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Articles 31 - 43 of 43
Full-Text Articles in Neurosurgery
Chronic Inflammation And Apoptosis Propagate In Ischemic Cerebellum And Heart Of Non-Human Primates, Sandra A. Acosta, Sherwin Mashkouri, Diana Nwokoye, Jea Y. Lee, Cesar V. Borlongan
Chronic Inflammation And Apoptosis Propagate In Ischemic Cerebellum And Heart Of Non-Human Primates, Sandra A. Acosta, Sherwin Mashkouri, Diana Nwokoye, Jea Y. Lee, Cesar V. Borlongan
Neurosurgery and Brain Repair Faculty Publications
The major pathological consequences of cerebral ischemia are characterized by neurological deficits commonly ascribed to the infarcted tissue and its surrounding region, however, brain areas, as well as peripheral organs, distal from the original injury may manifest as subtle disease sequelae that can increase the risks of co-morbidities complicating the disease symptoms. To evaluate the vulnerability of the cerebellum and the heart to secondary injuries in the late stage of transient global ischemia (TGI) model in non-human primates (NHP), brain and heart tissues were collected at six months post-TGI. Unbiased stereological analyses of immunostained tissues showed significant Purkinje cells loss …
Updates On And Advances In Therapeutic Strategies For Traumatic Brain Injury, Samantha M. Portis, Paul R. Sanberg
Updates On And Advances In Therapeutic Strategies For Traumatic Brain Injury, Samantha M. Portis, Paul R. Sanberg
Neurosurgery and Brain Repair Faculty Publications
No abstract provided.
Hippocampal Cholinergic Neurostimulating Peptide As A Possible Modulating Factor Against Glutamatergic Neuronal Disability By Amyloid Oligomers, Toyohiro Sato, Yoshiaki Ohi, Daisuke Kato, Masayuki Mizuno, Hiroshi Takase, Tetsuko Kanamori, Cesar V. Borlongan, Akira Haji, Noriyuki Matsukawa
Hippocampal Cholinergic Neurostimulating Peptide As A Possible Modulating Factor Against Glutamatergic Neuronal Disability By Amyloid Oligomers, Toyohiro Sato, Yoshiaki Ohi, Daisuke Kato, Masayuki Mizuno, Hiroshi Takase, Tetsuko Kanamori, Cesar V. Borlongan, Akira Haji, Noriyuki Matsukawa
Neurosurgery and Brain Repair Faculty Publications
Despite having pathological changes in the brain associated with Alzheimer's disease (AD), some patients have preserved cognitive function. A recent epidemiological study has shown that diet, exercise, cognitive training, and vascular risk monitoring interventions may reduce cognitive decline in at-risk elderly people in the general population. However, the details of molecular mechanisms underlying this cognitive function preservation are still unknown. Previous reports have demonstrated that enriched environments prevent the impairment of hippocampal long-term potentiation (LTP) through β2-adrenergic signals, when LTP is incompletely suppressed by synthetic amyloid-β (Aβ) oligomers. The cholinergic network from the medial septal nucleus (MSN) is also a …
Genetic And Histological Alterations Reveal Key Role Of Prostaglandin Synthase And Cyclooxygenase 1 And 2 In Traumatic Brain Injury–Induced Neuroinflammation In The Cerebral Cortex Of Rats Exposed To Moderate Fluid Percussion Injury, Hideki Shojo, Cesar V. Borlongan, Tadashi Mabuchi
Genetic And Histological Alterations Reveal Key Role Of Prostaglandin Synthase And Cyclooxygenase 1 And 2 In Traumatic Brain Injury–Induced Neuroinflammation In The Cerebral Cortex Of Rats Exposed To Moderate Fluid Percussion Injury, Hideki Shojo, Cesar V. Borlongan, Tadashi Mabuchi
Neurosurgery and Brain Repair Faculty Publications
After the initial insult in traumatic brain injury (TBI), secondary neurodegeneration occurs that is intimately associated with neuroinflammation. Prostaglandin (PG) synthases and cyclooxygenase (COX) 1 and 2 may contribute to inflammation in the brain. Temporal and spatial expression features of PG and COX1 and 2 following trauma may guide the development of antineuroinflammation strategies. Here, we examined PG synthase signaling and COX1 and 2 gene expression levels and COX-1- and 2-positive cell types and their temporal localization in TBI-induced brain in an effort to reveal their participation in the disease’s evolving neuroinflammation. Using brain samples from the cerebral cortex of …
Mobile Stroke Unit (Msu): The Future Of Acute Stroke Treatment, Waldo R. Guerrero
Mobile Stroke Unit (Msu): The Future Of Acute Stroke Treatment, Waldo R. Guerrero
Neurosurgery and Brain Repair Faculty Publications
No abstract provided.
Lateral Access Surgery For The Thoracolumbar Spine, Luiz Pimenta, William Smith, William Taylor, Juan Uribe
Lateral Access Surgery For The Thoracolumbar Spine, Luiz Pimenta, William Smith, William Taylor, Juan Uribe
Neurosurgery and Brain Repair Faculty Publications
No abstract provided.
The Effect Of The Retroperitoneal Transpsoas Minimally Invasive Lateral Interbody Fusion On Segmental And Regional Lumbar Lordosis, Tien V. Le, Andrew C. Vivas, Elias Dakwar, Ali A. Baaj, Juan S. Uribe
The Effect Of The Retroperitoneal Transpsoas Minimally Invasive Lateral Interbody Fusion On Segmental And Regional Lumbar Lordosis, Tien V. Le, Andrew C. Vivas, Elias Dakwar, Ali A. Baaj, Juan S. Uribe
Neurosurgery and Brain Repair Faculty Publications
Background. The minimally invasive lateral interbody fusion (MIS LIF) in the lumbar spine can correct coronal Cobb angles, but the effect on sagittal plane correction is unclear. Methods. A retrospective review of thirty-five patients with lumbar degenerative disease who underwent MIS LIF without supplemental posterior instrumentation was undertaken to study the radiographic effect on the restoration of segmental and regional lumbar lordosis using the Cobb angles on pre- and postoperative radiographs. Mean disc height changes were also measured. Results. The mean follow-up period was 13.3 months. Fifty total levels were fused with a mean of 1.42 levels …
Early Outcomes Of Minimally Invasive Anterior Longitudinal Ligament Release For Correction Of Sagittal Imbalance In Patients With Adult Spinal Deformity, Armen R. Deukmedjian, Elias Dakwar, Amir Ahmadian, Donald A. Smith, Juan S. Uribe
Early Outcomes Of Minimally Invasive Anterior Longitudinal Ligament Release For Correction Of Sagittal Imbalance In Patients With Adult Spinal Deformity, Armen R. Deukmedjian, Elias Dakwar, Amir Ahmadian, Donald A. Smith, Juan S. Uribe
Neurosurgery and Brain Repair Faculty Publications
The object of this study was to evaluate a novel surgical technique in the treatment of adult degenerative scoliosis and present our early experience with the minimally invasive lateral approach for anterior longitudinal ligament release to provide lumbar lordosis and examine its impact on sagittal balance. Methods. All patients with adult spinal deformity (ASD) treated with the minimally invasive lateral retroperitoneal transpsoas interbody fusion (MIS LIF) for release of the anterior longitudinal ligament were examined. Patient demographics, clinical data, spinopelvic parameters, and outcome measures were recorded. Results. Seven patients underwent release of the anterior longitudinal ligament (ALR) to …
Peripheral Nerve Repair With Cultured Schwann Cells: Getting Closer To The Clinics, Maria Carolina O. Rodrigues, Antonio Antunes Rodrigues, Loren E. Glover, Julio Voltarelli, Cesar V. Borlongan
Peripheral Nerve Repair With Cultured Schwann Cells: Getting Closer To The Clinics, Maria Carolina O. Rodrigues, Antonio Antunes Rodrigues, Loren E. Glover, Julio Voltarelli, Cesar V. Borlongan
Neurosurgery and Brain Repair Faculty Publications
Peripheral nerve injuries are a frequent and disabling condition, which affects 13 to 23 per 100.000 persons each year. Severe cases, with structural disruption of the nerve, are associated with poor functional recovery. The experimental treatment using nerve grafts to replace damaged or shortened axons is limited by technical difficulties, invasiveness, and mediocre results. Other therapeutic choices include the adjunctive application of cultured Schwann cells and nerve conduits to guide axonal growth. The bone marrow is a rich source of mesenchymal cells, which can be differentiated in vitro into Schwann cells and subsequently engrafted into the damaged nerve. Alternatively, undifferentiated …
Toward Personalized Cell Therapies: Autologous Menstrual Blood Cells For Stroke, Maria Carolina O. Rodrigues, Loren E. Glover, Nathan Weinbren, Jessica A. Rizzi, Kazutaka Shinozuka, Naoki Tajiri, Yuji Kaneko, Paul R. Sanberg, Julie G. Allickson, Nicole Kuzmin-Nichols, Svitlana Garbuzova-Davis, Julio Cesar Voltarelli, Eduardo Cruz, Cesar V. Borlongan
Toward Personalized Cell Therapies: Autologous Menstrual Blood Cells For Stroke, Maria Carolina O. Rodrigues, Loren E. Glover, Nathan Weinbren, Jessica A. Rizzi, Kazutaka Shinozuka, Naoki Tajiri, Yuji Kaneko, Paul R. Sanberg, Julie G. Allickson, Nicole Kuzmin-Nichols, Svitlana Garbuzova-Davis, Julio Cesar Voltarelli, Eduardo Cruz, Cesar V. Borlongan
Neurosurgery and Brain Repair Faculty Publications
Cell therapy has been established as an important field of research with considerable progress in the last years. At the same time, the progressive aging of the population has highlighted the importance of discovering therapeutic alternatives for diseases of high incidence and disability, such as stroke. Menstrual blood is a recently discovered source of stem cells with potential relevance for the treatment of stroke. Migration to the infarct site, modulation of the inflammatory reaction, secretion of neurotrophic factors, and possible differentiation warrant these cells as therapeutic tools. We here propose the use of autologous menstrual blood cells in the restorative …
Polymers, Encapsulation, And Artifical Organs (Report On Session 26.0), Paul R. Sanberg, Thomas B. Freeman, David W. Cahill
Polymers, Encapsulation, And Artifical Organs (Report On Session 26.0), Paul R. Sanberg, Thomas B. Freeman, David W. Cahill
Neurosurgery and Brain Repair Faculty Publications
No abstract provided.
Neural Basis Of Behavior: Pharmacological Effects In Brain Injury And Degenerative Syndromes, Paul R. Sanberg
Neural Basis Of Behavior: Pharmacological Effects In Brain Injury And Degenerative Syndromes, Paul R. Sanberg
Neurosurgery and Brain Repair Faculty Publications
No abstract provided.
Influence Of Donor Age On The Survival Of Human Embryonic Dopaminergic Neural Grafts, T. B. Freeman, G. M. Nauert, P. R. Sanberg, J. H. Kordower
Influence Of Donor Age On The Survival Of Human Embryonic Dopaminergic Neural Grafts, T. B. Freeman, G. M. Nauert, P. R. Sanberg, J. H. Kordower
Neurosurgery and Brain Repair Faculty Publications
No abstract provided.