Medical Specialties Commons^™

‘Joining The Dots: Linking Prenatal Drug Exposure To Childhood And Adolescence’ – Research Protocol Of A Population Cohort Study, Kate Lawler, Mithilesh Dronavalli, Andrew Page, Evelyn Lee, Hannah Uebel, Barbara Bajuk, Lucinda Burns, Michelle Dickson, Charles Green, Lauren Dicair, John Eastwood, Ju Lee Oei

Faculty, Staff and Student Publications

INTRODUCTION: Prenatal drug exposure (PDE) is one of the most important causes of child harm, but comprehensive information about the long-term outcomes of the families is difficult to ascertain. The

METHODS AND ANALYSIS: Information from routinely collected administrative databases was linked for all births registered in New South Wales (NSW), Australia between 1 July 2001 and 31 December 2020 (n=1 834 550). Outcomes for seven mutually exclusive groups of children with varying prenatal exposure to maternal substances of addiction, including smoking, alcohol, prescription/illicit drugs and neonatal abstinence syndrome will be assessed. Key exposure measures include maternal drug use type, maternal …

Nardilysin-Regulated Scission Mechanism Activates Polo-Like Kinase 3 To Suppress The Development Of Pancreatic Cancer, Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways. Here, we find that development of apoptotic resistance and metastasis of KrasG12D-driven PDAC in mice is accelerated by deleting Plk3, explaining the often-reduced Plk3 expression in human PDAC. Importantly, a 41-kDa Plk3 (p41Plk3) that contains the entire kinase domain at the N-terminus (1-353 aa) is activated by scission of the precursor p72Plk3 at Arg354 by metalloendopeptidase nardilysin (NRDC), and the resulting p32Plk3 C-terminal Polo-box domain (PBD) is removed by proteasome degradation, preventing the inhibition of p41Plk3 by PBD. We find …

Genomes Of Bacteroides Ovatus, B Cellulosilyticus, B Uniformis, Phocaeicola Vulgatus, And P Dorei Isolated From Gut Cavernous Fistulous Tract Micropathologies In Crohn’S Disease, Vaidhvi Singh, Gail West, Claudio Fiocchi, Fabio Cominelli, Caryn E Good, Michael R Jacobs, Alexander Rodriguez-Palacios

Faculty, Staff and Student Publications

Surgically removed bowels from Crohn's disease patients exhibit a novel form of micropathologies known as cavernous fistulous tract microlesions (CavFT), resembling fissures. We announce the genomes/plasmids and antimicrobial resistance genes of six CavFT bacterial isolates representing the Bacteroidota genera Bacteroides and Phocaeicola. Plasmids were identified in Bacteroides cellulosilyticus and Phocaeicola vulgatus.

Targeted Deletion Of Nr2f2 And Vcam1 In Theca Cells Impacts Ovarian Follicular Development: Insights Into Polycystic Ovary Syndrome?†, Nicholes R Candelaria, Joanne S Richards

Faculty, Staff and Students Publications

Defining features of polycystic ovary syndrome (PCOS) include elevated expression of steroidogenic genes, theca cell androgen biosynthesis, and peripheral levels of androgens. In previous studies, we identified vascular cell adhesion molecule 1 (VCAM1) as a selective androgen target gene in specific NR2F2/SF1 (+/+) theca cells. By deleting NR2F2 and VCAM1 selectively in CYP17A1 theca cells in mice, we documented that NR2F2 and VCAM1 impact distinct and sometimes opposing theca cell functions that alter ovarian follicular development in vivo: including major changes in ovarian morphology, steroidogenesis, gene expression profiles, immunolocalization images (NR5A1, CYP11A1, NOTCH1, CYP17A1, INSL3, VCAM1, NR2F2) as well as …

Lead Compound Development Of Src-3 Inhibitors With Improved Pharmacokinetic Properties And Anticancer Efficacy, Dong Lu, Jianwei Chen, Li Qin, Imani Bijou, Ping Yi, Feng Li, Xianzhou Song, Kevin R Mackenzie, Xin Yu, Bin Yang, Sandipan Roy Chowdhury, James D Korp, Bert W O'Malley, David M Lonard, Jin Wang

Faculty, Staff and Students Publications

Steroid receptor coactivator 3 (SRC-3) is a critical mediator of many intracellular signaling pathways that are crucial for cancer proliferation and metastasis. In this study, we performed structure-activity relationship (SAR) exploration and drug-like optimization of the hit compound SI-2, guided by in vitro/in vivo metabolism studies and cytotoxicity assays. Our efforts led to the discovery of two lead compounds, SI-10 and SI-12. Both compounds exhibit potent cytotoxicity against a panel of human cancer cell lines and demonstrate acceptable pharmacokinetic properties. A biotinylated estrogen response element (ERE) pull-down assay demonstrated that SI-12 could disrupt the recruitment of SRC-3 and p300 in …

Typhlitis In A Neutropenic Patient, Alice He Bs, Wern Lynn Ng Md, Lay She Ng Md, Si Yuan Khor Md, Chandi Garg Md

Tower Health Research Day

No abstract provided.

Li-Fraumeni Syndrome And The Benefits Of Annual Comprehensive Screening: A Pancreatic Adenocarcinoma Case, Alice He Bs, Wern Lynn Ng Md, Faith Seltun Do, Lay She Ng Md, Si Yuan Khor Md, Elham Nasrollahi Md, Chandi Garg Md, Rong Rong Ge Md

Tower Health Research Day

No abstract provided.

Down Syndrome-Associated Arthritis Compared To Juvenile Idiopathic Arthritis: Similarities And Differences In Clinical Presentation And Outcomes, Irene Chern, Jordan Jones

Tower Health Research Day

No abstract provided.

Ems Versus Attending Physician Opinion On The Destination Of Patients Presenting To The Emergency Department By Ambulance, Patrick Boyle, Nikki Rimlinger, Traci Deaner, Adam Sigal

Tower Health Research Day

No abstract provided.

Neonatal Onset Multisystem Inflammatory Disease Presenting As An Urticarial Rash In A Newborn, Irene Chern, Dana Toib

Tower Health Research Day

No abstract provided.

Positive Predictor Factors Of Hip Mosaicplasty And Cartilage Repair: A Meta-Analysis Is It Comparable To Predictor Factors Of Mosaicplasty In The Knee?, Caroline E. Quindlen, Gene Shaffer Md, James Raphael Md, S. Ali Ghasemi Md

Tower Health Research Day

No abstract provided.

An Atypical Mechanism Of Thyroid Cartilage Fracture, Jack Grossweiler, Andrew Friedman, Michael Scharf, Matthew K. Nguyen, Jory P. Parson, Alexander Axelrad

Tower Health Research Day

No abstract provided.

Same Or Different? Resolution Of Diagnostic Difficulty Of Two Mixed Cell-Type Tumors In Ovarian Pathology., Sarah Ingram, Kelly Brenan, Priyanka Raju Md, Wei Shaw Do, Stever Sowers Pa

Tower Health Research Day

No abstract provided.

Electromechanical Dissociation Of Atria After Cardioversion- Clinical Case And Management Considerations., Devi Parvathy Jyothi Ramachandran Nair, Muhammad Umer Riaz Gondal, Muhammad Asad Hanif, Raesham Bukhari, Nayab Mirza, Rajesh Reddy

Tower Health Research Day

No abstract provided.

Lap-Bands, A Complication, Peter Aziz, Micah Mabe

Tower Health Research Day

No abstract provided.

Do Nsaids' Decrease Union Rates Following Joint Arthrodesis? A Meta-Analysis, Emerson Rowe, Julian Takagi-Stewart, Asif Ilyas, Sina Ramtin

Tower Health Research Day

No abstract provided.

Chronic Pneumonia In A 1-Year-Old Male, Saritha Beauchamp, Irene Chern, Emily Souder

Tower Health Research Day

No abstract provided.

Lower Extremity Trauma Is Associated With An Increased Rate Of New Mental Health Disorder Diagnosis And Suicide Attempt, Bela P. Delvadia, Julianna E. Holzer, Jacob S. Budin, Arjun Verma, Onyebuchi A. Imonugo, Olivia C. Lee, William F. Sherman

Tower Health Research Day

No abstract provided.

Understanding Vaccine Hesitancy: An Analysis Of Caregiver Influences On Pediatric Covid-19 Vaccination Decisions, Neiki Rokni, Shu Zhao Md, Matthew Nguyen, David Liu, Harrison Jordan Do, Jory Parson, Sidharth Sahni Do, Tanner Walsh Md, Ashley Henderson Md, Jennifer Higgins Md

Tower Health Research Day

No abstract provided.

Financial Toxicity In Genitourinary Cancer: Insights From Cdc National Health Interview Survey, Steven Leonard Bs, Emma Helstrom Bs, Andres Correa Md, Mohit Sindhani, Nicole Uzzo, Angela Y. Jia Md Phd, Alexander Kutikov Md, Robert Uzzo Md Mba, Sarah P. Psutka Md, Adam Calaway Md Mph, Zachary Klaassen Md, Michael Staehler Md Phd, Marc Smaldone Md Mshp, Christopher Jd Wallis Md Phd, Laura Bukavina Md Mph Msc

Tower Health Research Day

No abstract provided.

The Incidence And Impact Of Bisphosphonates On Multiple Myeloma, Bela P. Delvadia, Lacee Collins, Julianna E. Winter, Matthew W. Cole, Olivia C. Lee, William F. Sherman

Tower Health Research Day

No abstract provided.

Uti With A New Renal Mass: Chicken Or The Egg?, Grant Nugent, Adam Sigal, Courtney Cassella

Tower Health Research Day

No abstract provided.

Investigating Markers For Intracranial Hemorrhage Severity: Insights From Cbc Changes And Beyond, Mckenzie Locker, Kasey Chelemedos, Nataly Apollonsky

Tower Health Research Day

No abstract provided.

Virtual Reality Navigational Abnormalities In Patients With Bilateral Vestibular Loss, Kathryn Mozzochi, Maimuna Ahmad, Susan King, Anissa Boutabla, Alexander Panic, Faisal Karmali, Divya Chari, Richard Lewis

Tower Health Research Day

No abstract provided.

Sixty-Two Percent Of Abstracts From The American Association Of Hand Surgery Annual Meeting 2017-2020 Are Later Published, Tyson Stoker, Benjamin Millar, Lilah Fones, Asif Ilyas

Tower Health Research Day

No abstract provided.

Tick-Borne Disease In Central Pennsylvania: Considering Anaplasmosis, Kishan V. Patel, Fredrick T. Murphy, Jason G. Bankert, Alan J. Kivitz

Tower Health Research Day

No abstract provided.

Improving Awareness Of Surgical Ergonomics In Gynecologic Surgery, Priyanka Raju Md, Annika Eveland Md, Dominic Cammarano Do

Tower Health Research Day

No abstract provided.

A Case Report On A Personal Watercraft Induced Large Traumatic Rectal Injury, Sujay Deshpande, Jakob Nypaver, Bernice Yu, Abigail Coots, Adrian W. Ong, Christopher A Butts

Tower Health Research Day

No abstract provided.

Hiding In Plain Sight; Dermatologic Manifestation Of A Systemic Disease, Christopher Ignatz, David Young Do, Brian Chwiecko Md

Tower Health Research Day

No abstract provided.

Adductor Canal Regional Anesthetic Placement In Pediatric Patients For Knee Arthroscopy: Defining The Optimal Location And Analysis Of Other Trends, Isaac Jin, Christine Song, Sujay Deshpande, Andrew Yang, Ethan Schollaert, Neha Divi, Aysha Hasan Md

Tower Health Research Day

No abstract provided.