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Articles 151 - 180 of 188
Full-Text Articles in Dermatology
Pleomorphic Fibroma., Huyenlan Dinh Do, Cynthia L. Bartus Md, Nektarios I. Lountzis Md, Stephen M. Purcell Do
Pleomorphic Fibroma., Huyenlan Dinh Do, Cynthia L. Bartus Md, Nektarios I. Lountzis Md, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
In Vitro Three-Dimensional Skin Tissue Constructs, Tinashe Dereck Gombedza
In Vitro Three-Dimensional Skin Tissue Constructs, Tinashe Dereck Gombedza
Theses
Human skin provides fortification against peripheral threats which may compromise the integrity and health of the human body. Its presence as the largest human organ forms a protective barrier making it an effective first line of defence against pathogenic, chemical and physical damage. Tissue engineering technology has enabled the development of in vitro three-dimensional (3D) organotypic skin cultures in order to understand the skin's physiology and architecture. This advancement has enabled the use of 3D skin model platforms to study skin diseases and conditions as well as facilitate drug discovery, clinical research and cosmetic product development.
In this study, an …
The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică
The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică
Journal of Mind and Medical Sciences
As a 5-α reductase inhibitor, Finasteride has proven effective in ameliorating two conditions documented to be androgen dependent, namely male androgenic alopecia and benign prostatic hyperplasia. Therapeutic results are maintained as long as the drug is administered, with treatment cessation generally leading to the return of symptomatology for each condition. In addition, during the therapeutic phase, several adverse effects have been reported, some of which persist long or indefinitely after treatment cessation, known as “post-finasteride syndrome.”
Herein we present and discuss the most common finasteride side effects, along with a psycho-neuroendocrine rationale that could explain the persistence of many adverse …
Field Cancerization With Multiple Keratoacanthomas Successfully Treated With Topical And Intralesional 5-Fluorouracil, Stephen Hemperly Do, Sean Branch Do, Stephen M. Purcell Do
Field Cancerization With Multiple Keratoacanthomas Successfully Treated With Topical And Intralesional 5-Fluorouracil, Stephen Hemperly Do, Sean Branch Do, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
Paraneoplastic Pemphigus Presenting Like Toxic Epidermal Necrolysis, Huyenian Nguyen Do, Kelly L. Reed Do, Steven Oberlender Md, Phd, Stephen M. Purcell Do
Paraneoplastic Pemphigus Presenting Like Toxic Epidermal Necrolysis, Huyenian Nguyen Do, Kelly L. Reed Do, Steven Oberlender Md, Phd, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
Regulation Of Uv-Protective Pathways Downstream Of The Melanocortin 1 Receptor In Melanocytes, Erin M. Wolf Horrell
Regulation Of Uv-Protective Pathways Downstream Of The Melanocortin 1 Receptor In Melanocytes, Erin M. Wolf Horrell
Theses and Dissertations--Physiology
Malignant cutaneous melanoma is the deadliest form of skin cancer, and a majority of melanoma diagnoses are a result of exposure to ultraviolet (UV) radiation. UV radiation causes DNA damage, which if not repaired correctly via nucleotide excision repair (NER) can result in mutations and melanomagenesis. The melanocortin 1 receptor (MC1R) is a Gs protein coupled receptor located on melanocyte plasma membranes and is involved in protecting the skin from UV induced damage. MC1R signaling results in the activation of two protective pathways: 1) induction of eumelanin synthesis downstream of micropthalmia-associated transcription factor (MITF) and 2) acceleration of NER …
Disseminated Mycobacterium Tuberculosis With Ulceronecrotic Cutaneous Disease Presenting As Cellulitis, Kelly L. Reed Do, Nektarios I. Lountzis Md
Disseminated Mycobacterium Tuberculosis With Ulceronecrotic Cutaneous Disease Presenting As Cellulitis, Kelly L. Reed Do, Nektarios I. Lountzis Md
Department of Medicine
No abstract provided.
Darkening And Eruptive Nevi During Treatment With Erlotinib, Stephen Hemperly Do, Tanya Ermolovich Do, Nektarios I. Lountzis Md, Hina A. Sheikh Md, Stephen M. Purcell Do
Darkening And Eruptive Nevi During Treatment With Erlotinib, Stephen Hemperly Do, Tanya Ermolovich Do, Nektarios I. Lountzis Md, Hina A. Sheikh Md, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
Erythrodermic Dermatomyositis, Huyenian Nguyen Do, Joshua M. Levin Md, Stephen Purcell Do
Erythrodermic Dermatomyositis, Huyenian Nguyen Do, Joshua M. Levin Md, Stephen Purcell Do
Department of Medicine
No abstract provided.
Squamous Cell Carcinoma, Keratoacanthoma-Type Within A Tattoo, Elise Grgurich Do, Nektarios I. Lountzis Md, Stephen Purcell Do
Squamous Cell Carcinoma, Keratoacanthoma-Type Within A Tattoo, Elise Grgurich Do, Nektarios I. Lountzis Md, Stephen Purcell Do
Department of Medicine
No abstract provided.
Cutaneous Pseudolymphoma Due To Lamotrigine: First Reported Case, Kelly L. Reed Do, Kelly Quinn Do, Anthony J. Gust Md
Cutaneous Pseudolymphoma Due To Lamotrigine: First Reported Case, Kelly L. Reed Do, Kelly Quinn Do, Anthony J. Gust Md
Department of Medicine
No abstract provided.
Scalp Arteriovenous Fistula With Intracranial Communication, Stephen Hemperly Do, Richard Mccalin Md, Stephen M. Purcell Do
Scalp Arteriovenous Fistula With Intracranial Communication, Stephen Hemperly Do, Richard Mccalin Md, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
Eosinophilic Pustular Folliculitis, Ryan Owen Do, Arthur C. Sosis Md, Stephen M. Purcell Do
Eosinophilic Pustular Folliculitis, Ryan Owen Do, Arthur C. Sosis Md, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
Darkening And Eruptive Nevi During Treatment With Erlotinib (Poster), Stephen Hemperly Do, Tanya Ermolovich Do, Nektarios I. Lountzis Md
Darkening And Eruptive Nevi During Treatment With Erlotinib (Poster), Stephen Hemperly Do, Tanya Ermolovich Do, Nektarios I. Lountzis Md
Department of Medicine
No abstract provided.
Subacute Cutaneous Lupus Erythematosus With Erythema Multiforme-Like Lesions: Consideration For Rowell Syndrome, Kelly L. Reed Do, Steven Oberlender Md, Phd, Stephen M. Purcell Do
Subacute Cutaneous Lupus Erythematosus With Erythema Multiforme-Like Lesions: Consideration For Rowell Syndrome, Kelly L. Reed Do, Steven Oberlender Md, Phd, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
Herpes Zoster Duplex Bilateralis, Sean Branch Do, Arthur C. Sosis Md, Stephen M. Purcell Do
Herpes Zoster Duplex Bilateralis, Sean Branch Do, Arthur C. Sosis Md, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
In Vivo Bioluminescence Imaging To Evaluate Systemic And Topical Antibiotics Against Community-Acquired Methicillin-Resistant Staphylococcus Aureus-Infected Skin Wounds In Mice, Yi Guo, Romela Irene Ramos, John S. Cho, Niles P. Donegan, Ambrose L. Cheung, Lloyd S. Miller
In Vivo Bioluminescence Imaging To Evaluate Systemic And Topical Antibiotics Against Community-Acquired Methicillin-Resistant Staphylococcus Aureus-Infected Skin Wounds In Mice, Yi Guo, Romela Irene Ramos, John S. Cho, Niles P. Donegan, Ambrose L. Cheung, Lloyd S. Miller
Dartmouth Scholarship
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) frequently causes skin and soft tissue infections, including impetigo, cellulitis, folliculitis, and infected wounds and ulcers. Uncomplicated CA-MRSA skin infections are typically managed in an outpatient setting with oral and topical antibiotics and/or incision and drainage, whereas complicated skin infections often require hospitalization, intravenous antibiotics, and sometimes surgery. The aim of this study was to devel
Trigeminal Trophic Syndrome, Ryan Owen Do, Joshua M. Levin Md, Stephen M. Purcell Do
Trigeminal Trophic Syndrome, Ryan Owen Do, Joshua M. Levin Md, Stephen M. Purcell Do
Department of Medicine
No abstract provided.
Desmoplastic Fibroblastoma (Collagenous Fibroma), Filomena Scolas Do, Tanya Ermolovich Do, Sean Branch Do, Alan J. Shienbaum Do, Sidney Jacoby
Desmoplastic Fibroblastoma (Collagenous Fibroma), Filomena Scolas Do, Tanya Ermolovich Do, Sean Branch Do, Alan J. Shienbaum Do, Sidney Jacoby
Department of Medicine
No abstract provided.
Drug-Induced Linear Iga Bullous Dermatosis, Luis A. Soro Do, Tanya Ermolovich Do
Drug-Induced Linear Iga Bullous Dermatosis, Luis A. Soro Do, Tanya Ermolovich Do
Department of Medicine
No abstract provided.
Merkel Cell Carcinoma, Cynthia L. Bartus Md, Steven Oberlender Md, Phd, Christian W. Oram Do
Merkel Cell Carcinoma, Cynthia L. Bartus Md, Steven Oberlender Md, Phd, Christian W. Oram Do
Department of Medicine
No abstract provided.
Secondary Cutaneous Plasmacytoma In A Patient With Multiple Myeloma, Joshua M. Levin Md, Christian W. Oram Do
Secondary Cutaneous Plasmacytoma In A Patient With Multiple Myeloma, Joshua M. Levin Md, Christian W. Oram Do
Department of Medicine
No abstract provided.
Linear Psoriasis Of The Isolated Type, Tatyana Groysman Do, Marc W. Levin Md
Linear Psoriasis Of The Isolated Type, Tatyana Groysman Do, Marc W. Levin Md
Department of Medicine
No abstract provided.
Keratinocyte-Targeted Expression Of Human Laminin Γ2 Rescues Skin Blistering And Early Lethality Of Laminin Γ2 Deficient Mice., Tracy L Adair-Kirk, Gail L Griffin, Michelle J Meyer, Diane G Kelley, Jeffrey H Miner, Douglas R Keene, M Peter Marinkovich, J Michael Ruppert, Jouni Uitto, Robert M Senior
Keratinocyte-Targeted Expression Of Human Laminin Γ2 Rescues Skin Blistering And Early Lethality Of Laminin Γ2 Deficient Mice., Tracy L Adair-Kirk, Gail L Griffin, Michelle J Meyer, Diane G Kelley, Jeffrey H Miner, Douglas R Keene, M Peter Marinkovich, J Michael Ruppert, Jouni Uitto, Robert M Senior
Department of Dermatology and Cutaneous Biology Faculty Papers
Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin chains. Laminin-332 modulates epithelial cell processes, such as adhesion, migration, and differentiation and is prominent in many embryonic and adult tissues. In skin, laminin-332 is secreted by keratinocytes and is a key component of hemidesmosomes connecting the keratinocytes to the underlying dermis. In mice, lack of expression of any of the three Laminin-332 chains result in impaired anchorage and detachment of the epidermis, similar to that seen in human junctional epidermolysis bullosa, and death occurs within a few days after birth. To bypass the early …
Livedoid Vasculopathy In The Setting Of Disseminated Intravascular Coagulation Diagnosed As Thrombotic Thrombocytopenic Purpura, Steven Oberlender Md, Phd, Anthony J. Gust Md, Christian W. Oram Do
Livedoid Vasculopathy In The Setting Of Disseminated Intravascular Coagulation Diagnosed As Thrombotic Thrombocytopenic Purpura, Steven Oberlender Md, Phd, Anthony J. Gust Md, Christian W. Oram Do
Department of Medicine
No abstract provided.
Car Seat Dermatitis - A Case Report, Marie S. Lewars Do, Joshua M. Levin Md, Stephen Purcell Do
Car Seat Dermatitis - A Case Report, Marie S. Lewars Do, Joshua M. Levin Md, Stephen Purcell Do
Department of Medicine
No abstract provided.
Abca12-Mediated Lipid Transport And Snap29-Dependent Trafficking Of Lamellar Granules Are Crucial For Epidermal Morphogenesis In A Zebrafish Model Of Ichthyosis., Qiaoli Li, Michael Frank, Masashi Akiyama, Shiu-Ying Ho, Hiroshi Shimizu, Christine Thisse, Bernard Thisse, Eli Sprecher, Jouni Uitto
Abca12-Mediated Lipid Transport And Snap29-Dependent Trafficking Of Lamellar Granules Are Crucial For Epidermal Morphogenesis In A Zebrafish Model Of Ichthyosis., Qiaoli Li, Michael Frank, Masashi Akiyama, Shiu-Ying Ho, Hiroshi Shimizu, Christine Thisse, Bernard Thisse, Eli Sprecher, Jouni Uitto
Department of Dermatology and Cutaneous Biology Faculty Papers
Zebrafish (Danio rerio) can serve as a model system to study heritable skin diseases. The skin is rapidly developed during the first 5-6 days of embryonic growth, accompanied by expression of skin-specific genes. Transmission electron microscopy (TEM) of wild-type zebrafish at day 5 reveals a two-cell-layer epidermis separated from the underlying collagenous stroma by a basement membrane with fully developed hemidesmosomes. Scanning electron microscopy (SEM) reveals an ordered surface contour of keratinocytes with discrete microridges. To gain insight into epidermal morphogenesis, we have employed morpholino-mediated knockdown of the abca12 and snap29 genes, which are crucial for secretion of lipids and …
Oral Fixed Drug Eruption Secondary To Isoniazid, Tanya Ermolovich Do, Tatyana Groysman Do
Oral Fixed Drug Eruption Secondary To Isoniazid, Tanya Ermolovich Do, Tatyana Groysman Do
Department of Medicine
No abstract provided.
Atypical Lymphocytic Lobular Panniculitis: A Distinct Eentity In The Spectrum Of Cutaneous Lymphoid Dyscrasia, Lusia S. Yi Do, Ms, Nicole Bright Do, Stephen Purcell Do
Atypical Lymphocytic Lobular Panniculitis: A Distinct Eentity In The Spectrum Of Cutaneous Lymphoid Dyscrasia, Lusia S. Yi Do, Ms, Nicole Bright Do, Stephen Purcell Do
Department of Medicine
No abstract provided.
Plexiform Neurofibroma Associated With Nf1, Stephen M. Purcell Do, Tatyana Groysman Do
Plexiform Neurofibroma Associated With Nf1, Stephen M. Purcell Do, Tatyana Groysman Do
Department of Medicine
No abstract provided.