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Full-Text Articles in Cardiology
Relation Of Reduced Preclinical Left Ventricular Diastolic Function And Cardiac Remodeling In Overweight Youth To Insulin Resistance And Inflammation, Rachana Dahiya, Sarah Schultz, Arun Dahiya, Jinlin Fu, Christopher Flatley, Danusia Duncan, John Cardinal, Karam Kostner, Nuala Byrne, Andrew Hills, Mark Harris, Louise Conwell, Gary Leong
Relation Of Reduced Preclinical Left Ventricular Diastolic Function And Cardiac Remodeling In Overweight Youth To Insulin Resistance And Inflammation, Rachana Dahiya, Sarah Schultz, Arun Dahiya, Jinlin Fu, Christopher Flatley, Danusia Duncan, John Cardinal, Karam Kostner, Nuala Byrne, Andrew Hills, Mark Harris, Louise Conwell, Gary Leong
Nuala Byrne
Insulin resistance (IR) and inflammation are associated with an increased risk of cardiovascular disease and may contribute to obesity cardiomyopathy. The earliest sign of obesity cardiomyopathy is impaired left ventricular (LV) diastolic function, which may be evident in obese children and adolescents. However, the precise metabolic basis of the impaired LV diastolic function remains unknown. The aims of this study were to evaluate cardiac structure and LV diastolic function by tissue Doppler imaging in overweight and obese (OW) youth and to assess the relative individual contributions of adiposity, IR, and inflammation to alterations in cardiac structure and function. We studied …