Open Access. Powered by Scholars. Published by Universities.®

Medical Specialties Commons™

Open Access. Powered by Scholars. Published by Universities.®

Surgery

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 4321 - 4350 of 5939

Full-Text Articles in Medical Specialties

Occlusal Outcome Of Non-Extraction And All First Premolars Extraction Treatment In Patients With Class-I Malocclusion., Adeel Tahir Kamal, Attiya Shaikh, Mubassar Fida Oct 2016

Occlusal Outcome Of Non-Extraction And All First Premolars Extraction Treatment In Patients With Class-I Malocclusion., Adeel Tahir Kamal, Attiya Shaikh, Mubassar Fida

Department of Surgery Docs

Abstract

OBJECTIVE:

Class-1 malocclusion commonly presents with crowding and poses an aesthetic concern to patients. An orthodontist may encounter a variety of dental problems and must handle them strategically to establish adequate occlusal relationships. Hence, this study was conducted to evaluate the occlusal characteristics of patients who have undergone non-extraction or all first premolars extraction treatment for class I malocclusion using the peer assessment rating (PAR) index.

METHODS:

The pre-treatment and post treatment dental casts of 94 subjects with class-I malocclusion were retrospectively screened. The sample was distributed into two groups, i.e., nonextraction and all first premolars extraction groups. The …


Exploration Of Variations In Positions Of Upper And Lower Incisors, Overjet, Overbite, And Irregularity Index In Orthodontic Patients With Dissimilar Depths Of Curve Of Spee., Nita Kumari, Mubassar Fida, Attiya Shaikh Oct 2016

Exploration Of Variations In Positions Of Upper And Lower Incisors, Overjet, Overbite, And Irregularity Index In Orthodontic Patients With Dissimilar Depths Of Curve Of Spee., Nita Kumari, Mubassar Fida, Attiya Shaikh

Department of Surgery Docs

Abstract

OBJECTIVE:

The position and arrangement of teeth as well as the entire scheme of occlusion differs from one individual to the other .The purpose of this study was to examine differences in position and inclination of incisors, overjet, overbite and lower arch crowding in subjects with different depths of curve of Spee and to determine correlations between depth of curve of Spee and these variables.

METHODS:

The sample comprised of 114 patients (55 females and 59 males) with fully erupted permanent second molars (age 12-25 years), having no history of previous orthodontic treatment, no craniofacial anomalies, and no missing …


Better Outcome Of Splenectomy In Younger Patients Suffering From Chronic Immune Thrombocytopenia, Sabah Saqib, Rizwan Hashim, Hasnain Zafar Oct 2016

Better Outcome Of Splenectomy In Younger Patients Suffering From Chronic Immune Thrombocytopenia, Sabah Saqib, Rizwan Hashim, Hasnain Zafar

Department of Surgery Docs

Abstract Immune thrombocytopenia purpura (ITP) may need splenectomy after failure of medical treatment. The aim of this study was to explore the outcome of splenectomy in chronic ITP and to point out factors which can predict better response to splenectomy. This retrospective chart review was conducted at the Aga Khan University Hospital, Karachi, and comprised adult patients who underwent splenectomy for ITP from October 2005 to December 2015. Of the 51 patients, 37(72.5%) were females and 14(27.5%) were males. The overall median age was 32 years (interquartile range: 18-65 years). Complete response was seen in 43(84.3%) patients, 2(4%) had response …


Age Estimation Of A Sample Of Pakistani Population Using Coronal Pulp Cavity Index In Molars And Premolars On Orthopantomogram, Sheikh Bilal Badar, Rabia Ghafoor, Farhan Raza Khan, Muhammad Hasan Hameed Oct 2016

Age Estimation Of A Sample Of Pakistani Population Using Coronal Pulp Cavity Index In Molars And Premolars On Orthopantomogram, Sheikh Bilal Badar, Rabia Ghafoor, Farhan Raza Khan, Muhammad Hasan Hameed

Department of Surgery Docs

The aim of the present study was to assess the validity of tooth-coronal index (TCI) in the age estimation. This retrospective charts review was conducted at the Aga Khan University Hospital, Karachi from January 2016 to March 2016, and comprised 315 teeth of 80 individuals. The teeth were analysed on Orthopantomogram. TCI was calculated for unrestored mandibular premolars and molars. Pearson's correlation was applied to assess correlation between chronological age and TCI. Besides, 30(37.5%) subjects were male and 50(62.5%) female, and 140(44.4%) teeth were of male subjects and 175(55.6%) were of females. The mean correlation coefficient between chronological age and …


Prevalence Of Musculoskeletal Disorders Among Dentists In Teaching Hospitals In Karachi, Muhammad Hasan Hameed, Rabia Ghafoor, Farhan Raza Khan, Sheikh Bilal Badar Oct 2016

Prevalence Of Musculoskeletal Disorders Among Dentists In Teaching Hospitals In Karachi, Muhammad Hasan Hameed, Rabia Ghafoor, Farhan Raza Khan, Sheikh Bilal Badar

Department of Surgery Docs

Work-related musculoskeletal pain is common among healthcare professionals, including dentists. This crosssectional study was conducted to determine the prevalence of work-related musculoskeletal disorders (MSDs) among dentists. This study was carried out from January to April 2016 at various teaching hospitals of Karachi, and comprised 230 dentists. A self-administered questionnaire, adapted from a validated Nordic questionnaire, was distributed among the participants. Descriptive statistics were computed and associations of interest were analysed using chi-square test. Of the 230 forms, 182(79.11%) were included after leaving out the incomplete ones. The overall prevalence of MSDs was 138(75.8%). The most frequent reasonsfor MSDs were lack …


Rotational Mal-Alignment After Reamed Intramedullary Nailing For Tibial Shaft Fracture, Sher Khan, Yasir Mohib, Rizwan Haroon Rashid, Haroon Rashid Oct 2016

Rotational Mal-Alignment After Reamed Intramedullary Nailing For Tibial Shaft Fracture, Sher Khan, Yasir Mohib, Rizwan Haroon Rashid, Haroon Rashid

Department of Surgery Docs

Abstract

Intra-medullary (IM) nailing is standard of care for unstable tibial shaft fractures. Malrotation is very common but it is under-recognised, inpart because of variation in normal anatomy and partly due to difficulty in accurately assessing rotation. This study was planned to evaluate the frequency of rotational mal-alignment after reamed tibia IMnailing. This cross-sectional study was conducted at Aga khan University Hospital, Karachi, and comprised patients with tibia shaft fractures managed with IMnailing from January to December 2014. All the patients were assessed intra-operatively for rotational alignment using the knee and ankle fluoroscopic images. There were 81 patients with a …


Versatility Of The Anterolateral Thigh Flap: An Akuh Experience, Muhammad Fazlur Rehman, Muhammad Asif Ahsan, Muhammad Ubaid Khan, Sami Ullah, Sara Khan Oct 2016

Versatility Of The Anterolateral Thigh Flap: An Akuh Experience, Muhammad Fazlur Rehman, Muhammad Asif Ahsan, Muhammad Ubaid Khan, Sami Ullah, Sara Khan

Department of Surgery Docs

Anterolateral thigh flap is used for reconstruction of various soft tissue defects. We planned the study to evaluate the versatility of the anterolateral thigh flap as it may be used for reconstruction of head and neck, torso and extremities with minimal donor-site morbidity. The retrospective study was conducted at Aga Khan University Hospital, Karachi, and comprised date from October 2012 to December 2015. Of the 75 patients in which anterolateral thigh flap was used for reconstruction, 6(8%) flaps did not survive. The overall flap survival was 69(92%). Anterolateral thigh flap was versatile enough to provide soft tissue coverage to defects …


Two Incision Mini Open Carpal Tunnel Release- A Minimally Invasive Alternative To Endoscopic Release, Pervaiz Hashmi, Rizwan Haroon Rashid, Moiz Ali, Yasir Mohib, Naveed Baloch Oct 2016

Two Incision Mini Open Carpal Tunnel Release- A Minimally Invasive Alternative To Endoscopic Release, Pervaiz Hashmi, Rizwan Haroon Rashid, Moiz Ali, Yasir Mohib, Naveed Baloch

Department of Surgery Docs

Abstract

Surgical techniques for carpal tunnel release are constantly evolving to reduce complications. This retrospective study was planned to identify the outcome and complications associated with a new operating technique for release of carpal tunnel using two incisions. It was conducted at the Aga Khan University Hospital, Karachi, and comprised patients undergoing surgical release of carpal tunnel syndrome (CTS) between January 2011 and December 2014. Of the 54 patients,38(70.4%) cases were of right-sided CTS. The mean operating time was 12.5±4.9 minutes. Complete relief from symptoms was observed in all the patients and the only complication noted was superficial infection in …


Peri-Operative Determinants Of Prolonged Cicu Stay After Coronary Artery Bypass Graft Surgery In Elderly At A Private Tertiary Care Hospital: A Case Control Study, Fazal Khan, Shiraz Hashmi, Syed Saad Naeem,, Benish Fatima, Hashim Hanif, Mubashir Zareen Khan, Saulat Hasnain Fatimi Oct 2016

Peri-Operative Determinants Of Prolonged Cicu Stay After Coronary Artery Bypass Graft Surgery In Elderly At A Private Tertiary Care Hospital: A Case Control Study, Fazal Khan, Shiraz Hashmi, Syed Saad Naeem,, Benish Fatima, Hashim Hanif, Mubashir Zareen Khan, Saulat Hasnain Fatimi

Department of Surgery Docs

Abstract

OBJECTIVE:

To explore peri-operative risk factors associated with prolonged stay in cardiac intensive care unit among patients undergoing isolated coronary artery bypass grafting.

METHODS:

This retrospective case control study was conducted at the Aga Khan University Hospital, Karachi, comprised medical records of patients who had undergone cardiothoracic revascularisation surgery from January 2006 to December 2013. The patients were grouped into cases and controls at a ratio of 1:2 on the basis of length of stay at cardiac intensive care unit, i.e. >72 hours andanalysis.

RESULTS:

Of the 999 patients, 333(33.3%) were cases and 666(66.6%) were controls. The mean age …


A 10-Year Review Of Indications For Penetrating Keratoplasty In A Tertiary Care Setting In Karachi Pakistan, Tanveer Anjum Chaudhry, Salman Naveed Sadiq, Zubaida Sirang, Maheen Akhtar Syed, Mustafa Kamal, Khabir Ahmad Oct 2016

A 10-Year Review Of Indications For Penetrating Keratoplasty In A Tertiary Care Setting In Karachi Pakistan, Tanveer Anjum Chaudhry, Salman Naveed Sadiq, Zubaida Sirang, Maheen Akhtar Syed, Mustafa Kamal, Khabir Ahmad

Department of Surgery Docs

Abstract

The retrospective study was conducted to determine the indications and outomes of penetrating keratoplasty(PKP) in a tertiary caresetting in Pakistan. All eyes that had undergone PKP between January 2005 and December 2014 at the Aga Khan University Hospital, Karachi, were included.Data were collected on the indications of PKP, graft survival (graft clarity at final follow-up), andbest corrected visual acuity (BCVA).Kaplan-Meier\'s method was usedto analyse graft survival.Out of 437 eyes, 383(87%) were for visual purpose. Trauma-related corneal scarring 113(26.2%) was the leading cause of PKP, followed by keratoconus 74(17.1%), redo graft 56(13%), infection-related corneal opacity 46(10.6%), corneal dystrophy 44(10.2%) and …


Bacterobilia In Acute Cholecystitis: Bile Cultures' Isolates, Antibiotic Sensitivities And Antibiotic Usage. A Study On A Pakistani Population, Yousaf Bashir Hadi, Muhammad Waqas, Hafiz Muhammad Umer,, Ammar Alam, Abdul Rehman Alvi, Muhammad Rizwan Khan, Amir Hafeez Shariff Oct 2016

Bacterobilia In Acute Cholecystitis: Bile Cultures' Isolates, Antibiotic Sensitivities And Antibiotic Usage. A Study On A Pakistani Population, Yousaf Bashir Hadi, Muhammad Waqas, Hafiz Muhammad Umer,, Ammar Alam, Abdul Rehman Alvi, Muhammad Rizwan Khan, Amir Hafeez Shariff

Department of Surgery Docs

Acute cholecystitis is one of the most common acute surgical conditions. Laparoscopic cholecystectomy remains the mainstay of treatment. In patients managed non-operatively, antibiotics play an important role in the treatment of cholecystitis. The current retrospective observational study was conducted at a tertiary care hospital in Karachi, and comprised medical records of patients admitted between 2008 and 2014with acute cholecystitis and in whom bile cultures were obtained. Of the 509 patients with a mean age of 51.15 ± 13.4years, early laparoscopic cholecystectomy (within 72hours) was performed on 473(92.9%) cases, while the rest underwent percutaneous cholecystostomy. Bile cultureswere positive in 171(33.6%) patients. …


Innovations In Cardiovascular Care: Historical Perspective, Contemporary Practice, Recent Trends And Future Directions, Hasanat Sharif, Mayera Tufail Oct 2016

Innovations In Cardiovascular Care: Historical Perspective, Contemporary Practice, Recent Trends And Future Directions, Hasanat Sharif, Mayera Tufail

Department of Surgery Docs

Abstract

Cardiovascular diseases continue to be a major cause of mortality and morbidity in the world population. First open heart procedure was performed by Gibbon in 1953, since then many advancements have been introduced to the field of cardiac surgery. Minimally invasive techniques were introduced, which include minimally invasive coronary artery bypass grafting (CABG), off-pump technique, minimally invasive valve surgery or transcatheter techniques to implant stentless or sutureless valves. The hybrid strategy to address coronary disease combines catheterisation procedures with standard surgical techniques. Cardiac imaging has also progressed to provide three-dimensional images of the heart, enabling surgeons to plan procedures …


Frequency And Predictors Of Recurrence Of Bladder Tumour On First Check Cystoscopy - A Tertiary Care Hospital Experience, Muhammad Farhan, Nazim Syed Muhammad, Jibran Ahmed, Hammad Ather Oct 2016

Frequency And Predictors Of Recurrence Of Bladder Tumour On First Check Cystoscopy - A Tertiary Care Hospital Experience, Muhammad Farhan, Nazim Syed Muhammad, Jibran Ahmed, Hammad Ather

Department of Surgery Docs

Abstract

OBJECTIVE:

To determine the frequency and predictors of non-muscle invasive bladder tumour recurrence on first-check cystoscopy after transurethral resection of bladder tumour.

METHODS:

This cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, from April to November 2014, and comprised patients with a suspected newly-diagnosed urothelial cancer. Patients with non-muscle invasive disease with complete resection of all visible lesions along with deep biopsy from the tumour base were included. Patients received standard adjuvant intravesical therapy according to their risk stratification and underwent a white-light check cystoscopy at 3 months to look for tumour recurrence. Association between clinico-pathological …


Exploring Patient And Family Satisfaction In Pediatric Neurological Surgery, Randa R. Barsoom, Todd A. Maugans, James F. Burrows, Paul Rosen Oct 2016

Exploring Patient And Family Satisfaction In Pediatric Neurological Surgery, Randa R. Barsoom, Todd A. Maugans, James F. Burrows, Paul Rosen

Student Papers, Posters & Projects

Introduction Patient and family satisfaction during outpatient visits is correlated with a continuance of care and likelihood to recommend the practice to others. Additionally, patient-family satisfaction can determine the success of the practice and influence medical outcomes. Utilizing a well-validated surveys instrument, patient and family satisfaction can be explored in the office setting. Methods During a consecutive 36 month period, a standardized and validated patient satisfaction survey instrument was provided to the family members of patients who presented to two pediatric neurosurgery clinics associated with Nemours Children's Health System. The completed surveys were analyzed statistically to identify correlations between overall …


Body Image And Quality Of Life Among Postsurgical Bariatric Patients, Amy Leigh White Oct 2016

Body Image And Quality Of Life Among Postsurgical Bariatric Patients, Amy Leigh White

Psychology Theses & Dissertations

In recent decades, bariatric surgery has become an increasingly popular intervention for the treatment of morbid obesity. Bariatric surgery leads to substantial improvements in physical health (e.g., weight loss, increased life expectancy) and psychological health (e.g., body image, quality of life). After bariatric surgery, many patients undergo subsequent surgical procedures to remove excess skin (“body contouring”), which are also associated with positive medical and psychological outcomes.

The present study sought to expand upon existing research into the psychosocial outcomes of bariatric surgery, investigate correlates of patients’ desire for body contouring, and determine whether presurgical motivations were associated with postsurgical outcomes. …


10-Year Outcome Of The Thoracic Endovascular Aortic Repair (Tevar) Procedure, James K. Wu Md, Timothy S. Misselbeck, Jacob Fink, Youssef Zaki Oct 2016

10-Year Outcome Of The Thoracic Endovascular Aortic Repair (Tevar) Procedure, James K. Wu Md, Timothy S. Misselbeck, Jacob Fink, Youssef Zaki

Department of Surgery

No abstract provided.


Evaluation And Management Of Sleep Disorders In The Hand Surgery Patient., Michael P. Gaspar, Patrick M. Kane, Sidney M. Jacoby, Patrick S. Gaspar, A. Lee Osterman Oct 2016

Evaluation And Management Of Sleep Disorders In The Hand Surgery Patient., Michael P. Gaspar, Patrick M. Kane, Sidney M. Jacoby, Patrick S. Gaspar, A. Lee Osterman

Department of Orthopaedic Surgery Faculty Papers

Despite posing a significant public health threat, sleep disorders remain poorly understood and often underdiagnosed and mismanaged. Although sleep disorders are seemingly unrelated, hand surgeons should be mindful of these because numerous conditions of the upper extremity have known associations with sleep disturbances that can adversely affect patient function and satisfaction. In addition, patients with sleep disorders are at significantly higher risk for severe, even life-threatening medical comorbidities, further amplifying the role of hand surgeons in the recognition of this condition.


Gastrointestinal Stromal Tumor (Gist) Of The Treitz’S Angle– A Very Rare Cause Of High Bowel Obstruction, Mădălina Elena Tobă, Dan Florin Ungureanu, Lota Corina Georgescu, Traian Pătraşcu Sep 2016

Gastrointestinal Stromal Tumor (Gist) Of The Treitz’S Angle– A Very Rare Cause Of High Bowel Obstruction, Mădălina Elena Tobă, Dan Florin Ungureanu, Lota Corina Georgescu, Traian Pătraşcu

Journal of Mind and Medical Sciences

Gastrointestinal stromal tumors (GIST) are somewhat rare gastrointestinal tumors - approximately 1% to 3% incidence, but they are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs are usually found in the stomach or small intestine but can occur anywhere within the gastrointestinal tract, even in extremely uncommon locations like duodeno-jejunal flexure. Only 3% – 5% of GISTs are located in the duodenum and tumors occurring in the angle of Treitz are even rarer, most published studies being case reports. These tumors have a size ranging from small lesions to large masses and can cause digestive bleeding or high …


A Retrospective Surgical Experience Regarding Open And Laparoscopic Procedures Of The Hepatic Hydatid Cyst With An Up To Date Complete Review Of The Literature And A Focus On Original Romanian Techniques, Diana Moldovan, Cosmin Alec Moldovan, Laurentiu Ungurianu, Dan Florin Ungureanu Sep 2016

A Retrospective Surgical Experience Regarding Open And Laparoscopic Procedures Of The Hepatic Hydatid Cyst With An Up To Date Complete Review Of The Literature And A Focus On Original Romanian Techniques, Diana Moldovan, Cosmin Alec Moldovan, Laurentiu Ungurianu, Dan Florin Ungureanu

Journal of Mind and Medical Sciences

Introduction: Even though the development of the recent anti-parasitic drugs has led to a high degree of efficiency, surgical treatment still remains the gold standard for a number of conditions. Material and method. The authors discuss a series of 90 cases in a multicenter and retrospective analysis that stretches over 20 years. Results and discussions. These cases have been diagnosed and treated – through different surgical methods, both classical and laparoscopic – for hepatic hydatid cysts. The paper also presents a short review of the major types of surgical procedures cited in the international literature, with a …


A Proposed Therapeutic Algorithm Based On Multiple Case Analysis Regarding The Repair Options Of Iatrogenic Biliary Lesions Following Open And Laparoscopic Surgery, Cosmin Alec Moldovan, Dan Florin Ungureanu, Vladimir Beliș Sep 2016

A Proposed Therapeutic Algorithm Based On Multiple Case Analysis Regarding The Repair Options Of Iatrogenic Biliary Lesions Following Open And Laparoscopic Surgery, Cosmin Alec Moldovan, Dan Florin Ungureanu, Vladimir Beliș

Journal of Mind and Medical Sciences

Introduction: the problem of the iatrogenic lesions of the main biliary pathways is far from being completely clarified and still represents a serious surgical situation, during both open and laparoscopic surgeries. The outcome of these situations is closely linked with the actual moment of discovery of the lesion and the surgical methods for repairing such defects and implies a great number of options, such as reconstructive, derivative and substitutive techniques. Objectives: the goal of this paper is to present an algorithm of choices and their consequences for clinical conduit in the case of iatrogenic biliary lesions discovered in …


Helicobacter Pylori: Types Of Diseases, Diagnosis, Treatment And Causes Of Therapeutic Failure, Cosmin Vasile Obleaga, Cristin Constantin Vere, Ionica Daniel Valcea, Mihai Calin Ciorbagiu, Emil Moraru, Cecil Sorin Mirea Sep 2016

Helicobacter Pylori: Types Of Diseases, Diagnosis, Treatment And Causes Of Therapeutic Failure, Cosmin Vasile Obleaga, Cristin Constantin Vere, Ionica Daniel Valcea, Mihai Calin Ciorbagiu, Emil Moraru, Cecil Sorin Mirea

Journal of Mind and Medical Sciences

Acute upper gastrointestinal lesions have a multifactorial etiology but, regardless of the cause, they are related to mucosal barrier destruction. Since Helicobacter pylori induces a superficial chronic gastritis with the infiltration of neutrophils in the mucosa, it was speculated that Helicobacter pylori infection could also cause bleeding lesions. The diagnosis, the proper treatment and the revaluation of its effectiveness actually represent the prophylaxis of some diseases such as peptic ulcer, gastric lymphoma or mucosa-associated lymphoid tissue (MALT) and gastric cancer. These diseases and their severe complications are life-threatening for the patient. Periodic renewal of the treatment and knowing the real …


Co-Existing Spinal Intradural Ependymal Cyst And Sacral Tarlov Cyst In Adult-Onset Tethered Cord Syndrome With Syringomyelia: Case Report And Literature Review, Hamid H. Rai, Muhammad F. Khan, Ather Enam, Imtiaz Hashmi Sep 2016

Co-Existing Spinal Intradural Ependymal Cyst And Sacral Tarlov Cyst In Adult-Onset Tethered Cord Syndrome With Syringomyelia: Case Report And Literature Review, Hamid H. Rai, Muhammad F. Khan, Ather Enam, Imtiaz Hashmi

Section of Neurosurgery

Background: Synchronous spinal intradural ependymal cysts and sacral Tarlov cysts in adult onset tethered cord syndrome are extremely rare.
Case description: A 23-year-old male presented with back pain radiating into both lower extremities, accompanied by acute onset of gait difficulty and sphincter dysfunction. Magnetic resonance imaging identified a low lying conus medullaris, syringomyelia with septations extending from T12 to S1, a tethered cord, and a thickened filum terminale with a sacral Tarlov cyst. The patient underwent a L3-4 laminectomy for decompression of syringomyelia and excision/biopsy of a space occupying lesion along with S1-2 laminectomy for cord untethering and Tarlov cyst …


Impact Of Hur Inhibition By The Small Molecule Ms-444 On Colorectal Cancer Cell Tumorigenesis., Fernando F. Blanco, Ranjan Preet, Andrea Aguado, Vikalp Vishwakarma, Laura E. Stevens, Alok Vyas, Subhash Padhye, Liang Xu, Scott J. Weir, Shrikant Anant, Nicole Meisner-Kober, Jonathan R. Brody, Dan A. Dixon Sep 2016

Impact Of Hur Inhibition By The Small Molecule Ms-444 On Colorectal Cancer Cell Tumorigenesis., Fernando F. Blanco, Ranjan Preet, Andrea Aguado, Vikalp Vishwakarma, Laura E. Stevens, Alok Vyas, Subhash Padhye, Liang Xu, Scott J. Weir, Shrikant Anant, Nicole Meisner-Kober, Jonathan R. Brody, Dan A. Dixon

Department of Surgery Faculty Papers

Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. Overexpression of the RNA-binding protein HuR (ELAVL1) occurs during colon tumorigenesis and is abnormally present within the cytoplasm, where it post-transcriptionally regulates genes through its interaction with 3'UTR AU-rich elements (AREs). Here, we examine the therapeutic potential of targeting HuR using MS-444, a small molecule HuR inhibitor. Treatment of CRC cells with MS-444 resulted in growth inhibition and increased apoptotic gene expression, while similar treatment doses …


Cellular And Morphological Alterations In The Vastus Lateralis Muscle As The Result Of Acl Injury And Reconstruction, Brian W. Noehren, Anders H. Andersen, Peter A. Hardy, Darren L. Johnson, Mary Lloyd Ireland, Katherine L. Thompson, Bruce Damon Sep 2016

Cellular And Morphological Alterations In The Vastus Lateralis Muscle As The Result Of Acl Injury And Reconstruction, Brian W. Noehren, Anders H. Andersen, Peter A. Hardy, Darren L. Johnson, Mary Lloyd Ireland, Katherine L. Thompson, Bruce Damon

Physical Therapy Faculty Publications

Background: Individuals who have had an anterior cruciate ligament (ACL) tear and reconstruction continue to experience substantial knee extensor strength loss despite months of physical therapy. Identification of the alterations in muscle morphology and cellular composition are needed to understand potential mechanisms of muscle strength loss, initially as the result of the injury and subsequently from surgery and rehabilitation.

Methods: We performed diffusion tensor imaging-magnetic resonance imaging and analyzed muscle biopsies from the vastus lateralis of both the affected and unaffected limbs before surgery and again from the reconstructed limb following the completion of rehabilitation. Immunohistochemistry was done to determine …


Four-Dimensional (4d) Subharmonic Aided Pressure Estimation For Monitoring Neoadjuvant Chemotherapy Response Of Breast Cancer, Kibo Nam, Maria Stanczak, Anush Sridharan, Adam C. Berger, Tiffany Avery, John R. Eisenbrey, Flemming Forsberg Sep 2016

Four-Dimensional (4d) Subharmonic Aided Pressure Estimation For Monitoring Neoadjuvant Chemotherapy Response Of Breast Cancer, Kibo Nam, Maria Stanczak, Anush Sridharan, Adam C. Berger, Tiffany Avery, John R. Eisenbrey, Flemming Forsberg

Department of Radiology Posters

Introduction

Neoadjuvant chemotherapy is a well-established treatment option for patients with non-metastatic breast cancer. The patient response is correlated with survival. However, the optimal method for monitoring neoadjuvant therapy response has not been established. One factor that may affect the response of neoadjuvant therapy is the interstitial fluid pressure (IFP). Increased IFP prevents an effective delivery of therapeutic agents and reduces the efficacy of the therapy. Recently, subharmonic-aided pressure estimation (SHAPE) using contrast-enhanced ultrasound (CEUS) has been developed and its potential was demonstrated in animals as a non-invasive technique for IFP measurements. The SHAPE method estimates IFP based on the …


Higher Body Mass Index (Bmi) And Low-Volume Surgeons Confer Increased Operative Complications In Anterior Spinal Exposures, Aisha Shaheen, Md, Mha, Naveed A. Rahman, Abhay Mathur, Bs, Deepika Koganti, Md, Pgy-4, Alec C. Beekley, Md, Facs, John R. Eisenbrey, Phd, Joshua A. Marks, Md, Michael S. Weinstein, Md, Facs, Fccm, Murray J. Cohen, Md, Facs Sep 2016

Higher Body Mass Index (Bmi) And Low-Volume Surgeons Confer Increased Operative Complications In Anterior Spinal Exposures, Aisha Shaheen, Md, Mha, Naveed A. Rahman, Abhay Mathur, Bs, Deepika Koganti, Md, Pgy-4, Alec C. Beekley, Md, Facs, John R. Eisenbrey, Phd, Joshua A. Marks, Md, Michael S. Weinstein, Md, Facs, Fccm, Murray J. Cohen, Md, Facs

Department of Surgery Posters

Background

Anterior spinal exposures performed by spine or vascular surgeons have a known complication rate of 2-11%. We present the largest single institution experience of anterior spinal exposures performed by Acute Care Surgeons.

The purpose of this study was to characterize the incidence of vascular and visceral injuries during spinal exposures and to identify risk factors contributing to operative complications during the exposure. We hypothesized that patients with a BMI >30 as well as low-volume surgeons (<20 >operations) would have an increased complication rate.

Poster presented at: American Association for Surgery of Trauma (AAST) in Hawaii


Prevalence And Determinants Of Metabolic Syndrome In Qatar: Results From A National Health Survey, Mohamed Al-Thani, Al Anoud M. Al-Thani, Sohaila Cheema, Javaid Sheikh, Ravinder Mamtani, Albert B. Lowenfels, Walaa F. Al-Chetachi, Badria Almalki, Shamseldin A. Hassan Khalifa, Ahmad O. Haj Bakri, Patrick Maisonneuve Sep 2016

Prevalence And Determinants Of Metabolic Syndrome In Qatar: Results From A National Health Survey, Mohamed Al-Thani, Al Anoud M. Al-Thani, Sohaila Cheema, Javaid Sheikh, Ravinder Mamtani, Albert B. Lowenfels, Walaa F. Al-Chetachi, Badria Almalki, Shamseldin A. Hassan Khalifa, Ahmad O. Haj Bakri, Patrick Maisonneuve

NYMC Faculty Publications

OBJECTIVES: To determine optimum measurements for abdominal obesity and to assess the prevalence and determinants of metabolic syndrome in Qatar.

DESIGN: National health survey.

SETTING: Qatar National STEPwise Survey conducted by the Supreme Council of Health during 2012.

PARTICIPANTS: 2496 Qatari citizens aged 18-64 representative of the general population.

PRIMARY AND SECONDARY OUTCOME MEASURES: Measure of obesity (body mass index, waist circumference or waist-to-height ratio) that best identified the presence of at least 2 other factors of metabolic syndrome; cut-off values of waist circumference; frequency of metabolic syndrome.

RESULTS: Waist circumference ≥102 for men and ≥94 cm for women was …


Department Of Surgery Update, September 2016, Wright State University Department Of Surgery Sep 2016

Department Of Surgery Update, September 2016, Wright State University Department Of Surgery

Department of Surgery Updates

A four page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity, and more.


Respiratory Rate Variability In Sleeping Adults Without Obstructive Sleep Apnea, Guillermo Gutierrez, Jeffrey Williams, Ghadah Alrehaili, Anna Mclean, Ramin Pirouz, Richard L. Amdur, Vivek Jain, Jalil Ahari, Amandeep Bawa, Shawn Kimbro Sep 2016

Respiratory Rate Variability In Sleeping Adults Without Obstructive Sleep Apnea, Guillermo Gutierrez, Jeffrey Williams, Ghadah Alrehaili, Anna Mclean, Ramin Pirouz, Richard L. Amdur, Vivek Jain, Jalil Ahari, Amandeep Bawa, Shawn Kimbro

Surgery Faculty Publications

Characterizing respiratory rate variability (RRV) in humans during sleep is challenging, since it requires the analysis of respiratory signals over a period of several hours. These signals are easily distorted by movement and volitional inputs. We applied the method of spectral analysis to the nasal pressure transducer signal in 38 adults with no obstructive sleep apnea, defined by an apnea‐hypopnea index <5, who underwent all‐night polysomnography (PSG). Our aim was to detect and quantitate RRV during the various sleep stages, including wakefulness. The nasal pressure transducer signal was acquired at 100 Hz and consecutive frequency spectra were generated for the length of the PSG with the Fast Fourier Transform. For each spectrum, we computed the amplitude ratio of the first harmonic peak to the zero frequency peak (H1/DC), and defined as RRV as (100 − H1/DC) %. RRV was greater during wakefulness compared to any sleep stage, including rapid‐eye‐movement. Furthermore, RRV correlated with the depth of sleep, being lowest during N3. Patients spent most their sleep time supine, but we found no correlation between RRV and body position. There was a correlation between respiratory rate and sleep stage, being greater in wakefulness than in any sleep stage. We conclude that RRV varies according to sleep stage. Moreover, spectral analysis of nasal pressure signal appears to provide a valid measure of RRV during sleep. It remains to be seen if the method can differentiate normal from pathological sleep patterns.


Spontaneous Hemarthrosis Of The Knee - Late Complication Of Flexible Femur Nailing: A Case Report., Indranil V Kushare, Matthew E. Oetgen, Suzanne J Walters Sep 2016

Spontaneous Hemarthrosis Of The Knee - Late Complication Of Flexible Femur Nailing: A Case Report., Indranil V Kushare, Matthew E. Oetgen, Suzanne J Walters

Orthopaedic Surgery Faculty Publications

We present a case report of acute spontaneous knee hemarthosis due to erosion of the nail through the knee joint capsule in a boy, seven months following retrograde flexible nailing for fractured femur. Careful positioning of the location of the insertion site of flexible nails and proper nail tip management are important to avoid this rare late complication.