular signatures in lung cancer that may guide treatment decisions.
  • Endoscopic Repair of Colon Perforations: Nonsurgical techniques for closing gestrointestinal defects may yiels benefits for patients undergoing colonoscopy.
  • INBRIEF: Stem Cells Seen Repairing Heart Attack Damage Over Time/Additional Blood Data May Improve Pediatric Leukemia Predictions/Pediatric Patients with Rare Tumor May benefit from Heated Chemotherapy/New Findings Refute Link Between UVA, Melanoma.
  • HOUSE CALL: Skin Cancer Screening: What is It and Who Should Get It ?: Types of skin cancer/Who should be screened ?/What to expect/Self-examination: Check your skin regularly and tell your …


Oncolog Volume 54, Number 11/12, November/December 2009, Dawn Chalaire, Joe Munch Nov 2009

Oncolog Volume 54, Number 11/12, November/December 2009, Dawn Chalaire, Joe Munch

OncoLog MD Anderson's Report to Physicians (All issues)

  • Treating Neurofibromatosis
  • Personalized Therapy for Lung Cancer
  • House Call: Genetic Screening for Cancer Risks Gives Patients Options


Oncolog, Volume 52, Number 09, September 2007, Sunni Hosemann, Diane Witter, Gabriel N. Hortobagyi Md Jan 2007

Oncolog, Volume 52, Number 09, September 2007, Sunni Hosemann, Diane Witter, Gabriel N. Hortobagyi Md

OncoLog MD Anderson's Report to Physicians (All issues)

  • Sparing Life and Limb
  • Can a Common Spice Be Use to Treat Cancer?
  • House Call: Your First Colonoscopy: Here's What You Can Expect
  • DiaLog: Targeted Therapies Are Here to Stay, by Gabriel N. Hortobagyi, MD


Oncolog, Volume 49, Number 06, June 2004, Kate O'Suilleabhain, Katie Prout Matias, Jack Roth Md Jun 2004

Oncolog, Volume 49, Number 06, June 2004, Kate O'Suilleabhain, Katie Prout Matias, Jack Roth Md

OncoLog MD Anderson's Report to Physicians (All issues)

  • Despite Initial Setbacks, Researchers Are Focusing on Antiangiogenic Therapy More Than Ever
  • Dynamic Contrast-Enhanced Magnetic Resonance Imaging Predicts Response to Antiangiogenesis Agents
  • "Smart Bombs": Targeted Therapies Home in on Increasingly Well-Defined Targets
  • House Call: Understanding Angiogenesis
  • DiaLog: Gene Therapy for Cancer: Safety First, by Jack Roth, MD, Chair, Department of Thoracic and Cardiovascular Surgery


Oncolog, Volume 49, Number 05, May 2004, David Galloway, Dawn Chalaire, Emil J. Freireich Md May 2004

Oncolog, Volume 49, Number 05, May 2004, David Galloway, Dawn Chalaire, Emil J. Freireich Md

OncoLog MD Anderson's Report to Physicians (All issues)

  • Experts Recommend Treating Cancer Pain in the Context of Other Symptoms
  • Protocols: Studies Examine Treatment for Cancer-Related Pain
  • Participation of Elderly Patients in Clinical Trials: Looking Beyond Age
  • House Call: From Cancer Research to Clinical Practice
  • DiaLog: The Next 20 Years: The Changing Face of Cancer Treatment, by Emil J. Freireich, MD, Director, Adult Leukemia Research Program


Oncolog, Volume 49, Number 03, March 2004, Beth Notzon, Katie Prout Matias Mar 2004

Oncolog, Volume 49, Number 03, March 2004, Beth Notzon, Katie Prout Matias

OncoLog MD Anderson's Report to Physicians (All issues)

  • Translational Research Speeds the Journey from Lab Results to Clinical Outcomes
  • New Tests Could One Day Predict Response to Chemotherapy and Presence of Metastatic Disease in Patients with Breast Cancer
  • House Call: Mind-Body Approaches for Patients with Cancer


Oncolog, Volume 47, Number 02, February 2002, Kerry L. Wright, Charles F. Leverbeck Md Feb 2002

Oncolog, Volume 47, Number 02, February 2002, Kerry L. Wright, Charles F. Leverbeck Md

OncoLog MD Anderson's Report to Physicians (All issues)

  • Molecular Therapies Target Bone Metastasis
  • "I'm Here to Help You" Patient Advocates Serve as Liaisons Between Patients and Care Centers
  • DiaLog: Patient Advocates: Solving Problems and Building Bridges, by Charles F. Leverback, MD, Associate Professor, Department of Gynecologic Oncology
  • House Call: Keeping the Heart Healthy in Patients with Cancer