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Articles 1231 - 1260 of 9443
Full-Text Articles in Medical Specialties
Preventing Delays In Initiation Of Radiation Therapy Following Breast Conserving Surgery – A Process Improvement, Catherine Oplinger, Msn, Rn, Ocn, Amb-B, Margaret Wight, Ba, Ods-C
Preventing Delays In Initiation Of Radiation Therapy Following Breast Conserving Surgery – A Process Improvement, Catherine Oplinger, Msn, Rn, Ocn, Amb-B, Margaret Wight, Ba, Ods-C
Kimmel Cancer Center Papers, Presentations, and Grand Rounds
Background
- In July of 2023 new guidelines were released by Commission on Cancer (COC) related to start of radiation treatment following definitive breast conserving surgery for patients who were not previously treated. (1)
- Previous tracking at our institution was reflective which did not allow for prevention of start of radiation falling outside of the sixty-day window recommended in the new guidelines.
- Discussion at a weekly tumor board indicated that a process improvement could benefit our patient outcomes by assuring start of radiation within the recommended guidelines.
- Clinical reasons such as chemotherapy following surgery, seroma, healing issues, or infection are acceptable …
Tumor-Associated Tractography Derived From High-Angular-Resolution Q-Space Mri May Predict Patterns Of Cellular Invasion In Glioblastoma, Owen P Leary, John P Zepecki, Mattia Pizzagalli, Steven A Toms, David D Liu, Yusuke Suita, Yao Ding, Jihong Wang, Renjie He, Caroline Chung, Clifton D Fuller, Jerrold L Boxerman, Nikos Tapinos, Richard J Gilbert
Tumor-Associated Tractography Derived From High-Angular-Resolution Q-Space Mri May Predict Patterns Of Cellular Invasion In Glioblastoma, Owen P Leary, John P Zepecki, Mattia Pizzagalli, Steven A Toms, David D Liu, Yusuke Suita, Yao Ding, Jihong Wang, Renjie He, Caroline Chung, Clifton D Fuller, Jerrold L Boxerman, Nikos Tapinos, Richard J Gilbert
Faculty, Staff and Student Publications
BACKGROUND: The invasion of glioblastoma cells beyond the visible tumor margin depicted by conventional neuroimaging is believed to mediate recurrence and predict poor survival. Radiomic biomarkers that are associated with the direction and extent of tumor infiltration are, however, non-existent.
METHODS: Patients from a single center with newly diagnosed glioblastoma (
RESULTS: In the principal enrollment cohort of patients with glioblastoma, all cases displayed tractography patterns with tumor-intersecting tract bundles extending into brain parenchyma, a phenotype which was reproduced in PDX mice as well as in a larger comparison cohort of glioblastoma patients (
CONCLUSIONS: QSI discriminates tumor-specific patterns of …
Volumetric Ct Assessment Of In Situ Induced Hepatic Lesions In A Transgenic Swine Model, Derek Smetanick, Danielle Stolley, David Fuentes, Natalie W Fowlkes, Faith Shakoor, Maria Sophia Stenkamp, Samantha Hicks, Steve Parrish, Erik Cressman
Volumetric Ct Assessment Of In Situ Induced Hepatic Lesions In A Transgenic Swine Model, Derek Smetanick, Danielle Stolley, David Fuentes, Natalie W Fowlkes, Faith Shakoor, Maria Sophia Stenkamp, Samantha Hicks, Steve Parrish, Erik Cressman
Faculty, Staff and Student Publications
The growth rate of in situ-induced hepatic lesions in an Oncopig large animal model is quantitatively assessed. Oncopigs (n = 9) received baseline triple-phase CT scans prior to lesion induction. Lesions were subsequently induced by delivering the Ad-Cre vector to four locations in the liver. Triple-phase CT scans were obtained weekly to track the growth of the lesions. Animals were sacrificed at 14, 21, or 28 days (n = 3 in each group). The overall success rate of lesion generation was ~78%. Histopathology sections consistently revealed lesions that were highly inflammatory and consisted of a large leukocyte population without clear …
Type I Met Inhibitors Cooperate With Pd-1 Blockade To Promote Rejection Of Hepatocellular Carcinoma, Ricardo Deazevedo, Madeline Steiner, Broderick X Turner, Arthur Liu, Sherwin Newton, Joanna Schmidt, Rachel Fleming, Angelica Tolentino, Ahmed O Kaseb, Michael A Curran
Type I Met Inhibitors Cooperate With Pd-1 Blockade To Promote Rejection Of Hepatocellular Carcinoma, Ricardo Deazevedo, Madeline Steiner, Broderick X Turner, Arthur Liu, Sherwin Newton, Joanna Schmidt, Rachel Fleming, Angelica Tolentino, Ahmed O Kaseb, Michael A Curran
Faculty, Staff and Student Publications
Blockade of the immune checkpoints programmed death-1 (PD-1) and cytotoxic lymphocyte antigen 4 has improved outcomes for patients with hepatocellular carcinoma (HCC), yet most still fail to achieve objective clinical benefit. MET plays key roles in both HCC tumorigenesis and immunosuppressive conditioning; however, inhibition of MET causes upregulation of PD-ligand 1 (PD-L1) suggesting the use of these inhibitors in the context of PD-1 blockade. We sought to investigate across the Hepa1-6, HCA-1 and diethylnitrosamine (DEN) models of HCC whether the combination of more specific type I versus more pleiotropic type II MET inhibitors would confer superior outcomes in combination with …
Enhancing Surgical Guidance: Deep Learning-Based Liver Vessel Segmentation In Real-Time Ultrasound Video Frames, Muhammad Awais, Mais Al Taie, Caleb S O'Connor, Austin H Castelo, Belkacem Acidi, Hop S Tran Cao, Kristy K Brock
Enhancing Surgical Guidance: Deep Learning-Based Liver Vessel Segmentation In Real-Time Ultrasound Video Frames, Muhammad Awais, Mais Al Taie, Caleb S O'Connor, Austin H Castelo, Belkacem Acidi, Hop S Tran Cao, Kristy K Brock
Faculty, Staff and Student Publications
Background/objectives: In the field of surgical medicine, the planning and execution of liver resection procedures present formidable challenges, primarily attributable to the intricate and highly individualized nature of liver vascular anatomy. In the current surgical milieu, intraoperative ultrasonography (IOUS) has become indispensable; however, traditional 2D ultrasound imaging's interpretability is hindered by noise and speckle artifacts. Accurate identification of critical structures for preservation during hepatectomy requires advanced surgical skills.
Methods: An AI-based model that can help detect and recognize vessels including the inferior vena cava (IVC); the right (RHV), middle (MHV), and left (LVH) hepatic veins; the portal vein (PV) and …
Tumour-Intrinsic Pdl1 Signals Regulate The Chk2 Dna Damage Response In Cancer Cells And Mediate Resistance To Chk1 Inhibitors, Clare E Murray, Anand V R Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara De La Peña Avalos, Cody M Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S Padron, Jacob T Boyd, Ryan Reyes, Curtis A Clark, Robert S Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R Conejo-Garcia, Lauren A Byers, Kavya Ramkumar, Anil K Sood, Jung-Min Lee, Christin E Burd, Ratna K Vadlamudi, Harshita B Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J Curiel
Tumour-Intrinsic Pdl1 Signals Regulate The Chk2 Dna Damage Response In Cancer Cells And Mediate Resistance To Chk1 Inhibitors, Clare E Murray, Anand V R Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara De La Peña Avalos, Cody M Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S Padron, Jacob T Boyd, Ryan Reyes, Curtis A Clark, Robert S Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R Conejo-Garcia, Lauren A Byers, Kavya Ramkumar, Anil K Sood, Jung-Min Lee, Christin E Burd, Ratna K Vadlamudi, Harshita B Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J Curiel
Faculty, Staff and Student Publications
Background: Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical immunopathological pathways mediating treatment resistance whose significance, mechanisms, and therapeutic targeting remain incompletely understood. Recent reports implicate tumour-intrinsic PDL1 signals in the DNA damage response (DDR), including promoting homologous recombination DNA damage repair and mRNA stability of DDR proteins, but many mechanistic details remain undefined.
Methods: We genetically depleted PDL1 from transplantable mouse and human cancer cell lines to understand consequences of tumour-intrinsic PDL1 signals in the DNA damage response. We complemented this work with studies of primary human tumours …
Comparison Of Sternotomy Access Versus Thoracotomy Access In The Surgical Treatment Of Aortic Coarctation: A Propensity Score-Matched Study, Ilya A. Soynov, Ksenya A. Rzayeva, Yuriy N. Gorbatykh, Yuriy Yu. Kulyabin, Artem V. Gorbatykh, Ilya A. Velyukhanov, Nataliya R. Nichay, Serezhan. Manukian, Saihuna A. Magbulova, Aleksey N. Arkhipov, Aleksander V. Bogachev-Prokophiev
Comparison Of Sternotomy Access Versus Thoracotomy Access In The Surgical Treatment Of Aortic Coarctation: A Propensity Score-Matched Study, Ilya A. Soynov, Ksenya A. Rzayeva, Yuriy N. Gorbatykh, Yuriy Yu. Kulyabin, Artem V. Gorbatykh, Ilya A. Velyukhanov, Nataliya R. Nichay, Serezhan. Manukian, Saihuna A. Magbulova, Aleksey N. Arkhipov, Aleksander V. Bogachev-Prokophiev
Journal of the Saudi Heart Association
Background: The search for the "Holy Grail" of surgical repair for aortic coarctation involves finding an access and correction method that successfully and consistently avoids aortic recoarctation and arterial hypertension. The controversy persists as there is still no consensus on the best surgical approach and technique to achieve these objectives. Objective: The objective of this study is to compare sternotomy and left thoracotomy as surgical techniques for treating patients with aortic coarctation and hypoplasia of the distal aortic arch. Methods: From January 2008 to December 2020, 103 patients (21 %) were performed using an extended oblique anastomosis. They were divided …
Hematopoietic Cell Transplant Compared With Standard Care In Adolescents And Young Adults With Sickle Cell Disease, Mark C. Walters, Mary Eapen, Yiwen Liu, Fuad El Rassi, Edmund K. Waller, John E. Levine, John J. Strouse, Joseph H. Antin, Suhag H. Parikh, Nitya Bakshi, Carlton D Dampier, Jennifer J. Jaroscak, Shayla Bergmann, Trish E. Wong, Vamsi K. Kota, Betty Sue Pace, Lazaros J. Lekakis, Premal D. Lulla, Robert Nickel, Kimberly A. Kasow, Uday R. Popat, Wally R. Smith, Lolie C. Yu, Nancy L. Difronzo, Nancy L. Geller, Naynesh Kamani, Elizabeth Sue Klings, Kathryn Hassell, Adam M. Mendizabal, Et Al
Hematopoietic Cell Transplant Compared With Standard Care In Adolescents And Young Adults With Sickle Cell Disease, Mark C. Walters, Mary Eapen, Yiwen Liu, Fuad El Rassi, Edmund K. Waller, John E. Levine, John J. Strouse, Joseph H. Antin, Suhag H. Parikh, Nitya Bakshi, Carlton D Dampier, Jennifer J. Jaroscak, Shayla Bergmann, Trish E. Wong, Vamsi K. Kota, Betty Sue Pace, Lazaros J. Lekakis, Premal D. Lulla, Robert Nickel, Kimberly A. Kasow, Uday R. Popat, Wally R. Smith, Lolie C. Yu, Nancy L. Difronzo, Nancy L. Geller, Naynesh Kamani, Elizabeth Sue Klings, Kathryn Hassell, Adam M. Mendizabal, Et Al
School of Medicine Faculty Publications
Disease-modifying therapies are standard of care (SOC) for sickle cell disease (SCD), but hematopoietic cell transplantation (HCT) has curative potential. We compared outcomes prospectively through 2-years after biologic assignment to a Donor or No Donor (SOC) Arm based on the availability of an HLA-matched sibling or unrelated donor (BMTCTN 1503; NCT02766465). A donor search was commenced after eligibility confirmation. The primary endpoint was the comparison of survival 2 years after biologic assignment between treatment arms. Power calculations required 60 participants on the Donor Arm and 140 on the No Donor Arm to determine if early transplant-related mortality might be balanced …
Social Determinants Of Health Curriculum For The Pediatric Clerkship, Caroline Roth, Amy Prudhomme, Kayla Griese, Robbie Beyl, Jessica Patrick-Esteve
Social Determinants Of Health Curriculum For The Pediatric Clerkship, Caroline Roth, Amy Prudhomme, Kayla Griese, Robbie Beyl, Jessica Patrick-Esteve
School of Medicine Faculty Publications
Introduction: Education on social determinants of health (SDH) aligns with national standards for medical education. However, there are minimal existing resources targeted to medical students specific to the care of the pediatric population. We designed a case-based curriculum on SDH for third-year medical students on their pediatric clerkship to address this deficit. Methods: Third-year medical students on their pediatric clerkship received a case-based flipped classroom educational series on SDH in four 10-minute segments. Students completed voluntary and anonymous surveys delivered via an electronic survey tool before and after completion of the curriculum. Surveys were a self-assessment of knowledge and skills …
Addressing Weight Bias Among Pediatric Healthcare Clinical Staff., Kathyrn Kyler, Codi Cutburth, Gayla Goleman, Sarah Hampl, Amy R. Beck
Addressing Weight Bias Among Pediatric Healthcare Clinical Staff., Kathyrn Kyler, Codi Cutburth, Gayla Goleman, Sarah Hampl, Amy R. Beck
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: Children with obesity may experience weight-based discrimination as a result of weight bias and stigma, which can have deleterious effects on their health and wellbeing, including increased risk of dysregulated, maladaptive, and disordered eating such as restriction, purging, and binging. Prior work has shown that weight bias occurs from healthcare workers caring for adults, but less is known about the prevalence of weight bias in the pediatric healthcare setting.
METHODS: We aimed to determine what proportion of pediatric healthcare professionals had attitudes of weight bias at our own institution by constructing a survey with questions from validated weight bias …
Anesthesia For Bronchoscopy-An Update, Basavana Goudra, Lalitha Sundararaman, Prarthna Chandar, Michael Green
Anesthesia For Bronchoscopy-An Update, Basavana Goudra, Lalitha Sundararaman, Prarthna Chandar, Michael Green
Department of Anesthesiology Faculty Papers
The field of interventional pulmonology has grown immensely and is increasingly recognized as a subspecialty. The new procedures introduced in the last decade pose unique challenges, and anesthesiologists need to readapt to their specific demands. In this review, we extensively discuss the pathophysiology, technical aspects, preprocedural preparation, anesthetic management, and postprocedural challenges of many new procedures such as navigational bronchoscopy, endobronchial valve deployment, and bronchial thermoplasty. Majority of these procedures are performed under general anesthesia with an endotracheal tube. Total intravenous anesthesia with rocuronium as a muscle relaxant seems to be the standard US practice. The easy availability and proven …
Targeting A Chemo-Induced Adaptive Signaling Circuit Confers Therapeutic Vulnerabilities In Pancreatic Cancer, Yohei Saito, Yi Xiao, Jun Yao, Yunhai Li, Wendao Liu, Arseniy E Yuzhalin, Yueh-Ming Shyu, Hongzhong Li, Xiangliang Yuan, Ping Li, Qingling Zhang, Ziyi Li, Yongkun Wei, Xuedong Yin, Jun Zhao, Seyed M Kariminia, Yao-Chung Wu, Jinyang Wang, Jun Yang, Weiya Xia, Yutong Sun, Eek-Hoon Jho, Paul J Chiao, Rosa F Hwang, Haoqiang Ying, Huamin Wang, Zhongming Zhao, Anirban Maitra, Mien-Chie Hung, Ronald A Depinho, Dihua Yu
Targeting A Chemo-Induced Adaptive Signaling Circuit Confers Therapeutic Vulnerabilities In Pancreatic Cancer, Yohei Saito, Yi Xiao, Jun Yao, Yunhai Li, Wendao Liu, Arseniy E Yuzhalin, Yueh-Ming Shyu, Hongzhong Li, Xiangliang Yuan, Ping Li, Qingling Zhang, Ziyi Li, Yongkun Wei, Xuedong Yin, Jun Zhao, Seyed M Kariminia, Yao-Chung Wu, Jinyang Wang, Jun Yang, Weiya Xia, Yutong Sun, Eek-Hoon Jho, Paul J Chiao, Rosa F Hwang, Haoqiang Ying, Huamin Wang, Zhongming Zhao, Anirban Maitra, Mien-Chie Hung, Ronald A Depinho, Dihua Yu
Faculty, Staff and Student Publications
Advanced pancreatic ductal adenocarcinomas (PDACs) respond poorly to all therapies, including the first-line treatment, chemotherapy, the latest immunotherapies, and KRAS-targeting therapies. Despite an enormous effort to improve therapeutic efficacy in late-stage PDAC patients, effective treatment modalities remain an unmet medical challenge. To change the status quo, we explored the key signaling networks underlying the universally poor response of PDAC to therapy. Here, we report a previously unknown chemo-induced symbiotic signaling circuit that adaptively confers chemoresistance in patients and mice with advanced PDAC. By integrating single-cell transcriptomic data from PDAC mouse models and clinical pathological information from PDAC patients, we identified …
A Stronger Impact On Career Development For Early- And Mid-Career Faculty, Daniel A Gorelick, Jason Gertz, Kaitlin J Basham, Lindsey S Treviño
A Stronger Impact On Career Development For Early- And Mid-Career Faculty, Daniel A Gorelick, Jason Gertz, Kaitlin J Basham, Lindsey S Treviño
Faculty, Staff and Students Publications
Nuclear receptors are important in normal physiology and disease. Physicians and scientists who study nuclear receptors organize and attend conferences and symposia devoted to foundational and translational nuclear receptor research, but the field lacks a platform for early-stage investigators and aspiring leaders. In 2019, Zeynep Madak-Erdogan, Rebecca Riggins, and Matthew Sikora founded Nuclear Receptor (NR) Interdisciplinary Meeting for Progress And Collaboration Together (IMPACT, https://nrimpact.com), a collaborative group designed for early- and mid-career faculty who study nuclear receptors in any context or organism [1]. NR IMPACT addresses challenges for early- and mid-career faculty. Here, we review the progress of NR IMPACT …
Lower Urinary Tract Symptoms, Depression And Sleep Problems; A Triple Whammy For Patients’ Health-Related Quality Of Life, Muhammad Salman, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Jeffery David Hughes, Junaid Habib Khan, Yusra Habib Khan, Tauqeer Hussain Mallhi
Lower Urinary Tract Symptoms, Depression And Sleep Problems; A Triple Whammy For Patients’ Health-Related Quality Of Life, Muhammad Salman, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Jeffery David Hughes, Junaid Habib Khan, Yusra Habib Khan, Tauqeer Hussain Mallhi
Bulletin of Faculty of Pharmacy Cairo University
Introduction: Lower urinary tract symptoms (LUTS) are characterized by voiding, storage and post-micturition symptoms. LUTS can have detrimental effects on various facets of patients’ quality of life. Therefore, this study was aimed to evaluate the association of LUTS with depression and sleep disturbances, and their impact on patients’ health-related quality of life (HRQOL).
Methods: A cross-sectional survey was conducted among a clinical sample of calcium channel blocker-users (n = 410), recruited via convenient sampling. Outcomes were assessed using validated Urdu translated instruments [LUTS: International Prostate Symptom Score; sleep problems: Jenkins sleep evaluation questionnaire (JSEQ); depression: Center for Epidemiologic Studies Short …
Using Geographic Momentary Assessment To Explore Spatial Environment Influences On Wellbeing In People With Hiv, Rayna E. Gasik, Ethan A. Smith, Simone J. Skeen, Stephanie Tokarz, Gretchen Clum, Erica Felker-Kantor, Katherine P. Theall
Using Geographic Momentary Assessment To Explore Spatial Environment Influences On Wellbeing In People With Hiv, Rayna E. Gasik, Ethan A. Smith, Simone J. Skeen, Stephanie Tokarz, Gretchen Clum, Erica Felker-Kantor, Katherine P. Theall
School of Public Health Faculty Publications
Place-based socio-economic and racial inequities contribute to health disparities among people with HIV (PWH). We used geographic ecological momentary assessment (GEMA) methodologies to explore the interplay between psychosocial outcomes in daily diaries and community spatial measures among PWH in New Orleans. PWH (N = 69) were recruited from a clinic-based cohort study. Micro-longitudinal data were collected via smartphone-based daily diaries and geospatial tracking over 14 days. First, correlations were run between diary derived outcomes (e.g., feeling safe in current location, stress), and spatial measures (e.g., violent crime, alcohol outlets, and vacant lots) within a half-mile buffer around each diary point …
Developmental-Status-Aware Transcriptional Decomposition Establishes A Cell State Panorama Of Human Cancers, Yikai Luo, Han Liang
Developmental-Status-Aware Transcriptional Decomposition Establishes A Cell State Panorama Of Human Cancers, Yikai Luo, Han Liang
Faculty, Staff and Student Publications
Background: Cancer cells evolve under unique functional adaptations that unlock transcriptional programs embedded in adult stem and progenitor-like cells for progression, metastasis, and therapeutic resistance. However, it remains challenging to quantify the stemness-aware cell state of a tumor based on its gene expression profile.
Methods: We develop a developmental-status-aware transcriptional decomposition strategy using single-cell RNA-sequencing-derived tissue-specific fetal and adult cell signatures as anchors. We apply our method to various biological contexts, including developing human organs, adult human tissues, experimentally induced differentiation cultures, and bulk human tumors, to benchmark its performance and to reveal novel biology of entangled developmental signaling in …
Prenatal Opioid And Alcohol Exposures: Association With Altered Placental Serotonin Transporter Structure And/Or Expression, Nune Darbinian, Nana Merabova, Gabriel Tatevosian, Sandra Adele, Armine Darbinyan, Mary F Morrison, C Lindsay Devane, Sammanda Ramamoorthy, Laura Goetzl, Michael E Selzer
Prenatal Opioid And Alcohol Exposures: Association With Altered Placental Serotonin Transporter Structure And/Or Expression, Nune Darbinian, Nana Merabova, Gabriel Tatevosian, Sandra Adele, Armine Darbinyan, Mary F Morrison, C Lindsay Devane, Sammanda Ramamoorthy, Laura Goetzl, Michael E Selzer
Faculty, Staff and Student Publications
Fetal exposures to many drugs of abuse, e.g., opioids and alcohol (EtOH), are associated with adverse neurodevelopmental problems in early childhood, including abnormalities in activity of the serotonin (5HT) transporter (SERT), which transports 5HT across the placenta. Little is known about the effects of these drugs on SERT expression. Pregnant women who used EtOH or opioids were compared to gestational age-matched controls using a structured questionnaire to determine prenatal substance exposure. Following elective pregnancy termination, placental membranous vesicles and exosomes were prepared from first and second trimester human placentas. Changes in EtOH- or opioid-exposed placental SERT expression and modifications were …
Dna-Binding Proteins From Mbd Through Zf To Ben: Recognition Of Cytosine Methylation Status By One Arginine With Two Conformations, Xing Zhang, Robert M Blumenthal, Xiaodong Cheng
Dna-Binding Proteins From Mbd Through Zf To Ben: Recognition Of Cytosine Methylation Status By One Arginine With Two Conformations, Xing Zhang, Robert M Blumenthal, Xiaodong Cheng
Faculty, Staff and Student Publications
Maintenance methylation, of palindromic CpG dinucleotides at DNA replication forks, is crucial for the faithful mitotic inheritance of genomic 5-methylcytosine (5mC) methylation patterns. MBD proteins use two arginine residues to recognize symmetrically-positioned methyl groups in fully-methylated 5mCpG/5mCpG and 5mCpA/TpG dinucleotides. In contrast, C2H2 zinc finger (ZF) proteins recognize CpG and CpA, whether methylated or not, within longer specific sequences in a site- and strand-specific manner. Unmethylated CpG sites, often within CpG island (CGI) promoters, need protection by protein factors to maintain their hypomethylated status. Members of the BEN domain proteins bind CGCG or CACG elements within CGIs to regulate gene …
Effective Deep Brain Stimulation For Obsessive-Compulsive Disorder After Failed Anterior Capsulotomy: Illustrative Cases, Anthony K Allam, Nisha Giridharan, Mohammed Hasen, Garrett P Banks, Gabriel Reyes, Huy Dang, Katherine E Kabotyanski, Alyssa G Hertz, Sarah R Heilbronner, Nicole Provenza, Eric A Storch, Wayne K Goodman, Sameer A Sheth
Effective Deep Brain Stimulation For Obsessive-Compulsive Disorder After Failed Anterior Capsulotomy: Illustrative Cases, Anthony K Allam, Nisha Giridharan, Mohammed Hasen, Garrett P Banks, Gabriel Reyes, Huy Dang, Katherine E Kabotyanski, Alyssa G Hertz, Sarah R Heilbronner, Nicole Provenza, Eric A Storch, Wayne K Goodman, Sameer A Sheth
Faculty, Staff and Students Publications
BACKGROUND: Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions) performed to relieve distress related to the obsessions. For patients with severe illness refractory to first-line pharmacotherapy and psychotherapy, neurosurgical treatments such as deep brain stimulation (DBS) and stereotactic lesioning are an option. The choice between DBS and lesioning is often driven by patient preference, but these options are not mutually exclusive. Here, the authors highlight the success of one surgical therapy (DBS) after the failure of another (lesioning).
OBSERVATIONS: Two patients with severe, treatment-refractory OCD underwent DBS lead implantation targeting the …
A Genome-Wide Association Study Identifies Genetic Determinants Of Hemoglobin Glycation Index With Implications Across Sex And Ethnicity, John S. House, Joseph H. Breeyear, Farida S. Akhtari, Violet Evans, John B. Buse, James Hempe, Alessandro Doria, Josyf C. Mychaleckyi, Vivian Fonseca, Mengyao Shi, Changwei Li, Shuqian Liu, Tanika N. Kelly, Daniel Rotroff, Alison A. Motsinger-Reif
A Genome-Wide Association Study Identifies Genetic Determinants Of Hemoglobin Glycation Index With Implications Across Sex And Ethnicity, John S. House, Joseph H. Breeyear, Farida S. Akhtari, Violet Evans, John B. Buse, James Hempe, Alessandro Doria, Josyf C. Mychaleckyi, Vivian Fonseca, Mengyao Shi, Changwei Li, Shuqian Liu, Tanika N. Kelly, Daniel Rotroff, Alison A. Motsinger-Reif
School of Medicine Faculty Publications
Introduction: We investigated the genetic determinants of variation in the hemoglobin glycation index (HGI), an emerging biomarker for the risk of diabetes complications. Methods: We conducted a genome-wide association study (GWAS) for HGI in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial (N = 7,913) using linear regression and additive genotype encoding on variants with minor allele frequency greater than 3%. We conducted replication analyses of top findings in the Atherosclerosis Risk in Communities (ARIC) study with inverse variance-weighted meta-analysis. We followed up with stratified GWAS analyses by sex and self-reported race. Results: In ACCORD, we identified single …
The Contribution Of Neutrophil Extracellular Traps To Coagulopathy In Patients With Covid-19-Related Thrombosis, Carolyn Enochs, Gabriela Delevati Colpo, Lucy Couture, Lynae Baskin, Ana E Cahuiche, Eunyoung Angela Lee, Shahid Nimjee, Louise D Mccullough
The Contribution Of Neutrophil Extracellular Traps To Coagulopathy In Patients With Covid-19-Related Thrombosis, Carolyn Enochs, Gabriela Delevati Colpo, Lucy Couture, Lynae Baskin, Ana E Cahuiche, Eunyoung Angela Lee, Shahid Nimjee, Louise D Mccullough
Faculty, Staff and Student Publications
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with hypercoagulability and increased incidence of thrombotic events. In this study, we investigated the levels of neutrophil extracellular trap biomarkers and von Willebrand factor to assess if these could predict the occurrence of a thrombotic event in COVID-19 patients. We enrolled 202 patients hospitalized with symptomatic COVID-19 infection. Of those, 104 patients did not experience any type of thrombotic events before or during their hospitalization. These patients were compared to the other cohort of 98, who experienced thrombotic events before or during their hospitalization. In total, …
Evaluation Of One Stage Bilateral Total Knee Arthroplasty Versus Staged Bilateral Total Knee Arthroplasty, Ahmed Sarhan Mazyon
Evaluation Of One Stage Bilateral Total Knee Arthroplasty Versus Staged Bilateral Total Knee Arthroplasty, Ahmed Sarhan Mazyon
Maaen Journal for Medical Sciences
Background: Complete knee replacement is a resolving method for treatment for severe osteoarthritis and rheumatoid arthritis that relieves pain and restores function. Individuals in necessary condition to do bilateral surgery total knee arthroplasty underwent two different surgical procedures, or one stage of surgery with one anesthesia session. Aim of the study: To compare the knee and functional outcome, safety, and possible complications between one stage and staged bilateral total knee arthroplasty. Patients and methods: An interventional study conducted in the Orthopedic Department in Al-Yarmouk Teaching Hospital and private hospital, Baghdad, Iraq during a time of three years from (June 2020 …
Right Heart Failure After Tricvalve Implantation For Symptomatic Torrential Tricuspid Regurgitation: A Case Report, King Sum Luk, Chun Kit Wong
Right Heart Failure After Tricvalve Implantation For Symptomatic Torrential Tricuspid Regurgitation: A Case Report, King Sum Luk, Chun Kit Wong
Journal of the Hong Kong College of Cardiology
Patients with symptomatic torrential tricuspid regurgitation (TR) presenting with right heart failure are associated with significant morbidity and mortality. While medical therapy is often ineffective, the perioperitive risks of surgical correction are high. Transcatheter TricValve implantation is one of the evolving therapeutic options for this condition with many unanswered questions. We reported a case of life-threatening right heart failure after transcatheter TricValve implantation despite initial improvement. Important considerations of TricValve implantation are discussed. In particular, careful patient selection and evaluation with perioperative echocardiogram are of paramount importance.
Y-27632 Targeting Rock1&2 Modulates Cell Growth, Fibrosis And Epithelial-Mesenchymal Transition In Hyperplastic Prostate By Inhibiting Β-Catenin Pathway., Shidong Shan, Min Su, Hejin Wang, Feng Guo, Yan Li, Yongying Zhou, Huan Liu, Lu Du, Junchao Zhang, Jizhang Qiu, Michael E. Disanto, Yuming Guo, Xinhua Zhang
Y-27632 Targeting Rock1&2 Modulates Cell Growth, Fibrosis And Epithelial-Mesenchymal Transition In Hyperplastic Prostate By Inhibiting Β-Catenin Pathway., Shidong Shan, Min Su, Hejin Wang, Feng Guo, Yan Li, Yongying Zhou, Huan Liu, Lu Du, Junchao Zhang, Jizhang Qiu, Michael E. Disanto, Yuming Guo, Xinhua Zhang
Cooper Medical School of Rowan University Departmental Research
Benign prostatic hyperplasia (BPH) is a prevalent condition affecting the male urinary system, with its molecular mechanisms of pathogenesis remaining unclear. Y-27632, a non-isoform-selective Rho kinase inhibitor, has shown therapeutic potential in various diseases but its effects on static factors and fibrosis in BPH remain unexplored. This study investigated human prostate tissues, human prostate cell lines, and BPH rat model using immunofluorescence, flow cytometry, quantitative reverse transcription polymerase chain reaction, western blotting, and cell counting kit-8. ROCK1 and ROCK2 were significantly up-regulated in BPH tissues, correlating with clinical parameters. Y-27632 targeted the inhibition of ROCK1 & ROCK2 expression and inhibited …
There Is "Thorn" Than Meets The Eye, Zaid Alnabulsi
There Is "Thorn" Than Meets The Eye, Zaid Alnabulsi
Conference Presentation Abstracts
No abstract provided.
Chronic Intestinal Pseudo-Obstruction: A Debilitating Complication Of Scleroderma, Pawan Gyawali
Chronic Intestinal Pseudo-Obstruction: A Debilitating Complication Of Scleroderma, Pawan Gyawali
Conference Presentation Abstracts
No abstract provided.
Myxedema Coma Due To Interrupted Levothyroxine Therapy, Tajuldeen Al Hasani
Myxedema Coma Due To Interrupted Levothyroxine Therapy, Tajuldeen Al Hasani
Conference Presentation Abstracts
No abstract provided.
A Rare Case Of An Immune Checkpoint Inhibitor-Induced Myopericarditis, Morgan Korn
A Rare Case Of An Immune Checkpoint Inhibitor-Induced Myopericarditis, Morgan Korn
Conference Presentation Abstracts
No abstract provided.
The Kitchen Sink Approach: A Case Of Idiopathic Non-Histaminergic Angioedema, Vickie Xin
The Kitchen Sink Approach: A Case Of Idiopathic Non-Histaminergic Angioedema, Vickie Xin
Conference Presentation Abstracts
No abstract provided.
Rheumatoid Arthritis And Anca Vasculitis Overlap: A Rare Case With Renal And Respiratory Involvement, Ayed Shahatit
Rheumatoid Arthritis And Anca Vasculitis Overlap: A Rare Case With Renal And Respiratory Involvement, Ayed Shahatit
Conference Presentation Abstracts
No abstract provided.