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Full-Text Articles in Allergy and Immunology
Longitudinal Investigation Of Natural Killer Cells And Cytokines In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Mieke Van Driel, Donald Staines, Kevin Ashton, Sharni Hardcastle, James Keane, Lotti Tajouri, Daniel Peterson, Sandra Ramos, Sonya Marshall-Gradisnik
Longitudinal Investigation Of Natural Killer Cells And Cytokines In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Mieke Van Driel, Donald Staines, Kevin Ashton, Sharni Hardcastle, James Keane, Lotti Tajouri, Daniel Peterson, Sandra Ramos, Sonya Marshall-Gradisnik
Lotti Tajouri
Background: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an etiologically unexplained disorder characterised by irregularities in various aspects of the immunological function. Presently, it is unknown whether these immunological changes remain consistent over time. This study investigates Natural Killer (NK) cell cytotoxic activity, NK cell subsets (CD56brightCD16- and CD56dimCD16+) and cytokines, over the course of a12 month period in patients with CFS/ME. Methods: The participants in the study comprised 65 (47.2 ± 11.5 years) CFS/ME participants and 21 (45.2 ±9.3 years) non-fatigued controls. Flow cytometry protocols were used to assess NK subsets and NK cytotoxic activity at various time points that …
Assessment Of Immune Function After Short-Term Administration Of Recombinant Human Growth Hormone In Healthy Young Males, Sandra B. Ramos, Ekua W. Brenu, Rhys Christy, A. Bon Gray, Lars Mcnaughton, Lotti Tajouri, Mieke Van Driel, Sonya M. Marshall-Gradisnik
Assessment Of Immune Function After Short-Term Administration Of Recombinant Human Growth Hormone In Healthy Young Males, Sandra B. Ramos, Ekua W. Brenu, Rhys Christy, A. Bon Gray, Lars Mcnaughton, Lotti Tajouri, Mieke Van Driel, Sonya M. Marshall-Gradisnik
Lotti Tajouri
Growth hormone (GH) is a commonly used drug aimed at improving sport performance. The aim of this study is to evaluate the immunomodulatory effects of short-term administration of recombinant GH (rhGH) in healthy young males. NK cell number, activity and phenotype, T cell number, CD4+ (Th1/Th2) cytokine production of IL2, IL4, IL6, IL10, TNF-a and IFN-y and CD4+/CD8+ ratio with particular attention to the possible correlation to IGF-I production were investigated. 30 males (27 ± 9 years) were randomly assigned to placebo (n = 15) or drug (rhGH) 1 mg/day groups (n = 15) with daily injection for 7 days. …