Oncology Commons^™

Oncology, Volume 56, Number 11-12, November - December 2011, Sarah Bronson, Zach-Bryan Bogannan-Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

• Transoral Laser Microsurgery for Laryngeal and Oropharyngeal Tumors: A minimally invasive surgery for treating cancers of the larynx and oropharynx has cute rates similar to those of open surgery and radiation therapy in selected patients.
• Exploring Causes of and Treatments for Neuropathy in Cancer Patients: Among the most troubling side effects of cancer treatment in some patient is chronic chemotherapy neuropathy syndrome, in which tingling, numbness, and pain in the hands and feet persist long after the completion of treatment
• Prostate Cancer Screening: Patient should understand the purpose and limitations of the prostate-specific antigen test
• HOUSE CALL: Smoking Cessation: Medications …

Oncology, Volume 56, Number 10, October 2011, Bryan Tutt, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

• Treating Cancer in Pregnant Patients: Pregnancy is usually a joyous, hopeful time; a cancer diagnosis can be devastating. When pregnancy and cancer occur together, they present special challenges for patients and physicians. Fortunately, these challenges often can be overcome by a multidisciplinary approach to treatment
• Compass: Non-Small Cell Lung Cancer: Stage IIIA-Many factors affect treatment sequences
• HOUSE CALL: Understanding Cancer Risk and Risk Factors: Your risk factors might affect your need for cancer screening

Oncology, Volume 56, Number 09, September 2011, Joe Munch, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

• Novel Agents for Castrate-Resistant Prostate Cancer Include Potent Androgen Blockers and Immunotherapies: Despite progress in screening and therapy, prostate cancer continues to be a leading cause of cancer death among men worldwide
• New Targeted Therapy Offers Hope in Relapsed Hodgkin and Anaplastic large-Cell Lymphoma: The U.S. Food and Drug Administration (FDA) has approved the first new drug for Hodgkin Lymphoma since 1977
• HOUSE CALL: Colorectal Cancer Screening: Risk factors determine who should be screened and how often
• IN BRIEF: Everolimus may Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer Patients

Chapter 01: The Making Cancer History® Voices Oral History Project, Stephen Tomasovic Phd, Tacey A. Rosolowski Phd

Interview Chapters

In this segment, Dr. Tomasovic provides an overview of the Historical Resources Center –which he founded-- and the Making Cancer History Voices Oral History Project that it oversees.

Oncology, Volume 56, Number 08, August 2011, Stephanie Deming, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

• Addressing the Cardiac Complications of Cancer Treatment: Patients with cancer surviving longer than ever after treatment, and new targeted therapy agents are being introduced into the clinic with increasing frequency. These advances are cause for optimism, but they have also led to an increased incidence of cardiac complications of cancer therapy
• Compass: Early- and Intermediate-Stage Gastric Cancer: Neoadjuvant of adjuvant treatments offer higher cure rates than surgery alone
• HOUSE CALL: Managing Disease-Related Fatigue- Patients and doctors offer can make fatigue less severe

Oncolog, Volume 56, Number 07, July 2011, Kate Newberry, Joe Munch

OncoLog MD Anderson's Report to Physicians (All issues)

• A New Era in Treating Patients Who Have Multiple Myeloma: During the past decade, several novel treatments have extended the median survival time for patients with multiple myeloma from less than 3 years to more than 7 years, and researchers are working to further improve treatment
• Landmark Trial Shows Potential of Low-Dose Computed Tomography for Lung Cancer Screening
• HOUSE CALL: Eating Healthier May Reduce Cancer Risk: Healthy eating habits may also increase energy and heart health
• IN BRIEF: Inotuzumab Ozogamicin Shows Promise for Acute Lymphoblastic Leukemia Treatment

Oncolog, Volume 56, Number 06, June 2011, John H. Mccool, Sunni Hoseman

OncoLog MD Anderson's Report to Physicians (All issues)

• MD Anderson Celebrates 70th Anniversary: Its first clinical facility was a converted Army barracks, its first headquarters was renovated residential estate near downtown Houston, and its first cancer research was conducted by four scientists in a former horse stable
• Compass: Stage II or III Soft Tissue Sarcoma-Chemotherapy and radiation therapy before or after surgery benefit patients

Oncolog, Volume 56, Number 04-05, April-May 2011, Zach Bohannan, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

• Understanding and Managing Multiple Endocrine Neoplasia Syndromes: Endocrine tumors caused by multiple endocrine neoplasia syndromes (MEN) pose a dual threat-both from the tumors' potential for growth or metastasis and from their hormonal secretions
• Two-Stage Resection and Improved Chemotherapy Regimens Lengthen Survival for Patients with Lever Metastasis from Colorectal Cancer
• HOUSE CALL: Saving a Life by Donating Stem Cells: Fact about stem cell transplants
• IN BRIEF: Study Reveals How EZH2 Protein Promotes Breast Tumor-Initiating Cell Growth

Oncolog, Volume 56, Number 03, March 2011, Bryan Tutt, Joe Munch

OncoLog MD Anderson's Report to Physicians (All issues)

• Glioblastoma Cure Remains Elusive Despite Treatment Advances: Aggressive surgery followed by radiation therapy and chemo-therapy offers hope of long-term survival for some patients with glioblastoma, but for most glioblastoma patients, the prognosis is poor
• Assessing and Addressing the Biological Effects of Stress in Cancer Patients: Stress has long been linked to cancer progression. But the precise mechanisms by which stress exacts its pro-tumor effects are not fully understood
• MD Anderson One of Four Centers to Test Cancer Cell Detection Chip: A new test that could monitor the effectiveness of cancer treatment
• HOUSE CALL: Yoga and Tai Chi: Two distinct disciplines …

Oncolog, Volume 56, Number 02, February 2011, Joe Munch, John Lebas

OncoLog MD Anderson's Report to Physicians (All issues)

• Risk-Based Cancer Screening: M.D. Anderson's revised guidelines offer more precise individualized recommendations on screening for common cancers.
• Screen Guidelines in Brief
• Electronic Navigation Biopsy for Peripheral Lung Lesion Diagnosis
• House Call: Couples and Cancer: Cancer-Related Issues Can Disrupt Relationships
• in Brief: Researchers Find Glioblastoma's Resistance to Treatment Rooted in Immunosuppression

Differences In Breast Cancer Tumor Size, Stage, And Survival By Socioeconomic Position In Young Women, Julie Maureen Tomaska

Walden Dissertations and Doctoral Studies

Although the incidence of breast cancer in women under 40 years of age is somewhat rare, young women tend to present with cancer that is more advanced and with poorer prognostic characteristics. This research will be important to providers, women and their families and those seeking to clarify screening guidelines. The purpose of this quantitative, retrospective, cohort study was to evaluate differences in prognostic characteristics by socioeconomic position (SIP). The cohort was comprised of females aged 18 to 39 with a primary diagnosis of breast cancer. Data were obtained from the Surveillance, Epidemiology and End Results registry for all primary …

Oncolog, Volume 56, Number 01, January 2011, Bryan Tutt, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

• New Drug Control Symptoms of Myeloproliferative Disorders and Improve Quality of Life for Patients: Recent clinical trials have demonstrated that a new class of drugs can effectively treat myeloproliferative disorders
• Compass: Metastatic Melanoma: Experimental treatments could be preferable to standard therapies for metastatic melanoma
• HOUS CALL: Breast Awareness: Guidelines recommend breast awareness rather than formal self-exams

Transition Experiences Of Adolescent Survivors Of Childhood Cancer: A Qualitative Investigation, Alana Delores Lopez

USF Tampa Graduate Theses and Dissertations

Adolescent survivors of childhood cancer are a growing population with unique needs as they face a combination of challenges associated with normal development and returning to life after treatment completion (Wakefield et al., 2010). One specific need identified in the research literature includes the effective delivery of transitional care and planning (Hewitt, Greenfield, & Stovall, 2005). It has been suggested that the provision of transition care and planning can help facilitate the shift from one phase of care to another and promote positive transition experiences (National Cancer Institute, 2008). The shift from off-treatment to post-treatment and school reintegration have been …

Case-Control Study Of Sunlight Exposure And Cutaneous Human Papillomavirus Seroreactivity In Basal Cell And Squamous Cell Carcinomas Of The Skin, Michelle R. Iannacone

USF Tampa Graduate Theses and Dissertations

Non-melanoma skin cancer (NMSC), comprised of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is the most common cancer in Caucasians. Ultraviolet radiation (UVR) exposure is the most important environmental risk factor for both BCC and SCC development. However, the precise relationship between UVR and the risk of NMSC is complex, and the relationship may differ by skin cancer type. It has been hypothesized that intermittent patterns and childhood sunlight exposure are important for BCC while continuous (chronic) and lifelong (i.e. childhood and adulthood) sunlight exposure is important for SCC. Epidemiologic studies have demonstrated that cutaneous human papillomavirus (HPV) …

Inhibition Of P53 Dna Binding Function By The Mdm2 Acidic Domain, Brittany Lynne Cross

USF Tampa Graduate Theses and Dissertations

MDM2 regulates p53 predominantly by promoting p53 ubiquitination. However, ubiquitination-independent mechanisms of MDM2 have also been implicated. Here we show that MDM2 inhibits p53 DNA binding activity in vitro and in vivo. MDM2 binding promotes p53 to adopt a mutant-like conformation, losing reactivity to antibody Pab1620, while exposing the Pab240 epitope. The acidic domain of MDM2 is required to induce p53 conformational change and inhibit p53 DNA binding. ARF binding to the MDM2 acidic domain restores p53 wild type conformation and rescues DNA binding activity. Furthermore, histone methyl transferase SUV39H1 binding to the MDM2 acidic domain also restores p53 wild …

The Mediating Role Of Social Support And Fulfillment Of Spiritual Needs In End Of Life Care, Kimberley A. Gryglewicz

USF Tampa Graduate Theses and Dissertations

End of life (EOL) caregiving can be a daunting and challenging endeavor as caregivers adjust to the ever-changing care demands associated with dying. Increased personal care, assisting with symptom and medication management, and attending to the emotional and spiritual needs of the dying person require caregivers to learn new tasks and to assume new roles such as social worker, nurse, and chaplain. As families continue to play an essential role in meeting the health care needs of their dying loved ones, it is imperative for social workers to understand the complexities of the end of life caregiving experience in order …