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Medical Specialties Commons™

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2026

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Articles 3841 - 3844 of 3844

Full-Text Articles in Medical Specialties

Development Of A Clinical Prediction Model To Guide The Selective Use Of Spect/Ct In Papillary Thyroid Cancer, Liya Zhu, Junik Son, Lu Wang, Haifeng Hou, Byeong Cheol Ahn Jan 2026

Development Of A Clinical Prediction Model To Guide The Selective Use Of Spect/Ct In Papillary Thyroid Cancer, Liya Zhu, Junik Son, Lu Wang, Haifeng Hou, Byeong Cheol Ahn

Research outputs 2022 to 2026

Background: Radioiodine whole-body scan (WBS) is routinely performed after radioiodine therapy in papillary thyroid cancer (PTC), but its two-dimensional nature limits anatomical localization. The addition of single-photon emission computed tomography/computed tomography (SPECT/CT) improves diagnostic accuracy; however, routine use exposes patients to additional radiation, longer imaging time, and higher costs. This study aimed to establish a predictive model to identify which patients with PTC are more likely to benefit by adding SPECT/CT imaging after WBS, enabling selective rather than routine use. Methods: This retrospective study included 265 patients with pathologically confirmed PTC who underwent postoperative radioiodine therapy followed by WBS and …

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Dose–Response Association Between Systemic And Dermatologic Glucocorticoid Use And Type 2 Diabetes Mellitus: A Nationwide Case–Control Study, David Vadsholt, Annika V. Kvist, Chano Sandiramoorthy, Joshua R. Lewis, Peter Vestergaard, Johan Røikjer, Nicklas H. Rasmussen Jan 2026

Dose–Response Association Between Systemic And Dermatologic Glucocorticoid Use And Type 2 Diabetes Mellitus: A Nationwide Case–Control Study, David Vadsholt, Annika V. Kvist, Chano Sandiramoorthy, Joshua R. Lewis, Peter Vestergaard, Johan Røikjer, Nicklas H. Rasmussen

Research outputs 2022 to 2026

Aims: To investigate the association and dose–response between systemic and topical glucocorticoids and odds of Type 2 diabetes mellitus. Materials and Methods: We conducted a nationwide case–control study using Danish registry data from 2013 to 2021. People aged 40 years or older with incident type 2 diabetes mellitus (n = 149 113) were matched 1:3 with controls (n = 447 339) by age, sex and weighted Charlson Comorbidity Index. Glucocorticoid exposure was defined as ≥ 1 prescription within 1 year before the date of diagnosis and ≥ 2 within 3 years and classified as systemic or topical. Conditional logistic regression …

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Emerging Blood-Based Biomarkers For The Detection Of Parenchymal Brain Metastasis: Current Progress And Future Perspectives, Désirée Sexauer, Elin S. Gray, Helen Rizos, Pauline Zaenker, Aaron B. Beasley Jan 2026

Emerging Blood-Based Biomarkers For The Detection Of Parenchymal Brain Metastasis: Current Progress And Future Perspectives, Désirée Sexauer, Elin S. Gray, Helen Rizos, Pauline Zaenker, Aaron B. Beasley

Research outputs 2022 to 2026

Parenchymal brain metastases of solid malignancies remain a significant clinical challenge, as they are often detected at later symptomatic stages, which are typically associated with worse prognosis. Delayed detection limits treatment options and contributes to poor outcomes, while early detection is critical for improving patient outcomes and quality of life. In this comprehensive review, we investigated the potential use and challenges of blood-based biomarkers, including circulating tumor cells, cell-free DNA, noncoding RNAs, extracellular vesicles, proteins, and other immune-related biomarkers, for the early detection of parenchymal brain metastasis. The use of blood-based liquid biopsies offers a promising avenue for early detection …

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Gwas Meta-Analysis Provides New Insights Into Uveal Melanoma Risk, Matthew D’Mellow, Huanwei Wang, Jane M. Palmer, Kari Hemminki, Colleen M. Cebulla, Aaron B. Beasley, Nikolaos E. Bechrakis, Antonia L. Pritchard, Karin W. Wadt, Peter A. Johansson, Lenha Mobuchon, Samantha Barlow, Kelly Brooks, Timothy Beckman, Catherine M. Olsen, Sunil K. Warrier, Lindsey Byrne, Helen Kalirai, Colette Mustard, Nathan Ingold, Asta Försti, Timothy Isaacs Jan 2026

Gwas Meta-Analysis Provides New Insights Into Uveal Melanoma Risk, Matthew D’Mellow, Huanwei Wang, Jane M. Palmer, Kari Hemminki, Colleen M. Cebulla, Aaron B. Beasley, Nikolaos E. Bechrakis, Antonia L. Pritchard, Karin W. Wadt, Peter A. Johansson, Lenha Mobuchon, Samantha Barlow, Kelly Brooks, Timothy Beckman, Catherine M. Olsen, Sunil K. Warrier, Lindsey Byrne, Helen Kalirai, Colette Mustard, Nathan Ingold, Asta Försti, Timothy Isaacs

Research outputs 2022 to 2026

Objective: The aim of this research is to identify germline genetic variants that predispose to uveal melanoma (UM) using data from nine studies involving 5839 individuals with UM (3853 novel) and 349,863 healthy controls. Methods: Five novel UM genome-wide association studies (GWAS) were performed and included for meta-analysis with four previously published UM GWAS. A fixed-effects inverse-variance weighted (IVW) meta-analysis was performed by combining data from these nine UM case-control cohorts. A follow-up transcriptome-wide association study (TWAS) was conducted to identify candidate target genes at UM risk loci. Genetic correlations with melanoma-related phenotypes were measured to elucidate UM’s genetic architecture. …

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