Open Access. Powered by Scholars. Published by Universities.®

Medical Specialties Commons™

Open Access. Powered by Scholars. Published by Universities.®

Journal Articles

Discipline
Institution
Keyword
Publication Year
File Type

Articles 1411 - 1440 of 2016

Full-Text Articles in Medical Specialties

Hyperplastic Cardiac Sarcoma Recurrence, M. A. Shariff, J. A. Abreu, F. Durrani, E. Daniele, K. C. Bowman, S. Sadel, K. T. Asgarian, J. T. Mcginn Jr., J. P. Nabagiez Jan 2015

Hyperplastic Cardiac Sarcoma Recurrence, M. A. Shariff, J. A. Abreu, F. Durrani, E. Daniele, K. C. Bowman, S. Sadel, K. T. Asgarian, J. T. Mcginn Jr., J. P. Nabagiez

Journal Articles

Primary cardiac sarcomas are rare tumors with a median survival of 6-12 months. Data suggest that an aggressive multidisciplinary approach may improve patient outcome. We present the case of a male who underwent resection of cardiac sarcoma three times from the age of 32 to 34. This report discusses the malignant nature of cardiac sarcoma and the importance of postoperative multidisciplinary care.

Go to article

Right Heart Transvalvular Embolus With High Risk Pulmonary Embolism In A Recently Hospitalized Patient: A Case Report Of A Therapeutic Challenge, G. K. Acharya, A. M. Adedayo, H. Prabhu, D. R. Brinster, P. Mir Jan 2015

Right Heart Transvalvular Embolus With High Risk Pulmonary Embolism In A Recently Hospitalized Patient: A Case Report Of A Therapeutic Challenge, G. K. Acharya, A. M. Adedayo, H. Prabhu, D. R. Brinster, P. Mir

Journal Articles

Thrombus-in-transit is not uncommon in pulmonary embolism but Right Heart Transvalvular Embolus (RHTVE) complicating this is rare. A 54-year-old obese male with recent hospitalization presented with severe dyspnea and collapse. Initial investigations revealed elevated d-dimer and troponin. CTA showed saddle pulmonary embolus and bedside echocardiogram revealed right ventricular (RV) pressure overload and dilatation (RV > 41 mm), McConnell's sign, and mobile echodensity attached to tricuspid valve. Patient was immediately resuscitated and promptly transferred for surgical embolectomy under cardiopulmonary bypass. A long segment of embolus traversing through the tricuspid valve and extensive bilateral pulmonary artery embolus were removed. IVC filter was placed …

Go to article

Developments In Intervertebral Disc Disease Research: Pathophysiology, Mechanobiology, And Therapeutics, K. T. Weber, T. D. Jacobsen, R. Maidhof, J. Virojanapa, C. Overby, O. Bloom, S. Quraishi, M. Levine, N. O. Chahine Jan 2015

Developments In Intervertebral Disc Disease Research: Pathophysiology, Mechanobiology, And Therapeutics, K. T. Weber, T. D. Jacobsen, R. Maidhof, J. Virojanapa, C. Overby, O. Bloom, S. Quraishi, M. Levine, N. O. Chahine

Journal Articles

Low back pain is a leading cause of disability worldwide and the second most common cause of physician visits. There are many causes of back pain, and among them, disc herniation and intervertebral disc degeneration are the most common diagnoses and targets for intervention. Currently, clinical treatment outcomes are not strongly correlated with diagnoses, emphasizing the importance for characterizing more completely the mechanisms of degeneration and their relationships with symptoms. This review covers recent studies elucidating cellular and molecular changes associated with disc mechanobiology, as it relates to degeneration and regeneration. Specifically, we review findings on the biochemical changes in …

Go to article

Exploratory Study For Identifying Systemic Biomarkers That Correlate With Pain Response In Patients With Intervertebral Disc Disorders, K. T. Weber, S. Satoh, D. O. Alipui, J. Virojanapa, M. Levine, C. Sison, S. Quraishi, O. Bloom, N. O. Chahine Jan 2015

Exploratory Study For Identifying Systemic Biomarkers That Correlate With Pain Response In Patients With Intervertebral Disc Disorders, K. T. Weber, S. Satoh, D. O. Alipui, J. Virojanapa, M. Levine, C. Sison, S. Quraishi, O. Bloom, N. O. Chahine

Journal Articles

Molecular events that drive disc damage and low back pain (LBP) may precede clinical manifestation of disease onset and can cause detrimental long-term effects such as disability. Biomarkers serve as objective molecular indicators of pathological processes. The goal of this study is to identify systemic biochemical factors as predictors of response to treatment of LBP with epidural steroid injection (ESI). Since inflammation plays a pivotal role in LBP, this pilot study investigates the effect of ESI on systemic levels of 48 inflammatory biochemical factors (cytokines, chemokines, and growth factors) and examines the relationship between biochemical factor levels and pain or …

Go to article

A Rare Case Of Aortic Dissection Presenting As Pure Transient Global Amnesia, H. Kaveeshvar, R. Kashouty, V. Loomba, N. Yono Jan 2015

A Rare Case Of Aortic Dissection Presenting As Pure Transient Global Amnesia, H. Kaveeshvar, R. Kashouty, V. Loomba, N. Yono

Journal Articles

Transient global amnesia (TGA) is a well-described neurological phenomenon. Clinically, it manifests with the sudden onset of a paroxysmal, transient loss of anterograde memory and disorientation but with intact consciousness. Typically, symptoms last for only a few hours. We present an unusual case of aortic dissection presenting with pure TGA in a patient, who had a positive outcome. This is the second case report of a patient with aortic dissection presenting with pure TGA syndrome, but it is the first case in which the patient survived.

Go to article

Dynamic Reciprocity Between Cells And Their Microenvironment In Reproduction, J. T. Thorne, T. R. Segal, S. Chang, S. Jorge, J. H. Segars, P. C. Leppert Jan 2015

Dynamic Reciprocity Between Cells And Their Microenvironment In Reproduction, J. T. Thorne, T. R. Segal, S. Chang, S. Jorge, J. H. Segars, P. C. Leppert

Journal Articles

Dynamic reciprocity (DR) refers to the ongoing, bidirectional interaction between cells and their microenvironment, specifically the extracellular matrix (ECM). The continuous remodeling of the ECM exerts mechanical force on cells and modifies biochemical mediators near the cell membrane, thereby initiating cell-signaling cascades that produce changes in gene expression and cell behavior. Cellular changes, in turn, affect the composition and organization of ECM components. These continuous interactions are the fundamental principle behind DR, and its critical role throughout development and adult tissue homeostasis has been extensively investigated. While DR in the mammary gland has been well described, we provide direct evidence …

Go to article

Selective Impairment Of Spatial Cognition Caused By Autoantibodies To The N-Methyl-D-Aspartate Receptor, E. H. Chang, B. T. Volpe, M. Mackay, C. Aranow, C. Kowal, P. Mattis, R. Berlin, S. Mader, T. S. Huerta, P. T. Huerta, B. Diamond, +3 Additional Authors Jan 2015

Selective Impairment Of Spatial Cognition Caused By Autoantibodies To The N-Methyl-D-Aspartate Receptor, E. H. Chang, B. T. Volpe, M. Mackay, C. Aranow, C. Kowal, P. Mattis, R. Berlin, S. Mader, T. S. Huerta, P. T. Huerta, B. Diamond, +3 Additional Authors

Journal Articles

Patients with systemic lupus erythematosus (SLE) experience cognitive abnormalities in multiple domains including processing speed, executive function, and memory. Here we show that SLE patients carrying antibodies that bind DNA and the GluN2A and GluN2B subunits of the N-methyl-d-aspartate receptor (NMDAR), termed DNRAbs, displayed a selective impairment in spatial recall. Neural recordings in a mouse model of SLE, in which circulating DNRAbs penetrate the hippocampus, revealed that CA1 place cells exhibited a significant expansion in place field size. Structural analysis showed that hippocampal pyramidal cells had substantial reductions in their dendritic processes and spines. Strikingly, these abnormalities became evident at …

Go to article

Lifetime Prevalence, Age Of Risk, And Genetic Relationships Of Comorbid Psychiatric Disorders In Tourette Syndrome, M. E. Hirschtritt, P. C. Lee, D. L. Pauls, Y. Dion, M. A. Grados, R. A. King, P. Sandor, W. M. Mcmahon, G. J. Lyon, C. A. Mathews, +4 Additional Authors Jan 2015

Lifetime Prevalence, Age Of Risk, And Genetic Relationships Of Comorbid Psychiatric Disorders In Tourette Syndrome, M. E. Hirschtritt, P. C. Lee, D. L. Pauls, Y. Dion, M. A. Grados, R. A. King, P. Sandor, W. M. Mcmahon, G. J. Lyon, C. A. Mathews, +4 Additional Authors

Journal Articles

IMPORTANCE: Tourette syndrome (TS) is characterized by high rates of psychiatric comorbidity; however, few studies have fully characterized these comorbidities. Furthermore, most studies have included relatively few participants (

Go to article

Abnormal Resting State Fmri Activity Predicts Processing Speed Deficits In First-Episode Psychosis, M. Argyelan, J. A. Gallego, D. G. Robinson, T. Ikuta, D. Sarpal, M. John, P. B. Kingsley, J. M. Kane, A. K. Malhotra, P. R. Szeszko Jan 2015

Abnormal Resting State Fmri Activity Predicts Processing Speed Deficits In First-Episode Psychosis, M. Argyelan, J. A. Gallego, D. G. Robinson, T. Ikuta, D. Sarpal, M. John, P. B. Kingsley, J. M. Kane, A. K. Malhotra, P. R. Szeszko

Journal Articles

Little is known regarding the neuropsychological significance of resting state functional magnetic resonance imaging (rs-fMRI) activity early in the course of psychosis. Moreover, no studies have used different approaches for analysis of rs-fMRI activity and examined gray matter thickness in the same cohort. In this study, 41 patients experiencing a first-episode of psychosis (including N = 17 who were antipsychotic drug-naive at the time of scanning) and 41 individually age-and sex-matched healthy volunteers completed rs-fMRI and structural MRI exams and neuropsychological assessments. We computed correlation matrices for 266 regions-of-interest across the brain to assess global connectivity. In addition, independent component …

Go to article

Expanded Genetic Screening Panel For The Ashkenazi Jewish Population, B. Baskovich, I. Peter, J. H. Cho, G. Atzmon, L. Clark, J. Yu, T. Lencz, I. Pe'er, H. Ostrer, C. Oddoux, +7 Additional Authors Jan 2015

Expanded Genetic Screening Panel For The Ashkenazi Jewish Population, B. Baskovich, I. Peter, J. H. Cho, G. Atzmon, L. Clark, J. Yu, T. Lencz, I. Pe'er, H. Ostrer, C. Oddoux, +7 Additional Authors

Journal Articles

PURPOSE: Carrier screening programs that identify the presence of known mutations have been effective for reducing the incidence of autosomal recessive conditions in the Ashkenazi Jewish (AJ) population and other populations. Yet, these programs have not realized their full potential. Furthermore, many known autosomal recessive and dominant conditions are not screened for and the molecular basis of other conditions for which screening might be offered is unknown. METHODS: Through literature review and annotation of full sequenced genomes from healthy individuals, we expanded the list of mutations. Mutations were identified in a sample of 128 fully sequenced AJ genomes that were …

Go to article

Prenatal Exposure To Maternal Smoking And Symptom Severity Among Offspring With First-Episode Nonaffective Psychosis, F. Bernardini, C. R. Wan, A. Crisafio, S. H. Massey, M. T. Compton Jan 2015

Prenatal Exposure To Maternal Smoking And Symptom Severity Among Offspring With First-Episode Nonaffective Psychosis, F. Bernardini, C. R. Wan, A. Crisafio, S. H. Massey, M. T. Compton

Journal Articles

No abstract provided.

Go to article

Role Of Social Media And The Internet In Pathways To Care For Adolescents And Young Adults With Psychotic Disorders And Non-Psychotic Mood Disorders, M. L. Birnbaum, A. F. Rizvi, Christoph Correll, J. M. Kane Jan 2015

Role Of Social Media And The Internet In Pathways To Care For Adolescents And Young Adults With Psychotic Disorders And Non-Psychotic Mood Disorders, M. L. Birnbaum, A. F. Rizvi, Christoph Correll, J. M. Kane

Journal Articles

AIMS: Although psychosis often occurs during adolescence, there has been little research on how the ubiquitously used Internet and social media could impact pathways to care. We examined how youth with psychotic spectrum disorders (PSD) versus non-psychotic mood disorders (NPMD) use online resources in the early illness stages. METHODS: Social media use and pathways to care data were collected using a semi-structured interview from 80 youth (PSD = 40 and NPMD = 40) aged 12-21 years within 2 years of symptom onset. RESULTS: A total of 97.5% of participants (mean age = 18.3 years) regularly used social media, spending approximately …

Go to article

Evaluating The Impact Of Cannabis Use On Thalamic Connectivity In Youth At Clinical High Risk Of Psychosis, L. Buchy, T. D. Cannon, A. Anticevic, K. Lyngberg, K. S. Cadenhead, B. A. Cornblatt, D. O. Perkins, L. J. Seidman, M. T. Tsuang, J. Addington, +5 Additional Authors Jan 2015

Evaluating The Impact Of Cannabis Use On Thalamic Connectivity In Youth At Clinical High Risk Of Psychosis, L. Buchy, T. D. Cannon, A. Anticevic, K. Lyngberg, K. S. Cadenhead, B. A. Cornblatt, D. O. Perkins, L. J. Seidman, M. T. Tsuang, J. Addington, +5 Additional Authors

Journal Articles

No abstract provided.

Go to article

Evaluating The Relationship Between Cannabis Use And Iq In Youth And Young Adults At Clinical High Risk Of Psychosis, L. Buchy, L. J. Seidman, K. S. Cadenhead, T. D. Cannon, B. A. Cornblatt, E. F. Walker, S. W. Woods, C. E. Bearden, D. H. Mathalon, J. Addington, +4 Additional Authors Jan 2015

Evaluating The Relationship Between Cannabis Use And Iq In Youth And Young Adults At Clinical High Risk Of Psychosis, L. Buchy, L. J. Seidman, K. S. Cadenhead, T. D. Cannon, B. A. Cornblatt, E. F. Walker, S. W. Woods, C. E. Bearden, D. H. Mathalon, J. Addington, +4 Additional Authors

Journal Articles

Among people with psychosis, those with a history of cannabis use show better cognitive performance than those who are cannabis naive. It is unknown whether this pattern is present in youth at clinical high risk (CHR) of psychosis. We evaluated relationships between IQ and cannabis use while controlling for use of other substances known to impact cognition in 678 CHR and 263 healthy control (HC) participants. IQ was estimated using the Vocabulary and Block Design subtests of the Wechsler Abbreviated Scale of Intelligence. Drug and alcohol use severity and frequency were assessed with the Alcohol and Drug Use Scale, and …

Go to article

Contributions Of Early Cortical Processing And Reading Ability To Functional Status In Individuals At Clinical High Risk For Psychosis, R. Carrion, B. A. Cornblatt, D. Mclaughlin, J. Chang, A. M. Auther, R. H. Olsen, D. C. Javitt Jan 2015

Contributions Of Early Cortical Processing And Reading Ability To Functional Status In Individuals At Clinical High Risk For Psychosis, R. Carrion, B. A. Cornblatt, D. Mclaughlin, J. Chang, A. M. Auther, R. H. Olsen, D. C. Javitt

Journal Articles

Background: There is a growing recognition that individuals at clinical high risk need intervention for functional impairments, along with emerging psychosis, as the majority of clinical high risk (CHR) individuals show persistent deficits in social and role functioning regardless of transition to psychosis. Recent studies have demonstrated reduced reading ability as a potential cause of functional disability in schizophrenia, related to underlying deficits in generation of mismatch negativity (MMN). The present study extends these findings to subjects at CHR. Methods: The sample consisted of 34 CHR individuals and 33 healthy comparison subjects (CNTLs) from the Recognition and Prevention (RAP) Program …

Go to article

The Impact Of Psychosis On The Course Of Cognition: A Prospective, Nested Case-Control Study In Individuals At Clinical High-Risk For Psychosis, R. Carrion, D. Mclaughlin, A. M. Auther, R. Olsen, Christoph Correll, B. A. Cornblatt Jan 2015

The Impact Of Psychosis On The Course Of Cognition: A Prospective, Nested Case-Control Study In Individuals At Clinical High-Risk For Psychosis, R. Carrion, D. Mclaughlin, A. M. Auther, R. Olsen, Christoph Correll, B. A. Cornblatt

Journal Articles

BACKGROUND: Although cognitive deficits in patients with schizophrenia are rooted early in development, the impact of psychosis on the course of cognitive functioning remains unclear. In this study a nested case-control design was used to examine the relationship between emerging psychosis and the course of cognition in individuals ascertained as clinical high-risk (CHR) who developed psychosis during the study (CHR + T). METHOD: Fifteen CHR + T subjects were administered a neurocognitive battery at baseline and post-psychosis onset (8.04 months, s.d. = 10.26). CHR + T subjects were matched on a case-by-case basis on age, gender, and time to retest …

Go to article

Postnatal Neurodevelopmental Expression And Glutamate-Dependent Regulation Of The Znf804a Rodent Homologue, E. H. Chang, A. Kirtley, T. S. Chandon, P. Borger, S. Husain-Krautter, V. Vingtdeux, A. Malhotra Jan 2015

Postnatal Neurodevelopmental Expression And Glutamate-Dependent Regulation Of The Znf804a Rodent Homologue, E. H. Chang, A. Kirtley, T. S. Chandon, P. Borger, S. Husain-Krautter, V. Vingtdeux, A. Malhotra

Journal Articles

The zinc finger protein ZNF804A rs1344706 variant is a replicated genome-wide significant risk variant for schizophrenia and bipolar disorder. While its association with altered brain structure and cognition in patients and healthy risk allele carriers is well documented, the characteristics and function of the gene in the brain remains poorly understood. Here, we used in situ hybridization to determine mRNA expression levels of the ZNF804A rodent homologue, Zfp804a, across multiple postnatal neurodevelopmental time points in the rat brain. We found changes in Zfp804a expression in the rat hippocampus, frontal cortex, and thalamus across postnatal neurodevelopment. Zfp804a mRNA peaked at postnatal …

Go to article

Responses To Tobacco Smoking-Related Health Messages In Young People With Recent-Onset Schizophrenia, D. J. Coletti, M. Brunette, M. John, J. M. Kane, A. Malhotra, D. G. Robinson Jan 2015

Responses To Tobacco Smoking-Related Health Messages In Young People With Recent-Onset Schizophrenia, D. J. Coletti, M. Brunette, M. John, J. M. Kane, A. Malhotra, D. G. Robinson

Journal Articles

Virtually no research has examined the responses of youth with recent-onset psychosis (ROP) to smoking-related health warnings. We examined predictors of response and tested hypotheses that participants with ROP would (a) assess warnings as less effective than a healthy comparison (HC) group, and (b) assess video warnings as more effective than pictures. ROP participants (n = 69) hadtreatment; the HC group (n = 79) had no major mental illness. Participants viewed 10 pictorial warnings, 8 videos depicting similar messages, and were interviewed regarding tobacco use, health literacy, and smoking knowledge. We assessed response at baseline and at 4-week follow-up. ROP …

Go to article

Personality Domains, Duration Of Untreated Psychosis, Functioning, And Symptom Severity In First-Episode Psychosis, M. Compton, R. Bakeman, Y. Alolayan, P. M. Balducci, F. Bernardini, B. Broussard, A. Crisafio, S. Cristofaro, S. Johnson, C. R. Wan, +1 Additional Author Jan 2015

Personality Domains, Duration Of Untreated Psychosis, Functioning, And Symptom Severity In First-Episode Psychosis, M. Compton, R. Bakeman, Y. Alolayan, P. M. Balducci, F. Bernardini, B. Broussard, A. Crisafio, S. Cristofaro, S. Johnson, C. R. Wan, +1 Additional Author

Journal Articles

OBJECTIVES: Early-course psychotic disorders have been extensively studied in terms of phenomenology, but little is known about the influence of personality traits on clinical features of first-episode psychosis. The aim of this study was to explore how the "big five" personality domains (neuroticism, extraversion, openness, agreeableness, and conscientiousness) are associated with treatment delay (duration of untreated psychosis, DUP), functioning, and positive and negative symptom severity. METHODS: Data for these analyses were obtained from 104 participants enrolled from psychiatric inpatient units in Atlanta, Georgia, between August 2008 and March 2011. The NEO Five-Factor Inventory (NEO-FFI) was used to assess personality domains, …

Go to article

Psychosis Prevention: A Modified Clinical High Risk Perspective From The Recognition And Prevention (Rap) Program, B. A. Cornblatt, R. Carrion, A. Auther, D. Mclaughlin, R. H. Olsen, M. John, C. U. Correll Jan 2015

Psychosis Prevention: A Modified Clinical High Risk Perspective From The Recognition And Prevention (Rap) Program, B. A. Cornblatt, R. Carrion, A. Auther, D. Mclaughlin, R. H. Olsen, M. John, C. U. Correll

Journal Articles

OBJECTIVE: Early intervention and prevention of psychosis remain a major challenge. Prediction would be greatly advanced with improved ability to identify individuals at true risk, which, at present, is moderate at best. The authors tested a modified strategy to improve prediction by selecting a more homogeneous high-risk sample (attenuated positive symptom criteria only, age range of mid-teens to early 20s) than is currently standard, combined with a systematic selection of neurodevelopmental deficits. METHOD: A sample of 101 treatment-seeking adolescents (mean age, 15.9 years) at clinical high risk for psychosis were followed clinically for up to 5 years (mean follow-up time, …

Go to article

Cardiovascular And Cerebrovascular Risk Factors And Events Associated With Second-Generation Antipsychotic Compared To Antidepressant Use In A Non-Elderly Adult Sample: Results From A Claims-Based Inception Cohort Study, C. U. Correll, B. I. Joffe, L. M. Rosen, T. B. Sullivan, R. T. Joffe Jan 2015

Cardiovascular And Cerebrovascular Risk Factors And Events Associated With Second-Generation Antipsychotic Compared To Antidepressant Use In A Non-Elderly Adult Sample: Results From A Claims-Based Inception Cohort Study, C. U. Correll, B. I. Joffe, L. M. Rosen, T. B. Sullivan, R. T. Joffe

Journal Articles

This is a study of the metabolic and distal cardiovascular/cerebrovascular outcomes associated with the use of second-generation antipsychotics (SGAs) compared to antidepressants (ADs) in adults aged 18-65 years, based on data from Thomson Reuters MarketScan (R) Research Databases 2006-2010, a commercial U.S. claims database. Interventions included clinicians' choice treatment with SGAs (allowing any comedications) versus ADs (not allowing SGAs). The primary outcomes of interest were time to inpatient or outpatient claims for the following diagnoses within one year of SGA or AD discontinuation: hypertension, ischemic and hypertensive heart disease, cerebrovascular disease, diabetes mellitus, hyperlipidemia, and obesity. Secondary outcomes included the …

Go to article

Examining The Psychosis Continuum, P. Derosse, K. H. Karlsgodt Jan 2015

Examining The Psychosis Continuum, P. Derosse, K. H. Karlsgodt

Journal Articles

The notion that psychosis may exist on a continuum with normal experience has been proposed in multiple forms throughout the history of psychiatry. However, in recent years there has been an exponential increase in efforts aimed at elucidating what has been termed the 'psychosis continuum'. The present review seeks to summarize some of the more basic characteristics of this continuum and to present some of the recent findings that provide support for its validity. While there is still considerable work to be done, the emerging data holds considerable promise for advancing our understanding of both risk and resilience to psychiatric …

Go to article

Reliability Of An Fmri Paradigm For Emotional Processing In A Multisite Longitudinal Study, D. G. Gee, S. C. Mcewen, J. K. Forsyth, K. M. Haut, C. E. Bearden, K. S. Cadenhead, H. Mirzakhanian, B. A. Cornblatt, D. Olvet, T. D. Cannon, +14 Additional Authors Jan 2015

Reliability Of An Fmri Paradigm For Emotional Processing In A Multisite Longitudinal Study, D. G. Gee, S. C. Mcewen, J. K. Forsyth, K. M. Haut, C. E. Bearden, K. S. Cadenhead, H. Mirzakhanian, B. A. Cornblatt, D. Olvet, T. D. Cannon, +14 Additional Authors

Journal Articles

Multisite neuroimaging studies can facilitate the investigation of brain-related changes in many contexts, including patient groups that are relatively rare in the general population. Though multisite studies have characterized the reliability of brain activation during working memory and motor functional magnetic resonance imaging tasks, emotion processing tasks, pertinent to many clinical populations, remain less explored. A traveling participants study was conducted with eight healthy volunteers scanned twice on consecutive days at each of the eight North American Longitudinal Prodrome Study sites. Tests derived from generalizability theory showed excellent reliability in the amygdala ( Erho2 = 0.82), inferior frontal gyrus (IFG; …

Go to article

Subcortical Modulation In Auditory Processing And Auditory Hallucinations, T. Ikuta, P. Derosse, M. Argyelan, K. H. Karlsgodt, P. B. Kingsley, P. R. Szeszko, A. K. Malhotra Jan 2015

Subcortical Modulation In Auditory Processing And Auditory Hallucinations, T. Ikuta, P. Derosse, M. Argyelan, K. H. Karlsgodt, P. B. Kingsley, P. R. Szeszko, A. K. Malhotra

Journal Articles

Hearing perception in individuals with auditory hallucinations has not been well studied. Auditory hallucinations have previously been shown to involve primary auditory cortex activation. This activation suggests that auditory hallucinations activate the terminal of the auditory pathway as if auditory signals are submitted from the cochlea, and that a hallucinatory event is therefore perceived as hearing. The primary auditory cortex is stimulated by some unknown source that is outside of the auditory pathway. The current study aimed to assess the outcomes of stimulating the primary auditory cortex through the auditory pathway in individuals who have experienced auditory hallucinations. Sixteen patients …

Go to article

White Matter Microstructure In The Executive Network Associated With Aggression In Healthy Adolescents And Young Adults, K. H. Karlsgodt, A. A. Bato, M. A. Blair, P. Derosse, P. Szeszko, A. K. Malhotra Jan 2015

White Matter Microstructure In The Executive Network Associated With Aggression In Healthy Adolescents And Young Adults, K. H. Karlsgodt, A. A. Bato, M. A. Blair, P. Derosse, P. Szeszko, A. K. Malhotra

Journal Articles

Predicting which individuals may engage in aggressive behavior is of interest in today's society; however, there is little data on the neural basis of aggression in healthy individuals. Here, we tested whether regional differences in white matter (WM) microstructure were associated with later reports of aggressive tendencies. We recontacted healthy young adults an average of 3 years after they underwent research MRI scans. Via electronic survey, we administered the Buss Perry Aggression Questionnaire. We divided aggression into Aggressive Thoughts (Anger and Hostility subscales) and Aggressive Acts (Verbal and Physical subscales) and used Tract-Based Spatial Statistics to test the relationship of …

Go to article

The Accumbofrontal Tract: Diffusion Tensor Imaging Characterization And Developmental Change From Childhood To Adulthood, K. H. Karlsgodt, M. John, T. Ikuta, P. Rigoard, B. D. Peters, P. Derosse, A. K. Malhotra, P. R. Szeszko Jan 2015

The Accumbofrontal Tract: Diffusion Tensor Imaging Characterization And Developmental Change From Childhood To Adulthood, K. H. Karlsgodt, M. John, T. Ikuta, P. Rigoard, B. D. Peters, P. Derosse, A. K. Malhotra, P. R. Szeszko

Journal Articles

The presence of an anatomical connection between the orbitofrontal cortex and ventral striatum, forming a so-called reward network, is well established across species. This connection has important implications for reward processing and is relevant to a number of neuropsychiatric disorders. Moreover, white matter (WM) is known to continue to mature across adolescence and into early adulthood, and developmental change in the reward network is an important component of models of decision making and risk taking. Despite the importance of this connection, the underlying WM has only recently been characterized in humans histologically, and not yet in-vivo using brain imaging. Here, …

Go to article

Treatment Of Early Non-Response In Patients With Schizophrenia: Assessing The Efficacy Of Antipsychotic Dose Escalation, A. Loebel, L. Citrome, C. U. Correll, J. Xu, J. Cucchiaro, J. M. Kane Jan 2015

Treatment Of Early Non-Response In Patients With Schizophrenia: Assessing The Efficacy Of Antipsychotic Dose Escalation, A. Loebel, L. Citrome, C. U. Correll, J. Xu, J. Cucchiaro, J. M. Kane

Journal Articles

No abstract provided.

Go to article

Self-Awareness Of Functional Impairment In Individuals At Clinical High-Risk For Psychosis, D. M. Olvet, R. E. Carrion, A. M. Auther, B. A. Cornblatt Jan 2015

Self-Awareness Of Functional Impairment In Individuals At Clinical High-Risk For Psychosis, D. M. Olvet, R. E. Carrion, A. M. Auther, B. A. Cornblatt

Journal Articles

AimsA major public health concern associated with schizophrenia is the long-term disability that involves an inability to function independently in the community. An individual's self-awareness of functional impairment may be a significant factor contributing to long-term disability. In fact, subjective interpretation of one's illness impacts treatment participation and adherence, and is linked to poor outcomes. However, it remains unclear how illness-related functional impairment is perceived by individuals prior to the onset of psychosis. This study aims to examine the relationship between clinician-based and self-report assessments of functioning, as well as the contribution of clinical symptoms to this relationship in individuals …

Go to article

Age And Sex Effects On Corpus Callosum Morphology Across The Lifespan, D. M. Prendergast, B. Ardekani, T. Ikuta, M. John, B. Peters, P. Derosse, R. Wellington, A. K. Malhotra, P. Szeszko Jan 2015

Age And Sex Effects On Corpus Callosum Morphology Across The Lifespan, D. M. Prendergast, B. Ardekani, T. Ikuta, M. John, B. Peters, P. Derosse, R. Wellington, A. K. Malhotra, P. Szeszko

Journal Articles

The corpus callosum (CC) is the largest interhemispheric white matter tract in the human brain, and is characterized by pronounced differences in morphology among individuals. There are limited data, however, regarding typical development, sex differences, and the neuropsychological correlates of individual differences within CC subregions. Magnetic resonance (MR) imaging exams were collected in a large cohort (N=305) of healthy individuals (ages 8-68). We used a highly reliable program to automatically identify the midsagittal plane and obtain CC subregion measures according to approaches described by Witelson [1989]: Brain 112:799-835 and Hampel et al. [1998]: Arch Neurol 55:193-198 and a measure of …

Go to article

A Randomized Comparison Of Aripiprazole And Risperidone For The Acute Treatment Of First-Episode Schizophrenia And Related Disorders: 3-Month Outcomes, D. G. Robinson, J. A. Gallego, M. John, G. Petrides, Y. Hassoun, J. P. Zhang, L. Lopez, R. J. Braga, M. Naraine, N. Bennett, J. Greenberg, T. Lencz, C. U. Correll, J. M. Kane, A. K. Malhotra, +4 Additional Authors Jan 2015

A Randomized Comparison Of Aripiprazole And Risperidone For The Acute Treatment Of First-Episode Schizophrenia And Related Disorders: 3-Month Outcomes, D. G. Robinson, J. A. Gallego, M. John, G. Petrides, Y. Hassoun, J. P. Zhang, L. Lopez, R. J. Braga, M. Naraine, N. Bennett, J. Greenberg, T. Lencz, C. U. Correll, J. M. Kane, A. K. Malhotra, +4 Additional Authors

Journal Articles

Research findings are particularly important for medication choice for first-episode patients as individual prior medication response to guide treatment decisions is unavailable. We describe the first large-scale double-masked randomized comparison with first-episode patients of aripiprazole and risperidone, 2 commonly used first-episode treatment agents. One hundred ninety-eight participants aged 15-40 years with schizophrenia, schizophreniform disorder, schizoaffective disorder or psychotic disorder Not Otherwise Specified, and who had been treated in their lifetime with antipsychotics for 2 weeks or less were randomly assigned to double-masked aripiprazole (5-30mg/d) or risperidone (1-6mg/d) and followed for 12 weeks. Positive symptom response rates did not differ (62.8% …

Go to article

First Prev Next Last