Medical Specialties Commons^™

Ven In Combination With 10-Day Dec In Newly Diagnosed Elderly Or Relapsed/Refractory Acute Myeloid Leukemia, And High-Risk Myelodysplastic Syndrome: Long Term Follow-Up Of A Phase 2 Trial, Mahesh Swaminathan, Courtney D Dinardo, Abhishek Maiti, Naveen Pemmaraju, Maro Ohanian, Navel G Daver, Guillermo Garcia-Manero, Ghayas C Issa, Gautam Borthakur, Farhad Ravandi, Guillermo Montalban-Bravo, Tapan M Kadia, Yesid Alvarado, Elias J Jabbour, Nicholas J Short, William G Wierda, Nitin Jain, Steven M Kornblau, Lucia Masarova, Sherry A Pierce, Wei Qiao, Jing Ning, Hagop Kantarjian, Marina Y Konopleva

Faculty, Staff and Student Publications

No abstract provided.

Bone-Induced Her2 Promotes Secondary Metastasis In Hr+/Her2- Breast Cancer, Rahat Alam, Anna Reva, David G Edwards, Bree M Lege, Laura S Munoz-Arcos, Carolina Reduzzi, Swarnima Singh, Xiaoxin Hao, Yi-Hsuan Wu, Zeru Tian, Laura M Natalee, Gargi Damle, Deniz Demircioglu, Yixian Wang, Ling Wu, Elisabetta Molteni, Dan Hasson, Bora Lim, Zbigniew Gugala, Jerry E Chipuk, Julie E Lang, Joseph A Sparano, Chonghui Cheng, Massimo Cristofanilli, Han Xiao, Xiang H-F Zhang, Igor L Bado

Faculty, Staff and Students Publications

Bone metastases can disseminate to secondary sites and promote breast cancer progression creating additional clinical challenges. The mechanisms contributing to secondary metastasis are barely understood. Here, we evaluate the prediction power of Her2-expressing (Her2E) circulating tumor cells (CTCs) after analyzing over 13,000 CTCs from a cohort of 137 metastatic breast cancer (MBC) patients with initial HR+/Her2− status and employ preclinical models of bone metastasis (BM) to validate the role of Her2E CTCs in multi-organ metastases. While Her2 expression was higher in patients with bone metastasis, experimental analyses revealed that Her2E CTCs derived from bone lesions were more dependent on Her2 …

Prdm1 Is A Key Regulator Of The Nkt-Cell Central Memory Program And Effector Function, Gengwen Tian, Gabriel A Barragan, Hangjin Yu, Claudia Martinez-Amador, Akshaya Adaikkalavan, Xavier Rios, Linjie Guo, Janice M Drabek, Osmay Pardias, Xin Xu, Antonino Montalbano, Chunchao Zhang, Yanchuan Li, Amy N Courtney, Erica J Di Pierro, Leonid S Metelitsa

Faculty, Staff and Students Publications

Natural killer T cells (NKTs) are a promising platform for cancer immunotherapy, but few genes involved in the regulation of NKT therapeutic activity have been identified. To find regulators of NKT functional fitness, we developed a CRISPR/Cas9-based mutagenesis screen that uses a guide RNA (gRNA) library targeting 1,118 immune-related genes. Unmodified NKTs and NKTs expressing a GD2-specific chimeric antigen receptor (GD2.CAR) were transduced with the gRNA library and exposed to CD1d+ leukemia or CD1d-GD2+ neuroblastoma cells, respectively, over six challenge cycles in vitro. Quantification of gRNA abundance revealed enrichment of PRDM1-specific gRNAs in both NKTs and GD2.CAR NKTs, a result …

College Healthcare Providers: Are They Prepared To Treat Students Following A Disclosure Of Sexual Assault?, Torrie Piasecki, Lindsay Gietzen

Pacific Journal of Health

Sexual assault is happening on university and college campuses. This study aims to explore the gap in care relative to how on-campus healthcare providers respond to college students following a disclosure of sexual assault and the access to resources provided to them. A sample of seven providers from two major college campuses in Stockton, CA responded to a questionnaire about formal disclosures of sexual assault. Each participant self-reported their knowledge of trauma-informed care (TIC) and what they understand about their campus resources for survivors of sexual assault. Results from participants who completed the survey indicated that although most knew where …

Analysis Of Vaginal Vs Cesarean Deliveries Based On Gestational Age In Ama Oneworld Pregnancies, Brittany Hauke, Melanie Menning, Peter Schindler

Posters and Presentations: Family Medicine

No abstract provided.

Prevalence And Trends Of Polypharmacy Among U.S. Adults On Statin, 1999–2018, Mohamed A. Badheeb, Riyadh Saif Md, Ibrahim Hassan Md, Mostafa Elbanna Md, Shady Abohashem Md

Posters

Polypharmacy is increasing among cardiovascular patients, but national data on trends in statin users are limited. This study evaluated polypharmacy prevalence and trends among U.S. adults on statins, focusing on differences by age, gender, race/ethnicity, education, poverty, insurance, and statin adherence.

The Effects Of E-Liquid Aerosol ± Flavors On The Planktonic Growth Of Porphyromonas Gingivalis, Taylor Ahles, Skyler Gronkiewicz, Saskia Mourra, Dominic Palazzolo

Research Projects

A balance of commensal and pathogenic bacteria in the oral cavity is essential for optimal oral and systemic health. Our previous studies demonstrate that E- liquid aerosol ± flavors (particularly cinnamon) are detrimental to several strains of oral commensal streptococcal bacteria. However, very little information is available concerning the effects of E-liquid aerosols on oral pathogens. For this reason, Porphyromonas gingivalis, a pathogenic anaerobe and critical contributor to periodontal disease, was chosen for this study. Objective: This study aims to determine the effect of E-liquid aerosol ± flavors on the planktonic growth of P. gingivalis. Methods: P. gingivalis, initially grown …

Calling The Burn Center: Why Do Our Referring Hospitals Call Us?, Moon Usman Md, Alisa Savetamal

Posters

This study seeks to analyze and evaluate referral data received by a single state burn center, focusing on the allocation of resources for referrals and consultations, and determining the proportion of these that result in patient admissions.

The Second Ever Reported Case Of Acute Bacterial Native Valve Endocarditis Caused By Streptococcus Thoraltensis, Shaun Abid Md, Anton Stolear, Maxim Dulgher, Stuart Zarich

Posters

Streptococcus thoraltensis is a gram-positive coccus first described by Devriese et al. in 1997, who isolated it from the vaginal fluids and intestines of pigs [1]. This species has subsequently been isolated from rabbit feces [2], the human oral cavity [3], placenta [4], and in only five reported cases, the human blood [5]. To our knowledge, only one other case of native valve bacterial endocarditis due to this bacterium has ever been reported [5], as well as a single case of prosthetic valve bacterial endocarditis [6]. Intravenous drug use (IVDU) is a strong risk factor for infective endocarditis. The organisms …

A Heart Full Of Nails: Complex Management Of Multiple Nail Gun Cardiac Injuries, Shaun Abid Md, Stuart Zarich

Posters

A 54-year-old male presented after a suicide attempt, suffering severe cardiac and extracardiac injuries from firing a nail gun into both temples (Figure 1A) and his chest. Imaging showed six 5cm nails embedded in his heart: two in the left ventricle, two in the right ventricle, one traversing the ascending aorta into the left atrium, and one entering the right ventricle from the left parasternal chest wall (Figure 1B, C, D). These injuries resulted in hemorrhagic pericardial effusion with tamponade, acute aortic regurgitation, mitral valve/pulmonary artery perforations, and a ventricular septal defect.

When The Farm Turns Fatal: A Rare Infection Causing Heart Block, Shaun Abid Md, Anton Stolear, Sumedh Iyengar, Yussif Issaka Md, Vanessa Agberien Md, Stuart Zarich

Posters

Brucellosis, a zoonotic bacterial infection caused by Brucella species, is typically acquired through contact with infected livestock or consumption of unpasteurized dairy products. It can manifest with various systemic symptoms but is rarely associated with cardiac complications, particularly conduction disturbances such as heart block. When brucellosis does affect the heart, it may result in endocarditis, myocarditis, or, more infrequently, conduction abnormalities. This report describes an unusual case of brucellosis-induced complete heart block in an elderly woman who recently returned from a farm in Colombia, a region where brucellosis is endemic.

Acute Rheumatic Fever Presenting With Isolated Myocarditis And Right Coronary Artery Occlusion, Sumedh Iyengar, Md Mashiul Alam, Shaun Abid Md, Evgeny Shkolnik, Stuart Zarich

Posters

Acute Rheumatic Fever (ARF) and rheumatic heart disease continues to be a major health hazard in most developing countries.

Coronary artery obstruction has long been regarded as an uncommon complication of rheumatic heart disease and has rarely been reported in ARF.

The Profound Role Of An Adult Survivor Program Adaptive Sports Retreat On Quality Of Life And Self Perception For Adult Burn Survivors, Roselle E. Crombie Md/Mph, Facs, Faba, Theresa E. Abrams Lcsw, Phd, Cindy Rutter Bsn, Lmft, Josh Mishell Ba, Philip E. Fidler Md

Posters

Mental health struggles amongst adult burn survivors has recently been documented as an ongoing need for therapy in peer reviewed journals.1 Although there are many robust programs, camps, reintegration programs and support systems through child life for children, the analogous programs for adults are lacking in comparison to the pediatric ones. Ten years ago, a subset of this author group ran an adult adaptive sports survivor program in conjunction with a national burn meeting. At that time, all the participants, mental health providers and participating surgeons were able to experience the profound impact a program like this can have on …

Single Dose Nivolumab And Ipilimumab Treatment Causing Complete And Durable Response In Extensive Stage - Small Cell Lung Cancer Complicated By Severe Sensory Autoimmune Neuropathy, Aaron Lobo Md, Nur Rahman Md, Nicholas Blondin Md, Neal Fischbach

Posters

The use of immune checkpoint inhibitors (ICI) in recent years has increasingly emerged as a second-line treatment in the management of extensive-stage small cell lung cancer (ES-SCLC) compared to conventional chemotherapy alone.

The use of combined ICI therapy by inhibiting two distinct pathways in patients with ES-SCLC has been evaluated in clinical trials. The increase incidence of immune related adverse events (Ir-AE) in these trials due to excessive immune system activation or multiple organ disorders has posed serious clinical challenges.

Here we report a dramatic and durable response to combined immune checkpoint blockade without chemotherapy and discuss the relationship between …

Complete Closure Of Chronic Ankle Ulcerations In The Presence Of Lymphadema With Use Of Adipose Stem Cell Injectable Allograft, A Case Report, Orlexia Thomas Dpm, Francois M. Lokenye Dpm, Jasmine Sheikh Bs, Lady Paula Dejesus Dpm, Facfas, Facpm, Dwsp

Posters

This case illustrates the promising role of adipose stem cell injectable allografts in the management of complex chronic wounds, particularly in patients presenting with lymphedema and fat pad atrophy.

Risk And Outcomes Of Pregnancy-Related Acute Kidney Injury: A Cohort In Bronx, Ny, Erica Marnet, Mayssaa Hoteit, Isbell Crevantes, Sonail Gupta, Ladan Golestaneh

Posters

Pregnancy-related acute kidney injury (PR-AKI) has been increasing in incidence and is associated with worse maternofetal outcomes. The goal of this study is to examine risk and hospitalization outcomes of PR-AKI compared to pregnancy without AKI in a low-income, minoritized population in Bronx, New York

Reevaluating Informed Consent: Integrating Shared Decision-Making Into Spinal Surgery For Better Patient Outcomes., Jeffrey N Wang, Mohamed A Elhakeem, Matthew J Mesimer, Paul G Mastrokostas, Salman Ahmad, Tim Reed, Brandon Klein, Lucas E Bartlett, Adam D Bitterman, Andrew Megas

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Study Design: Narrative review.

Objectives: The objectives of this study were to answer the following questions: (1) What is the quality of informed consent in spine surgery, including both neurosurgery and orthopaedic spine surgery? (2) What limitations impede the ability of surgeons to engage in effective shared decision-making (SDM) and obtain adequate informed consent? (3) What strategies and solutions may improve the quality of informed consent and SDM? (4) What factors decrease the incidence of litigation in spine surgery?

Methods: N/A.

Results: SDM is a collaborative process where patients are involved in their treatment choices through open communication about risks, …

Triangular Fibrocartilage Complex: An Anatomical And Medical Illustration Study., Hallie Tiburzi, Carlos A G Machado, Massimo S D'Antoni, R Shane Tubbs

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Recent advances in small-joint arthroscopy and cutting-edge magnetic resonance imaging systems have enabled orthopedic surgeons to perform more complex repairs of the wrist. Such repairs can include those of the triangular fibrocartilage complex (TFCC) of the wrist that necessitates a reappraisal of its morphometry with special emphasis on the relationship between its articular disc (AD) and surrounding tissues. The TFCC AD is a fibrocartilaginous, biconcave structure located between the ulnar styloid process and the carpal bones of the wrist. We carefully dissected and measured the ADs of 58 wrists from 34 embalmed cadavers (20 females, 14 males) and fabricated three-dimensional …

Examining The Role Of Corticosteroids In The Management Of Acute Interstitial Pneumonia: A Systematic Review., Carlos Valladares, Aalia Narvel, Bianna Koutsenko, Alexa Simonetti, Fatima Mossolem, Alexis Chow, Samrat Gollapudi, Usmaan Al-Shehab, Nicholas Averell, Katherine Chiapaikeo-Poco, Adam Kaplan

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Acute interstitial pneumonia (AIP), also known as Hamman-Rich syndrome, is a rapidly progressive interstitial lung disease. In addition to being challenging to diagnose, AIP is also difficult to treat. The mortality rate of AIP is greater than 70% due to the disease's rapid progression. Furthermore, survivors are likely to develop chronic interstitial lung disease as a sequela. Treatment primarily focuses on supportive care, which consists of oxygenation through mechanical ventilation, administration of broad-spectrum antibiotics, and the use of corticosteroids. Although the use of steroids as empiric treatment is controversial and results on its mortality benefit are variable, some studies …

Limbgod(Pat. Pending): Wearable Garment For Amputation Prevention, Naomi Choi Dpm, Mba, Phuc An Dinh Bs, Ms, Eric Lee Bs, Francois M. Lokenye Dpm

Posters

Approximately 1.6 million people in the U.S. have lower limb amputations, which is expected to double by 2050 (Wong et al.). Socio-economic factors: income, education, rural residency & race, impact amputation risk (Okesina et al.), with Black Americans 70% are more likely to undergo major lower limb amputations than white Americans, even after adjusting for care access & comorbidities (Feinglass et al., Holman et al., Regenbogen et al.). Within 5 years, up to 50% of first-time amputees require another amputation (Dilingham et al., Glaser et al.) & those with comorbidities face a 77% five-year mortality rate (Fortington et al.).

Predictors Of Incidence Of Candida Endocarditis In Patients With Candidemia: Insights From The National Inpatient Sample (2016-2020, Didien Meyahnwi Md, Tawanda Zinyandu, Ashraf Ahmed, Isaac Opoku Md

Posters

This study identifies critical predictors of CE incidence in patients with candidemia, including IV drug use, male gender, and the presence of prosthetic devices. These findings highlight the importance of targeted surveillance and management strategies in vulnerable populations.

A Rising Threat: Epidemiologic Trends In Incidence, Mortality, And Cost Of Candida Endocarditis In The United States, Didien Meyahnwi Md, Ashraf Ahmed, Tawanda Zinyandu, Isaac Opoku Md

Posters

Candida Endocarditis (CE) is a rare yet critical form of infective endocarditis (IE), accounting for approximately 1% of all IE cases. In light of the evolving epidemiology of candidemia, this study aims to elucidate any associated shifts in the epidemiology of CE within the United States.

Patient Care Technician Led Reduction In Blood Culture Contamination Rates, Elena Estrella Pct, Elissa Reyes Msn, Rn, Ccrn, Bethany Zoufaly Msn, Rn, Jennifer O'Neil Bsn, Rn, Anne M. Aquila Dnp, Rn, Cenp

Posters

Purpose:

To decrease blood culture contamination by improving staff competency

Adipose Injectable Filler With Use Of Meshed Dermal Matrix And Porcine Urinary Bladder Matrix For The Management Of A Complex Achilles Wound, Francois M. Lokenye Dpm, Orlexia Thomas Dpm, Mariam Kamil Bs, Lady Paula Dejesus Dpm, Facfas, Facpm, Dwsp

Posters

Chronic Achilles wounds present a significant clinical challenge due to limited vascularity, high mechanical stress, and the complex anatomy of the posterior lower leg.

Regenerative medicine offers a promising alternative to traditional wound management through the use of advanced biologic materials.

This case highlights a novel approach utilizing a combination of adipose-derived injectable filler, acellular dermal matrix, and porcine urinary bladder matrix to enhance tissue regeneration, provide structural support, and promote wound healing.

Dual Circulatory Support With Ecmo And Mcs Devices Is Associated With Shorter Hospital Stay Without Compromising Heart Transplant Survival, Tawanda Zinyandu, Abhinav Aggarwal, Ashraf Ahmed, Isaac Opoku Md, Didien Meyahnwi Md, Yussuf Isaka Md, Stuart Zarich, Carlos Davila

Posters

• ECMO is commonly used as a bridge to heart transplantation in critically ill patients.
• Additional MCS devices (e.g., Impella, IABP) may be used alongside ECMO to enhance cardiac output.
• The effect of dual circulatory support vs. ECMO alone on post-transplant survival is unclear especially after 2018, when the heart allocation system was revised to reduce waitlist times for MCS patients.

Discussion Of “Biggest” Problems Facing Burn Units Today; A Survey Based Analysis And Discussion From Our Aba Burn Surgeon Forum Workgroups 2024, Roselle E. Crombie Md/Mph Facs Faba, Alexandra Lacey Md, Facs, Faba, Kathleen Romanowski Md, Facs, Faba

Posters

Burn Units are a unique environment and microcosm of patients. Additionally, there have been certain factors contributing to what burn care providers consider the most important challenges facing optimal delivery of care. Formally exploring these issues may elucidate solutions by gathering different perspectives.

1st Place Contest Entry: Effectiveness Of Intravesical Bcg In The Treatment Of Nonmuscle Invasive Bladder Cancer: An Umbrella Review, Gerald Obinna Ozota

Eric M. Scandrett Graduate Library Research Prize

This is Gerald Obinna Ozota's submission for the 2025 Eric M. Scandrett Graduate Research Prize, which won first place. It contains their essay on using library resources, their bibliography, and a summary of their research project on conducting a systematic literature search to identify all relevant systematic reviews and meta-analyses investigating the effectiveness of intravesical Bacillus Calmette-Guerin (BCG) on Non-muscle-invasive Bladder Cancer (NIMBC).

Gerald is a student in the Ph.D. in Pharmaceutical Sciences program at Chapman University. Their faculty mentor is Dr. Lawrence Brown.

Editorial: Promoting Patient-Centered Care For Pediatric Rheumatology Across Africa, Wafa Hamdi, Angela Migowa

Paediatrics and Child Health, East Africa

Pediatric rheumatology remains an evolving field in Africa, where challenges such as limited specialist availability, diagnostic delays, and inadequate public awareness hinder optimal patient care (1). Similarly, research in this field remains scarce, with a significant lack of data needed to define the spectrum and clinical expression of these diseases. Capturing real-world experiences and field reports is invaluable, as it provides critical insights to identify key areas for action and develop strategies to advance research in Africa. This collection of six manuscripts offers valuable perspectives on various aspects of pediatric rheumatic diseases, including caregiver experiences, diagnostic challenges, therapeutic patient education, …

A Survey On The Use Of Continuous Positive Airway Pressure In Newborn Care In Kenya In 2017–2018, Jemma L. Wright, Emma Haddon, Helen Nabwera, Fiona M. Dickinson, Mary Jo Hoare, Pamela Godia, Judith Maua, Mercy K. Sammy, Bridget C. Naimoi, Onesmus Muchemi

Centre of Excellence in Women and Child Health

Background

Globally, complications of preterm birth are the leading cause of under-5-mortality. Respiratory distress syndrome (RDS) is a common and life-threatening complication among preterm infants. Continuous positive airway pressure (CPAP) is a relatively simple and effective intervention that is recommended for RDS treatment. However, appropriate infrastructure and processes are required to ensure that it is used safely, effectively and sustainably. This study describes how CPAP was used in newborn care in Kenya between 2017–2018. Our aim was to identify enablers, barriers and gaps in CPAP use.

Methods

A cross-sectional survey was carried out across all newborn baby units in Kenya …

Qtc Comparison Between Neonates At Risk For Neonatal Opioid Withdrawal Syndrome And Healthy Non-Opioid Exposed Neonates, Kevin Lam, Susan C.A. Adeniyi-Jones, Md, Gary Peltz, Walter K. Kraft

Department of Pharmacology, Physiology, and Cancer Biology Posters

Introduction

• While neonatal electrocardiograms (ECGs) are typically read, QTc can be difficult to assess due to immense variability within the first week of life
• In neonates with in utero opioid exposure, there was no difference in mean QTc between those receiving placebo or ondansetron for five days post-delivery in a clinical trial (NCT01965704)