Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Sciences (2)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Clinical Epidemiology (1)
- Diagnosis (1)
- Digestive System Diseases (1)
-
- Diseases (1)
- Health Services Research (1)
- Hepatology (1)
- Life Sciences (1)
- Medical Molecular Biology (1)
- Medical Pharmacology (1)
- Medical Toxicology (1)
- Natural Products Chemistry and Pharmacognosy (1)
- Nursing (1)
- Other Nursing (1)
- Patient Safety (1)
- Pharmacy and Pharmaceutical Sciences (1)
- Physiology (1)
- Public Health (1)
- Public Health Education and Promotion (1)
- Institution
- Keyword
-
- Acute kidney injury (1)
- Alcoholic liver disease (1)
- All-cause mortality (1)
- CB1 receptors (1)
- Dialysis facilities (1)
-
- Discharge home (1)
- Diuresis (1)
- Dorsal rhizotomy (1)
- Dorsal spinal stimulation (1)
- ESRD (1)
- Emergency department (1)
- FAAH (1)
- Fibrosis (1)
- Hepatorenal syndrome (1)
- Hospital readmissions (1)
- Hospitalization (1)
- Hypertension (1)
- Incident patients (1)
- Inflammation (1)
- Liver disease (1)
- Medullary interstitial cells (1)
- Natriuresis (1)
- Oxidative stress (1)
- PF-3845 (1)
- Renal afferent nerve (1)
- Renal medulla (1)
- Sodium excretion (1)
- Spontaneously hypertensive rats (1)
- Vasodilation (1)
Articles 1 - 5 of 5
Full-Text Articles in Nephrology
Novel Mechanisms And Biomarkers In Alcohol-Induced Organ Injury., Christine E. Dolin
Novel Mechanisms And Biomarkers In Alcohol-Induced Organ Injury., Christine E. Dolin
Electronic Theses and Dissertations
Background. Ethanol (EtOH) consumption is known to affect multiple organs; this is unsurprising, as the concentration of EtOH in the blood at relevant doses reaches the millimolar range. The overarching goal of this dissertation was to elucidate mechanisms of alcohol-induced organ injury, specifically the effects of alcohol on the hepatic extracellular matrix (ECM) proteome, the alcoholic hepatitis (AH) plasma peptidome, and the effects of alcohol on the renal cortex proteome and transcriptome. Methods. Mice were pair-fed ethanol-containing liquid diet chronically, and then some mice were administered lipopolysaccharide (LPS). Liver sections from these mice were processed in a series of increasingly …
Characteristics And Outcomes Of Patients Discharged Home From An Emergency Department With Acute Kidney Injury: A Population-Based Cohort Study, Rey Acedillo
Electronic Thesis and Dissertation Repository
We designed a population-based cohort study to describe the characteristics and outcomes of 6346 adults discharged home from an emergency department (ED) with acute kidney injury (AKI). Within 30 days of discharge, 149 (2.3%) patients died (stage 1: 2.1%, stage 2: 5.2%, and stage 3 AKI: 15.9%). We also compared 30-day mortality to patients hospitalized with AKI and patients discharged home with no AKI in two separate propensity score-matched analyses. An ED discharge versus hospitalization was associated with lower 30-day mortality (3.0% vs. 11.9%, relative risk (RR): 0.25, 95% confidence interval (CI): 0.21-0.30). An ED discharge home with AKI versus …
The Effect Of Dorsal Rhizotomy On Renal Sodium Excretion Following Dorsal Spinal Stimulation, Tanko Tijani Ahmed
The Effect Of Dorsal Rhizotomy On Renal Sodium Excretion Following Dorsal Spinal Stimulation, Tanko Tijani Ahmed
All Graduate Theses, Dissertations, and Other Capstone Projects
Hypertension is one of the most common risk factors in the development of heart disease, stroke and end stage renal failure. Sympathetic overactivity is believed to be one of the main mechanism behind resistant hypertension. Renal denervation has been used to treat resistant hypertension, although this procedure is an invasive one. Spinal cord stimulation (SCS) is a known modality to treat ischemic pain, angina pectoris, and peripheral vascular diseases. In previous studies in this laboratory, unilateral spinal cord stimulation in spontaneously hypertensive rat (SHR) at 67% of the motor threshold increased urinary sodium and water excretion significantly, without affecting mean …
Factors Associated With Hospital Readmissions Among United States Dialysis Facilities, Amber B. Paulus
Factors Associated With Hospital Readmissions Among United States Dialysis Facilities, Amber B. Paulus
Theses and Dissertations
Hospital readmissions are a major burden for patients with end stage renal disease (ESRD). On average, one in three hospital discharges among patients with ESRD are followed by a readmission within 30 days. Currently, dialysis facilities are held accountable for readmissions via the ESRD Quality Incentive Program standardized readmission ratio (SRR) clinical measure. However, little is known about facility-level factors associated with readmission. Additionally, unlike other standardized measures of quality in the dialysis setting, incident patients within their first 90-days of dialysis are included in the performance calculation. This study analyzed CMS Dialysis Facility Report data from 2013 to 2016 …
Diuretic, Natriuretic, And Vasodepressor Activity Of A Lipid Fraction Enhanced In Medium Of Cultured Mouse Medullary Interstitial Cells By A Selective Faah Inhibitor, Zdravka P. Daneva
Diuretic, Natriuretic, And Vasodepressor Activity Of A Lipid Fraction Enhanced In Medium Of Cultured Mouse Medullary Interstitial Cells By A Selective Faah Inhibitor, Zdravka P. Daneva
Theses and Dissertations
The relationship between the endocannabinoid system in the renal medulla and the long-term regulation of blood pressure is not well understood. To investigate the possible role of the endocannabinoid system in renomedullary interstitial cells, mouse medullary interstitial cells (MMICs) were obtained, cultured and characterized for their responses to treatment with a selective inhibitor of fatty acid amide hydrolase (FAAH), PF-3845. Treatment of MMICs with PF-3845 increased cytoplasmic lipid granules detected by Sudan Black B staining and multilamellar bodies identified by transmission electron microscopy. HPLC analyses of lipid extracts of MMIC culture medium revealed a 205nm-absorbing peak that showed responsiveness to …