Oncology Commons^™

Thrombospondin-1 Signaling Mechanisms Regulating Pigment Epithelium-Derived Factor Expression And Lipolytic Activity In Prostate Cancer, Nizar Khamjan

Theses and Dissertations

Background: Prostate cancer (PCa) is the most common cancer that occurs in men in the United States. To grow, tumors need to induce new blood vessels growth, a process called angiogenesis. Thus, tumors down regulate molecules that inhibit this process. Two such molecules that are down-regulated in PCa are thrombospondin-1 (TSP-1) and pigment epithelium-derived factor (PEDF). Interestingly, both of these proteins also function in regulating lipid metabolism. Our lab has data to suggest that TSP-1 induces PEDF expression and lipid catabolism (lipolysis), the hydrolysis of triglycerides into fatty acids and a glycerol, in PCa cells; however, the molecular pathway of …