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Articles 961 - 990 of 2152
Full-Text Articles in Medical Specialties
Immunological Aspects Of Neoplastic Diseases, V. Radhakrishna
Immunological Aspects Of Neoplastic Diseases, V. Radhakrishna
Henry Ford Hospital Medical Journal
The immunological approach to neoplastic disease is gaining favor because malignant tumors are associated with immunodeficient states. Mesenchymal tumors have been seen in renal allograft recipients. The discovery of carcinoembryonic antigen, alfafetoprotein and other protein antigens associated with malignant diseases are other factors. Spontaneous regression of malignant neoplasm has been attributed to an effective immunologic process in the host. Identification of tumor specific antigens may explain these spontaneous tumor regressions. It may not be too optimistic to expect tumor vaccine of some sort within the next few years. B.C.G. and other nonspecific immunostimulants are under investigation for treatment of malignant …
Productivity Of The Roll-Streak Method To Perform Anaerobic Bacteriology In The Routine Clinical Laboratory, Thomas R. Neblett
Productivity Of The Roll-Streak Method To Perform Anaerobic Bacteriology In The Routine Clinical Laboratory, Thomas R. Neblett
Henry Ford Hospital Medical Journal
Data presented are derived from one year of performing routine clinical anaerobic bacteriology by the roll-streak tube method. 826 specimens from 1508 (54.8%) contained anaerobes. 162 specimens were polymicrobic (19.6%) and contained 528 strains of a total of 1051 isolated (50.2 %). 479 blood specimens contained 525 strains of anaerobes. Propionibacterium, considered a contaminant, occurred 209/210 times in blood as the sole isolate. Bacteroides occurred alone or polymicrobically 308 times and comprised 54.7% of the blood isolates and 32.5% of the total anaerobic genera isolated. Clostridium, Peptococcus and Fusobacterium were the next most frequently occurring anaerobes. The roll-streak method is …
Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research
Henry Ford Hospital Medical Journal
No abstract provided.
Clarke M. Mccoll M.D. In Memoriam 1898-1976, Dwight C. Ensign
Clarke M. Mccoll M.D. In Memoriam 1898-1976, Dwight C. Ensign
Henry Ford Hospital Medical Journal
No abstract provided.
Surgical Techniques For Arthrodesis Of Two To Four Adjacent Spinal Vertebrae Throughout The Entire Spinal Column, Kent K. Wu
Henry Ford Hospital Medical Journal
Surgical techniques for cervical, thoracic and lumbar spinal fusions have been described. So far, 51 such fusions have been performed with satisfactory results.
Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research
Henry Ford Hospital Medical Journal
No abstract provided.
Cushing's Disease: Spontaneous Remission Following Severe Headache, Raymond C. Mellinger
Cushing's Disease: Spontaneous Remission Following Severe Headache, Raymond C. Mellinger
Henry Ford Hospital Medical Journal
A young woman was found to have persistent Cushing's syndrome one year after surgical removal of both hyperplastic adrenal glands. Improvement followed pituitary irradiation butshe developed skin pigmentation. Remission of the adrenal hyperfunction occurred only after several months of therapy with o,p'-DDD. Within 15 months, the recurrent disorder required a second course of DDD with resulting adrenal insufficiency. Eighteen months later, however, steroid supplements were no longer required and increasing Cortisol levels indicated still another imminent relapse. There was no enlargement of the sella turcica. The patient had received no treatment whatever for nearly nine months when she experienced a …
Endoscopic Retrograde Pancreatic Duct Cannulation (Erpc): An Aid To Pancreatic Surgery, C. Grodsinsky, B. Schuman, B. E. Brush
Endoscopic Retrograde Pancreatic Duct Cannulation (Erpc): An Aid To Pancreatic Surgery, C. Grodsinsky, B. Schuman, B. E. Brush
Henry Ford Hospital Medical Journal
Retrograde endoscopic pancreatic duct cannulation for evaluation of patients with chronic pancreatitis is reviewed over the last two years. Of 40 patients that were endoscoped, 30 had a successful pancreatogram. The X-ray findings fell into three groups: 1) single and multiple stenosis, 2) diffuse narrowing, and 3) apparently normal duct. This procedure proved of value in ruling out or delaying surgical operation in 10 persons. Twenty-one patients underwent operations. Thirteen had a 95% pancreatectomy, one had drainage of a necrotic collection thought to be a pseudocyst and one had a pseudocyst resected. One had a gastrojejunostomy and vagotomy bypassing a …
Multiple Myeloma In A 23-Year-Old Man: A Case Report, C. K. Ma, K. Maeda, R. Waldmann, J. W. Rebuck
Multiple Myeloma In A 23-Year-Old Man: A Case Report, C. K. Ma, K. Maeda, R. Waldmann, J. W. Rebuck
Henry Ford Hospital Medical Journal
A case is reported of multiple myeloma in a 23-year-old man, including extensive clinical studies and postmortem examination. Multiple myeloma for this age group is considered to be extremely rare.
Infections Due To Trichosporon Cutaneum, An Uncommon Systemic Pathogen, Tom Madhavan, John Eisses, Edward L. Quinn
Infections Due To Trichosporon Cutaneum, An Uncommon Systemic Pathogen, Tom Madhavan, John Eisses, Edward L. Quinn
Henry Ford Hospital Medical Journal
Multiple isolations of T. Cutaneum from the blood stream of two patients enabled the authors to characterize the morphology, biochemical reactions and antibiotic susceptibility of T. Cutaneum. This organism appears to be an opportunistic pathogen and responds promptly to intravenous Amphotericin B or oral 5-Fluorocytosine.
Bupivacaine As A Local Anesthetic For Hernia Repair, Joseph L. Ponka, James A. Sapala
Bupivacaine As A Local Anesthetic For Hernia Repair, Joseph L. Ponka, James A. Sapala
Henry Ford Hospital Medical Journal
Bupivacaine hydrochloride is a safe, useful local anesthetic agent for repair of groin hernias. Prolonged anesthesia, lasting six hours or longer, was observed In 94 of WO patients. No toxic effects involving the central nervous system were observed using a 0.25% solution with epinephrine. Hypotension and cardiac arrhythmia occurred in one patient. Wound complications, such as hematomas and ecchymosis, were more common with Bupivacaine than when Chlorprocaine was used. However, painstaking hemostasis, which required ligation of even the tiniest blood vessels, reduced the wound complications. As experience is gained in the use of Bupivacaine, complications will be reduced to a …
Lymphangiography In Staging Carcinoma Of The Prostate. A Comparison With Operative Findings, Joseph C. Cerny, Malcolm Weckstein, Riad Farah
Lymphangiography In Staging Carcinoma Of The Prostate. A Comparison With Operative Findings, Joseph C. Cerny, Malcolm Weckstein, Riad Farah
Henry Ford Hospital Medical Journal
Pedal lymphangiography was performed In 30 patients who subsequently underwent radical retropubic prostatectomy, and radical pelvic lymphadenectomy. In 24 of 30 patients, lymphangiograms correctly predicted the presence or absence of nodal Involvement. In spite of certain limitations of the technique. It is considered an essential diagnostic study in patients considered for possible radical prostatic surgery, or in patients who may be candidates for external megavoltage radiotherapy to the prostate gland and its lymphatic drainage.
Palliative Urinary Diversion In Adenocarcinoma Of The Prostate, R. C. Youngman, Joseph C. Cerny
Palliative Urinary Diversion In Adenocarcinoma Of The Prostate, R. C. Youngman, Joseph C. Cerny
Henry Ford Hospital Medical Journal
Ten patients with inoperable prostatic carcinoma, producing ureteral obstruction and azotemia, underwent palliative urinary diversion. Good quality survivals of two months to three years were obtained. These results compare favorably with the good results seer) In gynecologic neoplasm of the bladder, colon and breast. In selected cases of carcinoma of the prostate, palliative urinary diversion is indicated when the prospects exist for further benefit from chemotherapy or radiotherapy.
Radical Retropubic Prostatectomy And Pelvic Lymphadenectomy In Carcinoma Of The Prostate, Riad N. Farah, Joseph C. Cerny
Radical Retropubic Prostatectomy And Pelvic Lymphadenectomy In Carcinoma Of The Prostate, Riad N. Farah, Joseph C. Cerny
Henry Ford Hospital Medical Journal
An operative technique Is described which combines regional pelvic lymphadenectomy with radical prostatectomy. The technique has been used on 30 patients with no operative mortality. Morbidity has been within acceptable limits. Thus far, only one patient has shown recurrence of the neoplasm.
Advances In The Radiation Therapy Of Carcinoma Of The Prostate, Joel Elliot White
Advances In The Radiation Therapy Of Carcinoma Of The Prostate, Joel Elliot White
Henry Ford Hospital Medical Journal
Basic principles of radiation biology and radiation tolerance are reviewed. The Implications for radiation therapy of newer staging techniques in carcinoma of the prostate such as exploratory laparotomy, lymphangiography, and bone marrow acid prosphatase are discussed. A technique for treating the prostate and para-aortic lymph nodes in continuity is presented. Complications and results of therapy are discussed.
Symposium On Carcinoma Of The Prostate — Introduction, Joseph C. Cerny
Symposium On Carcinoma Of The Prostate — Introduction, Joseph C. Cerny
Henry Ford Hospital Medical Journal
No abstract provided.
Radionuclide Bone Imaging In The Evaluation Of Prostatic Cancer, Daniel S. Marks, William R. Eyler
Radionuclide Bone Imaging In The Evaluation Of Prostatic Cancer, Daniel S. Marks, William R. Eyler
Henry Ford Hospital Medical Journal
Radionuclide bone imaging is a rapid, easily performed, noninvasive method for evaluation of skeletal disease in carcinoma of the prostate, or any other malignancy. In a significant number of cases, it may provide the only evidence of metastases and frequently demonstrates more widespread Involvement than previously suspected. Thus, it may redirect the chosen course of therapy or localize sources of bone pain that are not radiographically apparent. Sixty-two percent of 42 patients studied were abnormal, of which 12% had no radiographic evidence of disease.
Bone Marrow Acid Phosphatase In The Evaluation Of Patients With Carcinoma Of The Prostate, Ronald Kabler, Riad Farah, Kenneth Greenawald, Joseph C. Cerny
Bone Marrow Acid Phosphatase In The Evaluation Of Patients With Carcinoma Of The Prostate, Ronald Kabler, Riad Farah, Kenneth Greenawald, Joseph C. Cerny
Henry Ford Hospital Medical Journal
Based on experience with 30 men having clinical stage A and B adenocarcinoma of the prostate, the authors conclude that elevation of bone marrow acid phosphatase (BMAP) is a sensitive indicator of the disease state. BMAP revealed periprostatic or nodal Involvement when osseous metastases seemed absent. BMAP is considered essential in the evaluation of all patients with prostatic carcinoma. Patients who have false negative BMAP (and are not candidates for radical prostatectomy), should undergo lymphangiography and bone scan before radiation therapy or hormonal treatment is planned.
Immunologic Assessment In Patients With Prostatic Carcinoma, Richard C. Klugo
Immunologic Assessment In Patients With Prostatic Carcinoma, Richard C. Klugo
Henry Ford Hospital Medical Journal
The role of immune mechanisms in the development and control of prostatic carcinoma appears to be complicated by the endocrine response of some tumors. The progression of endocrine-independent tumors is more directly related to host-immune response. Evaluation of the role of chemotherapeutic agents must include their effect on the host-immune response. The use of BCC in patients with metastatic prostatic carcinoma produces no alteration in cell-mediated immunity but produces local tumor necrosis. The use of nonspecific antigens to enhance host-immune response may be more effective when used as adjuvant therapy in earlier stages of prostatic adenocarcinoma.
Hormonal And Chemotherapeutic Management Of Disseminated Carcinoma Of The Prostate, Robert W. Brownlee
Hormonal And Chemotherapeutic Management Of Disseminated Carcinoma Of The Prostate, Robert W. Brownlee
Henry Ford Hospital Medical Journal
The management of disseminated prostatic carcinoma with hormonal and chemotherapeutic agents is discussed. Hormonal manipulation consists of ablative as well as additive modalities. A new agent, Adriamycin, has shown some effectiveness In selected cases. Significant difficulties are encountered in assessing the objective state of remission of patients undergoing therapy. Further advances through co-operative, randomized clinical trials must be sought. The development of additional chemotherapeutic agents will hopefully expand our horizons.
Changes In Serum Testosterone After Bilateral Orchiectomy In Patients With Metastatic Carcinoma Of The Prostate, Richard Senn, Riad Farah, Julius Ohorodnik, Joseph C. Cerny
Changes In Serum Testosterone After Bilateral Orchiectomy In Patients With Metastatic Carcinoma Of The Prostate, Richard Senn, Riad Farah, Julius Ohorodnik, Joseph C. Cerny
Henry Ford Hospital Medical Journal
From a study of 38 patients, it may be concluded that, first, changes in serum testosterone levels of patients undergoing orchiectomy for metastatic carcinoma of the prostate are unrelated to the clinical course of the patient; second, no clear correlation exists between quantitative Leydig cell counts and levels of plasma testosterone; and, third, exacerbation of metastatic disease is observed while plasma testosterone remains in the castrate range. These observations question the exact function of the Leydig cell and its role in androgen production, and indicate that prostatic neoplasms have varying degrees of response to reduced androgen levels and/or androgen-Iike substances …
The Effects Of Immobility On Long Bone Remodelling In The Rhesus Monkey, Charles C. Schock, Frank R. Noyes, Michael M. Crouch, Catharina H. E. Mathews
The Effects Of Immobility On Long Bone Remodelling In The Rhesus Monkey, Charles C. Schock, Frank R. Noyes, Michael M. Crouch, Catharina H. E. Mathews
Henry Ford Hospital Medical Journal
Using Frost's method for undecalcified bone sections, long bones of the lower extremities of ten rhesus monkeys were examined following two months' immobilization and compared with thirteen controls. A decrease in appositional rate and in the surface extent of the ossification process were noted in the immobilized animals. No typical change in resorption was noted. The immobilized animals showed a decreased cortical-total area ratio. These findings suggest that a decrease in activity affects bone by depressing functions mediated by the osteoblast without necessarily evoking an Increased remodelling response.
Sjogren's Syndrome: Relationship Between Ocular Findings And Parotid Sialograms, A. O. Carbone, C. F. Petrozzi, J. Delcarpio, J. A. Zegarra
Sjogren's Syndrome: Relationship Between Ocular Findings And Parotid Sialograms, A. O. Carbone, C. F. Petrozzi, J. Delcarpio, J. A. Zegarra
Henry Ford Hospital Medical Journal
This study evaluates the incidence and severity of the ocular findings and its correlation with the parotid gland changes, as demonstrated by sialography, in 82 patients with Sjogren's syndrome. It is shown that the ocular component of the syndrome manifests rather autonomously with respect to the accompanying collagen disease and that there seems to be only a tentative trend towards a positive correlation between the ocular and parotid findings. Sjogren's syndrome immunologically is closer to the collagen diseases than to the so-called organ-specific autoimmune diseases.
Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research
Henry Ford Hospital Medical Journal
No abstract provided.
Supportive Care Of The Leukemic Patient, Ellis J. Van Slyck
Supportive Care Of The Leukemic Patient, Ellis J. Van Slyck
Henry Ford Hospital Medical Journal
The outlook for the patient with leukemia or lymphoma has been improved by the exponential expansion of basic scientific knowledge in physical chemistry and microbiology, added to much new clinical information based on large cooperative group studies. Most of this progress derives, not from a specific treatment for the disease, but from better understanding and use of multiple support measures. These include the availability of blood components, such as red blood cell, platelet and granulocyte concentrates, better protective isolation measures, and greater expertise in the recognition and treatment of bacterial, fungal, and viral infections in immunosuppressed patients. In addition, the …