Medical Specialties Commons^™

Use Of Checkpoint Inhibitors In Gray Zone Lymphoma, Yensy Mariana Zelaya Rosales, Juliene Lima Mesquita, Yhasmine Delles Oliveira Garcia, Fernando Ricardo Fernandes Paz, Naiana Castelo Branco Campos, Joa˜O Paulo De Vasconcelos Leita˜O, Francisco Da´Rio Rocha Filho, Ricardo Vale Albino Oliveira Filho, Rome´Lia Pinheiro Gonc¸Alves Lemes, Fernando Barroso Duarte

Hematology/Oncology and Stem Cell Therapy

Checkpoint inhibitors, cancer immunotherapies, are the new forms of treatment for gray zone lymphoma, a rare subtype that combines the characteristics of both Hodgkin and non-Hodgkin disease forms. Programmed cell death protein 1/programmed cell death ligand 1 (PD-L1/PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) modulate the immune system function. Immunological checkpoints can be stimulatory or inhibitory, and tumors can use these checkpoints to protect against immune system attacks. This is a case report of a difficult diagnosis and describes the most current treatment using checkpoint inhibitors, through the review of the clinical record of a patient diagnosed with gray area …

High Expression Of Long Noncoding Rna Norad Is Associated With Poor Clinical Outcomes In Non-M3 Acute Myeloid Leukemia Patients, Mohammad Masoud Eslami, Mina Soufizomorrod, Mohammad Ahmadvand

Hematology/Oncology and Stem Cell Therapy

Objective/Background: Dysregulation of long noncoding RNA NORAD has been identified in human solid tumors. However, the expression profile of NORAD and its clinical implications in acute myeloid leukemia (AML) is unclear. The current study aimed to explore the NORAD expression status and its clinical significance in non-M3 AML patients. Methods: NORAD expression was evaluated in 60 de novo non-M3 AML patients and 49 healthy individuals using quantitative reverse transcription–polymerase chain reaction method. The correlation between NORAD transcription levels and clinicopathologic characteristics was statistically studied. Results: Compared with the healthy controls, NORAD was consistently higher in non-M3 AML patients (p = …

Prophylactic Pretransplant Ganciclovir To Reduce Cytomegalovirus Infection After Hematopoietic Stem Cell Transplantation, Daniel R. Reed, Gina R. Petroni, Melissa West, Caroline Jones, Abeer Alfaraj, Paige G. Williams, Kathlene Degregory, Kyle Grose, Sandra Monson, Indumathy Varadarajan, Leonid Volodin, Gerald R. Donowitz, Tamila L. Kindwall-Keller, Karen K. Ballen

Hematology/Oncology and Stem Cell Therapy

Objective/Background: Cytomegalovirus (CMV) reactivation remains a serious complication after allogeneic hematopoietic cell transplantation (HCT) occurring in approximately 60–70% of CMV-seropositive HCT recipients. CMV reactivation leads to adverse outcomes including end-organ damage, graft-versus-host disease, and graft failure. Methods: Ganciclovir was administered pretransplant at 5 mg/kg twice daily intravenously from the start of conditioning to Day T-2 to CMV-seropositive patients receiving their first allogeneic HCT. CMV DNA was monitored weekly until at least Day 100 posttransplant. Results: A total of 109 consecutive patients were treated, median age 57 (range 20–73) years. Of these, 36 (33%) patients had a CMV reactivation within the …

Azacitidine Maintenance Therapy Postallogeneic Stem Cell Transplantation In Poorrisk Acute Myeloid Leukemia, Amany R. Keruakous, Jennifer Holter-Chakrabarty, Sarah A. Schmidt, Mohamad O. Khawandanah, George Selby, Carrie Yuen

Hematology/Oncology and Stem Cell Therapy

Objective/Background: Allogeneic hematopoietic stem cell transplant (HSCT) is the potential curative modality for poor-risk acute myeloid leukemia (AML), relapse remains the main reason for transplant failure. Early-phase studies showed azacitidine is safe for post-transplant maintenance therapy in AML. Methods: We performed a single institutional prospective cohort study to evaluate the benefit of azacitidine maintenance therapy following allogeneic HSCT in poor-risk AML. The main objective of this study is to generate a hypothesis aiming to optimize post-transplantation outcomes in poor-risk AML. Forty-nine adults with poor-risk AML who underwent allogeneic HSCT were evaluated in a nonrandomized prospective cohort fashion. Thirty-one participants received …

Current Practice Of Oral Care For Hematopoietic Stem Cell Transplant Patients: A Survey Of The Eastern Mediterranean Blood And Marrow Transplantation Group, Hani Mawardi, Nathaniel Treister, Osama Felemban, Waleed Alamoudi, Ghada Algohary, Abdulrahman Alsultan, Nawal Alshehri, Illias Tazi, Marwan Shaheen, Mohamed Alsharani, Salem Alshemmari, Mutlu Arat, Mohamed Amine Bekadja, Murtadha Al-Khabori, Samar Okaily, Natasha Ali, Husam Abujazar, Wasil Jastaniah, Amir Ali Hamidieh, Sharukh Hashmi, Mahmoud Aljurf

Hematology/Oncology and Stem Cell Therapy

Introduction: The oral cavity is one of the most common sites impacted by hematopoietic stem cell transplantation (HSCT) with acute complications including mucositis, bleeding, salivary gland dysfunction, infection, and taste alteration. These complications may result in significant morbidity and can negatively impact outcomes such as length of stay and overall costs. As such, oral care during HSCT for prevention and management of oral toxicities is a standard component of transplant protocols at all centers. The objective of this study was to evaluate the current oral care practices for patients during HSCT at different transplant centers within the Eastern Mediterranean region. …

Outcomes Of Patients With Thrombocytopenia Evaluated At Hematology Subspecialty Clinics, Zaid H. Abdel Rahman, Kevin C. Miller, Hiba Jabbour, Yaser Alkhatib, Vijaya Donthireddy

Hematology/Oncology and Stem Cell Therapy

Background: Thrombocytopenia is a frequently encountered laboratory abnormality and a common reason for hematology referrals. Workup for thrombocytopenia is not standardized and frequently does not follow an evidence-based algorithm. We conducted a systematic analysis to evaluate the laboratory testing and outcomes of patients evaluated for thrombocytopenia at hematology clinics in a tertiary referral center between 2013 and 2016. Patient and methods: We performed a comprehensive chart review for patients evaluated for thrombocytopenia during the study period. Patients were followed for 1 year from the initial hematology evaluation and assessed for the development of a hematologic malignancy, rheumatologic, or infectious diseases …

Therapeutic Roles Of Antibody Drug Conjugates (Adcs) In Relapsed/Refractory Lymphomas, Hamza Hashmi, Alicia Darwin, Taiga Nishihori

Hematology/Oncology and Stem Cell Therapy

Relapsed or refractory lymphoma is commonly treated with combination chemoimmunotherapy and cellular immunotherapy. Modest response rates and associated toxicities are obstacles to achieving durable remission using traditional cytotoxic chemotherapy, especially in frail patients with advanced disease. Antibody drug conjugates represent a new class of novel targeted agents with significant improvement in therapeutic efficacy in the treatment of lymphomas. Several of these agents, which offer improved targeting, greater potency, and better therapeutic index over traditional chemotherapy, are changing the treatment landscape for lymphomas and other hematological malignancies. Despite the therapeutic potential of these agents, the delivery and release of cytotoxic agents …

Radiotherapy And Immunotherapy In Melanoma Brain Metastases, Amir Anvari, Pegah Sasanpour, Mania Rajabzadeh Kheradmardi

Hematology/Oncology and Stem Cell Therapy

Background and objective: Melanoma brain metastasis (MBM) generally portends a dismal prognosis. Simultaneous use of radiotherapy (RT) and immune checkpoint inhibitor (ICI) therapy demonstrated tremendous promise and emerged as the new standard. This meta-analysis was conducted to evaluate survival outcomes and toxicities of this combination in patients with MBM. Data analyses were performed using Comprehensive Meta-Analysis software (version 2) and IBM SPSS software (version 27). Methods: A systematic literature search of PubMed, EMBASE, and the Cochrane Library (via Wiley) was conducted using PICOS/PRISMA selection protocol and included studies to evaluate survival and safety-associated outcomes of ICI + RT for the …

Rota Ablation – When There Is No Other Option. A Complex Case Of 86 Years Old Male With Multiple Comorbids Presenting With Stemi, Tooba Sahar, Asaad Akbar Khan, Taha Abdul Rehman, Danish Iltaf Satti

Journal of Community Hospital Internal Medicine Perspectives

The aim of this report is to explore the direct and long-term outcome in a high risk patient who was treated with rotational atherectomy (RA) to assist the placement of drug eluting stents in heavily calcified lesions. The patient presented with acute STEMI and had severely calcified Left main stem (LMS) disease, requiring plaque modification before coronary angioplasty and stent implantation. As the patient was elderly, with multiple comorbids including a number of coronary interventions, a decision of conservative management was made. Patient then re-presented with typical chest pain and pulmonary edema. A Heart Team meeting was called and high …

Reply To The Letter To The Editor Titled “Before Blaming Legionella For Severe Rhabdomyolysis, Consider Alternative Triggers”, Harish Gopalakrishna, Ahmad Al-Abdouh, Gayatri Nair, Vinod Solipuram, Ammer Bekele

Journal of Community Hospital Internal Medicine Perspectives

No abstract provided.

The Effects Of Dynamic® Taping On Vertical Jumps In Adolescent Volleyball Players With Low Medial Longitudinal Arch, Dilek Hande Esen, Nihan Kafa, Nevin Atalay Guzel, Cengiz Akarcesme

Baltic Journal of Health and Physical Activity

Introduction: Taping has long been used by health professionals to provide mechanical support for the musculoskeletal system. However, there is insufficient evidence to demonstrate the effect of Dynamic® taping. The aim of this study was to investigate the effect of Dynamic® taping on vertical jump and medial longitudinal arch height in adolescent volleyball players with navicular drop. Material and Methods: 23 female athletes participated in the study (mean age of 15.22 ± 1.54 years). The medial longitudinal arch height was evaluated with the navicular drop test. Vertical jumping was measured with the VERT® device (Mayfonk Athletic, USA). On the first …

Outcomes Of Patients Diagnosed With Chronic Lymphocytic Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation: Results From A Tertiary Care Center, Swe Mar Linn, Ram Vasudevan Nampoothiri, Carol Chen, Ivan Pasic, Zeyad Al-Shaibani, Wilson Lam, Arjun Datt Law, Fotios V. Michelis, Dennis D.H. Kim, Armin Gerbitz, Jeffrey Lipton, Rajat Kumar, Jonas Mattsson, Auro Viswabandya

Hematology/Oncology and Stem Cell Therapy

Background: Allogeneic hematopoietic stem cell transplantation (allo-HCT) is currently the only curative treatment for patients with chronic lymphocytic leukemia (CLL). Methods: We analyzed the outcomes of 93 patients (median age: 52 years) who underwent allo-HCT at our center between 1989 and 2019. Results: After a median follow-up of 35 months, relapse was observed in 15.1% (n = 14) patients. The estimated 2-year non-relapse mortality, relapse-free survival, and overall survival (OS) were 38.1%, 54.2%, and 58.7%, respectively. The ECOG performance status 2 (hazard ratio [HR]: 4.1; p = .001) and use of total body irradiation (in a myeloablative conditioning regimen; HR: …

The Impact Of Beta-Blocker Use At The Time Of Hematopoietic Cell Transplantation On The Development Of Acute And Chronic Graftversus- Host Disease, Arjun Patel, Guru Subramanian Guru Murthy, Mehdi Hamadani, Aniko Szabo, Jennifer M. Knight

Hematology/Oncology and Stem Cell Therapy

Sympathetic nervous system activation plays a role in the development of acute and chronic graft-versus-host disease (GVHD) following allogeneic hematopoietic cell transplantation (HCT). Primary objective was to compare the cause-specific hazard of grade II-IV and III-IV acute GVHD (aGVHD) and chronic GVHD (cGVHD) in the context of ß-blocker use and type (selective vs. non-selective). Secondary objectives included overall survival (OS), relapse-free survival (RFS), and cumulative incidence of relapse, non-relapse mortality (NRM), and grade II-IV and III-IV aGVHD and cGVHD. The current study included 151 patients ages 18 and older diagnosed with hematological malignancies who underwent reduced intensity conditioning allogeneic HCT …

Effects Of Different Types Of Allogeneic Hematopoietic Stem Cell Transplantation Donors On Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia During The Tyrosine Kinase Inhibitor Era: A Systematic Review And Meta-Analysis, Ben Ponvilawan, Weerapat Owattanapanich, Nipith Charoenngam, Smith Kungwankiattichai

Hematology/Oncology and Stem Cell Therapy

Background: Matched donor (MD) allogeneic hematopoietic stem cell transplantation (allo- HSCT) is currently the preferred choice of treatment for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) patients who have achieved complete remission. This systematic review and meta-analysis was conducted to investigate the effects of allo-HSCTs from different donor types for Ph+ ALL patients who received tyrosine kinase inhibitors (TKIs). Methods: Studies in EMBASE and MEDLINE between inception and December 2020 were identified using search terms related to ‘‘Ph+ ALL” and ‘‘HSCT.” Eligible studies were studies with Ph+ ALL patients who received a TKI and allo-HSCT. The primary outcomes of interest—the …

Improved Quality Of Life Of Sickle Cell Disease Patients Post Allogeneic Stem Cell Transplant: Another Indication For Transplant, Bader Ali Aljaafri, Mohammad Fahad Albawardi, Abdulaziz Yahya Alghamdi, Khaled Mohammad Altowairgi, Yazeed Saleh Alhoshan, Bader Alahmari, Husam Alsadi, Mazin Ahmed, Mohammed Alnahdi, Zied Aljubour, Mohsen Alzahrani

Hematology/Oncology and Stem Cell Therapy

Introduction: Sickle Cell Disease (SCD) is among the most frequently inherited diseases worldwide. The severity of SCD ranges from mild to severe, and the disease involves multiple complications, including pulmonary hypertension, stroke, recurrent vaso-occlusive crises, end-organ damage, and an increased mortality risk. Allogeneic hematopoietic cell transplantation (HCT) is potentially a curative option for patients with SCD.

Objectives of the Study: The study objective was to assess the quality of life of adolescent and adult SCD patients receiving HCT pre-and post-transplant.

Methods: An analytical cross-sectional study was conducted. SCD patients with at least one year of follow-up after HCT were interviewed …

What Are We Missing In Adult Obstructive Sleep Apnea Clinical Evaluation? Review Of Official Guidelines, Eduardo J. Correa, Carlos O´Connor-Reina, Laura Rodriguez-Alcalá, Diego M. Conti, Alberto Rabino, Peter M. Baptista, Maria-Teresa Garcia-Iriarte, Guillermo Plaza

International Journal of Orofacial Myology and Myofunctional Therapy

Purpose: This article presents a narrative review of current recommendations for the clinical evaluation and management of adult patients with obstructive sleep apnea (OSA) to identify points missing from a myofunctional perspective.

Methods: The authors reviewed current official guidelines for adult patients with OSA, searching clinical evaluation and treatment recommendations for myofunctional therapy.

Results: None of the current guidelines for evaluation of adult OSA recommend performing a myofunctional evaluation. Only two guidelines consider myofunctional therapy (MFT) as a treatment modality for adult patients with OSA.

Conclusion: Despite the role of the pharyngeal dilator muscles as an …

Impact Of Effective Orifice Area Index Of Mitral Valve Prosthesis On Postoperative Pulmonary Artery Pressure And Functional Tricuspid Valve Regurgitation, Loay Aly Fathy Aljunaidy, Zakaria Mostafa Elmashtoly, Sameh Hassan Morsy Elameen, Abdallah Sami Mahmoud

Al-Azhar International Medical Journal

Background: One of the common complications following mitral valve replacement is patient-prothesis mismatch. This problem can lead to unfavorable consequences that mimic residual mitral stenosis.

Aim of the present study: Evaluating the incidence of patient-prosthesis mismatch, its associated predictors, and how it can influence the pulmonary hypertension and late tricuspid valve regurge.

Methods: From September 2020 to December 2022, 100 consecutive patients (75 females), underwent MVR. The mean age was 46.78±9.59 years and mean EF was 61.84±7.68 %. The patients were divided according to the EOAI into: non-mismatch group (54%), moderate mismatch group (32%) and severe mismatch group (14%).

Results: …

The Efficacy Of Intraoperative Intrauterine Iud Insertion During Cesarean Section, Ehab Hassanin Mohammad, El Metwally Farouk El Shahat, Mohamed Atef Ibrahim Abd Eldaim

Al-Azhar International Medical Journal

Background: The intrauterine contraceptive device (IUD) can be placed at a caesarean section (CS) for the first time in a woman's life. If the IUD is safe and effective for CS scars, they may use it as a long-acting reversible contraception. Objectives: to evaluate CS intraoperative intrauterine IUD implantation. Subjects and methods: The Al-Azhar University Faculty of Medicine's Obstetrics & Gynecology Department conducted a randomised controlled experiment on 40 women. Results: Our population had 5.2% significant bleeding, displacement, and infection and 12.8% discontinuation. 0% failed. After 2 months, 87.2% of patients were satisfied. Conclusion: Tubal ligation and immediate postplacental implantation …

Comparison Between Percutaneous And Open Repair In Acutetendon Achilles Rupture In Active Young Patients, Abd-Elhakeem Abdullah Farrag, Mohammed Nasr Akl, Aktham Amin Ahmed

Al-Azhar International Medical Journal

Background; The Achilles tendon is the strongest and most often torn tendon in the human body and it is known that this rupture rate is rising in the third or fourth decade of life and it affects males more frequently. The majority of ruptures happen when doing sports. Aim and objectives; to compare between percutaneous and open repair of acute Achilles tendon rupture in active young patients who want to go back to resume activity following the repair. Patients and methods:30 participants were included in this prospective comparative research and randomly assigned to groups A and B. (each consists of …

Comparative Study Between Subthreshold (Micropulse) Laser Direct Application To The Edematous Macula Versus Direct Application To The Peripheral Healthy Retina In The Treatment Of Diabetic Macular Edema., Eslam Mahmoud Abdou Alharif, Hamed Nasr El-Din Taha, Mohamed Abdulbadie Rashed

Al-Azhar International Medical Journal

Background: Subthreshold (micropulse) laser is an effective modality in the treatment of diabetic macular edema that avoids possible complications of conventional laser photocoagulation and anti-vascular endothelial growth factor. Regardless of where the laser is applied, the retinal pigment epithelium is crucial for repair of both outer and inner blood retinal barriers.

Aim: To evaluate both anatomical and functional outcomes of direct application of subthreshold (micropulse) laser to the edematous macula versus to the peripheral healthy retina.

Patient and methods: This prospective interventional comparative randomized study was carried out on 30 eyes with diabetic macular edema divided into two groups. Group …

Correlation Of Tei Index Assessed By Different Echocardiographic Methods In Patient With Acute Myocardial Infarction Receiving Different Reperfusion Treatment In Comparison With Ef And Diastolic Function, Mahmoud Elsayed Nofal, Abdelhamid Esmail Abdelhamid, Mohamed Hesham Hassan Ezzat

Al-Azhar International Medical Journal

Background: Acute myocardial infarction (AMI) is a common cardiac condition with high morbidity and mortality worldwide. A common complication of AMI is heart failure (HF). HF is the most significant predictor of mortality among AMI patients. So, a significant echocardiographic measurement for post-AMI patient is to assess the left ventricular systolic function via left ventricular ejection fraction (LVEF). As such, Tei index, which simultaneously measures relaxation and contraction velocities, may be of a prognostic importance in those presenting with AMI that may go unmissed with the isolated evaluation of LVEF. Objectives: this work was done to correlate MPI evaluated by …

Efficacy Of Dexamethasone On Latent Phase During Induction Of Labour, Yehia Abd Elsalam Wafa, Abd Elmonaem Mohammed Zakaria, Youssef Hassan Ahmed Rizk

Al-Azhar International Medical Journal

Background: The hypothalamus, pituitary gland, and adrenal glands form the axis around which the process of giving birth revolves. Fetal adrenal steroid hormones change the noncontractile myometrium into the contractile state, affecting the placenta and membranes, Aim: The objective of this research was to determine the effect of intramuscular dexamethasone injection on the time among labor induction and the commencement of active phase of labor, as well as the duration of active phase. Patients and Methods: This was a double-blind, randomized, controlled trial conducted on pregnant women visiting the maternity ward of Al-Hussein University hospital for a period of 12 …

Tinnitus Treatment For Adult: A Meta Analytic Study, Mohamed Ahmed Mohamed Ali, Ahmed Mohamed Seleim

Al-Azhar International Medical Journal

Background: Tinnitus is regarded as a puzzling issue, and there are currently no generally agreed-upon solutions to basic concerns concerning its pathogenesis, course, and ideal therapy. Aim and objectives: to conduct a Meta analytic review of different types of treatment of tinnitus, to provide a better picture for the benefits and comparisons of efficacy of different types of tinnitus treatment, summarizing all types of treatment, providing the best appropriate treatment. Subjects and methods: This meta-analysis study included 33 studies were included 24 were RCT, 6 were prospective studies, 3 were retrospective studies. Among the 33 included studies there were a …

A Comparison Study Between Transosseous Pull Out And Anchors In Gamekeeper’S Injury, Mohamed Mohamed Bissar, Hassan Mahmoud Baraka, Amro Ahmed Fouaad, Ayman Shwky Morad

Al-Azhar International Medical Journal

Background: When the thumb's metacarpophalangeal (M.C.P.) joint has a ligamentous lesion, the joint becomes noticeably unstable, which is common. Aim: to assess the functional and clinical outcomes of two different reconstruction methods of the metacarpophalangeal joint (ulnar side) of the thumb (pullout suture & anchor) in unstable injuries. Subject and Methods: This was a prospective study of 30 cases admitted to Al-Azhar University Hospitals (El Hussein Hospital and Sayed Galal Hospital) with ligamentous injuries of the MCP joint (ulnar side) from August 2018 until February 2022. Results: Regarding outcome distribution among the studied patients, we found that 19 (63.3%) were …

Evaluation Of Laser Ablation In Treatment Of Pilonidal Sinus Short Title: Laser In Pilonidal Sinus, Muhammad Fathy Sharaf, Ibrahim Aboulfotoh Muhammad, Bilal Muhammad Mansour

Al-Azhar International Medical Journal

Background: Pilonidal sinus (PNS) is defined as a tract or cavity in subcutaneous tissue of natal cleft of the sacrococcygeal area. PNS usually complicated by repeated infection and chronic inflammation. It is a widespread condition with a reported incidence of 26 per 100,000. Despite being a benign illness, it limits patients' everyday activities due to discomfort, discharge, and occasionally unpleasant odder.

Aim of the study: The purpose of this research is to assess the efficacy of laser ablation as a less invasive method for treating PNS.

Patients and methods: This case series study was performed on 30 patients collectively who …

The Prevalence Of Sicca Symptoms And Secondary Sjogren In Patients With Rheumatoid Arthritis And It’S Association To Disease Activity, Mostafa A. Doma, Amin A. Abdel-Hady, Abdelhafeez M. Moshri, Ghada M. Mousa

Al-Azhar International Medical Journal

Background: Sjogren disorder (SS) is a persistent foundational immune system sickness of obscure etiology that can happen alone prevalently Sjogren or in relationship with a fundamental connective tissue illness, most regularly rheumatoid joint pain (RA) or lupus erythematosus. Aim: To determine commonness of dryness side effects and optional Sjogren's disorder in patients with rheumatoid joint pain and their relationship with illness movement. Patients and Methods: This cross-sectional review was directed on 100 patients with rheumatoid joint pain chose from the people who went to the short term branch of the Division of Restoration and Rheumatology of Al-Azhar College Clinic in …

Continuous Versus Intermittent Oxytocin Infusion Throughout The Active Phase Of Labor: A Randomized Controlled Trial, Mohammed Mohammed Gebreil, Ahmed Muhamed Ahmed Abdelmoaty, Hany Mahrous Elsayed Mansour

Al-Azhar International Medical Journal

Background: Modern obstetric practice includes augmentation of labour, which leads to progressive cervicovaginal effacement and dilation as well as childbirth. The use of several acceptable procedures has significantly improved induction's safety and reliability in recent years. Aim and objectives: to contrast the effects of oxytocin infusions that are continuous with those that are intermittent during labor's active phase. Subjects and methods: 200 pregnant women participated in an interventional, randomised clinical research at El-Hussein University Hospital's Obstetrics and Gynecology Division. Two equal groups made up this study. Group (A): 100 pregnant women who had continuous oxytocin infusion labour induction made up …

Clinical Patterns Of Covid19 In Different Types Of Ckd Patients, Mohamed Elshahat Mahmoud Mousa, Ahmed Alaa Eldin Ahmed, Alsayed Mohamed Rashed, Mohammad Abo-Ghabsha

Al-Azhar International Medical Journal

Background - Nephrologists have been at the forefront of clinical care of patients with COVID-19 as kidney-related complications, including chronic kidney disease (CKD), glomerular disease, and severe electrolyte derangements, are frequently encountered.

Aim - to estimate the effect of Covid-19 viral infection on chronic kidney disease patients and to determine clinical characteristics of disease.

Patients and Methods - A retrospective case study for 50 patients with Chronic Kidney Disease from stage 1 to stage 5 presented with covid 19 infection which confirmed by PCR to El Sheikh Zyed Al Nahyan hospital from 1st of August 2021 to 1st of January …

Community-Acquired Pneumonia Among Hospitalized Children: Risk Factors, Characteristics, And Outcomes, Marwa Taha, Hanaa Abdel-Wahab

Journal of Medicine in Scientific Research

Background Community-acquired pneumonia (CAP) represents one of the main causes of mortality and morbidity among under-five children worldwide. More than 75% of these fatalities are caused by severe pneumonia. Objectives to identify the potential risk factors associated with severe CAP among under-five children hospitalized with CAP. Patients and Methods This prospective observational study was conducted on children, aged 1 to 59 months, who were admitted with CAP to the Department of Pediatrics, Mataria Teaching Hospital, Egypt. Based on World Health Organization (WHO) guidelines, patients were classified into two groups; CAP and severe CAP. Data including demographic, children's history, clinical assessment, …

Effect Of Levosemindan On Outcome Of Coronary Artery Bypass Grafting Surgery In Patient With Impaired Left Ventricular Systolic Function, Khaled Mohammed Abdallah, Zakaria Moustafa Elmashtoly, Bahaa Abd-Aljawad Hassan Elkhonezy

Al-Azhar International Medical Journal

Background: Coronary artery bypass grafting (CABG) is often complicated by hemodynamic instability, especially in cases with decreased left ventricular ejection fraction (LVEF). Levosimendan as inotropic agent can be used in those patients. Objective: To assess morbidity and mortality rates up to 6 months following CABG surgery in patients with LVEF equals 35%, who were given Levosimendan. Patients and methods: 40 patients with preoperative LVEF ≤ 35% underwent elective CABG were retrospectively analyzed between March 2020 and April 2022 at Al-Azhar University Hospitals. Levosemindan was used in continuously-given bolus-free infusion at a range from 0.05 to 0.2 ug/kg/min prior surgery. Hemodynamic …