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Full-Text Articles in Oncology
Rna-Seq Analysis Of Localized Mst1/Stk4 Expression In Prostate Cancer, Damien Ready
Rna-Seq Analysis Of Localized Mst1/Stk4 Expression In Prostate Cancer, Damien Ready
Master's Theses (2009 -)
The SKT4-encoded MST1 is a serine-threonine protein kinase and has known associations with many diseases and cancer.MST1 plays a critical component of the Hippo tumor suppressor pathway responsible for limiting cell division and promoting apoptosis.Loss of MST1 function is associated with poor prognostic outcomes for cancers, though the mechanism is not well understood.There is increasing evidence that dysregulation of MST1 can lead to castration-resistant prostate cancer (CRPCa), an aggressive cancer with limited treatment options.To better understand the mechanistic underpinnings of CRPCa progression, C4-2 prostate cancer cells were engineered toexpress MST1 protein directed to a particular subcellular region: membrane, nucleus, or …