Medical Specialties Commons^™

Objective User Engagement With Mental Health Apps: Systematic Search And Panel-Based Usage Analysis., A. Baumel, F. Muench, S. Edan, J. Kane

Journal Articles

BACKGROUND: Understanding patterns of real-world usage of mental health apps is key to maximizing their potential to increase public self-management of care. Although developer-led studies have published results on the use of mental health apps in real-world settings, no study yet has systematically examined usage patterns of a large sample of mental health apps relying on independently collected data.

OBJECTIVE: Our aim is to present real-world objective data on user engagement with popular mental health apps.

METHODS: A systematic engine search was conducted using Google Play to identify Android apps with 10,000 installs or more targeting anxiety, depression, or emotional …

Quality Of Life Outcomes Following Organ-Sparing Sbrt In Previously Irradiated Recurrent Head And Neck Cancer, E. Gogineni, I. Zhang, Z. Rana, M. Marrero, G. Gill, A. Sharma, A. C. Riegel, S. Teckie, M. Ghaly

Journal Articles

No abstract provided.

Cold-Inducible Rna-Binding Protein Induces Neutrophil Extracellular Traps In The Lungs During Sepsis, Y. Ode, M. Aziz, H. Jin, A. Arif, J. G. Nicastro, P. Wang

Journal Articles

No abstract provided.

Extracellular Cold Inducible Rna-Binding Protein Mediates Binge Alcohol-Induced Brain Hypoactivity And Impaired Cognition In Mice, A. Jacob, Y. Ma, E. Nasiri, M. Ochani, J. Carrion, S. Peng, M. Brenner, P. T. Huerta, P. Wang

Journal Articles

No abstract provided.

Neurogenesis In Neurodegenerative Diseases: Role Of Mfg-E8, C. Cheyuo, M. Aziz, P. Wang

Journal Articles

No abstract provided.

Author Correction: Chd3 Helicase Domain Mutations Cause A Neurodevelopmental Syndrome With Macrocephaly And Impaired Speech And Language., L. S. Blok, J. Rousseau, J. Twist, S. Ehresmann, M. Takaku, H. Venselaar, L. H. Rodan, M. G. Bialer, C. Moore, M. Blyth, +90 Additional Authors

Journal Articles

© 2019, The Author(s). The original version of this Article contained an error in the spelling of the author Laurence Faivre, which was incorrectly given as Laurence Faive. This has now been corrected in both the PDF and HTML versions of the Article.

De Novo Interstitial Deletion Of 9q In A Pediatric Patient With Global Developmental Delay., D. Keselman, R. Singh, N. Cohen, Z. Fefer

Journal Articles

Cytogenomic microarray (CMA) methodologies, including array comparative genomic hybridization (aCGH) and single-nucleotide polymorphism-detecting arrays (SNP-array), are recommended as the first-tier test for the evaluation of imbalances associated with intellectual disability, autism, and multiple congenital anomalies. The authors report on a child with global developmental delay (GDD) and a de novo interstitial 7.0 Mb deletion of 9q21.33q22.31 detected by aCGH. The patient that the authors report here is noteworthy in that she presented with GDD and her interstitial deletion is not inclusive of the 9q22.32 locus that includes the PTCH1 gene, which is implicated in Gorlin syndrome, or basal cell nevus …

Persistent Cloaca And Caudal Duplication In A Monovular Twin, A Rare Case Report, N. Cohen, M. N. Ahmed, R. Goldfischer, N. Zaghloul

Journal Articles

© 2019 Introduction: A cloaca occurs when genitourinary tract and bowel converge into a common channel. We report a case of partial caudal duplication, persistent cloaca and vestigial appendage in a monovular female twin infant. Presentation of case: This is a monochorinonic-diamniotic twin born at 36 weeks with apgars of 9/9. She had a duplicated labia with two clitorises, and a partially formed accessory foot with 2 toes protruding from the right gluteal region. There was anal atresia and a punctate urethral opening in the right genitalia through which she voided spontaneously. X-ray of the accessory foot had rudimentary metatarsals …

Pleiotropic Meta-Analysis Of Cognition, Education, And Schizophrenia Differentiates Roles Of Early Neurodevelopmental And Adult Synaptic Pathways, M. Lam, W. D. Hill, J. W. Trampush, J. Yu, E. Knowles, G. Davies, E. Stahl, P. Derosse, A. K. Malhotra, T. Lencz, +58 Additional Authors

Journal Articles

No abstract provided.

Abnormal Involuntary Movement Scale In Tardive Dyskinesia: Minimal Clinically Important Difference, M. Stacy, M. Sajatovic, J. M. Kane, A. J. Cutler, G. S. Liang, C. F. O'Brien, C. U. Correll

Journal Articles

No abstract provided.

Lithium For The Maintenance Treatment Of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Discontinuation Study, R. L. Findling, N. K. Mcnamara, M. Pavuluri, J. A. Frazier, M. Rynn, R. Scheffer, V. Kafantaris, A. Robb, M. Delbello, P. Taylor-Zapata, +7 Additional Authors

Journal Articles

No abstract provided.

Propensity-Matched Analysis Of Patient-Reported Outcomes For Neoadjuvant Chemotherapy Prior To Radical Cystectomy, M. A. Feuerstein, L. Goldstein, B. Reaves, A. Sun, M. Goltzman, B. A. Morganstern, A. Shabsigh, D. F. Bajorin, J. E. Rosenberg, B. H. Bochner, +7 Additional Authors

Journal Articles

© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: To evaluate patient-reported outcomes (PROs) for bladder cancer patients undergoing neoadjuvant chemotherapy (NAC) prior to radical cystectomy (RC) using longitudinal data and propensity-matched scoring analyses. Methods: 155 patients with muscle-invasive bladder cancer scheduled for RC completed the European Organization for Research and Treatment of Cancer questionnaires, EORTC QLQ-C30, EORTC QLQ-BLM30, Fear of Recurrence Scale, Mental Health Inventory and Satisfaction with Life Scale within 4 weeks of surgery. A propensity-matched analysis was performed comparing pre-surgery PROs among 101 patients who completed NAC versus 54 patients who did not receive NAC. We …

Pathophysiology Of Osteoarthritis, Lara Stover

Nursing Student Class Projects (Formerly MSN)

Osteoarthritis (OA) is one of the most common joint diseases worldwide, and especially in the United States. This disease can cause chronic pain and disability, and can impair a patient’s quality of life and ability to perform activities of daily living. There are many different factors that can contribute to the development, progression, and severity of OA. Chronic inflammation and the inflammatory response is the primary pathological process that contributes to the development of OA. With the number of cases of OA expected to increase in the United States, it is important that primary care providers have an understanding of …

Determinant Roles Of Dendritic Cell-Expressed Notch Delta-Like And Jagged Ligands On Anti-Tumor T Cell Immunity, Elena E. Tchekneva, Mounika U.L. Goruganthu, Roman V. Uzhachenko, Portia L. Thomas, Anneliese Antonucci, Irina Chekneva, Michael Koenig, Longzhu Piao, Anwari Akhter, Maria Teresa P. De Anquino, Parvathi Ranganathan, Nicholas Long, Thomas Magliery, Anna Valujskikh, Jason V. Evans, Rajeswara R. Arasada, Pierre P. Massion, David P. Carbone, Anil Shanker, Mikhail M. Dikov

Faculty & Staff Scholarship

Background: Notch intercellular communication instructs tissue-specific T-cell development and function. In this study, we explored the roles of dendritic cell (DC)-expressed Notch ligands in the regulation of T-cell effector function. Methods: We generated mice with CD11c lineage-specific deletion of Notch Delta-like ligand (Dll)1 and Jagged (Jag)2. Using these genetically-ablated mice and engineered pharmacological Notch ligand constructs, the roles of various Delta-like and Jagged ligands in the regulation of T-cell-mediated immunity were investigated. We assessed tumor growth, mouse survival, cytokine production, immunophenotyping of myeloid and lymphoid populations infiltrating the tumors, expression of checkpoint molecules and T-cell function in the experimental settings …

Depression Among Epileptic Patients And Its Association With Drug Therapy In Sub-Saharan Africa: A Systematic Review And Meta-Analysis., Getenet Dessie, Henok Mulugeta, Cheru Tesema Leshargie, Fasil Wagnew, Sahai Burrowes

BACKGROUND: Despite the high prevalence of epilepsy in sub-Saharan Africa and the established relationship between depression and epilepsy, the extent of comorbid epilepsy and depression in the region is still poorly understood. The objective of this systematic review and meta-analysis is to address this gap in the literature by determining the pooled prevalence of depression among epileptic patients in sub-Saharan Africa.

METHODS: A systematic desk review and electronic web-based search of PubMed, Google Scholar, EMBASE, PsycINFO and the World Health Organization's Hinari portal (which includes the SCOPUS, African Index Medicus, and African Journals Online databases) conducted from December 2, 2017 …

Conduction Abnormalities After Transcatheter Aortic Valve Replacement, S. Kanjanauthai, K. Bhasin, L. Pirelli, C. A. Kliger

Journal Articles

© RADCLIFFE CARDIOLOGY 2019 Transcatheter aortic valve replacement (TAVR) has been established as a therapeutic option for patients with severe symptomatic aortic stenosis who are of intermediate or higher surgical risk. Several periprocedural complications are reduced with newer transcatheter heart valve generations; however, conduction abnormalities and the need for permanent pacemaker implantation have remained unchanged and are the most frequent TAVR complications. The close relationship of the atrioventricular node and left bundle branch to the subaortic region explains these potential conduction abnormalities. This article highlights conduction abnormalities after TAVR with a focus on basic conduction system anatomy in relation to …

Differential Bacterial Colonization And Biofilm Formation On Punctal Occluders, M. Hadjiargyrou, E. D. Donnenfeld, L. M. Grillo, H. D. Perry

Journal Articles

© 2019 by the authors. Dry eye is a common condition that is treated primarily by topical lubricants, immunomodulation, and a variety of punctal and canalicular plugs (occluders). Biofilm formation has been reported as an ongoing problem with the clinical use of occluders. In order to explore the role of biofilm formation on occluders, we tested the bacteria strain, Staphylococcus aureus, with three different types of occluders, Delta R , Odyssey R , and Alphamed R . Scanning electron microscopy (SEM) of these occluders revealed a variation in surface appearance, with Odyssey R being the smoothest (but with grooves), followed …

Anti-Inflammatory Effects Of Apocynin On Dextran Sulfate Sodium-Induced Mouse Colitis Model, Y. J. Hwang, S. J. Nam, W. Chun, S. I. Kim, S. C. Park, C. D. Kang, S. J. Lee

Journal Articles

© 2019 Hwang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background and aim Various drugs have been developed for inflammatory bowel disease (IBD), but still there are limitations in the treatment due to the insufficient responses and significant adverse effects of immunosuppressant. Apocynin is an NADPH-oxidase inhibitor with established safety profiles. We aimed to investigate the protective efficacy of apocynin in IBD using chemicalinduced mouse colitis model. Method We induced experimental …

Imi – Defining And Classifying Myopia: A Proposed Set Of Standards For Clinical And Epidemiologic Studies, D. I. Flitcroft, M. He, J. B. Jonas, M. Jong, K. Naidoo, K. Ohno-Matsui, J. Rahi, S. Resnikoff, S. Vitale, L. Yannuzzi

Journal Articles

© 2019 The Authors. PURPOSE. We provide a standardized set of terminology, definitions, and thresholds of myopia and its main ocular complications. METHODS. Critical review of current terminology and choice of myopia thresholds was done to ensure that the proposed standards are appropriate for clinical research purposes, relevant to the underlying biology of myopia, acceptable to researchers in the field, and useful for developing health policy. RESULTS. We recommend that the many descriptive terms of myopia be consolidated into the following descriptive categories: myopia, secondary myopia, axial myopia, and refractive myopia. To provide a framework for research into myopia prevention, …

Colonic Diffuse Large B-Cell Lymphoma Hidden In Actinomycosis, S. H. Lee, S. J. Nam, S. J. Lee, S. C. Park, C. D. Kang, D. H. Choi, J. M. Park, S. K. Lee

Journal Articles

Actinomycosis can mask malignant diseases. This paper reports a case of colonic diffuse large B-cell lymphoma (DLBCL), which was misdiagnosed as abdominal actinomycosis. A 76-year-old woman presented with right flank pain and weight loss. Abdominal CT and colonoscopy revealed a huge ascending colon mass. Despite the initial impression of a malignancy, a colonoscopic biopsy revealed no malignant cells, but sulfur granules and a filamentous organism suggesting actinomycosis. Intravenous penicillin G was administered under the impression of abdominal actinomycosis but her condition deteriorated rapidly. Follow up CT showed markedly increased colon mass and new multiple nodular lesions around the ascending colon. …

Choosing Core Outcomes For Use In Clinical Trials In Ophthalmology: Perspectives From Three Ophthalmology Outcomes Working Groups, I. J. Saldanha, J. T. Le, S. D. Solomon, M. X. Repka, E. K. Akpek, T. Li, N. Afshari, A. Ambrus, H. Perry, A. Wenick, +29 Additional Authors

Journal Articles

No abstract provided.

Safety And Efficacy Of Amniotic Cytokine Extract In The Treatment Of Dry Eye Disease., E. Yeu, D. F. Goldberg, F. S. Mah, K. A. Beckman, J. I. Luchs, J. D. Solomon, D. E. White, P. K. Gupta

Journal Articles

No abstract provided.

Nonemergent Percutaneous Coronary Intervention On An Unprotected Left Main Coronary Artery Supported With Impella® Heart Pump In Patients Ineligible For Surgical Revascularization, P. M. Meraj, S. Dixon, J. Moses, K. Ibrahim, A. Schäfer, I. Akin, J. Hill, T. Schreiber, W. W. O'Neill

Journal Articles

© 2019 Perwaiz M. Meraj et al. Objectives. We sought to assess if ineligibility to coronary artery bypass grafting (CABG) constitutes a risk factor in patients who underwent a nonemergent unprotected left main coronary artery (ULMCA) percutaneous coronary intervention (PCI) with prophylactic Impella® heart pump support. Background. ULMCA PCI in patients not deemed eligible for CABG is associated with significantly worse outcomes compared to ULMCA PCI in eligible patients. Methods. Patients from the cVAD Registry and the PROTECT II trial who underwent a nonemergent ULMCA PCI were identified. We compared in-hospital mortality and major adverse cardiac and cerebrovascular event (MACCE) …

Myocardial Fibrosis And Arrhythmogenesis In Elite Athletes, S. A. Ahmad, N. Khalid, E. Shlofmitz, L. Chhabra

Journal Articles

No abstract provided.

The Role Of Novel Oral Anticoagulants And Antiplatelet Therapy After Percutaneous Coronary Intervention: Individualizing Therapy To Optimize Outcomes, E. Shlofmitz, R. Shlofmitz, M. S. Lee

Journal Articles

No abstract provided.

Effect Of Negative Pressure Wound Therapy On Wound Complications Post-Pancreatectomy, M. P. Kuncewitch, A. U. Blackham, C. J. Clark, R. M. Dodson, G. B. Russell, E. A. Levine, P. Shen

Journal Articles

No abstract provided.

Use Of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide For Chronic Wound Treatment, A. R. Oropallo

Journal Articles

© 2019 Lippincott Williams and Wilkins.All right reserved. Background: Chronic wounds represent a significant financial burden to the healthcare system and a quality-of-life burden to patients. Many chronic wounds have elevated bioburden in the form of biofilm, which has been associated with delayed wound healing. This study examined the use of a native type I collagen matrix with the antimicrobial polyhexamethylene biguanide (PCMP) in the management of bioburden and treatment of chronic, nonhealing wounds over 12 weeks. Methods: A prospective case series of PCMP enrolled adults ≥18 years old with a nonhealing wound. At week 0, the wound was prepared …

Longitudinal Low Density Lipoprotein Cholesterol Goal Achievement And Cardiovascular Outcomes Among Adult Patients With Familial Hypercholesterolemia: The Cascade Fh Registry, P. B. Duell, S. S. Gidding, R. L. Andersen, T. Knickelbine, L. Anderson, E. Gianos, P. Shrader, I. Kindt, E. C. O'Brien, J. W. Knowles, +17 Additional Authors

Journal Articles

© 2019 [The Author/The Authors] Background and aims: There are limited data from the US on outcomes of patients in specialty care for familial hypercholesterolemia (FH). Methods: CASCADE FH Registry data were analyzed to assess longitudinal changes in medication usage, in low density lipoprotein cholesterol (LDL-C) levels, and the rate of major adverse cardiovascular events (MACE (myocardial infarction, coronary revascularization, stroke or transient ischemic attack) in adults with FH followed in US specialty clinics. Results: The cohort consisted of 1900 individuals (61% women, 87% Caucasian), with mean age of 56 ± 15 years, 37% prevalence of ASCVD at enrollment, mean …

Periarticular Injection And Continuous Femoral Nerve Block Versus Continuous Femoral Nerve Block Alone On Postoperative Opioid Consumption And Pain Control Following Total Knee Arthroplasty: Randomized Controlled Trial, D. Dimaculangan, J. F. Chen, R. B. Borzio, J. J. Jauregui, V. J. Rasquinha, A. V. Maheshwari

Journal Articles

© 2017 Continuous femoral nerve block (CFNB) has been used to prevent the breakthrough pain after total knee arthroplasty (TKA). Multimodal drug injection (PMDI) has also been shown to decrease opioid consumption and pain. We investigated whether the use of PMDI further improves analgesic and rehabilitation outcomes when used in conjunction with CFNB. This is a prospective randomized controlled study of 44 patients undergoing primary TKA. The treatment group (n = 23) received a PMDI of combined ropivacaine, epinephrine, ketorolac and morphine, and the controlled group (n = 21) received saline at wound closure. Total opioid consumption, pain scores, knee …

Optimum Anatomic Socket Position And Sizing For The Direct Anterior Approach: Impingement And Instability, N. Mercer, E. Hawkins, L. Menken, A. Deshmukh, P. Rathod, J. A. Rodriguez

Journal Articles

© 2019 A comprehensive strategy is important for ensuring reproducible and safe acetabular component sizing and positioning. Presented here is our approach for anatomic acetabular component positioning in direct anterior total hip arthroplasty. This strategy has evolved with our understanding of the ramifications of socket sizing and positioning on instability and impingement. Data collected by a single surgeon (J.A.R.) between 2009 and 2011 influenced our current paradigm. We compare the sizing and positioning parameters of the anterior and posterior approach, thus demonstrating how the 2 are different. By highlighting these differences, we hope to provide a clear, defined approach to …