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Articles 841 - 870 of 1578
Full-Text Articles in Geriatrics
The Mason Music & Memory Initiative (M3i), Catherine J. Tompkins, Emily S. Ihara, Megumi Inoue, Christi Clark, Kristen Suthers Rumrill
The Mason Music & Memory Initiative (M3i), Catherine J. Tompkins, Emily S. Ihara, Megumi Inoue, Christi Clark, Kristen Suthers Rumrill
Case Studies from Age in Action
Educational Objectives
1. Explain the benefits of a nonpharmacological intervention, such as the M3I, for persons with dementia.
2. Describe the work of M3I and its collaboration with students and faculty throughout the state.
3.Highlight lessons learned and future directions for the M3I.
Virginianavigator/Gwep Community Outreach Training For Older Adults, Caregivers, And Service Programs, Adrienne Johnson, Kim Tarantino
Virginianavigator/Gwep Community Outreach Training For Older Adults, Caregivers, And Service Programs, Adrienne Johnson, Kim Tarantino
Case Studies from Age in Action
Educational Objectives
1. Demonstrate how VirginiaNavigator (VN) can support self-care and connecting with community resources.
2. Discuss how VN can assist service providers who work with older adults and their families.
3. Explain how VN relates to six focus areas of the Geriatrics Workforce Enhancement Program (GWEP) to improve the well-being of older adults.
The Senior Mentoring Program At Vcu’S School Of Medicine, Leland H. Waters, Madeline Mcintyre
The Senior Mentoring Program At Vcu’S School Of Medicine, Leland H. Waters, Madeline Mcintyre
Case Studies from Age in Action
Educational Objectives
1. To demonstrate the value of senior mentoring in geriatrics education for medical students.
2. To provide a framework for positively influencing student attitudes toward older adults.
3. To describe the underlying human relationships that contribute to patient-centered care.
4. To describe effective verbal and non-verbal skills to establish and build relationships.
Care Transitions: Empowering Older Adults With Post-Hospital Interventions, Karen Moeller
Care Transitions: Empowering Older Adults With Post-Hospital Interventions, Karen Moeller
Case Studies from Age in Action
Educational Objectives
1. Understand how Care Transitions Interventions® (CTI®) can decrease hospital readmission rates among older adults, ages 60 and over.
2. Recognize how CTI® services assist older adults to stay in their homes after hospitalization for 30 days or more without unnecessary readmissions.
3. Appreciate examples of ways Senior Connections, The Capital Area Agency on Aging, collaborates with community partners.
4. Identify how Senior Connections refers older adults and caregivers to community resources for effective utilization and outcomes.
Perceptions Of Risk Of Health Disparities Amid Previously Identified Political Corruption And Ageism In Slovakia, Marta N. Lukacovic, Deborah D. Sellnow-Richmond, Monika Durechova
Perceptions Of Risk Of Health Disparities Amid Previously Identified Political Corruption And Ageism In Slovakia, Marta N. Lukacovic, Deborah D. Sellnow-Richmond, Monika Durechova
International Crisis and Risk Communication Conference
This study examines the role of traditional versus new media’s impact on citizens’ perceptions of risk within elder care. We analyzed survey data from 112 Slovak citizens regarding their social network activity and perceptions of corruption, ageism, and health disparities in the Slovak elder care system. Previous research (Lukacovic, Sellnow-Richmond, & Durechova, under contract) identified three prominent sociopolitical issues present in the Slovak medical system among Slovak UGC discourse regarding Slovak healthcare inequity: corruption, threats to dignity, and discrimination. Here, we examined the extent to which social media users perceive the prevalence and subsequent risk of experiencing health disparities within …
A Rare Case Of Hiv-Induced Inflammatory Demyelinating Polyneuropathy., A. Sajan, S. Zahid, J. Stumph, D. Griepp, S. Saba, N. Ilyas, I. M. Mc Farlane
A Rare Case Of Hiv-Induced Inflammatory Demyelinating Polyneuropathy., A. Sajan, S. Zahid, J. Stumph, D. Griepp, S. Saba, N. Ilyas, I. M. Mc Farlane
Journal Articles
Background:Acute inflammatory demyelinating polyneuropathy (AIDP) is an uncommon form of neuropathy in HIV-infected patients that can cause pain, sensory disturbance, and motor weakness. Case presentation:A 23-year-old African American male with past medical history of Guillain-Barre Syndrome (GBS), Lyme disease, and sexually transmitted infections including syphilis and chlamydia presented with acute back pain radiating to bilateral lower extremities with worsening right foot weakness for four days. Cerebrospinal fluid (CSF) studies including meningoencephalitis panel were negative as well as blood tests for Lyme disease and HIV antibody testing. Patient was initially treated with penicillin for positive treponemal serology but without improvement in …
Pathophysiology Of Osteoarthritis, Lara Stover
Pathophysiology Of Osteoarthritis, Lara Stover
Nursing Student Class Projects (Formerly MSN)
Osteoarthritis (OA) is one of the most common joint diseases worldwide, and especially in the United States. This disease can cause chronic pain and disability, and can impair a patient’s quality of life and ability to perform activities of daily living. There are many different factors that can contribute to the development, progression, and severity of OA. Chronic inflammation and the inflammatory response is the primary pathological process that contributes to the development of OA. With the number of cases of OA expected to increase in the United States, it is important that primary care providers have an understanding of …
Toxic Environmental Risk Factors For Alzheimer's Disease: A Systematic Review, Oluwaseyi Olayinka, Olaniyi O. Olayinka, Brook T. Alemu, Muge Akpinar-Elci, George T. Grossberg
Toxic Environmental Risk Factors For Alzheimer's Disease: A Systematic Review, Oluwaseyi Olayinka, Olaniyi O. Olayinka, Brook T. Alemu, Muge Akpinar-Elci, George T. Grossberg
Community & Environmental Health Faculty Publications
There is growing evidence of a possible association between toxic environmental factors and Alzheimer’s disease (AD), a disabling neurodegenerative condition with no known cause. Previous reviews of toxic environmental factors for AD either focused on occupational exposures or used a non-systematic methodology. The objective of this systematic review is to assess the evidence on the link between AD and exposure to a variety of toxic environmental risk factors beyond the work environment. Structured database search was used to identify relevant studies. Twenty-nine eligible studies examining the effect of various toxic environmental agents including electromagnetic fields, solvents, pesticides, toxic metals, and …
Ua66/13/2 Ogden College Of Science & Engineering Public Health Centers, Wku Archives
Ua66/13/2 Ogden College Of Science & Engineering Public Health Centers, Wku Archives
WKU Archives Collection Inventories
Records related to Public Health Centers.
Do Cognitive Stimulating Activities Help Prevent The Development Of Dementia In Seniors Living In Latin America?, Sarah Kane
Theses and Graduate Projects
Dementia is a term used to describe a group of symptoms that alter a person’s intellectual functioning.1 It is caused by a variety of illnesses and can lead to memory impairment, decreased problem solving and decision making capacity, and diminished ability to perform everyday activites. It is estimated that approximately 50 million people worldwide currently have dementia and that number is expected to increase to 152 million by 2050. A majority of that increase can be attributed to the rise in those living with dementia in low- and middle-income countries. Latin America has the highest rates of dementia with a …
Associations Of Hemoglobin A1c With Cognition Reduced For Long Diabetes Duration, Jeremy M. Silverman, James Schmeidler, Pearl G. Lee, Neil B. Alexander, Michal Schnaider Beeri, Elizabeth Guerrero-Berroa, Rebecca K. West, Mary Sano, Martina Nabozny, Carolina Rodriguez Alvarez
Associations Of Hemoglobin A1c With Cognition Reduced For Long Diabetes Duration, Jeremy M. Silverman, James Schmeidler, Pearl G. Lee, Neil B. Alexander, Michal Schnaider Beeri, Elizabeth Guerrero-Berroa, Rebecca K. West, Mary Sano, Martina Nabozny, Carolina Rodriguez Alvarez
Publications and Research
Introduction: Associations of some risk factors with poor cognition, identified prior to age 75, are reduced or reversed in very old age. The Protected Survivor Model predicts this interaction due to enhanced survival of those with extended risk factor duration. In a younger sample, this study examines the association of cognition with the mean hemoglobin A1c risk factor over the time at risk, according to its duration.
Methods: The interaction of mean hemoglobin A1c (average = 9.8%), evaluated over duration (average = 116.8 months), was examined for overall cognition and three cognitive domains in a sample of 150 “young-old” veterans …
Elderly Bleeding Risk Of Direct Oral Anticoagulants In Nonvalvular Atrial Fibrillation: A Systematic Review And Meta-Analysis Of Cohort Studies, Jessika Lobraico-Fernandez, Salma Baksh, Eric C. Nemec
Elderly Bleeding Risk Of Direct Oral Anticoagulants In Nonvalvular Atrial Fibrillation: A Systematic Review And Meta-Analysis Of Cohort Studies, Jessika Lobraico-Fernandez, Salma Baksh, Eric C. Nemec
Physician Associate Studies Faculty Publications
Introduction The 2014 American Heart Association (AHA)/American College of Cardiology (ACC)/Heart Rhythm Society (HRS) guidelines recommend anticoagulation to reduce clot formation and the risk of thromboembolic events in patients with atrial fibrillation but does not specify guidelines for the elderly population. Direct oral anticoagulants (DOACs) are newer US FDA-approved alternatives to warfarin and include dabigatran, rivaroxaban, apixaban and edoxaban. The efficacy of DOACs is heavily researched, but few studies have evaluated their bleeding risk. Objectives This systematic review and meta-analysis investigates which DOAC has the lowest bleeding risk in elderly patients with nonvalvular atrial fibrillation (NVAF). Methods CINAHL and MEDLINE …
Evaluation Of A Cognitive Training Program And Its Effects On Healthy Older Adults, Nathan Jensen
Evaluation Of A Cognitive Training Program And Its Effects On Healthy Older Adults, Nathan Jensen
All Graduate Theses, Dissertations, and Other Capstone Projects
As one ages, some degree of cognitive decline is expected. Despite this, declines in cognitive abilities and the possibility of dementia is a common concern among older adults. In response to these concerns, a variety of cognitive training programs have been developed that aim to improve or maintain cognitive functioning. Prior literature has shown mixed or limited findings on cognitive changes after implementation of cognitive training. This study evaluated the effectiveness of a cognitive training program designed for older adults with no to minimal cognitive decline. The current study included 18 participants who engaged in two one-hour cognitive training sessions …
A Social Dance Intervention To Nourish Sustainable Quality Of Life Outlook In Geriatric Oncology Patients, Luis Alberto Aguilar Montalva
A Social Dance Intervention To Nourish Sustainable Quality Of Life Outlook In Geriatric Oncology Patients, Luis Alberto Aguilar Montalva
Phase 1
Importance: Social support is a major determinant of health for geriatric oncology patients. Nevertheless, no DMT program utilizes community building as an explicit focus of intervention.
Objective: To design a DMT that fosters a therapeutic approach which relies as much on the interpersonal relationships as on the intrapersonal journey. Design, setting, participants: 12 weeks observational trial of participants, from TJUH geriatric oncology patient population, as they progressed through two series of social dance workshops. The first series of six workshops happened on a weekly basis, with participants filling out a FACT-G survey pre and post involvement. The second series of …
Motivational Factors And Barriers Affecting Seniors' Decision To Relocate To A Senior Living Facility, Suja Chaulagain
Motivational Factors And Barriers Affecting Seniors' Decision To Relocate To A Senior Living Facility, Suja Chaulagain
Electronic Theses and Dissertations
This study aimed to explore factors affecting seniors' intention to relocate to a senior living facility. More specifically, the purpose of this study was to examine the influence of push and pull motivational factors and perceived barriers on seniors' intention to relocate to a senior living facility (SLF). In addition, the mediating role of perceived barriers on the relationships between push motivational factors and intention to relocate and pull motivational factors and intention to relocate were explored. The data of the study was collected from 363 seniors. Structural equation modeling (SEM) analysis was conducted to test the study hypotheses. The …
Motivational Interviewing In A Team-Based Wellness Clinic: Perceptions And Fidelity, Jodi M. Winship
Motivational Interviewing In A Team-Based Wellness Clinic: Perceptions And Fidelity, Jodi M. Winship
Theses and Dissertations
INTRODUCTION: Motivational Interviewing (MI) is an evidenced based counseling style to elicit health behavior change. Team-based student clinics are an ideal climate for students to learn and practice team-based care, yet little is understood as to how client-centered communication styles such as MI are implemented in a team setting.
PURPOSE: The purpose of this dissertation was to conduct an exploratory study using mixed methods to better understand how an MI training translates to team-based communication with clients, the factors impacting team-based implementation of MI, and how team-based MI impacts clients’ perceived autonomy at a student-led, interprofessional, team-based wellness clinic for …
Immersive Virtual Reality For The Management Of Pain In Community-Dwelling Older Adults., Sara Benham, Minhee Kang, Namrata Grampurohit
Immersive Virtual Reality For The Management Of Pain In Community-Dwelling Older Adults., Sara Benham, Minhee Kang, Namrata Grampurohit
Department of Occupational Therapy Faculty Papers
Immersive virtual reality (VR) can provide a high level of engagement and distraction analgesia to address pain. However, community-based applications of this technology for older adults have not been studied. The objective of this study was to examine the applicability and effectiveness of an immersive VR intervention for pain, depression, and quality of life (QOL) in older adults. This pretest–posttest, mixed-methods design included senior center members (n = 12) with pain that interfered with daily functioning. The outcomes included the Numeric Pain Rating Scale, Patient-Reported Outcomes Measurement Information System (PROMIS®) depression scale, World Health Organization Quality of Life …
Strategies And Challenges Associated With Recruiting Retirement Village Communities And Residents Into A Group Exercise Intervention, Rachel L. Duckham, Jamie L. Tait, Caryl A. Nowson, Kerrie M. Sanders, Dennis R. Taaffe, Keith D. Hill, Robin M. Daly
Strategies And Challenges Associated With Recruiting Retirement Village Communities And Residents Into A Group Exercise Intervention, Rachel L. Duckham, Jamie L. Tait, Caryl A. Nowson, Kerrie M. Sanders, Dennis R. Taaffe, Keith D. Hill, Robin M. Daly
Research outputs 2014 to 2021
BACKGROUND: Randomized controlled trials (RCTs) provide the highest level of scientific evidence, but successful participant recruitment is critical to ensure the external and internal validity of results. This study describes the strategies associated with recruiting older adults at increased falls risk residing in retirement villages into an 18-month cluster RCT designed to evaluate the effects of a dual-task exercise program on falls and physical and cognitive function.
METHODS: Recruitment of adults aged ≥65 at increased falls risk residing within retirement villages (size 60-350 residents) was initially designed to occur over 12 months using two distinct cohorts (C). Recruitment occurred via …
Keep The Beat With Heart Failure Education: A Quality Improvement Project, Brenda L. Peterson
Keep The Beat With Heart Failure Education: A Quality Improvement Project, Brenda L. Peterson
Master's Projects and Capstones
Abstract
Problem: Heart failure (HF), also known as congestive heart failure (CHF), is the number one diagnosis-related group (DRG) for people 65 years of age and older in the United States. This disease group is complicated and debilitating, requiring frequent hospitalizations with high mortality rates. The Joint Commission on Accreditation of Healthcare Organizations (JCAHO) has identified CHF as an area for improvement in hospitals.
Context: This was a quality improvement project for an integrated medical center in the Central Valley, California with over 19,000 HF patients. In 2018, for patients 65 years and older, HF is the third-most admitted DRG …
Manganese-Enhanced Magnetic Resonance Imaging: Overview And Central Nervous System Applications With A Focus On Neurodegeneration, Ryan A. Cloyd, Shon A. Koren, Jose F. Abisambra
Manganese-Enhanced Magnetic Resonance Imaging: Overview And Central Nervous System Applications With A Focus On Neurodegeneration, Ryan A. Cloyd, Shon A. Koren, Jose F. Abisambra
Physiology Faculty Publications
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and other body systems. MEMRI has since been employed in the investigation of physiology in many animal models and in humans. Here, we review historical perspectives that follow the evolution of applied MRI research into MEMRI with particular focus on its potential toxicity. Furthermore, we discuss the more current in vivo investigative uses of MEMRI in CNS investigations and …
Age-Tastic! An Evaluation Of An Evidence-Based Intervention For Older Adults, Manoj Pardasani, Jackie Berman, Mebane Powell
Age-Tastic! An Evaluation Of An Evidence-Based Intervention For Older Adults, Manoj Pardasani, Jackie Berman, Mebane Powell
Publications and Research
Background: Raising awareness of holistic health and safety among older adults is critical to enhancing their wellbeing in many cases, improving health outcomes and motivating positive behavioral changes. Age-Tastic! is a comprehensive health and safety promotion intervention that uses the concept of a competitive board game to entice older adults to participate and stay engaged.
Objective: The purpose of this study was to evaluate the impact of Age-Tastic! on the level of awareness, health literacy, self-efficacy and positive behavioral change among the participants.
Methods: A randomized control trial was conducted with 98 older adults assigned to an experimental and control …
Pharmacy Staff Perspectives On Alcohol And Medication Interaction Prevention Among Older Rural Adults, Faika Zanjani, Hannah Allen, Rachel Vickers Smith, Demetra Antimisiaris, Nancy E. Schoenberg, Catherine A. Martin, Richard Clayton
Pharmacy Staff Perspectives On Alcohol And Medication Interaction Prevention Among Older Rural Adults, Faika Zanjani, Hannah Allen, Rachel Vickers Smith, Demetra Antimisiaris, Nancy E. Schoenberg, Catherine A. Martin, Richard Clayton
Behavioral Science Faculty Publications
Older adults are at high risk for alcohol and medication interactions (AMI). Pharmacies have the potential to act as ideal locations for AMI education, as pharmacy staff play an important role in the community. This study examined the perspectives of pharmacy staff on AMI prevention programming messaging, potential barriers to and facilitators of older adult participation in such programming, and dissemination methods for AMI prevention information. Flyers, telephone calls, and site visits were used to recruit 31 pharmacy staff members who participated in semistructured interviews. A content analysis of interview transcriptions was conducted to identify major themes, categories, and subcategories. …
Distinct White Matter Changes Associated With Cerebrospinal Fluid Amyloid-Β1-42 And Hypertension, Omar M. Al-Janabi, Christopher A. Brown, Ahmed A. Bahrani, Erin L. Abner, Justin M. Barber, Brian T. Gold, Larry B. Goldstein, Richard R. Murphy, Peter T. Nelson, Nathan F. Johnson, Leslie M. Shaw, Charles D. Smith, John Q. Trojanowski, Donna M. Wilcock, Gregory A. Jicha
Distinct White Matter Changes Associated With Cerebrospinal Fluid Amyloid-Β1-42 And Hypertension, Omar M. Al-Janabi, Christopher A. Brown, Ahmed A. Bahrani, Erin L. Abner, Justin M. Barber, Brian T. Gold, Larry B. Goldstein, Richard R. Murphy, Peter T. Nelson, Nathan F. Johnson, Leslie M. Shaw, Charles D. Smith, John Q. Trojanowski, Donna M. Wilcock, Gregory A. Jicha
Sanders-Brown Center on Aging Faculty Publications
BACKGROUND: Alzheimer's disease (AD) pathology and hypertension (HTN) are risk factors for development of white matter (WM) alterations and might be independently associated with these alterations in older adults.
OBJECTIVE: To evaluate the independent and synergistic effects of HTN and AD pathology on WM alterations.
METHODS: Clinical measures of cerebrovascular disease risk were collected from 62 participants in University of Kentucky Alzheimer's Disease Center studies who also had cerebrospinal fluid (CSF) sampling and MRI brain scans. CSF Aβ1-42 levels were measured as a marker of AD, and fluid-attenuated inversion recovery imaging and diffusion tensor imaging were obtained to assess …
Optimizing Psychosocial Care Of Older Adults With Cancer: An Early Assessment And Intervention Model, Lora Rhodes, Lcsw, Andrew Chapman, Do, Facp
Optimizing Psychosocial Care Of Older Adults With Cancer: An Early Assessment And Intervention Model, Lora Rhodes, Lcsw, Andrew Chapman, Do, Facp
Department of Medical Oncology Posters
Background
Jefferson Multidisciplinary Senior Adult Oncology Center
History
- Established September 2010
- First multidisciplinary geriatric oncology evaluation center in the tristate area
Demographics
- 890 patients evaluated to date
- All tumor types
- Age 70 and above & Pre-transplant (Bone Marrow) evaluation age 65 and above
Format
- Consultative service
- Two sessions weekly
- Average evaluation time: two hours
Multidisciplinary Team
- Navigator, Medical Oncologist, Geriatrician, Pharmacist, Nutritionist, Social Worker
- As needed: Psychiatry, Rehab Medicine, Radiation Oncology, Surgery
Hyperhomocysteinemia As A Risk Factor For Vascular Contributions To Cognitive Impairment And Dementia, Brittani R. Price, Donna M. Wilcock, Erica M. Weekman
Hyperhomocysteinemia As A Risk Factor For Vascular Contributions To Cognitive Impairment And Dementia, Brittani R. Price, Donna M. Wilcock, Erica M. Weekman
Physiology Faculty Publications
Behind only Alzheimer’s disease, vascular contributions to cognitive impairment and dementia (VCID) is the second most common cause of dementia, affecting roughly 10–40% of dementia patients. While there is no cure for VCID, several risk factors for VCID, such as diabetes, hypertension, and stroke, have been identified. Elevated plasma levels of homocysteine, termed hyperhomocysteinemia (HHcy), are a major, yet underrecognized, risk factor for VCID. B vitamin deficiency, which is the most common cause of HHcy, is common in the elderly. With B vitamin supplementation being a relatively safe and inexpensive therapeutic, the treatment of HHcy-induced VCID would seem straightforward; however, …
Glimepiride Administered In Chow Reversibly Impairs Glucose Tolerance In Mice, Dana M. Niedowicz, Sabire Özcan, Peter T. Nelson
Glimepiride Administered In Chow Reversibly Impairs Glucose Tolerance In Mice, Dana M. Niedowicz, Sabire Özcan, Peter T. Nelson
Sanders-Brown Center on Aging Faculty Publications
Sulfonylureas are a class of antidiabetes medications prescribed to millions of individuals worldwide. Rodents have been used extensively to study sulfonylureas in the laboratory. Here, we report the results of studies treating mice with a sulfonylurea (glimepiride) in order to understand how the drug affects glucose homeostasis and tolerance. We tested the effect of glimepiride on fasting blood glucose, glucose tolerance, and insulin secretion, using glimepiride sourced from a local pharmacy. We also examined the effect on glucagon, gluconeogenesis, and insulin sensitivity. Unexpectedly, glimepiride exposure in mice was associated with fasting hyperglycemia, glucose intolerance, and decreased insulin. There was no …
Conference Proceedings: Aurora Scientific Day 2018
Conference Proceedings: Aurora Scientific Day 2018
Journal of Patient-Centered Research and Reviews
This journal supplement includes selected abstracts from among the more than 50 presented at the 44th annual Aurora Scientific Day research symposium. Held May 25, 2018, in Milwaukee, Wisconsin, Aurora Scientific Day provides a forum for original research conducted by faculty, fellows, residents, and other allied health professionals affiliated with Aurora Health Care, an integrated health system with hospitals and clinics in Wisconsin and Illinois.
Octo- And Nonagenarians' Outlook On Life And Death When Living With An Implantable Cardioverter Defibrillator: A Cross-Sectional Survey, Ingela Thylén, Debra K. Moser, Anna Strömberg
Octo- And Nonagenarians' Outlook On Life And Death When Living With An Implantable Cardioverter Defibrillator: A Cross-Sectional Survey, Ingela Thylén, Debra K. Moser, Anna Strömberg
Nursing Faculty Publications
Background: Elderly individuals are increasingly represented among patients with implantable cardioverter defibrillators (ICD), but data describing life with an ICD are scarse among octo- and nonagenarians. Moreover, few studies have reported those elderly patients’ perspective on timly discussions concerning what shock deactivation involves, preferences on battery replacement, and their attitudes about turning off the ICD nearing end-of-life. Consequently, the aim of the study was to describe outlooks on life and death in octo- and nonagenarian ICD-recipients.
Methods: Participants were identified via the Swedish Pacemaker- and ICD-registry, with 229 octo- and nonagenarians (82.0 ± 2.2 years, 12% female) completing the survey …
P-21 Activated Kinase As A Molecular Target For Chemoprevention In Diabetes, Kyle Dammann, Vineeta Khare, Clyde Coleman, Henrik Berdel, Christoph Gasche
P-21 Activated Kinase As A Molecular Target For Chemoprevention In Diabetes, Kyle Dammann, Vineeta Khare, Clyde Coleman, Henrik Berdel, Christoph Gasche
Surgery Faculty Publications
Hypothesis: Anti-diabetic drugs modulate p-21 activated kinase (PAK) signaling. Introduction: Type 2 diabetes mellitus (T2DM) is a chronic inflammatory disease associated with increased cancer risk. PAK signaling is implicated in cellular homeostasis when regulated, and cancer when unrestrained. Recent reports provided a role for PAK signaling in glucose homeostasis, but the role of PAKs in the pathogenesis of T2DM is unknown. Here, we performed a mini-meta-analysis to explore if anti-diabetic drugs modify PAK signaling pathways, and provide insight regarding modulation of these pathways, to potentially reduce diabetes-associated cancer risk. Methods: PAK interacting partners in T2DM were identified using the online …
Older Adults' Health Care Utilization A Year After Experiencing Fear Or Distress From Hurricane Sandy, Laura P Sands, Yimeng Xie, Rachel Pruchno, Allison Heid, Yili Hong
Older Adults' Health Care Utilization A Year After Experiencing Fear Or Distress From Hurricane Sandy, Laura P Sands, Yimeng Xie, Rachel Pruchno, Allison Heid, Yili Hong
Rowan-Virtua School of Osteopathic Medicine Departmental Research
OBJECTIVE: To determine whether self-reports of disaster-related psychological distress predict older adults' health care utilization during the year after Hurricane Sandy, which hit New Jersey on October 29, 2012.
METHODS: Respondents were from the ORANJ BOWL Study, a random-digit dialed sample from New Jersey recruited from 2006 to 2008. Medicare hospital, emergency department (ED) and outpatient claims data from 2012 and 2013 were matched to 1607 people age 65 and older in 2012 who responded to follow-up surveys conducted from July 2013 to July 2015 to determine their hurricane-related experiences.
RESULTS: In total, 7% (107) of respondents reported they experienced …