Medical Specialties Commons^™

Rsv-Encoded Ns2 Promotes Epithelial Cell Shedding And Distal Airway Obstruction, R. M. Liesman, U. J. Buchholz, C. L. Luongo, A. D. Proia, J. P. Divicenzo, P. L. Collins, R. J. Pickles

Osteopathic Medicine, Jerry M. Wallace School of

Respiratory syncytial virus (RSV) infection is the major cause of bronchiolitis in young children. The factors that contribute to the increased propensity of RSV-induced distal airway disease compared with other commonly encountered respiratory viruses remain unclear. Here, we identified the RSV-encoded nonstructural 2 (NS2) protein as a viral genetic determinant for initiating RSV-induced distal airway obstruction. Infection of human cartilaginous airway epithelium (HAE) and a hamster model of disease with recombinant respiratory viruses revealed that NS2 promotes shedding of infected epithelial cells, resulting in two consequences of virus infection. First, epithelial cell shedding accelerated the reduction of virus titers, presumably …

Effects Of Vitamin D3 And Its Chemical Analogs On The Growth Of Hodgkin’S Lymphoma, In Vitro, Rajendra Ghardbaran, Bo Zhang, Luis Valerio, Onyekwere Onwumere, Madeline Wong, Jason Mighty, Stephen Redenti

Publications and Research

Objective: Vitamin D receptor (VDR) activities have been noted for a number of B cell malignancies which showed varying sensitivities to vitamin D3 (1,25-dihydroxyvitamin D3, VD3, calcitriol) and its synthetic analogs. The objective of this study was to address the potential effects of VD3 and vitamin D3 analogs (VDAs) on the growth of Hodgkin’s lymphoma (HL), a malignant pathology of B cell origin, in vitro.

Results: Immunofluorescence staining showed the expression of VDR by primary Hodgkin’s (H) and Reed–Sternberg (RS)—HRS-tumor cells in HL histological sections. Western blot analyses revealed expression of VDR in the HL cell lines Hs445, HDLM2, KMH2, …

Search And Rescue: The Importance Of Using Tracking Systems In Rural 135 Operations, April Larsen, Brent D. Bowen

Student Works

In January 2020, under the NextGen initiative put in place by the Federal Aviation Administration (FAA), all aircraft flying in controlled airspace, both general aviation and commercial operations, will be required to have an Automatic Dependent Surveillance – Broadcast (ADS–B) system installed and operational. However, this is not required for Title 14 Code of Federal Regulations (CFR) Part 135 operations taking place outside of controlled airspace. Part 135 of the Federal Aviation Regulations (FAR) refers to aircraft operating as on-demand or air taxi services. A substantial amount of these operator’s bases, as well as flights, are conducted outside of controlled …

3 Cm Researchers Honored With Endowed Chairs, Children's Mercy Hospital

Our Story Continues

Susan Abdel-Rahman, PharmD received the Marion Merrell Dow/Missouri Chair in Pediatric Clinical Pharmacology. Shao Jiang, MD received the Frederick J. McCoy Endowed Chair in Plastic Surgery and Craniofacial Research. Cy Nadler, PhD received the Josh Barnds and Stella Carlson Endowed Professorship for Autism.

A Novel Function Of Membrane-Associated Collagen In Cancer Metastasis, Hui Zhang, Ren Xu

Markey Cancer Center Faculty Publications

No abstract provided.

The Vitamin C, Thiamine And Steroids In Sepsis (Victas) Protocol: A Prospective, Multi-Center, Double-Blind, Adaptive Sample Size, Randomized, Placebo-Controlled, Clinical Trial., David N. Hager, Michael H. Hooper, Gordon R. Bernard, Laurence W. Busse, E. Wesley Ely, Alpha A. Fowler, David F. Gaieski, Alex Hall, Jeremiah S. Hinson, James C. Jackson, Gabor D. Kelen, Mark Levine, Christopher J. Lindsell, Richard E. Malone, Anna Mcglothlin, Richard E. Rothman, Kert Viele, David W. Wright, Jonathan E. Sevransky, Greg S. Martin

Department of Emergency Medicine Faculty Papers

BACKGROUND: Sepsis accounts for 30% to 50% of all in-hospital deaths in the United States. Other than antibiotics and source control, management strategies are largely supportive with fluid resuscitation and respiratory, renal, and circulatory support. Intravenous vitamin C in conjunction with thiamine and hydrocortisone has recently been suggested to improve outcomes in patients with sepsis in a single-center before-and-after study. However, before this therapeutic strategy is adopted, a rigorous assessment of its efficacy is needed.

METHODS: The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) trial is a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled trial. It will enroll …

Diagnostic Utility Of Genome-Wide Dna Methylation Testing In Genetically Unsolved Individuals With Suspected Hereditary Conditions., Erfan Aref-Eshghi, Eric G Bend, Samantha Colaiacovo, Michelle Caudle, Rana Chakrabarti, Melanie Napier, Lauren Brick, Lauren Brady, Deanna Alexis Carere, Michael A Levy, Jennifer Kerkhof, Alan Stuart, Maha Saleh, Arthur L Beaudet, Chumei Li, Maryia Kozenko, Natalya Karp, Chitra Prasad, Victoria Mok Siu, Mark A Tarnopolsky, Peter J Ainsworth, Hanxin Lin, David I Rodenhiser, Ian D Krantz, Matthew A Deardorff, Charles E Schwartz, Bekim Sadikovic

Paediatrics Publications

Conventional genetic testing of individuals with neurodevelopmental presentations and congenital anomalies (ND/CAs), i.e., the analysis of sequence and copy number variants, leaves a substantial proportion of them unexplained. Some of these cases have been shown to result from DNA methylation defects at a single locus (epi-variants), while others can exhibit syndrome-specific DNA methylation changes across multiple loci (epi-signatures). Here, we investigate the clinical diagnostic utility of genome-wide DNA methylation analysis of peripheral blood in unresolved ND/CAs. We generate a computational model enabling concurrent detection of 14 syndromes using DNA methylation data with full accuracy. We demonstrate the ability of this …

Abstract 103: Clinical Process And Outcome Improvements Based On Within Site Communication: Insights From The Patient Navigator Acute Myocardial Infarction And Heart Failure Program, Nancy M. Albert, Tyler J Gluckman, Robert Mcnamara, Gregg C. Fonarow, Adnan Malik, Ralph G. Brindis, Di Lu, Smita Negi, Susan Rogers, Julie Mobayed

Articles, Abstracts, and Reports

Background: Team communication about hospital quality efforts in acute myocardial infarction and heart failure (AMI-HF) may affect compliance with hospital transitional care metrics.

Methods: At 2 years, hospitals (n=35) participating in the Patient Navigator Program completed surveys on 5 types of communication (sharing meeting minutes, regular team meetings or conference calls with team leaders, a shared checklist, and electronic medical record (EMR)-directed communication) supporting program implementation. Results were assessed for association with 3 outcomes (30-day unadjusted AMI-HF readmission and in-hospital risk adjusted AMI death) and 14 processes: left ventricular systolic dysfunction evaluation, prescription of renin-angiotensin system and beta-blocker medications; identifying …

Orthokeratinized Odontogenic Cyst (Ooc): Clinicopathological And Radiological Features Of A Series Of 10 Cases, Nasir Ud Din, Maha Zubair, Jamshid Abdul-Ghafar, Zia Ullah Khan, Zubair Ahmad

Department of Pathology and Laboratory Medicine

Background: Orthokeratinized Odontogenic Cyst (OOC) is a rare, developmental odontogenic cyst which was considered in the past to be a variant of Odontogenic keratocyst (OKC) later renamed as keratocystic odontogenic tumor (KCOT). The treatment of OOC is by enucleation and the prognosis, following enucleation is excellent with a recurrence rate of less than 2%. On the other hand, OKC has a recurrence rate between 8 and 25% after enucleation. Thus it is important to differentiate between the two entities.
Methods: All cases reported in our section as OOC during the period 2013 to 2018 were retrieved from the surgical pathology …

Comparison Of Administratively Collected (Icd-10) Vs. Prospectively Collected Adverse Event Data, Joseph G. O'Sullivan

OHSU-PSU School of Public Health Annual Conference

Background: Accurate adverse event reporting is vital for analyzing outcomes and implementing the proper systemic efforts to improve them. Complication reporting and tracking has implications in medical practice, billing, and ultimately patient safety.

Objectives: To determine accuracy of complications reported in administrative data compared to prospectively obtained data.

Methods: A total of 1,213 patients undergoing spine surgery were followed over a two-year period (January 2011 to December 2012) sampled at a single institution. All patients undergoing spine surgery were eligible for inclusion in the study. Prospective data collection of adverse events was accomplished using OrthoSAVES, a standardized …

A New Method For Assessing Smoking Behavior In Orthopaedic Patients, David Gallacher

OHSU-PSU School of Public Health Annual Conference

“A New Method for Assessing Smoking Behavior in Orthopaedic Patients”

Background:Tobacco use is associated with post-operative complications and self-reporting often introduces a bias that underestimates the true exposure. Traditional tobacco testing methods, including serum cotinine are associated with issues of specificity, as they do not differentiate active smokers from those on nicotine replacement therapies (NRTs). This study intends to evaluate the effectiveness of point-of-care carbon monoxide (CO) breathalyzer test to assess patient smoking status and to differentiate active smokers from those using NRTs.

Methods:Eligible patients will be >18 years old and indicated for joint or fracture surgery at …

Validity Of An Atopic Dermatitis Outcome Measure For Real-World Clinical Practice, Christina Topham, Dylan Haynes, Molly Brazil, Eric Simpson

OHSU-PSU School of Public Health Annual Conference

Introduction: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the United States. AD is associated with reduced quality of life and substantial financial costs, making it burdensome at an individual and population level. Disease severity outcome measures are validated tools to assess severity and therapeutic response. Recent consensus statements have identified gold-standard outcome measures for AD in clinical trials, but further work is needed evaluating outcome measures feasible for clinical practice.

Objective: To investigate the validity and feasibility of the product of investigator global assessment and body surface area (IGA x BSA) as an outcome measure …

Improving Access To Rare Disease Clinical Trials Through Telemedicine, Dylan Haynes, Christina Topham, Teri Greiling

OHSU-PSU School of Public Health Annual Conference

Introduction: Rare diseases affect nearly 400 million individuals worldwide. The geographic density of any single disease, however, can prohibit access to care and research efforts. Telemedicine has improved access barriers in the clinical setting, though its application in rare disease trials has not been evaluated.

Objective: To assess the impact on access to care of videoconferencing in a rare disease clinical trial.

Materials and Methods: Preliminary analysis was performed on the first five participants to complete our ongoing trial (NCT03485976) evaluating the efficacy of ixekizumab for the treatment of pityriasis rubra pilaris. Participants were required to travel to Oregon Health …

The Effect Of Teenagers' Sleeping Deprivation On Cognition/Academic Outcome And Obesity, Dongyub Back

Annual Graduate Student Symposium

Sleeping disorder, deprivation, and deficient are common public health problem. Nearly 70 million American have chronic sleep disorders(Sleep Deprivation and Deficiency. 2019). Sleep deprivation is well known as a significant cause which increases the risk of a mental and physical health problem such as poor self-esteem, memory loss, obesity, and diabetes. This literature research focused on the sleeping deprivation of deficient of students. Also, trying to find the relation between sleeping derivation and students' health, education, and well-being will be reviewed by previous research. To reveal the impact of sleeping deprivation and deficient, this research will provide the conclusion and …

Assessing The Criteria For Definition Of Perimembranous Ventricular Septal Defects In Light Of The Search For Consensus, Justin T. Tretter, Vi-Hue Tran, Seth Gray, Hieu Ta, Rohit S. Loomba, William O'Connor, Diane E. Spicer, Andrew C. Cook, Robert H. Anderson

Pathology and Laboratory Medicine Faculty Publications

Background: Discussions continue as to whether ventricular septal defects are best categorized according to their right ventricular geography or their borders. This is especially true when considering the perimembranous defect. Our aim, therefore, was to establish the phenotypic feature of the perimembranous defect, and to establish the ease of distinguishing its geographical variants.

Methods and results: We assessed unrepaired isolated perimembranous ventricular defects from six historic archives, subcategorizing them using the ICD-11 coding system. We identified 365 defects, of which 94 (26%) were deemed to open centrally, 168 (46%) to open to the outlet, and 84 (23%) to the inlet …

Incorporating Pathway Information Into Feature Selection Towards Better Performed Gene Signatures, Suyan Tian, Chi Wang, Bing Wang

Biostatistics Faculty Publications

To analyze gene expression data with sophisticated grouping structures and to extract hidden patterns from such data, feature selection is of critical importance. It is well known that genes do not function in isolation but rather work together within various metabolic, regulatory, and signaling pathways. If the biological knowledge contained within these pathways is taken into account, the resulting method is a pathway-based algorithm. Studies have demonstrated that a pathway-based method usually outperforms its gene-based counterpart in which no biological knowledge is considered. In this article, a pathway-based feature selection is firstly divided into three major categories, namely, pathway-level selection, …

A Curious Critic's Guide On Writing A Five-Star Student Evaluation: Five Lessons Learned From Food Blogging., Xiao Chi Zhang, Meryl Abrams, Dimitrios Papanagnou

Department of Emergency Medicine Faculty Papers

Timely feedback is critical in promoting learner self-reflection. When provided effectively, feedback can assist learners with the acquisition of new skills and knowledge in the ever-changing and complex landscape of healthcare. While the literature is replete on methods to provide feedback, faculty and supervisors receive little, if any, training on writing constructive feedback. Abbreviated comments (i.e., 'good job' or 'read more') provide little information on specific behaviors learners can change. As an avid food enthusiast and restaurant reviewer, I, too, am met with the challenge of writing a meaningful, constructive review (or evaluation) of a dining experience. To better assist …

Seasonal Changes In Sleep, Rpe, And Scoring Percentage In Division One Collegiate Female Basketball Players, Lindsay Perrin, Dr. Stephen Rossi

Honors College Theses

Basketball season occurs over several months and involves heavy traveling, training, competing, and scholarly duties. These demands do not allow much time for rest and recovery. A lack in the quantity and quality of sleep can reduce the ability to manage stress and reduce recovery from training and competition. This can affect the health and well-being of the athlete and their success on the court. In college, sleep schedules may change from high school by staying up later and sleeping in more. College students typically sleep between six and seven hours a night which is less than the recommended nine …

Peritoneal Dialysis Vintage And Glucose Exposure But Not Peritonitis Episodes Drive Peritoneal Membrane Transformation During The First Years Of Pd., Maria Bartosova, Betti Schaefer, Karel Vondrak, Peter Sallay, Christina Taylan, Rimante Cerkauskiene, Maria Dzierzega, Gordana Milosevski-Lomic, Rainer Büscher, Ariane Zaloszyc, Philipp Romero, Felix Lasitschka, Bradley A. Warady, Franz Schaefer, Akos Ujszaszi, Claus Peter Schmitt

Manuscripts, Articles, Book Chapters and Other Papers

The impact of peritoneal dialysis (PD) associated peritonitis on peritoneal membrane integrity is incompletely understood. Children are particularly suited to address this question, since they are largely devoid of preexisting tissue damage and life-style related alterations. Within the International Peritoneal Biobank, 85 standardized parietal peritoneal tissue samples were obtained from 82 children on neutral pH PD fluids with low glucose degradation product (GDP) content. 37 patients had a history of peritonitis and 16 of the 37 had two or more episodes. Time interval between tissue sampling and the last peritonitis episode was 9 (4, 36) weeks. Tissue specimen underwent digital …

Expanding International Health Curriculum For The Internal Medicine Residency At Mmc, Brian King, Hassan Mahmoud, Anthony Pastore

Thinking Matters Symposium Archive

While internal medicine residents at Maine Medical Center provide care for many refugees and immigrants, there is not a formal international health curriculum to equip residents to care for this vulnerable population. Since 2002, 3,793 refugees have arrived in Maine for resettlement. Our aim was to survey residents about their interest in added international health instruction and design an educational curriculum for these physicians.

Benefits Of Onsite Health Programs In The Corporate Setting, Nathan Cook

Thinking Matters Symposium Archive

Worksite health care clinics and corporate wellness programs are becoming a staple of companies at all levels. Companies are finding that having onsite healthcare clinics as well as comprehensive wellness programs are not only good incentives for employees but actually able to save large amounts of money with injury prevention, decrease in lost productivity and a number of other factors. A 2010 meta- analysis looking at the Return-Of Investment (ROI) found that there was an average of $3.27 per dollar spent on wellness initiatives ROI. Yearly savings can be upwards of $225,000 in some cases as the Sygenta Crop Production …

Program Proposal For Occupational Therapy In Post-Bariatric Surgery Aftercare Program, Deborah Ruediger

Occupational Therapy Collection

The focus of the poster presentation is to create a program proposal to include occupational therapy intervention after bariatric surgery to incorporate what the clients value in their occupations into a program that builds new and healthy habits. Most healthcare systems focus solely on the medical and nutritional aspects of weight loss after bariatric surgery. This focus limits the client as it does not address the modification of their occupations and maladaptive behaviors to ensure long-term success. Through the introduction of this program, the goal is to integrate occupational therapy as a standard of care post-bariatric surgery to ensure the …

Automated Assessment Of Acute Aortic Dissection On Thoracic Ct Using Deep Learning, Varun Singh, Richard Gorniak, Md, Adam Flanders, Md, Paras Lakhani, Md

Department of Radiology Posters

Purpose

To assess the efficacy of deep convolutional neural networks (DCNNs ) in differentiating acute aortic dissections from non-dissected aortas on thoracic CT.

Implementing Zero/Neutral Displacement Iv Connectors To Reduce Blood Stream Infections, Kirsten Mitchell, Barbara Mcclaskey

Posters

Catheter related blood stream infections are a major problem in the United States and account for over $225 million each year with over 1,300 infections occurring each day. By researching the most effective type of IV connector, health care providers can provide the best and safest care possible to patients requiring IV access. Zero/neutral IV connectors may be the answer to decreasing these infections as they produce no reflux in the connector which is a breeding ground for bacteria and occlusions. This literature review found that zero/neutral connectors performed better than positive and negative IV connectors when comparing both reflux …

Accuracy Of Self-Collected Vaginal Swabs In The Diagnosis Of Bacterial Vaginosis, Vaginal Candidiasis, And Trichomoniasis, Anna Chase

Thinking Matters Symposium Archive

Vaginitis is the most common gynecological problem seen in primary care. It is estimated to account for 10 million primary care visits each year. The most common causes of vaginitis - responsible for up to 90% of cases - are bacterial vaginosis (BV), vaginal candidiasis (“yeast infections”), and trichomoniasis. The purpose of this evidence-based project was to evaluate whether self-collected vaginal swabs are as accurate as those collected by a provider during a speculum exam in the diagnosis of BV, yeast infections, and trichomoniasis.

In order to appropriately diagnose and treat vaginitis, samples from a vaginal swab are often required. …

Measuring Birth Trauma Rates In Maine Using Public Data, Mike Lapika

Thinking Matters Symposium Archive

An increasing number of states are creating databases that collect and organize health insurance claims from public and private health care payers. Since December 2016, at least 18 states have these “all-payer claims databases” (APCDs), including Maine. APCDs are intended to inform cost containment and quality improvement by increasing transparency and informing consumer choice. For this project, we assessed how Maine’s APCD data might be used to produce standardized quality measures across facilities in the state. Specifically, we tested a birth outcome quality measure developed by the Agency for Healthcare Research and Quality (AHRQ), Birth Trauma – Injury to Neonate …

Male Determining Gene Nix May Bring An End To Transmission Of Diseases Through Mosquitoes, Mohammed Mahdi

Thinking Matters Symposium Archive

Female mosquitoes take blood from humans to gain protein needed to produce eggs, and in the process they can transmit viruses, such as Zika, Dengue, and chikungunya, or parasites, such as malaria. Male mosquitoes do not transmit diseases. This literature review will examine what is known about how sex is determined in mosquitoes and how this can be used to manipulate the females that spread diseases to humans. Using CRISPR Cas9, the lab of Zhijian Tu removed the Nix gene from mosquito embryos; all of these were feminized. Ectopic overexpression of Nix gene product in mosquito embryos caused even genetically …

Physician Stress: Is The Electronic Health Record To Blame?, Zack Ward

Dissertations

The purpose of this study was to explore the potential relationship between Family Medicine physician burnout and the electronic health record. To do so, this study utilized the Copenhagen Burnout Inventory to assess burnout among physicians, along with specific questions regarding usage of the electronic health record and measurement of physician perceptions of the electronic health record. Members of the Kentucky Academy of Family Physicians were sent two separate invitations to participate in the study twice over a one-month period via email.

The study yielded no significant differences in Family Medicine physician demographics and their degree of burnout, or the …

Is The Current Concussion Protocol For Student Athletes Enough?, Trey Morgan, Barbara Mcclaskey

Posters

In the world of sports there are bound to be accidents and one of the most common kinds of accidents are concussions. It has been reported that 10-20% of high school student athletes will experience a concussion. The purpose of this study was to examine the current concussion protocol for student athletes and to identify the best practices for a diagnosis and follow-up to decrease the likelihood of any severe brain damage. The methodology was a literature review. Evidence in the literature reported that individual educational plans (IEP) have been shown to be good at helping student athletes get back …

Metabolism During Pregnancy And Postpartum: How Does It Change And What Factors Influence It?, Kristin Yoho

Masters Theses & Specialist Projects

PURPOSE: Pregnancy is a physically impactful process in a woman’s life. During this time, a woman will gain weight and research has shown that many women will retain some extra weight after delivery. Because of this, recovery in the postpartum period is pivotal to avoiding the implications of weight retention. The postpartum period is vastly understudied in both the research and medical communities and this gap between pregnancy and postpartum research needs to be bridged. Therefore, the purpose of this study was to investigate metabolic changes from pregnancy to postpartum and to study how factors such as sleep and breastfeeding …