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Medical Specialties Commons™

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2015

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Articles 1861 - 1890 of 2431

Full-Text Articles in Medical Specialties

Γ-Secretase Inhibitor Alleviates Acute Airway Inflammation Of Allergic Asthma In Mice By Downregulating Th17 Cell Differentiation, Weixi Zhang, Xueya Zhang, Anqun Sheng, Cuiye Weng, Tingting Zhu, Wei Zhao, Changchong Li Jan 2015

Γ-Secretase Inhibitor Alleviates Acute Airway Inflammation Of Allergic Asthma In Mice By Downregulating Th17 Cell Differentiation, Weixi Zhang, Xueya Zhang, Anqun Sheng, Cuiye Weng, Tingting Zhu, Wei Zhao, Changchong Li

Pediatrics Publications

T helper 17 (Th17) cells play an important role in the pathogenesis of allergic asthma. Th17 cell differentiation requires Notch signaling. γ-Secretase inhibitor (GSI) blocks Notch signaling; thus, it may be considered as a potential treatment for allergic asthma. The aim of this study was to evaluate the effect of GSI on Th17 cell differentiation in a mouse model of allergic asthma. OVA was used to induce mouse asthma model in the presence and absence of GSI. GSI ameliorated the development of OVA-induced asthma, including suppressing airway inflammation responses and reducing the severity of clinical signs. GSI also significantly …

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Long-Term Survival Rates After Resection For Locally Advanced Kidney Cancer: Memorial Sloan Kettering Cancer Center 1989 To 2012 Experience, W. M. Bazzi, D. D. Sjoberg, M. A. Feuerstein, A. Maschino, S. Verma, M. Bernstein, M. F. O'Brien, T. Jang, W. Lowrance, P. Russo, +1 Additional Author Jan 2015

Long-Term Survival Rates After Resection For Locally Advanced Kidney Cancer: Memorial Sloan Kettering Cancer Center 1989 To 2012 Experience, W. M. Bazzi, D. D. Sjoberg, M. A. Feuerstein, A. Maschino, S. Verma, M. Bernstein, M. F. O'Brien, T. Jang, W. Lowrance, P. Russo, +1 Additional Author

Journal Articles

Purpose: We analyzed the 23-year Memorial Sloan Kettering Cancer Center experience with surgical resection, and concurrent adrenalectomy and lymphadenectomy for locally advanced nonmetastatic renal cell carcinoma. Materials and Methods: We retrospectively reviewed the records of 802 patients who underwent nephrectomy with or without concurrent adrenalectomy or lymphadenectomy for locally advanced renal cell carcinoma, defined as stage T3 or greater and M0. Patients who received adjuvant treatment within 3 months of surgery or had fewer than 3 months of followup or bilateral renal masses at presentation were excluded from analysis. Five and 10-year progression-free and overall survival was estimated by the …

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Comparing Open Radical Cystectomy And Robot-Assisted Laparoscopic Radical Cystectomy: A Randomized Clinical Trial, B. H. Bochner, G. Dalbagni, D. D. Sjoberg, J. Silberstein, G. E. K. Paz, S. M. Donat, J. A. Coleman, S. Mathew, A. Vickers, G. C. Schnorr, M. A. Feuerstein, B. Rapkin, R. O. Parra, H. W. Herr, V. P. Laudone Jan 2015

Comparing Open Radical Cystectomy And Robot-Assisted Laparoscopic Radical Cystectomy: A Randomized Clinical Trial, B. H. Bochner, G. Dalbagni, D. D. Sjoberg, J. Silberstein, G. E. K. Paz, S. M. Donat, J. A. Coleman, S. Mathew, A. Vickers, G. C. Schnorr, M. A. Feuerstein, B. Rapkin, R. O. Parra, H. W. Herr, V. P. Laudone

Journal Articles

Background: Open radical cystectomy (ORC) and urinary diversion in patients with bladder cancer (BCa) are associated with significant perioperative complication risk. Objective: To compare perioperative complications between robot-assisted radical cystectomy (RARC) and ORC techniques. Design, setting, and participants: A prospective randomized controlled trial was conducted during 2010 and 2013 in BCa patients scheduled for definitive treatment by radical cystectomy (RC), pelvic lymph node dissection (PLND), and urinary diversion. Patients were randomized to ORC/PLND or RARC/PLND, both with open urinary diversion. Patients were followed for 90 d postoperatively. Intervention: Standard ORC or RARC with PLND; all urinary diversions were performed via …

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Development And Preliminary Testing Of Progress: A Web-Based Education Program For Prostate Cancer Survivors Transitioning From Active Treatment, S. M. Miller, S. V. Hudson, S. K. A. Hui, M. A. Diefenbach, L. Fleisher, M. Buyyounouski, C. Denlinger, C. Miyamoto, A. Reese, J. Baman, +6 Additional Authors Jan 2015

Development And Preliminary Testing Of Progress: A Web-Based Education Program For Prostate Cancer Survivors Transitioning From Active Treatment, S. M. Miller, S. V. Hudson, S. K. A. Hui, M. A. Diefenbach, L. Fleisher, M. Buyyounouski, C. Denlinger, C. Miyamoto, A. Reese, J. Baman, +6 Additional Authors

Journal Articles

This formative research study describes the development and preliminary evaluation of a theory-guided, online multimedia psycho-educational program (PROGRESS) designed to facilitate adaptive coping among prostate cancer patients transitioning from treatment into long-term survivorship. Guided by the Cognitive-Social Health Information Processing Model (C-SHIP) and using health communications best practices, we conducted a two-phase, qualitative formative research study with early stage prostate cancer patients (n = 29) to inform the Web program development. Phase 1 included individual (n = 5) and group (n = 12) interviews to help determine intervention content and interface. Phase 2 employed iterative user/usability testing (n = 12) …

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Decision-Making Processes Among Prostate Cancer Survivors With Rising Psa Levels: Results From A Qualitative Analysis, M. J. Shen, C. J. Nelson, E. Peters, S. F. Slovin, S. J. Hall, M. Hall, P. C. Herrera, E. A. Leventhal, H. Leventhal, M. A. Diefenbach Jan 2015

Decision-Making Processes Among Prostate Cancer Survivors With Rising Psa Levels: Results From A Qualitative Analysis, M. J. Shen, C. J. Nelson, E. Peters, S. F. Slovin, S. J. Hall, M. Hall, P. C. Herrera, E. A. Leventhal, H. Leventhal, M. A. Diefenbach

Journal Articles

Background. Prostate cancer survivors with a rising prostate-specific antigen (PSA) level have few treatment options, experience a heightened state of uncertainty about their disease trajectory that might include the possibility of cancer metastasis and death, and often experience elevated levels of distress as they have to deal with a disease they thought they had conquered. Guided by self-regulation theory, the present study examined the cognitive and affective processes involved in shared decision making between physicians and patients who experience a rising PSA after definitive treatment for prostate cancer. Methods. In-depth interviews were conducted with 34 prostate cancer survivors who had …

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A Quantitative Proteomics-Based Signature Of Platinum Sensitivity In Ovarian Cancer Cell Lines, G. Fan, K. O. Wrzeszczynski, C. Fu, G. Su, D. J. Pappin, R. Lucito, N. K. Tonks Jan 2015

A Quantitative Proteomics-Based Signature Of Platinum Sensitivity In Ovarian Cancer Cell Lines, G. Fan, K. O. Wrzeszczynski, C. Fu, G. Su, D. J. Pappin, R. Lucito, N. K. Tonks

Journal Articles

Although DNA encodes the molecular instructions that underlie the control of cell function, it is the proteins that are primarily responsible for implementing those instructions. Therefore quantitative analyses of the proteome would be expected to yield insights into important candidates for the detection and treatment of disease. We present an iTRAQ (isobaric tag for relative and absolute quantification)-based proteomic analysis of ten ovarian cancer cell lines and two normal ovarian surface epithelial cell lines. We profiled the abundance of 2659 cellular proteins of which 1273 were common to all 12 cell lines. Of the 1273, 75 proteins exhibited elevated expression …

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Oncologic Outcomes After Transoral Robotic Surgery : A Multi-Institutional Study, J. R. De Almeida, R. Li, J. S. Magnuson, R. V. Smith, E. Moore, G. Lawson, M. Remacle, I. Ganly, D. H. Kraus, F. C. Holsinger, +12 Additional Authors Jan 2015

Oncologic Outcomes After Transoral Robotic Surgery : A Multi-Institutional Study, J. R. De Almeida, R. Li, J. S. Magnuson, R. V. Smith, E. Moore, G. Lawson, M. Remacle, I. Ganly, D. H. Kraus, F. C. Holsinger, +12 Additional Authors

Journal Articles

IMPORTANCE: Large patient cohorts are necessary to validate the efficacy of transoral robotic surgery (TORS) in the management of head and neck cancer. OBJECTIVES: To review oncologic outcomes of TORS from a large multi-institutional collaboration and to identify predictors of disease recurrence and disease-specific mortality. DESIGN, SETTING, AND PARTICIPANTS: A retrospective review of records from 410 patients undergoing TORS for laryngeal and pharyngeal cancers from January 1, 2007, through December 31, 2012, was performed. Pertinent data were obtained from 11 participating medical institutions. INTERVENTIONS: Select patients received radiation therapy and/or chemotherapy before or after TORS. MAIN OUTCOMES AND MEASURES: Locoregional …

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Measurement Of Cochlear Implant Electrode Position From Intraoperative Post-Insertion Skull Radiographs: A Validation Study, M. Svrakic, D. R. Friedmann, P. M. Berman, A. J. Davis, J. T., Jr. Roland, M. A. Svirsky Jan 2015

Measurement Of Cochlear Implant Electrode Position From Intraoperative Post-Insertion Skull Radiographs: A Validation Study, M. Svrakic, D. R. Friedmann, P. M. Berman, A. J. Davis, J. T., Jr. Roland, M. A. Svirsky

Journal Articles

OBJECTIVE: To validate a method of measuring angular depth of insertion (aDOI) as well as positional depth of each electrode contact in a cochlear implant by using intraoperative postinsertion skull radiographs. STUDY DESIGN: Retrospective review. SETTING: Tertiary referral center. PATIENTS: Intraoperative postinsertion radiographs obtained from 18 cochlear implant recipients were chosen for analysis. One high-resolution computer tomography scan of the head with the electrode in place was also analyzed. One cadaveric temporal bone with an inserted electrode provided additional data for analysis. INTERVENTION: aDOI and position of each electrode contact were measured from the radiographs using readily available software. High-resolution …

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Multiple Radiolucencies Of The Jaws In A 6 Year Old, J.T. Hansford, R.D. Kelsch, M. Wiltz Jan 2015

Multiple Radiolucencies Of The Jaws In A 6 Year Old, J.T. Hansford, R.D. Kelsch, M. Wiltz

Journal Articles

No abstract provided.

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Notch Receptor Expression In Human Brain Arteriovenous Malformations, S. Hill-Felberg, H. H. Wu, S. A. Toms, A. R. Dehdashti Jan 2015

Notch Receptor Expression In Human Brain Arteriovenous Malformations, S. Hill-Felberg, H. H. Wu, S. A. Toms, A. R. Dehdashti

Journal Articles

The roles of the Notch pathway proteins in normal adult vascular physiology and the pathogenesis of brain arteriovenous malformations are not well-understood. Notch 1 and 4 have been detected in human and mutant mice vascular malformations respectively. Although mutations in the human Notch 3 gene caused a genetic form of vascular stroke and dementia, its role in arteriovenous malformations development has been unknown. In this study, we performed immunohistochemistry screening on tissue microarrays containing eight surgically resected human brain arteriovenous malformations and 10 control surgical epilepsy samples. The tissue microarrays were evaluated for Notch 1-4 expression. We have found that …

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Radionuclide Imaging: Past, Present And Future Outlook In The Diagnosis Of Infected Prosthetic Joints, L. Brammen, C. Palestro, H. Sinzinger Jan 2015

Radionuclide Imaging: Past, Present And Future Outlook In The Diagnosis Of Infected Prosthetic Joints, L. Brammen, C. Palestro, H. Sinzinger

Journal Articles

Objective: A serious complication of joint replacement surgery is infection, which results in prolonged invalidity as well as removal and subsequent re-implantation after lengthy antibiotic therapy. In terms of diagnostic imaging, nuclear medicine has presented several tracers and imaging modalities over the years to be used in prosthetic joint infection. The PubMed/MEDLINE literature database was systematically examined for publications on infection, arthroplasty, joint replacement, prosthetic joint, gallium, labeled leukocytes, sulfur colloid, antimicrobial peptides, Fluorine-18-fluorodeoxyglucose (F-18-FDG), positron emission tomography/computed tomography (PET-CT), and single-photon emission (SPET-CT). This was determined to be a comprehensive review, not a meta-analysis of prosthetic joint infection and …

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Detection Of Symptomatic Carotid Plaque Using Source Data From Mr And Ct Angiography: A Correlative Study, A. Gupta, H. Baradaran, E. E. Mtui, H. Kamel, A. Pandya, A. Giambrone, C. Iadecola, P. C. Sanelli Jan 2015

Detection Of Symptomatic Carotid Plaque Using Source Data From Mr And Ct Angiography: A Correlative Study, A. Gupta, H. Baradaran, E. E. Mtui, H. Kamel, A. Pandya, A. Giambrone, C. Iadecola, P. C. Sanelli

Journal Articles

BACKGROUND: Carotid plaque MRI has been a useful method to characterize vulnerable atherosclerotic plaque elements. Recent investigations have suggested that source images from CT angiography (CTA) and MR angiography (MRA) can identify the simple high-risk features of symptom-producing carotid artery plaque. We studied the correlation and relative diagnostic accuracies of CTA and MRA source images in detecting symptomatic carotid artery plaque. METHODS: Subjects were eligible if they had carotid stenosis between 50 and 99% and had MRA and CTA exams performed within 10 days of one another. We measured the soft (non-calcified) plaque and hard (calcified) plaque thickness on CTA …

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Evaluating Blood-Brain Barrier Permeability In Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage, J. Ivanidze, K. Kesavabhotla, O. N. Kallas, D. Mir, H. Baradaran, A. Gupta, A. Z. Segal, J. Claassen, P. C. Sanelli Jan 2015

Evaluating Blood-Brain Barrier Permeability In Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage, J. Ivanidze, K. Kesavabhotla, O. N. Kallas, D. Mir, H. Baradaran, A. Gupta, A. Z. Segal, J. Claassen, P. C. Sanelli

Journal Articles

BACKGROUND AND PURPOSE: Patients with SAH are at increased risk of delayed infarction. Early detection and treatment of delayed infarction remain challenging. We assessed blood-brain barrier permeability, measured as permeability surface area product, by using CTP in patients with SAH with delayed infarction. MATERIALS AND METHODS: We performed a retrospective study of patients with SAH with delayed infarction on follow-up NCCT. CTP was performed before the development of delayed infarction. CTP data were postprocessed into permeability surface area product, CBF, and MTT maps. Coregistration was performed to align the infarcted region on the follow-up NCCT with the corresponding location on …

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Emphysematous Pyelonephritis, N. Kim, S. Machnicki Jan 2015

Emphysematous Pyelonephritis, N. Kim, S. Machnicki

Journal Articles

No abstract provided.

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Prodromal Symptom Severity Predicts Accelerated Gray Matter Reduction And Third Ventricle Expansion Among Clinically High Risk Youth Developing Psychotic Disorders, Y. Chung, A. Jacobson, G. He, T. G. Van Erp, S. Mcewen, J. Addington, C. E. Bearden, K. Cadenhead, B. A. Cornblatt, T. D. Cannon, +8 Additional Authors Jan 2015

Prodromal Symptom Severity Predicts Accelerated Gray Matter Reduction And Third Ventricle Expansion Among Clinically High Risk Youth Developing Psychotic Disorders, Y. Chung, A. Jacobson, G. He, T. G. Van Erp, S. Mcewen, J. Addington, C. E. Bearden, K. Cadenhead, B. A. Cornblatt, T. D. Cannon, +8 Additional Authors

Journal Articles

A recent prospective longitudinal neuroimaging study of 274 prodromal risk syndrome subjects revealed that those who later developed full-blown psychotic symptoms exhibited accelerated gray matter loss and third ventricle expansion around the time of onset of psychosis. Previous studies also indicate that higher levels of unusual thought content during prodromal states are a significant predictor of psychosis in clinically high-risk youth (CHR). However, the relationship between clinical symptoms and changes in neuroanatomical structure has not been previously examined in the North American Prodrome Longitudinal Study (NAPLS) sample at the atlas level. In this report, we investigated whether symptom severity as …

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Attitudes Of Psychiatric Nurses About The Request For Euthanasia On The Basis Of Unbearable Mental Suffering(Ums), M. De Hert, L. Van Bos, K. Sweers, M. Wampers, J. De Lepeleire, C. U. Correll Jan 2015

Attitudes Of Psychiatric Nurses About The Request For Euthanasia On The Basis Of Unbearable Mental Suffering(Ums), M. De Hert, L. Van Bos, K. Sweers, M. Wampers, J. De Lepeleire, C. U. Correll

Journal Articles

INTRODUCTION: When psychiatric patients express a wish for euthanasia, this should first and foremost be interpreted as a cry for help. Due to their close day-to-day relationship, psychiatric nurses may play an important and central role in responding to such requests. However, little is known about nurses' attitudes towards euthanasia motivated by unbearable mental suffering. OBJECTIVES: The aim of this study was to provide insight into the attitudes and actions taken by psychiatric nurses when confronted with a patient's euthanasia request based on unbearable mental suffering (UMS). METHOD: A questionnaire was sent to 11 psychiatric hospitals in the Flemish part …

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Lithium In The Acute Treatment Of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Study, R. L. Findling, A. Robb, N. K. Mcnamara, M. N. Pavuluri, V. Kafantaris, R. Scheffer, J. A. Frazier, M. Rynn, M. Delbello, R. A. Kowatch, B. M. Rowles, J. Lingler, K. Martz, R. Anand, T. E. Clemons, P. Taylor-Zapata Jan 2015

Lithium In The Acute Treatment Of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Study, R. L. Findling, A. Robb, N. K. Mcnamara, M. N. Pavuluri, V. Kafantaris, R. Scheffer, J. A. Frazier, M. Rynn, M. Delbello, R. A. Kowatch, B. M. Rowles, J. Lingler, K. Martz, R. Anand, T. E. Clemons, P. Taylor-Zapata

Journal Articles

No abstract provided.

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Practice Effects Due To Serial Cognitive Assessment: Implications For Preclinical Alzheimer's Disease Randomized Controlled Trials, T. E. Goldberg, P. D. Harvey, K. A. Wesnes, P. J. Snyder, L. S. Schneider Jan 2015

Practice Effects Due To Serial Cognitive Assessment: Implications For Preclinical Alzheimer's Disease Randomized Controlled Trials, T. E. Goldberg, P. D. Harvey, K. A. Wesnes, P. J. Snyder, L. S. Schneider

Journal Articles

AbstractIntroduction Practice effects are characteristic of nearly all standard cognitive tasks when repeated during serial assessments and are frequently important confounders in clinical trials. Methods We summarize evidence that gains in neuropsychological test performance scores associated with practice effects occur as artifactual changes associated with serial testing within clinical trials. We identify and emphasize such gains in older, non–cognitively impaired individuals and estimate an effect size of 0.25 for composite cognitive measures in older populations assessed three times in a 6- to 12-month period. Results We identified three complementary approaches that can be used to attenuate practice effects: (1) massed …

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Joint Analysis Of Psychiatric Disorders Increases Accuracy Of Risk Prediction For Schizophrenia, Bipolar Disorder, And Major Depressive Disorder, R. Maier, G. Moser, C. M. Hultman, M. Landen, D. F. Levinson, K. S. Kendler, J. W. Smoller, N. R. Wray, S. H. Lee, T. Lencz, +7 Additional Authors Jan 2015

Joint Analysis Of Psychiatric Disorders Increases Accuracy Of Risk Prediction For Schizophrenia, Bipolar Disorder, And Major Depressive Disorder, R. Maier, G. Moser, C. M. Hultman, M. Landen, D. F. Levinson, K. S. Kendler, J. W. Smoller, N. R. Wray, S. H. Lee, T. Lencz, +7 Additional Authors

Journal Articles

Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk. However, for polygenic traits, such as psychiatric disorders, the accuracy of risk prediction is low. Here we use a multivariate linear mixed model and apply multi-trait genomic best linear unbiased prediction for genetic risk prediction. This method exploits correlations between disorders and simultaneously evaluates individual risk for each disorder. We show that the multivariate approach significantly increases the prediction accuracy for schizophrenia, bipolar disorder, and major depressive disorder in …

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Dissecting The Heterogeneity Of Treatment Response In First-Episode Schizophrenia, A. K. Malhotra Jan 2015

Dissecting The Heterogeneity Of Treatment Response In First-Episode Schizophrenia, A. K. Malhotra

Journal Articles

The Mental Health Centers for Intervention Development and Applied Research (CIDAR) program prioritized research to provide an evidence base for biomarker development. At the Zucker Hillside Hospital (ZHH), our CIDAR grant supported research on a comprehensive investigation of treatment response and outcome in first episode schizophrenia. Results provide evidence that baseline neuroimaging, neurocognitive, and genetic measures are significantly associated with clinical response to treatment, and that our currently available interventions can effectively treat aspects of psychotic illness, as well as potentially reduce comorbidity associated with illness. Future research may include combining modalities to more robustly predict response and identify treatment …

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Case Report: Methemoglobinemia Caused By Benzocain Spray – A Warning For Surgeons, J. Eisdorfer, J. Anwar, D. Rivadeneira Jan 2015

Case Report: Methemoglobinemia Caused By Benzocain Spray – A Warning For Surgeons, J. Eisdorfer, J. Anwar, D. Rivadeneira

Journal Articles

No abstract provided.

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Temporary Mechanical Circulatory Support: A Review Of The Options, Indications, And Outcomes, N. A. Gilotra, G. R. Stevens Jan 2015

Temporary Mechanical Circulatory Support: A Review Of The Options, Indications, And Outcomes, N. A. Gilotra, G. R. Stevens

Journal Articles

Cardiogenic shock remains a challenging disease entity and is associated with significant morbidity and mortality. Temporary mechanical circulatory support (MCS) can be implemented in an acute setting to stabilize acutely ill patients with cardiomyopathy in a variety of clinical situations. Currently, several options exist for temporary MCS. We review the indications, contraindications, clinical applications, and evidences for a variety of temporary circulatory support options, including the intra-aortic balloon pump (IABP), extracorporeal membrane oxygenation (ECMO), CentriMag blood pump, and percutaneous ventricular assist devices (pVADs), specifically the TandemHeart and Impella.

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Planning And Guidance Of Cardiac Resynchronization Therapy-Lead Implantation By Evaluating Coronary Venous Anatomy Assessed With Multidetector Computed Tomography, J. N. Catanzaro, J. N. Makaryus, R. Jadonath, A. N. Makaryus Jan 2015

Planning And Guidance Of Cardiac Resynchronization Therapy-Lead Implantation By Evaluating Coronary Venous Anatomy Assessed With Multidetector Computed Tomography, J. N. Catanzaro, J. N. Makaryus, R. Jadonath, A. N. Makaryus

Journal Articles

OBJECTIVES: We sought to evaluate the utility of multidetector computed tomography (MDCT) in preoperative planning of cardiac resynchronization therapy (CRT) device implantation. BACKGROUND: Variation in coronary venous anatomy can affect optimal lead placement and may warrant preimplantation visualization prior to CRT lead placement. METHODS: Prospective randomized enrollment of 29 patients (17 males; mean age at implant 66.7 +/- 12.8 years) was undertaken. Patients were randomized to preimplantation MDCT (GE((R)) 64-detector Lightspeed, n = 16) or no MDCT. Implantation was planned based on three-dimensional coronary venous reconstruction as visualized in the CT group. Measurement of coronary sinus (CS) angulation, CS ostial …

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Targeting Mutant Braf In Relapsed Or Refractory Hairy-Cell Leukemia, E. Tiacci, J. H. Park, L. De Carolis, S. S. Chung, A. Broccoli, S. Scott, F. Zaja, S. Devlin, K. R. Rai, M. S. Tallman, +31 Additional Authors Jan 2015

Targeting Mutant Braf In Relapsed Or Refractory Hairy-Cell Leukemia, E. Tiacci, J. H. Park, L. De Carolis, S. S. Chung, A. Broccoli, S. Scott, F. Zaja, S. Devlin, K. R. Rai, M. S. Tallman, +31 Additional Authors

Journal Articles

Background BRAF V600E is the genetic lesion underlying hairy-cell leukemia. We assessed the safety and activity of the oral BRAF inhibitor vemurafenib in patients with hairy-cell leukemia that had relapsed after treatment with a purine analogue or who had disease that was refractory to purine analogues. Methods We conducted two phase 2, single-group, multicenter studies of vemurafenib (at a dose of 960 mg twice daily) - one in Italy and one in the United States. The therapy was administered for a median of 16 weeks in the Italian study and 18 weeks in the U.S. STUDY: Primary end points were …

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Ultrasound In The Diagnosis And Management Of Pleural Effusions, N. J. Soni, R. Franco, M. I. Velez, D. Schnobrich, R. Dancel, M. I. Restrepo, P. H. Mayo Jan 2015

Ultrasound In The Diagnosis And Management Of Pleural Effusions, N. J. Soni, R. Franco, M. I. Velez, D. Schnobrich, R. Dancel, M. I. Restrepo, P. H. Mayo

Journal Articles

We review the literature on the use of point-of-care ultrasound to evaluate and manage pleural effusions. Point-of-care ultrasound is more sensitive than physical exam and chest radiography to detect pleural effusions, and avoids many negative aspects of computerized tomography. Additionally, point-of-care ultrasound can assess pleural fluid volume and character, revealing possible underlying pathologies and guiding management. Thoracentesis performed with ultrasound guidance has lower risk of pneumothorax and bleeding complications. Future research should focus on the clinical effectiveness of point-of-care ultrasound in the routine management of pleural effusions and how new technologies may expand its clinical utility. Journal of Hospital Medicine …

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Reply To: Nasal Endoscopy To Characterize Sinonasal Disease, A. E. Dixon, M. Castro, R. I. Cohen, L. B. Gerald, J. T. Holbrook, C. G. Irvin, S. Mohapatra, S. P. Peters, S. Rayapudi, R. A. Wise, +1 Additional Author Jan 2015

Reply To: Nasal Endoscopy To Characterize Sinonasal Disease, A. E. Dixon, M. Castro, R. I. Cohen, L. B. Gerald, J. T. Holbrook, C. G. Irvin, S. Mohapatra, S. P. Peters, S. Rayapudi, R. A. Wise, +1 Additional Author

Journal Articles

No abstract provided.

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Obstructive Sleep Apnea As A Risk Factor For Type 2 Diabetes Mellitus, P. Rajan, H. Greenberg Jan 2015

Obstructive Sleep Apnea As A Risk Factor For Type 2 Diabetes Mellitus, P. Rajan, H. Greenberg

Journal Articles

No abstract provided.

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Phase Ii Double-Blind Placebo-Controlled Randomized Study Of Armodafinil For Brain Radiation-Induced Fatigue, B. R. Page, E. G. Shaw, L. Lu, D. Bryant, D. Grisell, G. J. Lesser, D. C. Monitto, M. J. Naughton, S. R. Savona, M. D. Chan, +3 Additional Authors Jan 2015

Phase Ii Double-Blind Placebo-Controlled Randomized Study Of Armodafinil For Brain Radiation-Induced Fatigue, B. R. Page, E. G. Shaw, L. Lu, D. Bryant, D. Grisell, G. J. Lesser, D. C. Monitto, M. J. Naughton, S. R. Savona, M. D. Chan, +3 Additional Authors

Journal Articles

BACKGROUND: Common acute-term side effects of brain radiotherapy (RT) include fatigue, drowsiness, decreased physical functioning, and decreased quality of life (QOL). We hypothesized that armodafinil (a wakefulness-promoting drug known to reduce fatigue and increase cognitive function in breast cancer patients receiving chemotherapy) would result in reduced fatigue and sleepiness for patients receiving brain RT. METHODS: A phase II, multi-institutional, placebo-controlled randomized trial assessed feasibility of armodafinil 150 mg/day in participants receiving brain RT, from whom we obtained estimates of variability for fatigue, sleepiness, QOL, cognitive function, and treatment effect. RESULTS: From September 20, 2010, to October 20, 2012, 54 participants …

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Egfr And Her2: Is There A Role In Ovarian Cancer?, E. Teplinsky, F. Muggia Jan 2015

Egfr And Her2: Is There A Role In Ovarian Cancer?, E. Teplinsky, F. Muggia

Journal Articles

Advanced ovarian cancer carries a grim prognosis and development of targeted therapies to improve outcomes has become an active area of research in this disease. The epidermal growth factor receptor (EGFR) and HER2/neu have shown to be overexpressed in ovarian cancer and there have been several clinical trials evaluating anti-EGFR and HER2 therapies in ovarian cancer. Unfortunately, the drugs have shown minimal efficacy and more recent work has now focused on identifying mechanisms of resistance and alternative ways of targeting these pathways. This review will discuss the currently published trials with anti-EGFR and HER2 agents in ovarian cancer and the …

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Exon 4-Encoded Sequence Is A Major Determinant Of Cytotoxicity Of Apolipoprotein L1, A. K. Khatua, A. M. Cheatham, E. D. Kruzel, P. C. Singhal, K. Skorecki, W. Popik Jan 2015

Exon 4-Encoded Sequence Is A Major Determinant Of Cytotoxicity Of Apolipoprotein L1, A. K. Khatua, A. M. Cheatham, E. D. Kruzel, P. C. Singhal, K. Skorecki, W. Popik

Journal Articles

The apolipoprotein L1 (APOL1) gene (APOL1) product is toxic to kidney cells, and its G1 and G2 alleles are strongly associated with increased risk for kidney disease progression in African Americans. Variable penetrance of the G1 and G2 risk alleles highlights the significance of additional factors that trigger or modify the progression of disease. In this regard, the effect of alternative splicing in the absence or presence of G1 or G2 alleles is unknown. In this study we investigated whether alternative splicing of non-G1, non-G2 APOL1 (APOL1 G0) affects its biological activity. Among seven APOL1 exons, exons 2 and 4 …

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