Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Diseases (239)
- Medical Sciences (178)
- Oncology (169)
- Surgery (125)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (109)
-
- Public Health (96)
- Pediatrics (91)
- Life Sciences (52)
- Neoplasms (44)
- Orthopedics (44)
- Neurology (42)
- Therapeutics (42)
- Emergency Medicine (39)
- Medical Pathology (38)
- Cardiovascular Diseases (37)
- Chemicals and Drugs (37)
- Anatomy (35)
- Infectious Disease (35)
- Medical Pharmacology (35)
- Cardiology (34)
- Dermatology (34)
- Diagnosis (32)
- Medical Genetics (32)
- Surgical Procedures, Operative (31)
- Internal Medicine (30)
- Medical Immunology (29)
- Psychiatry and Psychology (28)
- Skin and Connective Tissue Diseases (27)
- Keyword
-
- COVID-19 (22)
- SARS-CoV-2 (14)
- Cancer (10)
- Case report (9)
- Immunotherapy (9)
-
- Oncology (8)
- Social determinants of health (8)
- Survival (8)
- Breast cancer (7)
- Meta-analysis (7)
- Obesity (7)
- Pediatric (7)
- Bariatric surgery (6)
- Pediatrics (6)
- Trauma (6)
- Aging (5)
- Artificial intelligence (5)
- Biomarkers (5)
- Chlamydia trachomatis (5)
- Diabetes (5)
- Inflammation (5)
- Osteoarthritis (5)
- Outcomes (5)
- Pregnancy (5)
- Sepsis (5)
- Thyroid cancer (5)
- Total knee arthroplasty (5)
- Alcohol (4)
- Alzheimer's disease (AD) (4)
- Assessment (4)
- Publication Year
- File Type
Articles 631 - 633 of 633
Full-Text Articles in Medical Specialties
Hiv-1 Tat Protein Promotes Neuronal Dysfunction Through Disruption Of Micrornas, J Robert Chang, Ruma Mukerjee, Asen Bagashev, Luis Del Valle, Tinatin Chabrashvili, Brian J. Hawkins, Johnny J. He, Bassel E. Sawaya
Hiv-1 Tat Protein Promotes Neuronal Dysfunction Through Disruption Of Micrornas, J Robert Chang, Ruma Mukerjee, Asen Bagashev, Luis Del Valle, Tinatin Chabrashvili, Brian J. Hawkins, Johnny J. He, Bassel E. Sawaya
School of Medicine Faculty Publications
Over the last decade, small noncoding RNA molecules such as microRNAs (miRNAs) have emerged as critical regulators in the expression and function of eukaryotic genomes. It has been suggested that viral infections and neurological disease outcome may also be shaped by the influence of small RNAs. This has prompted us to suggest that HIV infection alters the endogenous miRNA expression patterns, thereby contributing to neuronal deregulation and AIDS dementia. Therefore, using primary cultures and neuronal cell lines, we examined the impact of a viral protein (HIV-1 Tat) on the expression of miRNAs due to its characteristic features such as release …
Deregulation Of Micrornas By Hiv-1 Vpr Protein Leads To The Development Of Neurocognitive Disorders, Ruma Mukerjee, J Robert Chang, Luis Del Valle, Asen Bagashev, Monika M. Gayed, Randolph B. Lyde, Brian J. Hawkins, Eugen Brailoiu, Eric Cohen, Chris Power, S Ausim Azizi, Benjamin B. Gelman, Bassel E. Sawaya
Deregulation Of Micrornas By Hiv-1 Vpr Protein Leads To The Development Of Neurocognitive Disorders, Ruma Mukerjee, J Robert Chang, Luis Del Valle, Asen Bagashev, Monika M. Gayed, Randolph B. Lyde, Brian J. Hawkins, Eugen Brailoiu, Eric Cohen, Chris Power, S Ausim Azizi, Benjamin B. Gelman, Bassel E. Sawaya
School of Medicine Faculty Publications
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neuronal deregulation. The viral protein R (Vpr), a protein encoded by HIV-1, has been shown to alter the expression of various important cytokines and inflammatory proteins in infected and uninfected cells; however the mechanisms involved remain unclear. Using a human neuronal cell line, we found that Vpr can be taken up by neurons causing: (i) deregulation of calcium homeostasis, (ii) endoplasmic …
Ros Accumulation And Igf-Ir Inhibition Contribute To Fenofibrate/Pparalpha -Mediated Inhibition Of Glioma Cell Motility In Vitro, Justyna Drukala, Katarzyna Urbanska, Anna Wilk, Maja Grabacka, Ewa Wybieralska, Luis Del Valle, Zbigniew Madeja, Krzysztof Reiss
Ros Accumulation And Igf-Ir Inhibition Contribute To Fenofibrate/Pparalpha -Mediated Inhibition Of Glioma Cell Motility In Vitro, Justyna Drukala, Katarzyna Urbanska, Anna Wilk, Maja Grabacka, Ewa Wybieralska, Luis Del Valle, Zbigniew Madeja, Krzysztof Reiss
School of Medicine Faculty Publications
BACKGROUND: Glioblastomas are characterized by rapid cell growth, aggressive CNS infiltration, and are resistant to all known anticancer regimens. Recent studies indicate that fibrates and statins possess anticancer potential. Fenofibrate is a potent agonist of peroxisome proliferator activated receptor alpha (PPARalpha) that can switch energy metabolism from glycolysis to fatty acid beta-oxidation, and has low systemic toxicity. Fenofibrate also attenuates IGF-I-mediated cellular responses, which could be relevant in the process of glioblastoma cell dispersal. METHODS: The effects of fenofibrate on Glioma cell motility, IGF-I receptor (IGF-IR) signaling, PPARalpha activity, reactive oxygen species (ROS) metabolism, mitochondrial potential, and ATP production were …