Medical Specialties Commons^™

Flow In Sport Performance: A Systematic Review Of Psychological Mechanisms And Conceptual Gaps, Nanda Farah Muftia, Heny Setyawati, Donny Wira Yudha Kusuma, Churia Dina Rahmatin, Dewi Ayu Kusumaningtyas, Siti Baitul Mukarromah, Adi S

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Athletic performance is a psychologically complex process, with “flow” recognized as central to optimal performance. However, its emergence is often treated as automatic and lacks sufficient explanation through broader psychological mechanisms. Objective: This study synthesizes recent literature on flow in sport performance, emphasizing psychological mechanisms, situational determinants, and conceptual gaps. Methods: A systematic review was conducted following PRISMA 2020 guidelines. Eight peer-reviewed, English-language articles (published 2022-2026) retrieved exclusively from the Scopus database met the inclusion criteria and were analyzed using thematic synthesis. Result: Flow is a dynamic psychological process, not a static state. Supporting optimal athletic performance through enhanced …

Progressive Remodeling Of Global Protein Interaction Networks In A Mouse Model Of Tauopathy, Noah Lampl, Morgan C Stephens, Zihan Wang, Joseph T Nigro, Alejandro Rondon Ortiz, Ryan Hekman, Anna Lourdes F Cruz, Rebecca Roberts, Lulu Jiang, Juan Botas, Andrew Emili, Benjamin Wolozin

Faculty, Staff and Students Publications

Neurodegenerative disease is marked not just by loss of proteins or cells, but by dynamic rewiring of macromolecular interaction networks that precede and drive pathology. Here, we present a temporally resolved, systems-scale map of multi-protein complex remodeling in a tauopathy model, integrating co-fractionation mass spectrometry, quantitative phosphoproteomics, and machine learning to decode phosphorylation-dependent shifts in protein interactomes across disease progression. This interactomic atlas serves as a resource to investigate functional assemblies, including MAPT-Dpysl2 and Cyfip1-actin, as well as ptk2b-Kars/Dars and ptk2b-Msn-Farsb-complexes, that modulate early disease phenotypes in vivo. Notably, it captures the composition, dynamics, and regulatory state of protein complexes …

Progressive Remodeling Of Global Protein Interaction Networks In A Mouse Model Of Tauopathy, Noah Lampl, Morgan C Stephens, Zihan Wang, Joseph T Nigro, Alejandro Rondon Ortiz, Ryan Hekman, Anna Lourdes F Cruz, Rebecca Roberts, Lulu Jiang, Juan Botas, Andrew Emili, Benjamin Wolozin

Faculty, Staff and Students Publications

Neurodegenerative disease is marked not just by loss of proteins or cells, but by dynamic rewiring of macromolecular interaction networks that precede and drive pathology. Here, we present a temporally resolved, systems-scale map of multi-protein complex remodeling in a tauopathy model, integrating co-fractionation mass spectrometry, quantitative phosphoproteomics, and machine learning to decode phosphorylation-dependent shifts in protein interactomes across disease progression. This interactomic atlas serves as a resource to investigate functional assemblies, including MAPT-Dpysl2 and Cyfip1-actin, as well as ptk2b-Kars/Dars and ptk2b-Msn-Farsb-complexes, that modulate early disease phenotypes in vivo. Notably, it captures the composition, dynamics, and regulatory state of protein complexes …

The Commercialization Of Wellness: Gray Market Peptides & Cancer, Bryan M. Burt

Advances in Cancer Education and Quality Improvement

No abstract provided.

Recommendations For The Management Of Spontaneous Intracranial Hypotension With Spinal Longitudinal Epidural Csf Collection: A Delphi Study, Soyoun Choi, Ian Carroll, Deborah I. Friedman, Peter G. Kranz, Eugene Lee, Manjit Matharu, Simy Parikh, Henrik W. Schytz, Marcio N. Portes Souza, Yen-Feng Wang, Hsiangkuo Yuan, Mi Ji Lee

Department of Neurology Faculty Papers

BACKGROUND AND OBJECTIVES

Spontaneous intracranial hypotension (SIH) results from spinal CSF leakage. Epidural blood patch (EBP) is an important first-line treatment. However, pre-EBP, intra-EBP, and post-EBP practice varies widely owing to limited consensus guidance. We aimed to develop expert consensus statements to support clinical decision-making in SIH management, including peri-EBP practices, focusing on patients with spinal longitudinal epidural CSF collection (SLEC) before definitive leak type classification.

METHODS

An international multidisciplinary Delphi process was conducted between January 2024 and July 2025, involving experts in neurology, neurosurgery, radiology, and anesthesiology. Consensus was defined a priori as ≥70% agreement for strong agreement, 60%-69% …

From Burnout To Belonging: A Faculty Well-Being Director's Perspective On Leadership, Workplace Culture, Organizational Efficiency, And The Broader Role Of Physician Well-Being, Ajit K. Bisen

Advances in Cancer Education and Quality Improvement

Burnout remains a major challenge in health care, despite increasing investments in physician well-being initiatives. As the faculty well-being director for my department, my perspective on physician well-being has shifted from focusing primarily on individual resilience, mindfulness, and wellness initiatives to recognizing the important roles of leadership, workplace culture, and organizational efficiency. Physician well-being is an essential foundation for high-quality patient care, stronger teams, patient safety, quality improvement, and healthier organizations. Here, I discuss the 3 key shifts in thinking that have influenced my approach as faculty well-being director.

Life After Death, Mridula Nadamuni

Advances in Cancer Education and Quality Improvement

This poem explores the reflections of a physician following a poignant interaction with a patient, as each confronts the reality that time on Earth is limited.

Towards Upstate Well Center: Lessons Learned In Organizational Well-Being Over The Last Decade, Nayla M. Khoury, Asalim Thabet, Kerryanna M. Elhage, Jarrod L. Bagatell, Kaushal Nanavati, Leslie J. Kohman

Advances in Cancer Education and Quality Improvement

Background: Upstate Well has evolved over more than 10 years through the integration of multiple partners, programs, and initiatives. The scope and complexity have increased alongside stronger relationships, shared ownership, and supportive infrastructure.

Methods: This report analyzes implementation lessons learned through program development and impact assessment over 5 years.

Results: Upstate has a growing number of wellness champions across the institution, collaboration among multiple wellness programs, and lessons learned from select programs. Themes include (1) supportive infrastructure, including new full-time equivalent positions to support Upstate Well; (2) active collaboration between stakeholders, and appointed wellness champions in each department; (3) improved …

From Career Alignment To Action: Strengthening Academic Mentoring Through Structured Reflection, Fanni Farago, Julie Izzo, Courtney L. Holladay, Diane C. Bodurka, Michelle Hildebrandt, Suezen Salinas

Advances in Cancer Education and Quality Improvement

Background: As faculty roles and responsibilities become increasingly complex and demanding in contemporary academic medicine, fostering and sustaining faculty well-being has emerged as a critical organizational priority. In response to this need, this brief report describes early insights from the first year of implementation of the Academic Mentoring Program (AMP), a formal and expanding faculty mentoring initiative at UT MD Anderson. Our findings highlight the potential value of incorporating a structured career development assessment (CDA) tool into the mentee intake and engagement effort, evaluating development alignment, professional activities, and organizational expectations.

Methods: We conducted descriptive statistical analysis and qualitative thematic …

Pebbles In The Shoe: A Multidisciplinary Program To Identify And Resolve Workplace Inefficiencies In A Pediatric Oncology Division, Reeja Raj, Kate Gazouleas, Pavilia Francis, Nancy Gordon, Vidya Gopalakrishnan, Amy Heaton, Ishwaria Subbiah, Priti Tewari, Harjeet Singh, Aaron Walton, Shehla Razvi, Martha Askins, Lisa Triche, Karen Moody

Advances in Cancer Education and Quality Improvement

Introduction: Occupational burnout is a significant concern among pediatric oncology faculty and multidisciplinary staff, characterized by emotional depletion, detachment from work, or a diminished sense of professional achievement. Inefficient work processes can be important contributors to burnout. This report describes the implementation and outcomes of Pebbles in the Shoe (also referred to as Pebbles), a pediatric division–wide initiative designed to address workplace concerns and inefficiencies.

Methods: The Pebbles program was developed and led by our pediatric division's wellness task force. Division members were invited to anonymously submit work-related concerns and irritations through a QR code–accessible electronic form. Five discipline-based work …

Aligning Trainee Leave Policies Across Surgical Fellowships: Development Of A Division-Wide Framework For Leave And Program Completion, Helen M. Johnson, Mara B. Antonoff, Kelly K. Bree, Maxwell G. Lewis, Heather A. Lillemoe, Margaret S. Roubaud

Advances in Cancer Education and Quality Improvement

Background: Surgical fellows and program leaders face difficulties navigating parental, caregiver, medical, and personal leave due to variation in policies. A Division of Surgery (DoS) Trainee Leave and Parental Support Task Force was convened at The University of Texas MD Anderson Cancer Center to review existing requirements and develop a harmonized framework for trainee leave and fellowship program completion.

Methods: The Task Force conducted a comprehensive review of policies relevant to surgical fellow leave and graduation requirements, identified best practices, and drafted a DoS policy. The policy was refined iteratively through engagement with key stakeholders, including program directors, department chairs, …

Creating A Culture Of Well-Being By Removing Barriers To Participation In A Multi-Campus Cancer Center, Adam Siegman, Miranda M. Phillips, Jennifer Bickel

Advances in Cancer Education and Quality Improvement

Background: Healthcare professionals in geographically distributed cancer care settings may face barriers to accessing workforce well-being resources due to geographic distance, staffing constraints, and operational demands. Disconnect & Refresh was developed to improve access to restorative wellness opportunities across community-based cancer care sites.

Methods: Disconnect & Refresh was implemented at The University of Texas MD Anderson Cancer Center across 4 Houston area locations. The initiative included BeWell Paws, virtual reality meditation, chair yoga, and creative wellness activities delivered during the workday. Participation was voluntary and tracked through employee badge scans. Participants were invited to complete an anonymous post-event survey, and …

Faculty Growth Through Academic Career Development Committees, China Crowder, Rebekah Filson, Elizabeth Grubbs, Carin Hagberg, Anne Tsao

Advances in Cancer Education and Quality Improvement

Academic medical centers face ongoing challenges in providing structured, career -stage-–specific faculty development, mentorship, and leadership opportunities that effectively engage faculty throughout their academic careers. The Academic Career Development Committees at The University of Texas MD Anderson Cancer Center represent a structured, faculty-driven model designed to promote professional growth, mentorship, and leadership engagement across all career stages. Grounded in established principles of faculty development and mentorship in academic medicine, the Academic Career Development Committees foster cross-level collaboration, inclusive participation, and intentional skill-building. Outcomes were measured through participant evaluations, attendance and participation trends, mentorship engagement indicators, and qualitative feedback gathered from …

Leadforward: A Department-Based Leadership Development Program To Support Workforce Well-Being, Leisa A. Bryant, Denise Marshall, Loreal Williams, Miranda M. Phillips

Advances in Cancer Education and Quality Improvement

Introduction: Leadership development is increasingly recognized as an important strategy for supporting workforce engagement, professional growth, and succession planning in healthcare settings. To address leadership development needs within Food, Nutrition, and Patient Transportation (FNPT) departments, a structured leadership development program, LeadForward, was developed for emerging and midlevel leaders.

Project Description: LeadForward was implemented within the FNPT departments at a comprehensive cancer center. Ten participants completed the inaugural cohort. The curriculum was organized into 6 instructional modules designed to develop leadership competencies among emerging and midlevel leaders. Leadership outcomes were assessed using pre- and postprogram self-assessments across 14 leadership competency …

Standardized Preprocedure Protocolling Of Stereotactic Breast Biopsies Enables Device-Level Supply Chain Forecasting: A Multisite Quality Improvement Analysis, Megan Kalambo, Mike Everding, Maria Montemayor, Falguni Patel, Mohit Nath

Advances in Cancer Education and Quality Improvement

Background: Breast imaging depends on single-use, vendor-proprietary consumables produced by a concentrated set of manufacturers. During supply shortages in 2026, healthcare organizations faced urgent pressure to shift from reactive to proactive inventory management. Stereotactic breast biopsy needle shortages revealed that traditional forecasting based on procedure volume lacks the granularity needed for device-specific demand. We aimed to enable device-level forecasting through standardized preprocedure protocolling.

Methods: In a retrospective analysis of 1,456 stereotactic biopsies across 4 breast imaging sites (June 2025 to June 2026), compliance with a standardized electronic protocolling tool that captured lesion count and needle size (standard vs. petite) was …

Critical Daily Dose Warning Optimization In An Electronic Health Record At A Tertiary Cancer Center, Mckenzie Erwin, Sadika Eslaminejad, David Perez, Jesni Mathew

Advances in Cancer Education and Quality Improvement

Objectives: Clinical decision support is a form of health information technology utilized by electronic health records (EHRs) to reduce prescribing errors. The challenge of incorporating clinical decision support into medication workflows is balancing alert fatigue with clinical appropriateness. At our 777-bed tertiary cancer center, one form of interruptive clinical decision support is critical dose warnings that appear when the ordered dose deviates by a defined threshold from the maximum dose. Our tertiary cancer center relies on a third-party data vendor to provide maximum dose limits that are integrated into the EHR medication ordering process. At the time of project initiation, …

Implementation Of A Low-Cost Tobacco-Free Intervention In A Permanent Supportive Housing Program To Address Cancer Disparities Among People Who Have Experienced Homelessness, Ammar D. Siddiqi, Phoebe Wong, Cathy Crouch, Lorraine R. Reitzel

Advances in Cancer Education and Quality Improvement

Objectives: Permanent supportive housing residents who have experienced homelessness use tobacco products at elevated rates, contributing to higher cancer risk. Agencies that provide wraparound support services to this group are committed to rebuilding their stability by improving their health. Yet, their delivery of tobacco screening and cessation care is limited, as is information about their clients’ tobacco use behaviors. Here, we evaluated a low-cost intervention for an Albert Schweitzer Fellowship project conducted in a permanent supportive housing program with 650 adults who had experienced homelessness in Houston, Texas.

Materials and Methods: Between August 2024 and February 2025, client-facing staff members …

Evaluation Of Shortened Irinotecan Infusion Times And Adverse Effects Incidence For Gastrointestinal Medical Oncology Patients, Rachel N. Ochs, Daniel J. Donovan, Neha A. Betrabet, Wendy M. Covert

Advances in Cancer Education and Quality Improvement

Background: Irinotecan, a topoisomerase I inhibitor, is commonly used to treat gastrointestinal cancers. The infusion time of irinotecan is usually over 90 minutes; however, studies support the safety and feasibility of 30-minute infusions. A shortened infusion duration may improve patient quality of life, optimize infusion chair utilization, and reduce wait times. Faster infusion rates may increase the risk of acute cholinergic side effects, reported in up to 50% of patients (all grades). Current institutional practice in the gastrointestinal medical oncology (GIMO) clinic involves administering irinotecan over 90 minutes and using atropine as needed for reversing cholinergic symptoms. For patients who …

Unlocking Faculty Potential: A Quasi-Experimental Study Of Coaching And Academic Performance In Health Care Settings, Amanda Woods Herron, Katelyn J. Cavanaugh, Michelle Figliuolo Deveau, Courtney L. Holladay

Advances in Cancer Education and Quality Improvement

As faculty in academic medicine face mounting demands to excel in clinical care, research, teaching, and administrative responsibilities, interventions that support professional sustainability are increasingly critical. Coaching has emerged as a promising developmental strategy within health care leadership, yet its impact on research and clinical outcomes in academic medical centers remains underexplored. This quasi-experimental study evaluated the effectiveness of a coaching program using intentional change theory (ICT) as a conceptual framework. ICT emphasizes sustainable personal transformation through alignment between the ideal self and professional goals. We examined a sample of 189 coached clinical faculty and 200 matched peers who had …

Why Should A Data-Driven Cancer Center Prioritize Well-Being?, Peter Pisters

Advances in Cancer Education and Quality Improvement

No abstract provided.

The Future Of Wellness In Health Care, Jennifer Bickel

Advances in Cancer Education and Quality Improvement

No abstract provided.

Fgfr1/Klb-Mfg-E8 Maintains Microvascular Integrity And Adaptive Cardiac Remodeling, Sanskruti R Gare, Nasser H Alatawi, Xinyi Chen, Jiayan Zhang, Claire Ross, Oveena Fonseka, Yihua Han, Namrita Kaur, Andrea Ruiz-Velasco, Xiangjun Zhao, Yingjuan Liu, Riham R E Abouleisa, Susanne S Hille, Tao Wang, Sabu Abraham, Bernard D Keavney, Martin K Rutter, Elizabeth J Cartwright, Gareth Howell, Tamer M A Mohamed, Oliver J Müller, Wei Liu

Faculty, Staff and Students Publications

Background: Endothelial defects in the heart are a contributor to cardiac pathological remodeling and dysfunction, which can be influenced by cardiomyocytes. Here, we explore cardioprotective crosstalk between cardiomyocytes and endothelial cells under diabetic conditions.

Methods: Type 2 diabetes was induced in male and female mice using a high-fat, high-sucrose diet in conjunction with low-dose streptozotocin. Cardiomyocyte-specific deletion of FGFR1 (fibroblast growth factor receptor 1) or KLB (beta-Klotho) was achieved by crossing floxed mice with αMHC (alpha-myosin heavy chain)-Cre transgenic mice, while the treatment potential was assessed by recombinant adeno-associated virus 9 delivery systems or administration of recombinant protein. Various in …

Using Implementation Research Frameworks To Identify Facilitators And Barriers To Implementation Of Ferric Carboxymaltose Intravenous Iron Among Moderately Anemic Postpartum Women Participating In A Trial In India, Umesh Charantimath, Valerie L. Flax, Ashwini Dandappanavar, Anika Hannan, Mrityunjay C. Metgud, Avinash Kavi, Manjunath Somannavar, Shivaprasad S. Goudar, Simal Thind, Rosemary Frasso, Lauren Wiener, Sabrina Larosa, Cecilia Rasco, Elizabeth M. Mcclure, Richard Derman

College of Population Health Faculty Papers

Postpartum anemia affects approximately 75% of women in India. We conducted this implementation research (IR) related to the use of ferric carboxymaltose (FCM) intravenous (IV) iron as part of a trial in anemic postpartum women. The aim of the IR study was to understand potential facilitators and barriers to implementation of single-dose FCM IV iron. This is a mixed-methods study in three secondary-level healthcare facilities in Belagavi, India, designed to explore selected Consolidated Framework for Implementation Research constructs and Proctor’s framework elements. Quantitative data were gathered via surveys of postpartum women who received IV FCM (n = 308) and from …

Complete Atrioventricular Block Revealing Late-Onset Cardiac Fabry Disease: Diagnostic Role Of Native T1 Mapping, Nouhaila Bentama, Lamyae Bakamel, Jalal Tagueniti, Fatiha Ait Yahya, Brahim Meftout

Journal of the Saudi Heart Association

A 63-year-old man presented with symptomatic complete atrioventricular block requiring urgent pacemaker implantation. Evaluation revealed non-obstructive left ventricular hypertrophy with normal coronary arteries. Cardiac magnetic resonance showed diffusely reduced native T1 values and inferolateral late gadolinium enhancement, suggesting Fabry cardiomyopathy; amyloidosis was excluded by bone scintigraphy. Diagnosis was confirmed by markedly reduced alpha-galactosidase A activity, elevated lyso-Gb3, and a pathogenic hemizygous GLA variant (p.Asn215Ser). Enzyme replacement therapy with agalsidase beta was initiated, with early stabilization of myocardial deformation and septal thickness. This case highlights native T1 mapping as a key diagnostic biomarker in unexplained left ventricular hypertrophy.

Discover To Deliver Pediatric Futures: Viewpoints Of Future Medicine From A Pediatric Health Care System., Vanessa Watkins, Ken Chang, Laura Sarff, Jared Vavroch, Dawn Wolff, Lori A. Erickson

Manuscripts, Articles, Book Chapters and Other Papers

Pediatric health care systems face increasing uncertainty driven by rapid technological change, workforce shifts and shortages, environmental threats, and evolving family and community needs. Pediatrics requires future-focused considerations that go beyond adult systems, including family-centered care, developmental trajectories, and long-term societal impacts on child well-being. While the future cannot be predicted, futures medicine methods offer structured approaches to anticipate change and support proactive, values-driven planning. This Viewpoint describes the application of pediatric futures methods within an academic, independent nonprofit pediatric health system and proposes a practical framework that connects future readiness to strategic decision-making and daily care delivery. Futures medicine …

Murine Typhus In Georgia: Historical Context And A Probable Case Of Resurgence Where Previously-Thought Eradicated, Giovanni Mella-Velazquez, Christopher He, Bolanle Akinsola, Judson Miller

Journal of the Georgia Public Health Association

Background: Murine typhus, caused by Rickettsia typhi, is a flea-borne illness historically endemic to the southeastern United States, with initial cases reported in Atlanta, Georgia in 1913. Following vector control efforts, incidence declined significantly, and the disease was removed from the nationally notifiable disease list in 1987. While recent cases have been reported in select regions, murine typhus has not been documented in Georgia for decades. We present a pediatric case in Atlanta that may represent the first reported instance in nearly 40 years, suggesting possible reemergence in the Southeast.

Methods: We conducted a case report analysis of a pediatric …

Small Leucine-Rich Proteoglycans In Cancer: Three Decades Of Discovery, Gabriel J. Pascal, Sadie Kim, Christopher Xie, Maria Danial, Iris Barone, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Small leucine-rich proteoglycans (SLRPs) are a well-known family of extracellular matrix (ECM) molecules. They consist of five classes with 18 different protein cores originally recognized as having a physically supportive component to the extracellular structure and tissue integrity. There has been a significant conceptual shift from the original paradigm as mere contributors to ECM structure to the current concept of bioactive signaling molecules. Over the past three decades, SLRPs have evolved into critical modulators of signaling events in cells by contributing to the regulation of receptor activity and intercellular communication. They also affect key biological processes such as tissue remodeling, …

Time-Varying Spatial Ventricular Gradient Orientation Is Associated With Anthracycline Heart Failure, Andrea N. Rosas Diaz, Hans F. Stabenau, Patricia Tung, Jason Nelson, Gabriel Pajares Hurtado, Sarah Warack, Sanam Alilou, Arunashis Sau, Daniel B. Kramer, Aarti Asnani, Jonathan W. Waks

Division of Cardiology Faculty Papers

BACKGROUND

Anthracycline use is limited by cardiotoxicity resulting in heart failure (HF). The spatial ventricular gradient(SVG) is a vectorcardiographic measurement of myocardial electrical heterogeneity associated with sudden death and incident HF. It is unclear if serial measurement of SVG after anthracycline initiation can help predict subsequent HF.

OBJECTIVES

The objective of the study was to determine if time-varying SVG measurements are associated with anthracycline HF.

METHODS

Retrospective, single-center study of adult patients with cancer treated with anthracyclines between 1992 to 2019. Standard 12-lead electrocardiograms obtained within 6 months before and up to 5 years after anthracycline initiation were analyzed. Patients …

The Lateral Recovery Position In Medical Vs Dental Emergencies, John Regis, Steven Saxe, Jason Ciccotelli, Saskia Richter, Jessica Immonen

The Journal of Integrative Physiology

The lateral recovery position is widely used in prehospital and clinical settings to help maintain airway patency in unconscious patients who are breathing spontaneously. Tracheal anatomy and asymmetries in respiratory structures, along with gravitational effects on soft tissues, may influence the efficacy and safety of this positioning. Clinical nuances related to the setting and secondary health concerns interestingly create disagreement on preferred side for lateral placement. This article explores the anatomical and physiological considerations that support the lateral recovery position—focusing on tracheal asymmetry and its implications for airway patency—along with emergency medical practices in medical versus dental emergencies. It also …

Fulminant Seronegative Systemic Lupus Erythematosus With Class Iv/V Lupus Nephritis And Multisystem Involvement, Luisa Montoya, Abdel Martinez Borrego, Krystal Simono, Luis Alvarez, Jean Luis Cabrera, Brandon Cantazaro, Fatimah Bello

School of Medicine Publications

Seronegative systemic lupus erythematosus (SLE) poses a diagnostic challenge, particularly when patients develop organ-threatening disease despite negative traditional serologies. We report a fulminant case in a 24-year-old woman with congenital atrioventricular (AV) block, chronic pancytopenia, chronic kidney disease (CKD), and morbid obesity, who presented with progressive anasarca, dyspnea, dizziness, and cough. Laboratory evaluation revealed severe pancytopenia, nephrotic-range proteinuria 11–13 g/day (reference range: 0–150 mg/24 hours), and acute kidney injury. Renal biopsy demonstrated Class IV proliferative and Class V membranous lupus nephritis, despite negative antinuclear antibodies (ANA), anti–double-stranded DNA (anti-dsDNA) antibodies, anti-Smith (anti-Sm) antibodies, anti–Sjögren’s-syndrome–related antigen A (SSA) and antigen B …