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Full-Text Articles in Oncology
Blood Count Recovery Following Induction Therapy For Acute Myeloid Leukemia In Children Does Not Predict Survival, Lauren Pommert, Todd M. Cooper, Robert B. Gerbing, Lisa Brodersen, Michael Loken, Alan S. Gamis, Richard Aplenc, Todd A. Alonzo, Edwards Anders Kolb
Blood Count Recovery Following Induction Therapy For Acute Myeloid Leukemia In Children Does Not Predict Survival, Lauren Pommert, Todd M. Cooper, Robert B. Gerbing, Lisa Brodersen, Michael Loken, Alan S. Gamis, Richard Aplenc, Todd A. Alonzo, Edwards Anders Kolb
Manuscripts, Articles, Book Chapters and Other Papers
International Working Group (IWG) and European LeukemiaNet (ELN) response definitions are utilized to evaluate the efficacy of new agents for childhood acute myeloid leukemia (AML) for regulatory purposes. However, these criteria are not consistent with definitions used in pediatric AML trials or with standard pediatric practice to proceed with subsequent therapy cycles prior to IWG/ELN-defined count recovery. We retrospectively analyzed data from the two most recent Phase 3 pediatric AML clinical trials conducted by the Children’s Oncology Group (COG) to assess the incidence, timing, and prognostic significance of count recovery following induction chemotherapy. Of the patients with fewer than 5% …