Medical Specialties Commons^™

Clinical Significance Of Evaluation Of Some Metabolic And Hematological Parameters In Patients With Sudden Sensorineural Hearing Loss, Eman S. Abd El-Gaffar, Gehan M. S. Abd El-Salam, Hala M. Abd El-Samad

Journal of Medicine in Scientific Research

Background Sudden sens orineural hearing loss (SSNHL) is a medical emergency, being mostly an idiopathic disease. Understanding the pathogenesis of SSNHL may help physicians for diagnosis and intervention. Objective The aim of the present study was to investigate some metabolic and hematological parameters in patients with SSNHL and related them to their clinical condition. Patients and methods The study was conducted on 50 patients with SSNHL and 20 age-matched and sex-matched controls. Both groups were subjected to audiological and laboratory evaluation of their fasting blood sugar (FBS), lipid profile, thyroid function test, neutrophil–lymphocyte ratio, and platelet–lymphocyte ratio. Moreover, the relation …

The Prevalence Of Pulmonary Aspergillosis In Coronavirus Disease 19 (Covid-19) Patients In Shebin El-Kom Teaching Hospital In Egypt, Asmaa M. Soliman, Elham T. Awad, Mariam A. Fouad

Journal of Medicine in Scientific Research

Background A high rate of invasive fungal infection has been demonstrated among critically COVID-19 ill patients admitted to the ICU, with high odds of mortality. Simple and rapid risk stratification methods are mandatory to recognize severe patients. Objectives The aims was to study the prevalence of invasive fungal infection in Corona virus disease 19 (COVID-19) patients, the effect of some inflammatory markers that lead to the development and progression of invasive fungal infection and to assess the value of PCR in early and rapid detection of invasive fungal infection in immune compromised patients with COVID-19. Methods This study was conducted …

Evaluation The Role Of Conventional And Xpert Mtb/Rif Assays As Point-Of-Care Tests Of Mycobacterium Tuberculosis Infections, Especially During The Covid-19 Pandemic In Menoufia, Egypt, Asmaa M. Soliman, Elham T. Awad, Mariam A. Fouad, Moatz M. Elhefnay

Journal of Medicine in Scientific Research

Background Tuberculosis (TB) is a destructive pulmonary disease, which was the most fatal infectious disease in the world for many years before the COVID-19 outbreak. During pandemic, COVID-19 was the main concern in every clinic and there were overlapping respiratory diseases resulting in delaying of the diagnosis and treatment of TB. Xpert MTB/RIF assay and Ziehl–Neelsen (ZN) stain are the most commonly used point-of-care test (POCT) assays for TB that were endorsed by WHO allowing a quick treatment turnaround time of a few minutes or hours, hence avoiding patient loss to follow-up. The aim of the study was to evaluate …

A Study On Ecg And Cardiac Functional Changes In Patients With B-Thalassemia Major, Ahmed Khamis, Omnia S. El-Din, Randa M. Darwish

Journal of Medicine in Scientific Research

Background Cardiovascular complications such as heart failure and arrhythmias caused by 'iron-overload' cardiomyopathy are a leading cause of death in patients with thalassemia major (TM). Aims The study aims to determine the prevalence of cardiac complications in patients with B-TM. This will include cardiac function and electrocardiologic changes, as well as an examination of the relationship between these cardiac complications and various factors, including iron overload, in a 5-year cross-sectional study. Patients and methods After approval by the General Organization of Teaching Hospitals and Institutes' Ethics Review Committee, 40 patients with B-TM and 20 normal children meeting the inclusion criteria …

Forced Expiratory Volume In The Third Second And Its Derivatives For Diagnosis Of Airway Obstruction In Obese Patients, Manal S. H. El Hussini, Mohamed S. El Hussieny

Journal of Medicine in Scientific Research

Background Spirometry is a simple diagnostic tool for pulmonary diseases, as obstructive pulmonary disorders, especially in obese. Obesity is an increasing worldwide public health concern that contributes to many respiratory problems that affect both large and small airways. The traditional use of forced expiratory volume in the first second (FEV1) and FEV1/forced vital capacity (FVC) in defining large-airflow obstruction may be confined not only by the limitation of FVC maneuver, but also by the long time to reach plateau flow rate in geriatrics and in patients with moderate-to-severe airflow obstruction. FEV3 and its derivatives FEV1/FEV3 and FEV3/FVC are used for …

Contraception And Family Planning: Knowledge, Attitude, Pattern Of Use, And Barriers Among Females In Gharbia Governorate, Egypt, Hesham M. Borg, Salwa A. Atlam, Walid M. Daoud

Journal of Medicine in Scientific Research

Aims Most contraceptive methods are designed to be used by women due to the paucity of effective contraceptive options for men. This study aimed to assess knowledge, attitude, and family-planning (FP) practice among women of reproductive-age group in Gharbia Governorate, Egypt. Materials and materials A self-administered questionnaire was developed and adapted from previous studies. Scores were used to assess the levels of knowledge, attitude, and practice concerning FP. Results The questionnaire was answered by 430 women. Current use of contraceptives was stated by 81.9%. The commonest methods included intrauterine device (44%), oral pills (20.7%), and injectables (8.4%). Knowledge was good, …

Parents' Knowledge, Attitude And Practices Toward Oral Health Of Their Children With Primary Dentition: A Cross Sectional Study, Marwa Foad, Mennatallah Helal, Soad Abdel Moneim

Journal of Medicine in Scientific Research

Objective This cross-sectional study aims to assess parents' knowledge, attitude, and practices toward the oral health of their children with primary dentition. Patients and methods The study was performed in the Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Cairo University. Data were obtained through 301 questionnaires translated from English to Arabic, for the assessment of the parents' knowledge, attitude, and practices scores and via clinical examination of the children for the assessment of caries prevalence by calculation of their dmf scores. Results The majority of parents (90%) had adequate knowledge scores with a significantly strong negative correlation …

Anatomical Changes And Ovarian Reserve Assessment Following Methotrexate Therapy In Tubal Ectopic Pregnancy, Ayman S. Dawood, Hesham M. Borg, Mona K. Omar

Journal of Medicine in Scientific Research

Background Methotrexate (MTX) therapy for ectopic pregnancy (EP) is widely used as an alternative for surgical treatment. Its effects on ovarian reserve or pelvic anatomy are not well established. Aims The aim was to evaluate anatomical changes and ovarian reserve in cases of tubal EP treated by MTX therapy. Materials and methods A prospective cohort study was conducted at Tanta University. All patients with EP were enrolled. Eligible patients were treated by MTX. Ovarian reserve was assessed by anti-Mullerian hormone (AMH) level and antral follicle count (AFC) 3 months after treatment. Anatomical changes were assessed by laparoscopy 6 months after …

The Use Of Two 90-Degree Arc Intracorneal Ring Segments In Management Of Crab-Claw Topographic Pattern, Hazem A. Elnashar

Journal of Medicine in Scientific Research

Background Keratoconus and pellucid marginal degeneration (PMD) are bilateral, progressive, and ectatic corneal disorders characterized by thinning of the cornea. Aim To assess the visual and refractive outcome of using two 90-degree arc intrastromal corneal ring segments (ICRS) in the management of crab-claw topographic pattern. Patients and methods This study included 17 eyes of nine patients with crab-claw topographic patterns, either pellucid-like KC or PMD, needing ICRS. Preoperative evaluation included detailed ocular history, full ophthalmic examination, including uncorrected visual acuity (UCVA), manifest refraction, best spectacle-corrected visual acuity, and Pentacam. Results Regarding visual outcome, the mean UCVA improved significantly from 0.12 …

Effect Of Photorefractive Keratectomy Versus Laser In Situ Keratomileusis On Corneal Hysteresis In Moderate Myopic Eyes, Hussam Eldeen O. Elrashidy

Journal of Medicine in Scientific Research

Introduction Ablation procedures used for vision correction such as photorefractive keratectomy (PRK) or laser in situ keratomileusis (LASIK) flap creation produce massive changes within the corneal structure and biomechanical properties. These changes are due to thinning of the central cornea and disruption of continuity of the collagen lamellae. Several approaches to assessment of the biomechanical properties have been proposed. Refractive photoablation procedures that decrease corneal hysteresis (CH) and corneal resistance factor (CRF) have been shown by several studies; therefore, here in our study we are going to discuss the effect of PRK versus LASIK on the corneal biomechanics and stability …

Optical Coherence Tomography Angiography In Comparison With Fluorescein Angiography In Diabetic Retinopathy, Ghada Samir, Hussam E. O. Elrashidy

Journal of Medicine in Scientific Research

Background Diabetic retinopathy (DR) is a microvascular complication of diabetes, and it is a leading cause of blindness. Fluorescein angiography (FA) is a vitally crucial diagnostic tool for evaluating fundus features of diabetic retinopathy. Purpose The purpose of the study was to evaluate optical coherence tomography angiography (OCTA) in eyes with diabetic maculopathy (DM) compared with the findings in fundus fluorescein angiography. Design It is a cross-sectional study. Patients and methods The study involved 40 eyes of 40 patients suffering from DM. The patients' ages ranged from 30 to 66 years with a mean value of 51.4 ± 8.55 years, …

Comparative Study Between Medial Rectus Slanting Versus Medial Rectus Faden With Or Without Recession For Management Of Esotropia With Distance/Near Disparity: A Retrospective Study, Heba Metwally

Journal of Medicine in Scientific Research

Aims This study aimed to compare the efficacy of medial rectus slanting recession and the bilateral medial rectus Faden with or without recession in the management of any type of convergence excess esotropia with low or high accommodative convergence/accommodation ratio. Patients and methods A total of 38 patients with convergence excess esotropia were divided into group A, which underwent bilateral medial rectus recession according to the average angle of near and distance, and group B, which underwent bilateral medial rectus Faden technique with or without recession. All patients who met the inclusion criteria of the study had complete ophthalmic examination …

Bimedial Recti Slanted Recession Versus Bimedial Recti Y-Split Recession For Surgical Management Of Infantile-Onset Esotropia, Heba M. Ali

Journal of Medicine in Scientific Research

Context Bimedial recti Y-split recession is a new intervention for the weakening of the medial recti muscle in patients suffering infantile-onset esotropia. Few studies assessed the efficacy and safety of this procedure compared with other procedures that have been in use. Aims To evaluate bimedial recti slanted recession versus bimedial recti Y-split recession for surgical management of infantile-onset esotropia. Patients and methods This cohort study included patients with infantile esotropia. Patients were divided into two groups according to the procedure performed (bimedial recti Y-split recession or slanted recession). Patients were followed up on the first postoperative day, the first week, …

Torsion Of A Wandering Spleen: A Case Report With Emphasis On Image Findings, Ahmad Abdelhady, Mohammad El-Maghawri

Journal of Medicine in Scientific Research

No abstract provided.

The Effectiveness Of Chest Physiotherapy On Mechanically Ventilated Neonates With Respiratory Distress Syndrome: A Randomized Control Trial, Abeer E. S. Hamed, Rabab Salah El Din Mohamed

Journal of Medicine in Scientific Research

This study aimed to investigate the effect of chest physiotherapy on mechanically ventilated neonates with respiratory distress syndrome. Thirty neonates were concluded in the study where their age ranged from 1 to 28 days. They were divided into two equal groups. Group A was the control group that received medical treatment and mechanical ventilation. Group B or the study group has received the same treatment and the chest physiotherapy program. The physiotherapy session was conducted daily until the child was weaned off the ventilator. The results showed significant differences in vital signs, blood gases, oxygen saturation, respiratory stay, and hospital …

Grk2 Regulates Adp Signaling In Platelets Via P2y1 And P2y12., Xuefei Zhao, Matthew Cooper, James V Michael, Yanki Yarman, Aiden Baltz, J Kurt Chuprun, Walter J Koch, Steven E. Mckenzie, Maurizio Tomaiuolo, Timothy J Stalker, Li Zhu, Peisong Ma

Department of Medicine Faculty Papers

The critical role of G protein-coupled receptor kinase 2 (GRK2) in regulating cardiac function has been well documented for >3 decades. Targeting GRK2 has therefore been extensively studied as a novel approach to treating cardiovascular disease. However, little is known about its role in hemostasis and thrombosis. We provide here the first evidence that GRK2 limits platelet activation and regulates the hemostatic response to injury. Deletion of GRK2 in mouse platelets causes increased platelet accumulation after laser-induced injury in the cremaster muscle arterioles, shortens tail bleeding time, and enhances thrombosis in adenosine 5'-diphosphate (ADP)-induced pulmonary thromboembolism and in FeCl3-induced carotid …

Deep Inspiration And End Exhale Breathhold Evaluation For The Treatment Of Locally Advanced Pancreatic Adenocarcinoma Using The Viewray Mridian Linactm, Tatum Mcglynn

Masters Projects

Introduction

Radiation therapy has been limited in the treatment of locally advanced pancreatic cancer. This is due to the dose tolerance to nearby organs at risk and breathing motion. Advancements in radiation treatment technology have now allowed pancreatic patients to be treated to higher doses in fewer fractions using stereotactic body radiotherapy treatment. With the use of MRI-guided treatments, using the ViewRay MRIdian linac, doses can be escalated using online adaptive treatment planning and real time tracking. However, there has yet to be an optimal breathhold technique investigated that can aid in this process.

Methods

Five patients that had been …

Quantifying The Dosimetric Impact Of Target Margins In The Oligometastatic Setting, Jessica E. Strang

Masters Projects

Introduction

With advancements in cancer treatment therapies, patients are living longer with oligometastatic disease. These patients may have multiple targets and may be treated in a single isocenter to reduce overall treatment time. However, the most considerable risk of treating multiple lesions in a single isocenter is a geometric miss. It can be challenging to perform daily alignment of multiple lesions creating a need to prioritize one lesion alignment over others or abort treatment.

Methods

This study quantified the dosimetric impact of total lung exposure as the planning target volume (PTV) margin incrementally increased for multiple intrathoracic lesions.

The analysis …

Insights Into Microbiome And Metabolic Signatures Of Children Undergoing Peanut Oral Immunotherapy, Andrea C Blackman, Santosh Thapa, Alamelu Venkatachalam, Thomas D Horvath, Jessica K Runge, Sigmund J Haidacher, Kathleen M Hoch, Anthony M Haag, Ruth Ann Luna, Aikaterini Anagnostou

Faculty, Staff and Students Publications

BACKGROUND: Peanut oral immunotherapy has emerged as a novel, active management approach for peanut-allergic sufferers, but limited data exist currently on the role of the microbiome in successful desensitization.

OBJECTIVE: We examined the oral and gut microbiome in a cohort of 17 children undergoing peanut oral immunotherapy with the aim to identify the microbiome signatures associated with successful desensitization. We also set out to characterize their fecal metabolic profiles after successful therapy.

METHODS: Participants gradually built up their daily dose from 2 mg (starting dose) to 300 mg (maintenance dose) within approximately 40 weeks. We collected a buccal and stool …

Total Joint Implant Alloy Oxide Layer Cell-Induced Damage, Chandler K. Sears

Longitudinal Scholar's Project

Cobalt-Chromium alloy is commonly used in total joint arthroplasty (TJA). Several studies have investigated evidence of inflammatory-cell-induced-corrosion (ICIC) causing pitting in TJA retrieved implants. Others have determined that placing orthopedic alloys into lower pH solutions will increase the rate of corrosion. We have determined that electrochemical potential and corrosion rates of human knee synovial fluid show a variation greater than an order of magnitude. This means there is going to be a significant variation between a patient’s local environment of the TJA implant and may affect how macrophages interact with alloy oxide layers. Knee disability can be quantified by using …

Using Radformation Ezfluence Software To Simplify Three Field Breast Radiation Therapy Planning Compared To Field-In-Field Technique, Brianna L. Woodburn

Masters Projects

Purpose: To evaluate time savings, efficiency, and accuracy of an automated planning software.

Methods: 10 previously treated breast cancer patients with supraclavicular involvement were retrospectively planned using a monosiocentric field-in-field technique by both an automated treatment planning software and a human planner. Time spent on planning was recorded and after plans were generated, dose constraints and target coverage were measured to evaluate overall plan quality.

Results: Time spent for planning was significantly decreased when using a FIF plan generated by the automated planning software. CTV target coverage for both the breast and supraclavicular volumes and dose to OARs for both …

Foundations Of Intramedullary Femoral Shaft Fracture Fixation: Avoidance, Recognition, And Management Of Common Pitfalls, Christopher Kurnik, Jory Wasserburger, William Curtis, Tyler Chavez

Western Journal of Orthopaedics

Intramedullary nailing is an effective treatment of femoral shaft fractures. However, this procedure has several common complications and technical problems that can interfere with full recovery in some patients. The purpose of this review article is to expand on the literature with the authors’ own experiences to summarize the following common complications of femoral nailing: missed injuries, suboptimal surgical timing, malreduction, reaming errors, implant insertion errors, pain-management problems, and implant removal errors. Strategies are also identified to help avoid and manage these complications.

A Qualitative Exploration Of The Functional, Social, And Emotional Impacts Of The Covid-19 Pandemic On People Who Use Drugs, Erin L Kelly, Megan K Reed, Kathryn M Schoenauer, Kelsey Smith, Kristina Scalia-Jackson, Sequoia Kay Hill, Erica Li, Lara Weinstein

Department of Family & Community Medicine Faculty Papers

Since 2020, people who use drugs (PWUD) experienced heightened risks related to drug supply disruptions, contamination, overdose, social isolation, and increased stress. This study explored how the lives of PWUD changed in Philadelphia over a one-year period. Using semi-structured interviews with 20 participants in a Housing First, low-barrier medication for opioid use (MOUD) program in Philadelphia, the effects of the first year of the COVID-19 pandemic on the daily lives, resources, functioning, substance use, and treatment of PWUD were explored. Interviews were analyzed using a combination of directed and conventional content analysis. Six overarching themes emerged during data analysis: (1) …

Effects Of Ezfluence Planning Software On Dosimetric Parameter Compliance For Early-Stage Breast Cancer, Jackie Loomis

Masters Projects

Each year over 2 million women are given a breast cancer diagnosis and over half a million women succumb to the disease yearly. As technology advances in the world of radiation oncology, automated planning softwares, such as Radformation’s EZFluence, are being utilized to streamline the treatment planning process. This study was designed to investigate whether the automated plans are dosimetrically equivalent to traditionally planned 3D field in field tangential plans. Is there a disadvantage to using these automated softwares? Three different dosimetrists with varying backgrounds replanned 27 previously treated breast cancer patients and an assortment of comparisons were ran between …

Comparison Of Biological Measurement And Physical Estimates Of Space Radiation In The International Space Station, Kayo Yoshida, Megumi Hada, Akane Kizu, Kohei Kitada, Kiyomi Eguchi-Kasai, Toshiaki Kokubo, Takeshi Teramura, Sachiko Yano, Hiromi Hashizum Suzuki, Hitomi Watanabe, Gen Kondoh, Aiko Nagamatsu, Premkumar Saganti, Francis A. Cucinotta, Takashi Morita

Integrated Health Sciences Faculty Research

Nowadays, ordinary people can travel in space, and the possibility of extended durations in an environment such as moon of the Earth and Mars with higher space radiation exposures compared to past missions, is increasing. Until now, the physical doses of space radiation have been measured, but measurement of direct biological effects has been hampered by its low dose and low dose-rate effect. To assess the biological effects of space radiation, we launched and kept frozen mouse embryonic stem (ES) cells in minus eighty degree Celsius freezer in ISS (MELFI) on the International Space Station (ISS) for a maximum of …

Risk Factors For Reoperation Following Operative Fixation Of Distal Femur Fractures: A Report Of 73 Consecutive Cases, Aditya Desai, Victoria Oakes, John Pisquiy, Christopher Dodo, Ahmed A. Toreih, Wael Azzam, Amr Abdelgawad, Ahmed M. Thabet

Western Journal of Orthopaedics

Introduction: Various factors including patient demographics, fracture types, and fixation methods can affect the outcomes of distal femur fractures. This study aimed to analyze the risk factors for reoperation after operative fixation of these fractures. Methods: This was an institional review board (IRB) approved retrospective study of extra-articuilar, partial articular, and complete articular distal femur fractures treated with operative fixation at a Level I trauma center between 2008 and 2018. The study included a consecutive series of adult patients operatively treated for a distal femur fracture. The primary outcome was reoperation rate due to infection, non-union, or implant failure. Periprosthetic …

Case Report: Amyloid Deposits In The Flexor Tenosynovium Found During Primary Carpal Tunnel Releasetunnel Release, John B. Fuller, Kelly L. Scott, Moheb S. Moneim, Vann E. Schaffner, Natasha G. Dark, Deana M. Mercer

Western Journal of Orthopaedics

A 76-year-old female previously diagnosed with flexor tenosynovitis, presented to the clinic complaining of right wrist pain and numbness in her fingers. She was seen again after a rheumatologic workup, which was negative. It was noted that there was thenar atrophy when compared to the contralateral side. She was then scheduled for carpal tunnel release surgery. During surgery, a large area of synovitis was encountered. A radical synovectomy was performed and this tissue was sent for culture and pathology. The findings were most consistent with age-related amyloidosis. One week after surgery, the patient was contacted by telephone and reported that …

Regional Research-Practice-Policy Partnerships In Response To Climate-Related Disparities: Promoting Health Equity In The Pacific, Lawrence A. Palinkas, Meaghan O’Donnell, Susan Kemp, Jemaima Tiatia, Yvonette Duque, Michael Spencer, Rupa Basu, Kristine Idda Del Rosario, Kristin Diemer, Bonifacio Doma, David Forbes, Kari Gibson, Joshua Graff-Zivin, Bruce M. Harris, Nicola Hawley, Jill Johnston, Fay Lauraya, Nora Elizabeth F. Maniquiz, Jay Marlowe, Gordon C. Mccord, Imogen Nicholls, Smitha Rao, Angela Kim Saunders, Salvatore Sortino, Benjamin F. Springgate, David Takeuchi, Janette Ugsang, Vivien Villaverde

School of Medicine Faculty Publications

Although climate change poses a threat to health and well-being globally, a regional approach to addressing climate-related health equity may be more suitable, appropriate, and appealing to under-resourced communities and countries. In support of this argument, this commentary describes an approach by a network of researchers, practitioners, and policymakers dedicated to promoting climate-related health equity in Small Island Developing States and low- and middle-income countries in the Pacific. We identify three primary sets of needs related to developing a regional capacity to address physical and mental health disparities through research, training, and assistance in policy and practice implementation: (1) limited …

The Hearst Health Prize: The First Five Years, Alexa M. Waters, Alexis Skoufalos, Emily Frelick, Gregory Dorn, David B. Nash

Department of Family & Community Medicine Faculty Papers

The Hearst Health Prize is the first national annual award for excellence in population health. The prize was established "to discover, support, and showcase the work of an individual, group, organization, or institution that has successfully implemented a population health program or intervention that has made a measurable difference" in health outcomes. Now, 5 years since the award's inception, this article reflects on how submissions for the prize collectively mirror - and may even predict - changes within the field of population health. It examines how the most successful programs demonstrated genuine, measurable improvements in health outcomes and/or health behaviors. …

Dosimetric Comparison Of Static Imrt And Vmat Apbi Treatment Planning In The Prone Position For Breast Conservation Therapy, Kelly A. Foucher

Masters Projects

Introduction

Prevalence of early-stage breast cancer is increasing with the aid of preventative screenings and early diagnosis. The standard of care is transforming from conventional approaches with long treatment regimens towards hypofractionation and tissue sparing techniques. Based on studies over the past ten years, there are reasons to consider a partial-breast, hypo fractionated treatment option in the supine position. In practice, aPBI is often produced using several static intensity modulated beams to control dose to the normal breast tissue and limit dose to the heart and lungs. Patients may also be treated in the prone treatment setup in order to …