Medical Specialties Commons^™

The Effect Of Task Demands On Decision Making In Dynamic, Sport-Like Virtual Environments, Jeromy Alt, Paula L. Silva, Tehran Davis, Adam W. Kiefer, Ryan Macpherson

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

To determine if level of temporal pressure to arrive at a desired location explains decisions about passability of closing gaps between opponents encountered and how decisions change with task experience.

The Effect Of Ankle Foot Orthotics On Collegiate Athletes’ Sprint Biomechanics, Elizabeth A. Starns, Paige Tucker

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

Carbon composite dynamic response ankle foot orthotics (CCDRAFOs) are lightweight ankle braces originally made to help pathologically involved legs walk more efficiently¹. Since CCDRAFOs are traditionally not used on able-bodied individuals, there is limited information on the effects of CCDRAFOs on sprint performance of able-bodied athletes. However, the technology behind CCDRAFOs effectiveness has been suggested to have ergogenic aid properties^2-5. This study’s purpose was to evaluate the effects of CCDRAFOs on collegiate athletes’ lower extremity biomechanics, specifically ankle and knee joint angles.

Neurocognitive Performance Differences Between Athletes Who Are Deaf Or Hard-Of-Hearing And Athletes Who Are Hearing, Matthew P. Brancaleone, Jaclyn Caccese, James Onate

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

There are over 71,000 college students in the United States who are deaf or hard-of-hearing (D/HoH), with many participating in athletics. Athletes who are D/HoH have similar concussion rates to athletes who are hearing at the collegiate level. Differences in neurocognitive baseline performance between athletes who are D/HoH and athletes who are hearing may exist due to misunderstanding of written English instructions or differences in sensory processing. Therefore, the purpose of this study was to compare neurocognitive performance between athletes who are hearing and athletes who are D/HoH.

Using Standardized Patients As A Tool To Explore Student Critical Thinking, Sara Stiltner, Andrea Cripps

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

Standardized patients (SP) are a tool utilized regularly in athletic training to promote student confidence and independent thinking. SP are widely used in nursing, physical therapy, and in over 80% of medical education programs.¹ The use of SP to supplement student learning and career preparation, in the undergraduate setting has been a validated in increasing student confidence.³ SP’s are a tool that utilize an actor trained to portray a patient who has a specific medical condition or illness and the actor is trained to respond to the students in a consistent manner.^1,2 SP’s allow students the …

Dynamic Obstruction Of The Subglottis: A Subglottic Stenosis Mimic., Razmig Garabet, Lauren E Melley, Omar Ramadan, Robert T Sataloff

Otolaryngology (ENT) Resident Research

Laryngomalacia is characterized by dynamic obstruction of the upper airway. Early detection using dynamic observation across the respiratory cycle helps assume accurate diagnosis and effective management. We present a case of laryngomalacia that mimicked characteristics of subglottic stenosis which could have resulted in unnecessary surgery.

Pembrolizumab Versus Placebo As Adjuvant Therapy In Resected Stage Iib Or Iic Melanoma: Final Analysis Of Distant Metastasis-Free Survival In The Phase Iii Keynote-716 Study, Jason J. Luke, Paolo A. Ascierto, Muhammad A. Khattak, Luis De La Cruz Merino, Michele Del Vecchio, Piotr Rutkowski, Francesco Spagnolo, Jacek Mackiewicz, Vanna Chiarion-Sileni, John M. Kirkwood, Caroline Robert, Jean Jacques Grob, Federica De Galitiis, Dirk Schadendorf, Matteo S. Carlino, Xi Lawrence Wu, Mizuho Fukunaga-Kalabis, Clemens Krepler, Alexander M.M. Eggermont, Georgina V. Long

Research outputs 2022 to 2026

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.Pembrolizumab adjuvant therapy was shown to significantly improve recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) in patients with resected stage IIB or IIC melanoma in earlier analyses of the randomized, double-blind, phase III KEYNOTE-716 study (ClinicalTrials.gov identifier: …

Keratin 17 Modulates The Immune Topography Of Pancreatic Cancer, Lyanne Delgado-Coka, Michael Horowitz, Mariana Torrente-Goncalves, Lucia Roa-Peña, Cindy Leiton, Mahmudul Hasan, Sruthi Babu, Danielle Fassler, Jaymie Oentoro, Ji-Dong Bai, Emanuel Petricoin, Lynn Matrisian, Edik Matthew Blais, Natalia Marchenko, Felicia Allard, Wei Jiang, Brent Larson, Andrew Hendifar, Chao Chen, Shahira Abousamra, Dimitris Samaras, Tahsin Kurc, Joel Saltz, Luisa Escobar-Hoyos, Kenneth Shroyer

Kimmel Cancer Center Faculty Papers

BACKGROUND: The immune microenvironment impacts tumor growth, invasion, metastasis, and patient survival and may provide opportunities for therapeutic intervention in pancreatic ductal adenocarcinoma (PDAC). Although never studied as a potential modulator of the immune response in most cancers, Keratin 17 (K17), a biomarker of the most aggressive (basal) molecular subtype of PDAC, is intimately involved in the histogenesis of the immune response in psoriasis, basal cell carcinoma, and cervical squamous cell carcinoma. Thus, we hypothesized that K17 expression could also impact the immune cell response in PDAC, and that uncovering this relationship could provide insight to guide the development of …

Speech, Voice, And Language Outcomes Following Deep Brain Stimulation: A Systematic Review, Fatemeh Tabari, Joel I. Berger, Oliver Flouty, Brian Copeland, Jeremy D. Greenlee, Karim Johari

School of Medicine Faculty Publications

Background Deep brain stimulation (DBS) reliably ameliorates cardinal motor symptoms in Parkinson’s disease (PD) and essential tremor (ET). However, the effects of DBS on speech, voice and language have been inconsistent and have not been examined comprehensively in a single study. Objective We conducted a systematic analysis of literature by reviewing studies that examined the effects of DBS on speech, voice and language in PD and ET. Methods A total of 675 publications were retrieved from PubMed, Embase, CINHAL, Web of Science, Cochrane Library and Scopus databases. Based on our selection criteria, 90 papers were included in our analysis. The …

Fake Xanax: Designer Emerging Benzodiazepine Epidemic Linked To Morbidity And Mortality A Narrative Review, Alan D. Kaye, Joseph P. Tassin, William C. Upshaw, Camille M. Robichaux, Mark V. Frolov, Mark M. Dupaquier, Julia E. Fox, Jeffrey Sterritt, Jibin Mathew, Sahar Shekoohi, Adam M. Kaye, Amber N. Edinoff

School of Dentistry Faculty Publications

Etizolam is a thienodiazepine derivative which produces an anxiolytic effect similar to benzodiazepines such as alprazolam (Xanax). Like classic benzodiazepines, etizolam has a high affinity towards the GABAA receptor, and allosterically potentiates the effects of GABA resulting in neuronal hyperpolarization related to chloride influx. When taken in therapeutic doses, etizolam produces a similar effect to Xanax. Counterfeit Xanax tablets contain variable amounts of etizolam. Tablets with high amounts of etizolam can cause toxicity if ingested, especially when combined with other substances. When toxic symptoms occur in patients, they may include severe sedation, unconsciousness, and depression of the medullary respiratory center. …

Peripheral Nerve Stimulation Of The Shoulder: A Technical Primer, Sailesh Arulkumar, Elisa E. Neuchat, Eric Ly, Austin Ingwei Ly, Kiana Fahimipour, Mehul J. Desai

School of Medicine Faculty Publications

Scapulalgia or shoulder pain accounts for 16% of all musculoskeletal complaints in the healthy adult population and becomes more common as we age. When this pain exceeds 3 months in duration, it is deemed to be chronic, and typically treated in an escalating manner. Spanning a continuum of conservative and non-conservative measures, chronic shoulder pain treatments range from rest and physical therapy to surgery. Since each patient presents with a unique spectrum of symptoms a customized treatment plan is often required. Over the lifetime of many of these patients, a variety of treatment options are required. One of these treatment …

Recent Advances In The Prevention And Treatment Of Decompensated Cirrhosis And Acute-On-Chronic Liver Failure (Aclf) And The Role Of Biomarkers, Jonel Trebicka, Ruben Hernaez, Debbie Lindsay Shawcross, Alexander L Gerbes

Faculty, Staff and Students Publications

The progression of cirrhosis with clinically significant portal hypertension towards decompensated cirrhosis remains clinically challenging and the evolution towards acute-on-chronic liver failure (ACLF), with one or more extrahepatic organ failures, is associated with very high mortality. In the last decade, significant progress has been made in the understanding of the mechanisms leading to decompensation and ACLF. As portal hypertension advances, bacterial translocation across an impaired gut barrier culminates in endotoxaemia, systemic inflammation and cirrhosis-associated immune dysfunction (CAID). Gut-derived systemic inflammation and CAID have become the logical targets for innovative therapies that prevent hepatic decompensation episodes and the progression to ACLF.Furthermore, …

Clinical, Genetic, And Cognitive Correlates Of Seizure Occurrences In Phelan-Mcdermid Syndrome, Tess Levy, Jacob Gluckman, Paige M Siper, Danielle Halpern, Jessica Zweifach, Rajna Filip-Dhima, J Lloyd Holder, M Pilar Trelles, Kristina Johnson, Jonathan A Bernstein, Elizabeth Berry-Kravis, Craig M Powell, Latha Valluripalli Soorya, Audrey Thurm, Joseph D Buxbaum, Mustafa Sahin, Alexander Kolevzon, Siddharth Srivastava

Duncan NRI Faculty and Staff Publications

Background: Phelan-McDermid syndrome (PMS) is a genetic neurodevelopmental disorder caused by SHANK3 haploinsufficiency and is associated with an increased risk for seizures. Previous literature indicates that around one third of individuals with PMS also have epilepsy or seizures, with a wide range of types and ages of onset. Investigating the impact of seizures on intellectual and adaptive functioning for PMS is a primary concern for caregivers and is important to understanding the natural history of this syndrome.

Methods: We report on results from 98 individuals enrolled in a prospective, longitudinal study. We detailed seizure frequency, type, and age of onset, …

Mustang: Multi-Sample Spatial Transcriptomics Data Analysis With Cross-Sample Transcriptional Similarity Guidance, Seyednami Niyakan, Jianting Sheng, Yuliang Cao, Xiang Zhang, Zhan Xu, Ling Wu, Stephen T C Wong, Xiaoning Qian

Faculty, Staff and Students Publications

Spatially resolved transcriptomics has revolutionized genome-scale transcriptomic profiling by providing high-resolution characterization of transcriptional patterns. Here, we present our spatial transcriptomics analysis framework, MUSTANG (MUlti-sample Spatial Transcriptomics data ANalysis with cross-sample transcriptional similarity Guidance), which is capable of performing multi-sample spatial transcriptomics spot cellular deconvolution by allowing both cross-sample expression-based similarity information sharing as well as spatial correlation in gene expression patterns within samples. Experiments on a semi-synthetic spatial transcriptomics dataset and three real-world spatial transcriptomics datasets demonstrate the effectiveness of MUSTANG in revealing biological insights inherent in the cellular characterization of tissue samples under study.

Phenome-Wide Identification Of Therapeutic Genetic Targets, Leveraging Knowledge Graphs, Graph Neural Networks, And Uk Biobank Data, Lawrence Middleton, Ioannis Melas, Chirag Vasavda, Arwa Raies, Benedek Rozemberczki, Ryan S Dhindsa, Justin S Dhindsa, Blake Weido, Quanli Wang, Andrew R Harper, Gavin Edwards, Slavé Petrovski, Dimitrios Vitsios

Faculty, Staff and Students Publications

The ongoing expansion of human genomic datasets propels therapeutic target identification; however, extracting gene-disease associations from gene annotations remains challenging. Here, we introduce Mantis-ML 2.0, a framework integrating AstraZeneca's Biological Insights Knowledge Graph and numerous tabular datasets, to assess gene-disease probabilities throughout the phenome. We use graph neural networks, capturing the graph's holistic structure, and train them on hundreds of balanced datasets via a robust semi-supervised learning framework to provide gene-disease probabilities across the human exome. Mantis-ML 2.0 incorporates natural language processing to automate disease-relevant feature selection for thousands of diseases. The enhanced models demonstrate a 6.9% average classification power …

Disparities In Accessing Specialty Behavioral Health Services During The Covid-19 Pandemic And Why We Need Pediatric Integrated Primary Care., Ayanda Chakawa, Trista Perez Crawford, Leslee Belzer, Hung-Wen Yeh

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Youth unmet behavioral health needs are at public health crisis status and have worsened since the onset of the coronavirus disease 2019 pandemic (Covid-19). Integrating behavioral health services into pediatric primary care has shown efficacy in addressing youth behavioral health needs. However, there is limited guidance on facilitating equitable access to care in this setting, including in triaging access to co-located services (i.e., onsite outpatient behavioral health services with only the behavioral health provider) or to specialty behavioral health services in other clinics within larger health systems.

METHODS: A retrospective, comparative study was conducted to examine variability in access …

Healthcare Disparities Are Associated With Eligibility And Enrollment In Clinical Trials In Louisiana, Conner Hartupee, Denise Danos, Eileen Mederos, Augusto Ochoa, Valentine Nfonsam, Omeed Moaven

Surgery Research Symposium

No abstract provided.

Taruma Plus Burn: Which Comes First?, Anastasiya Ivanko, Denise Danos, Jonathan E. Schoen, Hebert A. Phelan, Alison A. Smith, Jeffrey E. Carter

Surgery Research Symposium

No abstract provided.

The Safety Of Reboa Use In Obese And Non-Obese Trauma Patients, Iris Hunt, Omar Azmeh, Alan B. Marr, Patrick Greiffenstien, Lance Stuke, Alison Smith

Surgery Research Symposium

No abstract provided.

Disparities In Access To Care In The Multimodality Treatment Of Primary Nonmetastatic Liver Cancers And Their Impact On Patient Outcomes In State Of Louisiana, Sanchit Sachdeva, Mckenzie Hargis, Andrew G. Chapple, Hannah R. Malinosky, Mohammad El Afishat, John Lyons, James C. Watson, Mary Maluccio, Valentine N. Nfonsam, Omeed Moaven

Surgery Research Symposium

No abstract provided.

Abdominal Pseudoaneurysms In Patients With High-Grade Traumatic Injuries, Alexis Scheuermann, Meredyth Berard, Shivani Jain, Harrison Travis, Marquinn Duke, Jennifer Rhodes, Hector Ferral, Alexandra Fairchild, Bahri Ustunsoz, Alison Smith

Surgery Research Symposium

No abstract provided.

Surgeons, Who’S Watching The Kids?, Jeanette Zavala, Ikenna Ifearulundu, Chrissy Guidry, Jeffanne E. Millien, John P. Hunt, Alison Smith

Surgery Research Symposium

No abstract provided.

Disparities In Surgical Care Outcomes In Patients With Nonmetastatic Gastric Cancer In Louisiana, K. Maupin, C. Hartupee, D. Danos, O. Moaven

Surgery Research Symposium

No abstract provided.

Supercharged And Delayed Thoracodorsal And Dorsal Intercostal Artery Perforator Flaps For Autologous Breast Reconstruction: A Case Report, Adeem Nachabe, Mohammed S. Rais, Mark A. Maier, Hugo St. Hilaire, Robert J. Allen

Surgery Research Symposium

No abstract provided.

The Impact Of The 2014 Medicaid Expansion On Trends In Stage Of Colon Cancer At Presentation, Katherine Pavleszek, Denise Danos, Linzi Paul, Mohammed Rais, Elyse Bevier-Rawls, Gabrielle Prezkop, Lindsey Gade, Valentine Nfonsam

Surgery Research Symposium

No abstract provided.

Identifying Disparities In Surgical Management And Outcomes Of Patients With Primary Liver Cancer In Louisiana, Mckenzie Hargis, Denise Danos, Hannah R. Malinosky, Mohammad Al Efishat, John Lyons, James C. Watson, Mary Maluccio, Omeed Moaven

Surgery Research Symposium

No abstract provided.

The Inflammatory Response Of Geriatric Burn Patients, Sophia Trinh, Jenna Dennis, Cameron Fontenot, Jeffery Hobden, Jonathan Schoen, Herbert Phelan, Jeffrey Carter, Alison Smith

Surgery Research Symposium

No abstract provided.

Penetrating Traumatic Cardiac Arrest: Can Prehospital Blood Administration Result In Signs Of Life Upon Arrival To Trauma Center?, Connor Latiolais, Hall M. Braud, Elizabeth Lacy, Michael Hirchak, Blake Platt, Juan Duchesne, Lance Stuke, Emily Nichols, David Rayburn, Megan Marino, Tom Dransfield, Alison A. Smith

Surgery Research Symposium

No abstract provided.

Parkes Weber Syndrome Caused By A Somatic Map2k1 Mutation, N. Strat, Rebecca Brantley, R. Zambrano, M. Masoumy, I. Hill, C. Sheahan, M. Cable, J. D'Souza, D. Leblanc

Surgery Research Symposium

No abstract provided.

Pop! Goes The Gallbladder? A Successful Outcome Of Hemorrhagic Cholecystitis: A Case Report, Mohammed S. Rais, Jose A. Cruz Alaya, Christa Zino, Clifton Mcginness, John P. Hunt, Alan B. Marr, Patrick Greiffenstein, Alison A. Smith

Surgery Research Symposium

No abstract provided.

Prehospital Needle Decompression Of Suspected Tension Pneumothorax: Outcomes And Consequences, Harrison Travis, Gilbert Andry, Colin Rutner, Michael Maristany, Elizabeth Lacy, Kaleb Derouen, Alison Smith, Patrick Greiffenstein

Surgery Research Symposium

No abstract provided.