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Articles 571 - 579 of 579
Full-Text Articles in Medical Specialties
Basement Membrane And Repair Of Injury To Peripheral Nerve: Defining A Potential Role For Macrophages, Matrix Metalloproteinases, And Tissue Inhibitor Of Metalloproteinases-1, Monique La Fleur, Johnnie L. Underwood, Daniel A. Rappolee, Zena Werb
Basement Membrane And Repair Of Injury To Peripheral Nerve: Defining A Potential Role For Macrophages, Matrix Metalloproteinases, And Tissue Inhibitor Of Metalloproteinases-1, Monique La Fleur, Johnnie L. Underwood, Daniel A. Rappolee, Zena Werb
Department of Obstetrics and Gynecology Research Publications
Injury to a peripheral nerve is followed by a remodeling process consisting of axonal degenera- tion and regeneration. It is not known how Schwann cell–derived basement membrane is pre- served after injury or what role matrix metalloproteinases (MMPs) and their inhibitors play in axonal degeneration and regeneration. We showed that the MMPs gelatinase B (MMP-9), stromelysin-1 (MMP-3), and the tissue inhibitor of MMPs (TIMP)-1 were induced in crush and distal segments of mouse sciatic nerve after injury. TIMP-1 inhibitor activity was present in excess of proteinase activity in extracts of injured nerve. TIMP-1 protected basement mem- brane type IV collagen …
Hepatocyte Growth Factor And Its Receptor Are Expressed In Cardiac Myocytes During Early Cardiogenesis, Daniel A. Rappolee, Anand Iyer, Yogesh Patel
Hepatocyte Growth Factor And Its Receptor Are Expressed In Cardiac Myocytes During Early Cardiogenesis, Daniel A. Rappolee, Anand Iyer, Yogesh Patel
Department of Obstetrics and Gynecology Research Publications
In the mouse, the heart primordium arises when mesodermis set aside during gastrulation, is induced by pharyngeal endoderm, migrates ventrally to the midline of the embryo, forms a tube, and begins beating. Little is known of the molecular mechanisms that mediate the determination, mitosis, differentiation, and migration that lead to the beating heart. Transcripts for hepatocyte growth factor/scatter factor (HGF) and its receptor are coexpressed transiently and dynamically in the premyocardium but not in other heart progenitor cells. Transcripts for HGF ligand and receptor are first detected before cardiac function and looping and persist through the first looping stage, when …
Expression And Function Of Fgf-4 In Peri-Implantation Development In Mouse Embryos, Daniel A. Rappolee, Claudio Basilico, Yogesh Patel, Zena Werb
Expression And Function Of Fgf-4 In Peri-Implantation Development In Mouse Embryos, Daniel A. Rappolee, Claudio Basilico, Yogesh Patel, Zena Werb
Department of Obstetrics and Gynecology Research Publications
One of the earliest events in mammalian embryogenesis is the formation of the inner cell mass (ICM) and the subse- quent delamination of primitive endoderm. We have found that mRNA for fibroblast growth factor (FGF)-4, but not FGF-3, is expressed in preimplantation mouse blastocysts and that the FGF-4 polypeptide is present in ICM cells. ICM-like embryonal carcinoma cells and embryonic stem cells also express FGF-4. Conversely, differentiated embryonal carcinoma cells in the endoderm lineage express FGF-3, but not FGF-4 mRNA. Although mouse embryos expressed FGF-4 mRNA from the 1-cell stage, embryos cultured from the 2-cell through the blastocyst stage in …
Insulin-Like Growth Factor Ii Acts Through An Endogenous Growth Pathway Regulated By Imprinting In Early Mouse Embryos, Daniel A. Rappolee, Karin S. Sturm, Ole Behrendtsen, Gilbert A. Schultz, Roger A. Pedersen, Zena Werb
Insulin-Like Growth Factor Ii Acts Through An Endogenous Growth Pathway Regulated By Imprinting In Early Mouse Embryos, Daniel A. Rappolee, Karin S. Sturm, Ole Behrendtsen, Gilbert A. Schultz, Roger A. Pedersen, Zena Werb
Department of Obstetrics and Gynecology Research Publications
We present evidence that insulin-like growth factor II (IGF-II) mediates growth in early mouse embryos and forms a pathway in which imprinted genes influence development during preimplantation stages, mRNA and protein for IGF-II were expressed in preimplantation mouse embryos, but the related factors IGF-I and insulin were not. IGF-I and insulin receptors and the IGF-II/mannose-6-phosphate receptor were expressed. Exogenous IGF-II or IGF-I increased the cell number in cultured blastocysts, but a mutant form of IGF-II that strongly binds only the IGF-II receptor did not. Reduction of IGF-II expression by antisense IGF-II oligonucleotides decreased the rate of progression to the blastocyst …
Platelet A-Granule Fibrinogen, Albumin, And Immunoglobulin G Are Not Synthesized By Rat And Mouse Megakaryocytes, Prem Handagama, Daniel A. Rappolee, Zena Werb, Jack Levin, Dorothy F. Bainton
Platelet A-Granule Fibrinogen, Albumin, And Immunoglobulin G Are Not Synthesized By Rat And Mouse Megakaryocytes, Prem Handagama, Daniel A. Rappolee, Zena Werb, Jack Levin, Dorothy F. Bainton
Department of Obstetrics and Gynecology Research Publications
It has been assumed that endogenous synthesis by the platelet precursor cell, the bone marrow megakaryocyte, is the major source of platelet a-granule protein. To test this hypothesis, we used mRNA phenotyping to detect in megakaryocytes the presence of mRNA transcripts specific for various proteins. Our results indicate that megakaryocytes synthesize platelet factor 4, a protein relatively specific for platelets, but do not express mRNA transcripts for the fibrinogen, albumin, or IgG found in a-granules. We have previously shown that mega- karyocytes endocytose circulating proteins, including fibrino- gen, albumin, and IgG, and incorporate them into a-granules. Thus, platelets appear to …
Two Alkaline Phosphatase Genes Are Expressed During Early Development In The Mouse Embryo, Ann C. Hahnel, Daniel A. Rappolee, Jose Luis Millan, Thomas Manes, Carol A. Ziomek, Nicoleta G. Theodosiou, Zena Werb, Roger A. Pedersen, Gilbert A. Schultz
Two Alkaline Phosphatase Genes Are Expressed During Early Development In The Mouse Embryo, Ann C. Hahnel, Daniel A. Rappolee, Jose Luis Millan, Thomas Manes, Carol A. Ziomek, Nicoleta G. Theodosiou, Zena Werb, Roger A. Pedersen, Gilbert A. Schultz
Department of Obstetrics and Gynecology Research Publications
Alkaline phosphatase (AP) activity is stage specific in mouse embryos and may be associated with compaction and separation of trophectoderm from inner cell mass in preimplantation development. We previously sequenced a cDNA and two mouse AP genes that could contribute to the AP activity in embryos. Oligonucleotide primers were constructed from the three sequences and used in the reverse transcription-polymerase chain reaction technique to establish that two of the three AP isozymes are transcribed during preimplantation development. The predominant transcript (E-AP) is from a gene highly homologous to the human tissue-specific APs, but different from the mouse intestinal AP. Tissue …
Genes For Extracellular Matrix-Degrading Metalloproteinases And Their Inhibitor, Timp, Are Expressed During Early Mammalian Development, C. A. Brenner, R. R. Adler, D. A. Rappolee, R. A. Pedersen, Z Werb
Genes For Extracellular Matrix-Degrading Metalloproteinases And Their Inhibitor, Timp, Are Expressed During Early Mammalian Development, C. A. Brenner, R. R. Adler, D. A. Rappolee, R. A. Pedersen, Z Werb
Department of Obstetrics and Gynecology Research Publications
Extracellular matrix (ECM) remodeling accompanies cell migration, cell-cell interactions, embryo expansion, uterine implantation, and tissue invasion during mammalian embryogenesis. We have found that mouse embryos secrete functional ECM-degrading metalloproteinases, including collagenase and stromelysin, that are inhibitable by the tissue inhibitor of metalloproteinases (TIMP) and that are regulated during peri-implantation development and endoderm differentiation. mRNA transcripts for collagenase, stromelysin, and TIMP were detected as maternal transcripts in the unfertilized egg, were present at the zygote and cleavage stages, and increased at the blastocyst stage and with endoderm differentiation. These data suggest that metalloproteinases function in cell-ECM interactions during growth, development, and …
Developmental Expression Of Pdgf, Tgf-A, And Tgf-J Genes In Preimplantation Mouse Embryos, Daniel A. Rappolee, Carol A. Brenner, Richard Schultz, David Mark, Zena Werb
Developmental Expression Of Pdgf, Tgf-A, And Tgf-J Genes In Preimplantation Mouse Embryos, Daniel A. Rappolee, Carol A. Brenner, Richard Schultz, David Mark, Zena Werb
Department of Obstetrics and Gynecology Research Publications
Control of growth and differentiation during mammalian embryogenesis may be regulated by growth factors from embryonic or maternal sources. With the use of single-cell messenger RNA phenotyping, the simultaneous expression of growth factor transcripts in single or small numbers of preimplantation mouse embryos was examined. Transcripts for platelet-derived growth factor A chain (PDGF-A), trans- forming growth factor (TGF)-a, and TGF- 1, but not for four other growth factors, were found in whole blastocysts. TGF-cx, TGF-(31, and PDGF antigens were detected in blastocysts by immunocytochemistry. Both PDGF-A and TGF-a were detected as maternal transcripts in the unferilized ovulated oocyte, and again …
Ethnicity And Lifetimes: Self Concepts And Situational Contexts Of Ethnic Identity In Late Life, Mark Luborsky, Robert L. Rubinstein
Ethnicity And Lifetimes: Self Concepts And Situational Contexts Of Ethnic Identity In Late Life, Mark Luborsky, Robert L. Rubinstein
Anthropology Faculty Research Publications
This chapter reports on finding from a study of ethnic older men, aged 65 an older (Jewish, Irish, and Italian) who were widowed from 2 to 8 years after a long-term study. It focuses on life reorganization after the initial bereavement period. It identifies key issues in the process concerning continuity and change in identity reformulation, changes in health and activity patterns, ethnic identity and lingering attachment to the deceased spouse. Ethnicity as a dynamic life course process, shaped by contextual and historical dimensions, and personal meaning processes are highlighted. Supported by NIH# R01-AG005204