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Preoperative Angiotensin Converting Enzyme Inhibitor Or Angiotensin Receptor Blocker Use And Acute Dialysis: A Population Based Cohort Study, Mitesh K. Shah
Preoperative Angiotensin Converting Enzyme Inhibitor Or Angiotensin Receptor Blocker Use And Acute Dialysis: A Population Based Cohort Study, Mitesh K. Shah
Electronic Thesis and Dissertation Repository
Angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) use prior to major surgery is controversial. We performed a population based retrospective cohort study of 237,208 elderly patients (of whom 101,494 (42.8%) were ACEi or ARB users) who underwent major elective surgery from 1995 to 2010 in Ontario, Canada. The primary outcome was acute kidney injury treated with dialysis (AKI-D) within 14 days following surgery (810 (0.34%) patients). The secondary outcome was all-cause mortality within 90 days following surgery (11,089 (4.67%) patients). After adjusting for potential confounders, preoperative ACEi or ARB use was associated with a lower relative risk …