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Full-Text Articles in Oncology
Viral Epitope Scanning Reveals Correlation Between Seasonal Hcovs And Sars-Cov-2 Antibody Responses Among Cancer And Non-Cancer Patients, Salum J. Lidenge, Dicle Yalcin, Sydney J. Bennett, Owen Ngalamika, Brenda B. Kweyamba, Chacha J. Mwita, For Yue Tso, Julius Mwaiselage, John T. West, Charles Wood
Viral Epitope Scanning Reveals Correlation Between Seasonal Hcovs And Sars-Cov-2 Antibody Responses Among Cancer And Non-Cancer Patients, Salum J. Lidenge, Dicle Yalcin, Sydney J. Bennett, Owen Ngalamika, Brenda B. Kweyamba, Chacha J. Mwita, For Yue Tso, Julius Mwaiselage, John T. West, Charles Wood
School of Medicine Faculty Publications
Seasonal coronaviruses (HCoVs) are known to contribute to cross-reactive antibody (Ab) responses against SARS-CoV-2. While these responses are predictable due to the high homology between SARS-CoV-2 and other CoVs, the impact of these responses on susceptibility to SARS-CoV-2 infection in cancer patients is unclear. To investigate the influence of prior HCoV infection on anti-SARS-CoV-2 Ab responses among COVID-19 asymptomatic individuals with cancer and controls without cancers, we utilized the VirScan technology in which phage immunoprecipitation and sequencing (PhIP-seq) of longitudinal plasma samples was performed to investigate high-resolution (i.e., epitope level) humoral CoV responses. Despite testing positive for anti-SARS-CoV-2 Ab in …
Immunometabolic Reprogramming, Another Cancer Hallmark, Vijay Kumar, John H. Stewart
Immunometabolic Reprogramming, Another Cancer Hallmark, Vijay Kumar, John H. Stewart
School of Medicine Faculty Publications
Molecular carcinogenesis is a multistep process that involves acquired abnormalities in key biological processes. The complexity of cancer pathogenesis is best illustrated in the six hallmarks of the cancer: (1) the development of self-sufficient growth signals, (2) the emergence of clones that are resistant to apoptosis, (3) resistance to the antigrowth signals, (4) neo-angiogenesis, (5) the invasion of normal tissue or spread to the distant organs, and (6) limitless replicative potential. It also appears that non-resolving inflammation leads to the dysregulation of immune cell metabolism and subsequent cancer progression. The present article delineates immunometabolic reprogramming as a critical hallmark of …
Cancer As A Channelopathy—Appreciation Of Complimentary Pathways Provides A Different Perspective For Developing Treatments, Harry J. Hgould@Lsuhsc.Edu Gould, Dennis Paul
Cancer As A Channelopathy—Appreciation Of Complimentary Pathways Provides A Different Perspective For Developing Treatments, Harry J. Hgould@Lsuhsc.Edu Gould, Dennis Paul
School of Medicine Faculty Publications
Life depends upon the ability of cells to evaluate and adapt to a constantly changing environment and to maintain internal stability to allow essential biochemical reactions to occur. Ions and ion channels play a crucial role in this process and are essential for survival. Alterations in the expression of the transmembrane proteins responsible for maintaining ion balance that occur as a result of mutations in the genetic code or in response to iatrogenically induced changes in the extracellular environment is a characteristic feature of oncogenesis and identifies cancer as one of a constellation of diseases known as channelopathies. The classification …
Physical Activity In Older Adults With Metastatic Gastrointestinal Cancer: A Pilot And Feasibility Study, Justin C. Brown, Elizabeth Brighton, Nancy Campbell, Nadine J. Mccleary, Thomas A. Abrams, James M. Cleary, Peter C. Enzinger, Kimmie Ng, Douglas Rubinson, Brian M. Wolpin, Matthew B. Yurgelun, Jeffrey A. Meyerhardt
Physical Activity In Older Adults With Metastatic Gastrointestinal Cancer: A Pilot And Feasibility Study, Justin C. Brown, Elizabeth Brighton, Nancy Campbell, Nadine J. Mccleary, Thomas A. Abrams, James M. Cleary, Peter C. Enzinger, Kimmie Ng, Douglas Rubinson, Brian M. Wolpin, Matthew B. Yurgelun, Jeffrey A. Meyerhardt
School of Medicine Faculty Publications
No abstract provided.